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Q6PA06 (ATLA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Atlastin-2

EC=3.6.5.-
Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 2
Short name=ARL-6-interacting protein 2
Short name=Aip-2
Gene names
Name:Atl2
Synonyms:Arl6ip2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length583 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis By similarity.

Subunit structure

Interacts with REEP5 and RTN3. Ref.4

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.

Contains 1 GB1/RHD3-type G (guanine nucleotide-binding) domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6PA06-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6PA06-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 583583Atlastin-2
PRO_0000287107

Regions

Topological domain1 – 476476Cytoplasmic By similarity
Transmembrane477 – 49721Helical; Potential
Topological domain498 – 4992Lumenal Potential
Transmembrane500 – 52021Helical; Potential
Topological domain521 – 58363Cytoplasmic By similarity
Domain91 – 336246GB1/RHD3-type G
Nucleotide binding101 – 1088GTP By similarity
Nucleotide binding145 – 1473GTP By similarity
Nucleotide binding244 – 2452GTP By similarity
Nucleotide binding303 – 3064GTP By similarity
Coiled coil256 – 28429 Potential
Compositional bias18 – 214Poly-Arg

Amino acid modifications

Modified residue241Phosphoserine By similarity

Natural variations

Alternative sequence1 – 195195Missing in isoform 2.
VSP_025311

Experimental info

Sequence conflict4661K → R in BAE22763. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 9530B0F2077FE2D3

FASTA58366,224
        10         20         30         40         50         60 
MAEGDEAARR QQPQQGLRRR RQTSDSSVGV NHVSSTTSLG EDYEDDDLVN SDEVMKKPCP 

        70         80         90        100        110        120 
VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA GAFRKGKSFL LDFMLRYMYN 

       130        140        150        160        170        180 
KDSQSWIGGN NEPLTGFTWR GGCERETTGI QVWNEVFVID RPNGTKVAVL LMDTQGAFDS 

       190        200        210        220        230        240 
QSTIKDCATV FALSTMTSSV QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM 

       250        260        270        280        290        300 
FLIRDWSYPY EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 

       310        320        330        340        350        360 
LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR DLVEYFKAYI 

       370        380        390        400        410        420 
KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDVYCKSMEQ VCGGDKPYIA PSDLERKHLD 

       430        440        450        460        470        480 
LKEVALKQFR SVKKMGGDEF CRRYQDQLEA EIEETYANFI KHNDGKNIFY AARTPATLFA 

       490        500        510        520        530        540 
VMFAMYIISG LTGFIGLNSI AVLCNLVMGL ALTSLCTWAY VKYSGEFREI GTMIDQIAET 

       550        560        570        580 
LWEQVLKPLG DNLMEENIRQ SVTNSIKAGL TDQVSHHARL KTD 

« Hide

Isoform 2 [UniParc].

Checksum: 17BF792FB97242ED
Show »

FASTA38844,356

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Strain: C57BL/6J.
Tissue: Oocyte.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Eye.
[3]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Liver.
[4]"A class of dynamin-like GTPases involved in the generation of the tubular ER network."
Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH REEP5 AND RTN3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK135988 mRNA. Translation: BAE22763.1.
BC060501 mRNA. Translation: AAH60501.1.
CCDSCCDS37700.1. [Q6PA06-1]
RefSeqNP_062691.3. NM_019717.3. [Q6PA06-1]
NP_835151.2. NM_178050.4.
UniGeneMm.175403.

3D structure databases

ProteinModelPortalQ6PA06.
SMRQ6PA06. Positions 57-469.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ6PA06.

Proteomic databases

MaxQBQ6PA06.
PaxDbQ6PA06.
PRIDEQ6PA06.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000068282; ENSMUSP00000064758; ENSMUSG00000059811. [Q6PA06-1]
GeneID56298.
KEGGmmu:56298.
UCSCuc008dqe.1. mouse. [Q6PA06-1]

Organism-specific databases

CTD64225.
MGIMGI:1929492. Atl2.

Phylogenomic databases

eggNOGNOG325148.
GeneTreeENSGT00390000008959.
HOGENOMHOG000234332.
HOVERGENHBG062891.
InParanoidQ6PA06.
KOK17339.
OMAAREIYCK.
OrthoDBEOG7H4DTH.
PhylomeDBQ6PA06.
TreeFamTF105251.

Gene expression databases

ArrayExpressQ6PA06.
BgeeQ6PA06.
GenevestigatorQ6PA06.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
InterProIPR003191. Guanylate-bd_C.
IPR015894. Guanylate-bd_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF02263. GBP. 1 hit.
[Graphical view]
SUPFAMSSF48340. SSF48340. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEPS51715. G_GB1_RHD3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio312226.
PROQ6PA06.
SOURCESearch...

Entry information

Entry nameATLA2_MOUSE
AccessionPrimary (citable) accession number: Q6PA06
Secondary accession number(s): Q3UX01, Q7TMM3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot