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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial

Gene

sdha-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial (sdha-b), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (XELAEV_18031324mg), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (XELAEV_18033323mg), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (XELAEV_18037955mg), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial (sdha-a)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei278FADBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei311SubstrateBy similarity1
Active sitei343Proton acceptorBy similarity1
Binding sitei410SubstrateBy similarity1
Binding sitei443FADBy similarity1
Binding sitei454SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 76FADBy similarity6
Nucleotide bindingi94 – 109FADBy similarityAdd BLAST16
Nucleotide bindingi459 – 460FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processElectron transport, Transport, Tricarboxylic acid cycle
LigandFAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II A
Short name:
Fp
Gene namesi
Name:sdha-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-17344569 sdha

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000027230546 – 665Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrialAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiQ6PA58

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6PA58
SMRiQ6PA58
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001461
KOiK00234

Family and domain databases

Gene3Di3.50.50.60, 2 hits
3.90.700.10, 1 hit
InterProiView protein in InterPro
IPR003953 FAD-binding_2
IPR036188 FAD/NAD-bd_sf
IPR003952 FRD_SDH_FAD_BS
IPR037099 Fum_R/Succ_DH_flav-like_C_sf
IPR015939 Fum_Rdtase/Succ_DH_flav-like_C
IPR027477 Succ_DH/fumarate_Rdtase_cat_sf
IPR011281 Succ_DH_flav_su_fwd
IPR014006 Succ_Dhase_FrdA_Gneg
PfamiView protein in Pfam
PF00890 FAD_binding_2, 1 hit
PF02910 Succ_DH_flav_C, 1 hit
SUPFAMiSSF46977 SSF46977, 1 hit
SSF51905 SSF51905, 2 hits
SSF56425 SSF56425, 1 hit
TIGRFAMsiTIGR01816 sdhA_forward, 1 hit
TIGR01812 sdhA_frdA_Gneg, 1 hit
PROSITEiView protein in PROSITE
PS00504 FRD_SDH_FAD_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PA58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKVAPSR LLSRALQLAS RVQNCTPTVT TARRNFHFTV YGRKDTSAKV
60 70 80 90 100
SDSISTQYPV VDHEFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR
110 120 130 140 150
SHTVAAQGGI NAALGNMEDD DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP
160 170 180 190 200
ASVIELENYG MPFSRTEQGK IYQRAFGGQS LKYGKGGQAH RCCCVADRTG
210 220 230 240 250
HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL CMEDGSIHRF
260 270 280 290 300
RAKNTVIATG GYGRTFFSCT SAHTSTGDGT AMVTRAGLPC QDLEFVQFHP
310 320 330 340 350
TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM
360 370 380 390 400
TIEIREGRGC GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK
410 420 430 440 450
EPIPVLPTVH YNMGGIPTNY KGQVITHVNG EDRVVPGLYS CGEAASASVH
460 470 480 490 500
GANRLGANSL LDLVVFGRAC ALSIAESCKP GEAVPSIKEN AGEESVANLD
510 520 530 540 550
KLRYANGSTR TSEIRINMQK TMQNHAAVFR TGSVLKEGCE KLSVINSSMD
560 570 580 590 600
DIKTFDRGIV WNTDLVETLE LQNLMLCALQ TINGAEARKE SRGAHAREDY
610 620 630 640 650
KVRIDEYDFS KPLQGQQKKS FNEHWRKHTL SYVDKKGKVS LEYRPVIDTT
660
LNEDCASVPP AIRSY
Length:665
Mass (Da):72,854
Last modified:July 5, 2004 - v1
Checksum:i2C5F88CABBE479D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060446 mRNA Translation: AAH60446.1
RefSeqiNP_001083473.1, NM_001090004.1
UniGeneiXl.83156

Genome annotation databases

GeneIDi398946
KEGGixla:398946

Similar proteinsi

Entry informationi

Entry nameiSDHAA_XENLA
AccessioniPrimary (citable) accession number: Q6PA58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health