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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial

Gene

sdha-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.By similarity

Cofactori

FADBy similarity

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).By similarity
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (sdhb), Succinate dehydrogenase [ubiquinone] flavoprotein subunit B, mitochondrial (sdha-b), Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial (sdha-a)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei278FADBy similarity1
Binding sitei299SubstrateBy similarity1
Binding sitei311SubstrateBy similarity1
Active sitei343Proton acceptorBy similarity1
Binding sitei410SubstrateBy similarity1
Binding sitei443FADBy similarity1
Binding sitei454SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi71 – 76FADBy similarity6
Nucleotide bindingi94 – 109FADBy similarityAdd BLAST16
Nucleotide bindingi459 – 460FADBy similarity2

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial (EC:1.3.5.1By similarity)
Alternative name(s):
Flavoprotein subunit of complex II A
Short name:
Fp
Gene namesi
Name:sdha-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

  • Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45MitochondrionBy similarityAdd BLAST45
ChainiPRO_000027230546 – 665Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrialAdd BLAST620

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102Tele-8alpha-FAD histidineBy similarity1

Proteomic databases

PRIDEiQ6PA58.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6PA58.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001461.
KOiK00234.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PA58-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALLKVAPSR LLSRALQLAS RVQNCTPTVT TARRNFHFTV YGRKDTSAKV
60 70 80 90 100
SDSISTQYPV VDHEFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR
110 120 130 140 150
SHTVAAQGGI NAALGNMEDD DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP
160 170 180 190 200
ASVIELENYG MPFSRTEQGK IYQRAFGGQS LKYGKGGQAH RCCCVADRTG
210 220 230 240 250
HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL CMEDGSIHRF
260 270 280 290 300
RAKNTVIATG GYGRTFFSCT SAHTSTGDGT AMVTRAGLPC QDLEFVQFHP
310 320 330 340 350
TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM
360 370 380 390 400
TIEIREGRGC GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK
410 420 430 440 450
EPIPVLPTVH YNMGGIPTNY KGQVITHVNG EDRVVPGLYS CGEAASASVH
460 470 480 490 500
GANRLGANSL LDLVVFGRAC ALSIAESCKP GEAVPSIKEN AGEESVANLD
510 520 530 540 550
KLRYANGSTR TSEIRINMQK TMQNHAAVFR TGSVLKEGCE KLSVINSSMD
560 570 580 590 600
DIKTFDRGIV WNTDLVETLE LQNLMLCALQ TINGAEARKE SRGAHAREDY
610 620 630 640 650
KVRIDEYDFS KPLQGQQKKS FNEHWRKHTL SYVDKKGKVS LEYRPVIDTT
660
LNEDCASVPP AIRSY
Length:665
Mass (Da):72,854
Last modified:July 5, 2004 - v1
Checksum:i2C5F88CABBE479D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060446 mRNA. Translation: AAH60446.1.
RefSeqiNP_001083473.1. NM_001090004.1.
UniGeneiXl.83156.

Genome annotation databases

GeneIDi398946.
KEGGixla:398946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060446 mRNA. Translation: AAH60446.1.
RefSeqiNP_001083473.1. NM_001090004.1.
UniGeneiXl.83156.

3D structure databases

ProteinModelPortaliQ6PA58.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6PA58.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi398946.
KEGGixla:398946.

Phylogenomic databases

HOVERGENiHBG001461.
KOiK00234.

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.50.50.60. 2 hits.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD-binding_2.
IPR023753. FAD/NAD-binding_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR030664. SdhA/FrdA/AprA.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000171. SDHA_APRA_LASPO. 1 hit.
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF51905. SSF51905. 2 hits.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSDHAA_XENLA
AccessioniPrimary (citable) accession number: Q6PA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.