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Q6PA06

- ATLA2_MOUSE

UniProt

Q6PA06 - ATLA2_MOUSE

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Protein
Atlastin-2
Gene
Atl2, Arl6ip2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi101 – 1088GTP By similarity
Nucleotide bindingi145 – 1473GTP By similarity
Nucleotide bindingi244 – 2452GTP By similarity
Nucleotide bindingi303 – 3064GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTPase activity Source: InterPro
  3. identical protein binding Source: UniProtKB
  4. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. Golgi organization Source: UniProtKB
  2. endoplasmic reticulum organization Source: UniProtKB
  3. protein homooligomerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Atlastin-2 (EC:3.6.5.-)
Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 2
Short name:
ARL-6-interacting protein 2
Short name:
Aip-2
Gene namesi
Name:Atl2
Synonyms:Arl6ip2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1929492. Atl2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 476476Cytoplasmic By similarity
Add
BLAST
Transmembranei477 – 49721Helical; Reviewed prediction
Add
BLAST
Topological domaini498 – 4992Lumenal Reviewed prediction
Transmembranei500 – 52021Helical; Reviewed prediction
Add
BLAST
Topological domaini521 – 58363Cytoplasmic By similarity
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 583583Atlastin-2
PRO_0000287107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6PA06.
PaxDbiQ6PA06.
PRIDEiQ6PA06.

PTM databases

PhosphoSiteiQ6PA06.

Expressioni

Gene expression databases

ArrayExpressiQ6PA06.
BgeeiQ6PA06.
GenevestigatoriQ6PA06.

Interactioni

Subunit structurei

Interacts with REEP5 and RTN3.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6PA06.
SMRiQ6PA06. Positions 57-469.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 336246GB1/RHD3-type G
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili256 – 28429 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi18 – 214Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG325148.
GeneTreeiENSGT00390000008959.
HOGENOMiHOG000234332.
HOVERGENiHBG062891.
InParanoidiQ6PA06.
KOiK17339.
OMAiAREIYCK.
OrthoDBiEOG7H4DTH.
PhylomeDBiQ6PA06.
TreeFamiTF105251.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF02263. GBP. 1 hit.
[Graphical view]
SUPFAMiSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6PA06-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAEGDEAARR QQPQQGLRRR RQTSDSSVGV NHVSSTTSLG EDYEDDDLVN    50
SDEVMKKPCP VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA 100
GAFRKGKSFL LDFMLRYMYN KDSQSWIGGN NEPLTGFTWR GGCERETTGI 150
QVWNEVFVID RPNGTKVAVL LMDTQGAFDS QSTIKDCATV FALSTMTSSV 200
QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM FLIRDWSYPY 250
EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 300
LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR 350
DLVEYFKAYI KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDVYCKSMEQ 400
VCGGDKPYIA PSDLERKHLD LKEVALKQFR SVKKMGGDEF CRRYQDQLEA 450
EIEETYANFI KHNDGKNIFY AARTPATLFA VMFAMYIISG LTGFIGLNSI 500
AVLCNLVMGL ALTSLCTWAY VKYSGEFREI GTMIDQIAET LWEQVLKPLG 550
DNLMEENIRQ SVTNSIKAGL TDQVSHHARL KTD 583
Length:583
Mass (Da):66,224
Last modified:July 5, 2004 - v1
Checksum:i9530B0F2077FE2D3
GO
Isoform 2 (identifier: Q6PA06-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Show »
Length:388
Mass (Da):44,356
Checksum:i17BF792FB97242ED
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 195195Missing in isoform 2.
VSP_025311Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti466 – 4661K → R in BAE22763. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135988 mRNA. Translation: BAE22763.1.
BC060501 mRNA. Translation: AAH60501.1.
CCDSiCCDS37700.1. [Q6PA06-1]
RefSeqiNP_062691.3. NM_019717.3. [Q6PA06-1]
NP_835151.2. NM_178050.4.
UniGeneiMm.175403.

Genome annotation databases

EnsembliENSMUST00000068282; ENSMUSP00000064758; ENSMUSG00000059811. [Q6PA06-1]
GeneIDi56298.
KEGGimmu:56298.
UCSCiuc008dqe.1. mouse. [Q6PA06-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK135988 mRNA. Translation: BAE22763.1 .
BC060501 mRNA. Translation: AAH60501.1 .
CCDSi CCDS37700.1. [Q6PA06-1 ]
RefSeqi NP_062691.3. NM_019717.3. [Q6PA06-1 ]
NP_835151.2. NM_178050.4.
UniGenei Mm.175403.

3D structure databases

ProteinModelPortali Q6PA06.
SMRi Q6PA06. Positions 57-469.
ModBasei Search...

PTM databases

PhosphoSitei Q6PA06.

Proteomic databases

MaxQBi Q6PA06.
PaxDbi Q6PA06.
PRIDEi Q6PA06.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068282 ; ENSMUSP00000064758 ; ENSMUSG00000059811 . [Q6PA06-1 ]
GeneIDi 56298.
KEGGi mmu:56298.
UCSCi uc008dqe.1. mouse. [Q6PA06-1 ]

Organism-specific databases

CTDi 64225.
MGIi MGI:1929492. Atl2.

Phylogenomic databases

eggNOGi NOG325148.
GeneTreei ENSGT00390000008959.
HOGENOMi HOG000234332.
HOVERGENi HBG062891.
InParanoidi Q6PA06.
KOi K17339.
OMAi AREIYCK.
OrthoDBi EOG7H4DTH.
PhylomeDBi Q6PA06.
TreeFami TF105251.

Miscellaneous databases

NextBioi 312226.
PROi Q6PA06.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6PA06.
Bgeei Q6PA06.
Genevestigatori Q6PA06.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF02263. GBP. 1 hit.
[Graphical view ]
SUPFAMi SSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEi PS51715. G_GB1_RHD3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Oocyte.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Eye.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  4. "A class of dynamin-like GTPases involved in the generation of the tubular ER network."
    Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
    Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH REEP5 AND RTN3.

Entry informationi

Entry nameiATLA2_MOUSE
AccessioniPrimary (citable) accession number: Q6PA06
Secondary accession number(s): Q3UX01, Q7TMM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi