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Protein

Tumor-associated calcium signal transducer 2

Gene

Tacstd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May function as a growth factor receptor.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor-associated calcium signal transducer 2
Alternative name(s):
Parturition-related protein 1
Gene namesi
Name:Tacstd2
Synonyms:Prp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359498. Tacstd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 270246ExtracellularSequence analysisAdd
BLAST
Transmembranei271 – 29121HelicalSequence analysisAdd
BLAST
Topological domaini292 – 31726CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence analysisAdd
BLAST
Chaini25 – 317293Tumor-associated calcium signal transducer 2PRO_0000380188Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi27 – 271N-linked (GlcNAc...)Sequence analysis
Disulfide bondi67 ↔ 102PROSITE-ProRule annotation
Disulfide bondi113 ↔ 119PROSITE-ProRule annotation
Glycosylationi114 – 1141N-linked (GlcNAc...)Sequence analysis
Disulfide bondi121 ↔ 139PROSITE-ProRule annotation
Glycosylationi162 – 1621N-linked (GlcNAc...)Sequence analysis
Glycosylationi202 – 2021N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6P9Z6.
PRIDEiQ6P9Z6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010156.

Structurei

3D structure databases

ProteinModelPortaliQ6P9Z6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 13976Thyroglobulin type-1PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the EPCAM family.Curated
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFI6. Eukaryota.
ENOG4111M3B. LUCA.
HOGENOMiHOG000074086.
InParanoidiQ6P9Z6.
KOiK17288.
OrthoDBiEOG7HQN8S.
PhylomeDBiQ6P9Z6.
TreeFamiTF332767.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9Z6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARGLDLAPL LLLLLAMVAG FCTAQINCTC PTNKMTICNS NGPGGVCQCR
60 70 80 90 100
AIGSQVLVDC STLTSKCLLL KARMSARKSS RRLVNPSEHA ILDNDGLYDP
110 120 130 140 150
ECDDKGRFKA RQCNQTSVCW CVNSVGVRRT DKGDQSLRCD EVVRTHHILI
160 170 180 190 200
ELRHRPTDRA FNHSDLDSEL RRLFKERYKL HPSFLAAVHY EEPTIQIELQ
210 220 230 240 250
QNASQKGLRD VDIADAAYYF ERDIKGESLF VGRRGLDVQV RGEPLHVERT
260 270 280 290 300
LIYYLDEKPP QFSMKRLTTG LIAVIAVVAV ALVAGVVVLV VTNRRKSGKY
310
KKVELKELGE MRSEPSL
Length:317
Mass (Da):35,514
Last modified:July 5, 2004 - v1
Checksum:iE5EF46E2DBA7143F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371I → V in AAO67351 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY185508 mRNA. Translation: AAO67351.1.
BC060519 mRNA. Translation: AAH60519.1.
RefSeqiNP_001009540.2. NM_001009540.2.
UniGeneiRn.24809.

Genome annotation databases

GeneIDi494343.
KEGGirno:494343.
UCSCiRGD:1359498. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY185508 mRNA. Translation: AAO67351.1.
BC060519 mRNA. Translation: AAH60519.1.
RefSeqiNP_001009540.2. NM_001009540.2.
UniGeneiRn.24809.

3D structure databases

ProteinModelPortaliQ6P9Z6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010156.

Proteomic databases

PaxDbiQ6P9Z6.
PRIDEiQ6P9Z6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi494343.
KEGGirno:494343.
UCSCiRGD:1359498. rat.

Organism-specific databases

CTDi4070.
RGDi1359498. Tacstd2.

Phylogenomic databases

eggNOGiENOG410IFI6. Eukaryota.
ENOG4111M3B. LUCA.
HOGENOMiHOG000074086.
InParanoidiQ6P9Z6.
KOiK17288.
OrthoDBiEOG7HQN8S.
PhylomeDBiQ6P9Z6.
TreeFamiTF332767.

Miscellaneous databases

PROiQ6P9Z6.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR000716. Thyroglobulin_1.
[Graphical view]
PfamiPF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
SMARTiSM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57610. SSF57610. 1 hit.
PROSITEiPS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Huang Z., Myatt L., Ma R.Z.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiTACD2_RAT
AccessioniPrimary (citable) accession number: Q6P9Z6
Secondary accession number(s): Q6K0P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.