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Q6PA06

- ATLA2_MOUSE

UniProt

Q6PA06 - ATLA2_MOUSE

Protein

Atlastin-2

Gene

Atl2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 75 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GTPase tethering membranes through formation of trans-homooligomers and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi101 – 1088GTPBy similarity
    Nucleotide bindingi145 – 1473GTPBy similarity
    Nucleotide bindingi244 – 2452GTPBy similarity
    Nucleotide bindingi303 – 3064GTPBy similarity

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-KW
    3. identical protein binding Source: UniProtKB
    4. protein binding Source: MGI

    GO - Biological processi

    1. endoplasmic reticulum organization Source: UniProtKB
    2. Golgi organization Source: UniProtKB
    3. protein homooligomerization Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Atlastin-2 (EC:3.6.5.-)
    Alternative name(s):
    ADP-ribosylation factor-like protein 6-interacting protein 2
    Short name:
    ARL-6-interacting protein 2
    Short name:
    Aip-2
    Gene namesi
    Name:Atl2
    Synonyms:Arl6ip2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1929492. Atl2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 583583Atlastin-2PRO_0000287107Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6PA06.
    PaxDbiQ6PA06.
    PRIDEiQ6PA06.

    PTM databases

    PhosphoSiteiQ6PA06.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6PA06.
    BgeeiQ6PA06.
    GenevestigatoriQ6PA06.

    Interactioni

    Subunit structurei

    Interacts with REEP5 and RTN3.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ6PA06.
    SMRiQ6PA06. Positions 57-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 476476CytoplasmicBy similarityAdd
    BLAST
    Topological domaini498 – 4992LumenalSequence Analysis
    Topological domaini521 – 58363CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei477 – 49721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei500 – 52021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini91 – 336246GB1/RHD3-type GAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili256 – 28429Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi18 – 214Poly-Arg

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG325148.
    GeneTreeiENSGT00390000008959.
    HOGENOMiHOG000234332.
    HOVERGENiHBG062891.
    InParanoidiQ6PA06.
    KOiK17339.
    OMAiAREIYCK.
    OrthoDBiEOG7H4DTH.
    PhylomeDBiQ6PA06.
    TreeFamiTF105251.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR003191. Guanylate-bd_C.
    IPR015894. Guanylate-bd_N.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF02263. GBP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48340. SSF48340. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS51715. G_GB1_RHD3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6PA06-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAEGDEAARR QQPQQGLRRR RQTSDSSVGV NHVSSTTSLG EDYEDDDLVN    50
    SDEVMKKPCP VQIVLAHEDD HNFELDEEAL EQILLQEHIR DLNIVVVSVA 100
    GAFRKGKSFL LDFMLRYMYN KDSQSWIGGN NEPLTGFTWR GGCERETTGI 150
    QVWNEVFVID RPNGTKVAVL LMDTQGAFDS QSTIKDCATV FALSTMTSSV 200
    QVYNLSQNIQ EDDLQHLQLF TEYGRLAMEE IYQKPFQTLM FLIRDWSYPY 250
    EHSYGLEGGK QFLEKRLQVK QNQHEELQNV RKHIHNCFSN LGCFLLPHPG 300
    LKVATNPSFD GRLKDIDEDF KRELRNLVPL LLAPENLVEK EISGSKVTCR 350
    DLVEYFKAYI KIYQGEELPH PKSMLQATAE ANNLAAVAGA RDVYCKSMEQ 400
    VCGGDKPYIA PSDLERKHLD LKEVALKQFR SVKKMGGDEF CRRYQDQLEA 450
    EIEETYANFI KHNDGKNIFY AARTPATLFA VMFAMYIISG LTGFIGLNSI 500
    AVLCNLVMGL ALTSLCTWAY VKYSGEFREI GTMIDQIAET LWEQVLKPLG 550
    DNLMEENIRQ SVTNSIKAGL TDQVSHHARL KTD 583
    Length:583
    Mass (Da):66,224
    Last modified:July 5, 2004 - v1
    Checksum:i9530B0F2077FE2D3
    GO
    Isoform 2 (identifier: Q6PA06-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-195: Missing.

    Show »
    Length:388
    Mass (Da):44,356
    Checksum:i17BF792FB97242ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti466 – 4661K → R in BAE22763. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 195195Missing in isoform 2. 1 PublicationVSP_025311Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135988 mRNA. Translation: BAE22763.1.
    BC060501 mRNA. Translation: AAH60501.1.
    CCDSiCCDS37700.1. [Q6PA06-1]
    RefSeqiNP_062691.3. NM_019717.3. [Q6PA06-1]
    NP_835151.2. NM_178050.4.
    UniGeneiMm.175403.

    Genome annotation databases

    EnsembliENSMUST00000068282; ENSMUSP00000064758; ENSMUSG00000059811. [Q6PA06-1]
    GeneIDi56298.
    KEGGimmu:56298.
    UCSCiuc008dqe.1. mouse. [Q6PA06-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK135988 mRNA. Translation: BAE22763.1 .
    BC060501 mRNA. Translation: AAH60501.1 .
    CCDSi CCDS37700.1. [Q6PA06-1 ]
    RefSeqi NP_062691.3. NM_019717.3. [Q6PA06-1 ]
    NP_835151.2. NM_178050.4.
    UniGenei Mm.175403.

    3D structure databases

    ProteinModelPortali Q6PA06.
    SMRi Q6PA06. Positions 57-469.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6PA06.

    Proteomic databases

    MaxQBi Q6PA06.
    PaxDbi Q6PA06.
    PRIDEi Q6PA06.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068282 ; ENSMUSP00000064758 ; ENSMUSG00000059811 . [Q6PA06-1 ]
    GeneIDi 56298.
    KEGGi mmu:56298.
    UCSCi uc008dqe.1. mouse. [Q6PA06-1 ]

    Organism-specific databases

    CTDi 64225.
    MGIi MGI:1929492. Atl2.

    Phylogenomic databases

    eggNOGi NOG325148.
    GeneTreei ENSGT00390000008959.
    HOGENOMi HOG000234332.
    HOVERGENi HBG062891.
    InParanoidi Q6PA06.
    KOi K17339.
    OMAi AREIYCK.
    OrthoDBi EOG7H4DTH.
    PhylomeDBi Q6PA06.
    TreeFami TF105251.

    Miscellaneous databases

    NextBioi 312226.
    PROi Q6PA06.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6PA06.
    Bgeei Q6PA06.
    Genevestigatori Q6PA06.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR003191. Guanylate-bd_C.
    IPR015894. Guanylate-bd_N.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF02263. GBP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48340. SSF48340. 1 hit.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS51715. G_GB1_RHD3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Oocyte.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Eye.
    3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "A class of dynamin-like GTPases involved in the generation of the tubular ER network."
      Hu J., Shibata Y., Zhu P.-P., Voss C., Rismanchi N., Prinz W.A., Rapoport T.A., Blackstone C.
      Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH REEP5 AND RTN3.

    Entry informationi

    Entry nameiATLA2_MOUSE
    AccessioniPrimary (citable) accession number: Q6PA06
    Secondary accession number(s): Q3UX01, Q7TMM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 75 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3