Q6PA06 (ATLA2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Atlastin-2
EC=3.6.5.-

Alternative name(s):
ADP-ribosylation factor-like protein 6-interacting protein 2
Short name=ARL-6-interacting protein 2
Short name=Aip-2

Gene names

Name:	Atl2
Synonyms:	Arl6ip2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	583 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis By similarity.
Subunit structure	Interacts with REEP5 and RTN3. Ref.3
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the GBP family. Atlastin subfamily.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Transmembrane Transmembrane helix
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC Golgi organization Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum organization Inferred from sequence or structural similarity. Source: UniProtKB protein homooligomerization Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	endoplasmic reticulum Inferred from sequence or structural similarity. Source: UniProtKB endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro identical protein binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6PA06-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6PA06-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-195: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 583	583	Atlastin-2		PRO_0000287107
Regions
	Topological domain	1 – 476	476	Cytoplasmic By similarity
	Transmembrane	477 – 497	21	Helical; Potential
	Topological domain	498 – 499	2	Lumenal Potential
	Transmembrane	500 – 520	21	Helical; Potential
	Topological domain	521 – 583	63	Cytoplasmic By similarity
	Nucleotide binding	101 – 108	8	GTP Potential
	Nucleotide binding	173 – 177	5	GTP Potential
	Coiled coil	256 – 284	29	Potential
	Compositional bias	18 – 21	4	Poly-Arg
Amino acid modifications
	Modified residue	24	1	Phosphoserine By similarity
Natural variations
	Alternative sequence	1 – 195	195	Missing in isoform 2.		VSP_025311
Experimental info
	Sequence conflict	466	1	K → R in BAE22763. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 9530B0F2077FE2D3	FASTA	583	66,224
	10 20 30 40 50 60 MAEGDEAARR QQPQQGLRRR RQTSDSSVGV NHVSSTTSLG EDYEDDDLVN SDEVMKKPCP 70 80 90 100 110 120 VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA GAFRKGKSFL LDFMLRYMYN 130 140 150 160 170 180 KDSQSWIGGN NEPLTGFTWR GGCERETTGI QVWNEVFVID RPNGTKVAVL LMDTQGAFDS 190 200 210 220 230 240 QSTIKDCATV FALSTMTSSV QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM 250 260 270 280 290 300 FLIRDWSYPY EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 310 320 330 340 350 360 LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR DLVEYFKAYI 370 380 390 400 410 420 KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDVYCKSMEQ VCGGDKPYIA PSDLERKHLD 430 440 450 460 470 480 LKEVALKQFR SVKKMGGDEF CRRYQDQLEA EIEETYANFI KHNDGKNIFY AARTPATLFA 490 500 510 520 530 540 VMFAMYIISG LTGFIGLNSI AVLCNLVMGL ALTSLCTWAY VKYSGEFREI GTMIDQIAET 550 560 570 580 LWEQVLKPLG DNLMEENIRQ SVTNSIKAGL TDQVSHHARL KTD
	Isoform 2 [UniParc]. Checksum: 17BF792FB97242ED	FASTA	388	44,356
	10 20 30 40 50 60 MTSSVQVYNL SQNIQEDDLQ HLQLFTEYGR LAMEEIYQKP FQTLMFLIRD WSYPYEHSYG 70 80 90 100 110 120 LEGGKQFLEK RLQVKQNQHE ELQNVRKHIH NCFSNLGCFL LPHPGLKVAT NPSFDGRLKD 130 140 150 160 170 180 IDEDFKRELR NLVPLLLAPE NLVEKEISGS KVTCRDLVEY FKAYIKIYQG EELPHPKSML 190 200 210 220 230 240 QATAEANNLA AVAGARDVYC KSMEQVCGGD KPYIAPSDLE RKHLDLKEVA LKQFRSVKKM 250 260 270 280 290 300 GGDEFCRRYQ DQLEAEIEET YANFIKHNDG KNIFYAARTP ATLFAVMFAM YIISGLTGFI 310 320 330 340 350 360 GLNSIAVLCN LVMGLALTSL CTWAYVKYSG EFREIGTMID QIAETLWEQV LKPLGDNLME 370 380 ENIRQSVTNS IKAGLTDQVS HHARLKTD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Oocyte.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Strain: C57BL/6. Tissue: Eye.
[3]	"A class of dynamin-like GTPases involved in the generation of the tubular ER network." Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C. Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH REEP5 AND RTN3.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK135988 mRNA. Translation: BAE22763.1. BC060501 mRNA. Translation: AAH60501.1.
IPI	IPI00461142. IPI00474125.
RefSeq	NP_062691.3. NM_019717.2. NP_835151.2. NM_178050.3.
UniGene	Mm.175403.
3D structure databases
ProteinModelPortal	Q6PA06.
SMR	Q6PA06. Positions 57-469.
ModBase	Search...
PTM databases
PhosphoSite	Q6PA06.
Proteomic databases
PaxDb	Q6PA06.
PRIDE	Q6PA06.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000068282; ENSMUSP00000064758; ENSMUSG00000059811.
GeneID	56298.
KEGG	mmu:56298.
UCSC	uc008dqe.1. mouse.
Organism-specific databases
CTD	64225.
MGI	MGI:1929492. Atl2.
Phylogenomic databases
eggNOG	NOG325148.
GeneTree	ENSGT00390000008959.
HOGENOM	HOG000234332.
HOVERGEN	HBG062891.
InParanoid	Q6PA06.
OMA	QPHQGLR.
OrthoDB	EOG4255SJ.
Gene expression databases
ArrayExpress	Q6PA06.
Bgee	Q6PA06.
Genevestigator	Q6PA06.
Family and domain databases
InterPro	IPR003191. Guanylate-bd_C. IPR015894. Guanylate-bd_N. [Graphical view]
Pfam	PF02263. GBP. 1 hit. [Graphical view]
SUPFAM	SSF48340. GBP. 1 hit.
ProtoNet	Search...
Other
NextBio	312226.
SOURCE	Search...

Entry information

Entry name

ATLA2_MOUSE

Accession

Primary (citable) accession number: Q6PA06
Secondary accession number(s): Q3UX01, Q7TMM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program