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Protein

Protein fem-1 homolog A

Gene

fem1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein fem-1 homolog A
Short name:
FEM1a
Alternative name(s):
FEM1-alpha
Gene namesi
Name:fem1a
ORF Names:zgc:63483
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030131-5824. fem1a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 617617Protein fem-1 homolog APRO_0000324529Add
BLAST

Proteomic databases

PaxDbiQ6P9Z4.
PRIDEiQ6P9Z4.

Interactioni

Subunit structurei

Component of some E3 ubiquitin-protein ligase complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110111.

Structurei

3D structure databases

ProteinModelPortaliQ6P9Z4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati2 – 3231ANK 1Add
BLAST
Repeati40 – 7031ANK 2Add
BLAST
Repeati82 – 11130ANK 3Add
BLAST
Repeati115 – 14430ANK 4Add
BLAST
Repeati148 – 17730ANK 5Add
BLAST
Repeati181 – 21030ANK 6Add
BLAST
Repeati213 – 24230ANK 7Add
BLAST
Repeati245 – 27935TPR 1Add
BLAST
Repeati339 – 37234TPR 2Add
BLAST
Repeati482 – 52443ANK 8Add
BLAST
Repeati528 – 55730ANK 9Add
BLAST

Sequence similaritiesi

Belongs to the fem-1 family.Curated
Contains 9 ANK repeats.PROSITE-ProRule annotation
Contains 2 TPR repeats.Curated

Keywords - Domaini

ANK repeat, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG057774.
InParanoidiQ6P9Z4.
PhylomeDBiQ6P9Z4.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9Z4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDISAAVFNA ARDGKLKLMQ KLLINKSPEE RAALAEERTE GGTPLLIAAR
60 70 80 90 100
YGHLPVVHFL LERCGANVAL GGSVNFDGET IEGAPPLWAA SAAGHLPVVK
110 120 130 140 150
ALLEHGAPVN NTTLTNSTPL RAACFDGHLE IVRYLVEHQA DLEVANRHGH
160 170 180 190 200
TCLMISCYKG HREIAQFLLE KGADVNRKSV KGNTALHDCA ESGSLEIMKM
210 220 230 240 250
LLKCDARMER DGYGMTPLLA ASVTGHTNIV EFLVHQPRAS REQRIHALEL
260 270 280 290 300
LGATFVDKKR DLLGAMRYWR RAMELRWAGG QAGALEKPTA GPLVPAYDCS
310 320 330 340 350
REVSTAEELE ALITDPDDMR MQALLVRERI LGPAHPDTSY YIRYRGAVYA
360 370 380 390 400
DSGNFERCIR LWKYALDMQQ SNLEPLSPMT ASSFLSFAEL FSFVLQDRAK
410 420 430 440 450
GTLAARVSFQ DLMGVLSKSV REVERAVAQR ERPPEPPQFS KALSIILHLL
460 470 480 490 500
FLLQKLRCGP EQEHLKRQTV YRLLKLNPRA RGGHTPLHMA VDRDTTSVGR
510 520 530 540 550
YPVGRFPSLA VASLLLECGA DVDSRDYDNN TPLHIAAANG CPDIMAALIR
560 570 580 590 600
AGAHFDATNA AQQTAYQLLE AQSSGRHALH PLNHTTLQCL AARAVTAHRL
610
PYKGLISEQM EAFIELH
Length:617
Mass (Da):68,011
Last modified:July 5, 2004 - v1
Checksum:i40C5523DE8BA84BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060522 mRNA. Translation: AAH60522.1.
RefSeqiNP_956131.1. NM_199837.1.
UniGeneiDr.6352.

Genome annotation databases

GeneIDi327613.
KEGGidre:327613.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060522 mRNA. Translation: AAH60522.1.
RefSeqiNP_956131.1. NM_199837.1.
UniGeneiDr.6352.

3D structure databases

ProteinModelPortaliQ6P9Z4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000110111.

Proteomic databases

PaxDbiQ6P9Z4.
PRIDEiQ6P9Z4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi327613.
KEGGidre:327613.

Organism-specific databases

CTDi55527.
ZFINiZDB-GENE-030131-5824. fem1a.

Phylogenomic databases

eggNOGiKOG0508. Eukaryota.
COG0666. LUCA.
HOVERGENiHBG057774.
InParanoidiQ6P9Z4.
PhylomeDBiQ6P9Z4.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ6P9Z4.

Family and domain databases

Gene3Di1.25.40.20. 5 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 8 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 3 hits.
PROSITEiPS50297. ANK_REP_REGION. 2 hits.
PS50088. ANK_REPEAT. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFEM1A_DANRE
AccessioniPrimary (citable) accession number: Q6P9Z4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.