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Q6PA58

- SDHAA_XENLA

UniProt

Q6PA58 - SDHAA_XENLA

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Protein

Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial

Gene

sdha-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

FAD.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei278 – 2781FADBy similarity
Binding sitei299 – 2991SubstrateBy similarity
Binding sitei311 – 3111SubstrateBy similarity
Active sitei343 – 3431Proton acceptorBy similarity
Binding sitei410 – 4101SubstrateBy similarity
Binding sitei443 – 4431FADBy similarity
Binding sitei454 – 4541SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi71 – 766FADBy similarity
Nucleotide bindingi94 – 10916FADBy similarityAdd
BLAST
Nucleotide bindingi459 – 4602FADBy similarity

GO - Molecular functioni

  1. flavin adenine dinucleotide binding Source: InterPro
  2. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC

GO - Biological processi

  1. respiratory electron transport chain Source: UniProtKB
  2. succinate metabolic process Source: UniProtKB
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Flavoprotein subunit of complex II A
Short name:
Fp
Gene namesi
Name:sdha-a
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4343MitochondrionSequence AnalysisAdd
BLAST
Chaini44 – 665622Succinate dehydrogenase [ubiquinone] flavoprotein subunit A, mitochondrialPRO_0000272305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei102 – 1021Tele-8alpha-FAD histidineBy similarity

Proteomic databases

PRIDEiQ6PA58.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) sdha, iron-sulfur protein (IP) sdhb, and a cytochrome b560 composed of sdhc and sdhd. Interacts with sdhaf2/sdh5; interaction is required for FAD attachment (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6PA58.
SMRiQ6PA58. Positions 54-665.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG001461.
KOiK00234.

Family and domain databases

Gene3Di1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProiIPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view]
PfamiPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
SUPFAMiSSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsiTIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEiPS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6PA58-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALLKVAPSR LLSRALQLAS RVQNCTPTVT TARRNFHFTV YGRKDTSAKV
60 70 80 90 100
SDSISTQYPV VDHEFDAVVV GAGGAGLRAA FGLSEAGFNT ACITKLFPTR
110 120 130 140 150
SHTVAAQGGI NAALGNMEDD DWRWHFYDTV KGSDWLGDQD AIHYMTEQAP
160 170 180 190 200
ASVIELENYG MPFSRTEQGK IYQRAFGGQS LKYGKGGQAH RCCCVADRTG
210 220 230 240 250
HSLLHTLYGR SLRYDTSYFV EYFALDLLME NGECRGVIAL CMEDGSIHRF
260 270 280 290 300
RAKNTVIATG GYGRTFFSCT SAHTSTGDGT AMVTRAGLPC QDLEFVQFHP
310 320 330 340 350
TGIYGAGCLI TEGCRGEGGI LINSEGERFM ERYAPVAKDL ASRDVVSRSM
360 370 380 390 400
TIEIREGRGC GKDKDHVYLQ LHHLPPSQLA SRLPGISETA MIFAGVDVTK
410 420 430 440 450
EPIPVLPTVH YNMGGIPTNY KGQVITHVNG EDRVVPGLYS CGEAASASVH
460 470 480 490 500
GANRLGANSL LDLVVFGRAC ALSIAESCKP GEAVPSIKEN AGEESVANLD
510 520 530 540 550
KLRYANGSTR TSEIRINMQK TMQNHAAVFR TGSVLKEGCE KLSVINSSMD
560 570 580 590 600
DIKTFDRGIV WNTDLVETLE LQNLMLCALQ TINGAEARKE SRGAHAREDY
610 620 630 640 650
KVRIDEYDFS KPLQGQQKKS FNEHWRKHTL SYVDKKGKVS LEYRPVIDTT
660
LNEDCASVPP AIRSY
Length:665
Mass (Da):72,854
Last modified:July 5, 2004 - v1
Checksum:i2C5F88CABBE479D5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060446 mRNA. Translation: AAH60446.1.
RefSeqiNP_001083473.1. NM_001090004.1.
UniGeneiXl.83156.

Genome annotation databases

GeneIDi398946.
KEGGixla:398946.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060446 mRNA. Translation: AAH60446.1 .
RefSeqi NP_001083473.1. NM_001090004.1.
UniGenei Xl.83156.

3D structure databases

ProteinModelPortali Q6PA58.
SMRi Q6PA58. Positions 54-665.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6PA58.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398946.
KEGGi xla:398946.

Phylogenomic databases

HOVERGENi HBG001461.
KOi K00234.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .

Family and domain databases

Gene3Di 1.20.58.100. 1 hit.
3.90.700.10. 1 hit.
InterProi IPR003953. FAD_bind_dom.
IPR003952. FRD_SDH_FAD_BS.
IPR015939. Fum_Rdtase/Succ_DH_flav-like_C.
IPR027477. Succ_DH/fumarate_Rdtase_cat.
IPR011281. Succ_DH_flav_su_fwd.
IPR014006. Succ_Dhase_FrdA_Gneg.
[Graphical view ]
Pfami PF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view ]
SUPFAMi SSF46977. SSF46977. 1 hit.
SSF56425. SSF56425. 1 hit.
TIGRFAMsi TIGR01816. sdhA_forward. 1 hit.
TIGR01812. sdhA_frdA_Gneg. 1 hit.
PROSITEi PS00504. FRD_SDH_FAD_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry nameiSDHAA_XENLA
AccessioniPrimary (citable) accession number: Q6PA58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3