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Protein

Zinc finger protein 82

Gene

Zfp82

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 82
Short name:
Zfp-82
Alternative name(s):
Zinc finger protein 545
Gene namesi
Name:Zfp82
Synonyms:Kiaa1948, Znf545
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1890753. Zfp82.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002331651 – 530Zinc finger protein 82Add BLAST530

Proteomic databases

PaxDbiQ6P9Y7.
PRIDEiQ6P9Y7.

PTM databases

PhosphoSitePlusiQ6P9Y7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000098022.
CleanExiMM_ZFP82.
ExpressionAtlasiQ6P9Y7. baseline and differential.
GenevisibleiQ6P9Y7. MM.

Interactioni

Protein-protein interaction databases

BioGridi236978. 2 interactors.
STRINGi10090.ENSMUSP00000079647.

Structurei

3D structure databases

ProteinModelPortaliQ6P9Y7.
SMRiQ6P9Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 77KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri168 – 190C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 218C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri224 – 246C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri252 – 274C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri280 – 302C2H2-type 5; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri308 – 330C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri336 – 358C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri364 – 386C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri392 – 414C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri420 – 442C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri448 – 470C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri476 – 498C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri504 – 526C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P9Y7.
KOiK09228.
OMAiHQRIHFV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P9Y7.
TreeFamiTF341817.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARVSVVFSD VSIAFSQEEW ESLDLEQRNL YKDVMMENYH NVASLGCFIS
60 70 80 90 100
KPDVISLLEQ GKEPWKVVRQ RKPCPDSETK DETNQVFSEN GIYEMNLSQW
110 120 130 140 150
KIMERIGNSG LKSLLLKNGW ESRRKQERQE DPQEGYLSQV RHTSERVSSY
160 170 180 190 200
EKRALTTRQR IHFVEKPYEC NECGKAFRVR QQLTFHHRIH TGEKPYECKE
210 220 230 240 250
CGMAFRQTAH LTRHQRLHSG EKLYECKECG QAFIYGPELR AHQKLHTGEK
260 270 280 290 300
PYTCRECGKA FRVRGQLTLH QRIHTGEKPY VCQECGKAFR QLAHLTRHQK
310 320 330 340 350
LNVVDRLYEC KECGKDFLCG SGLRVHHKLH TGEKPYECKD CGKAFRVRQQ
360 370 380 390 400
LTLHQRSHTG EKPYECTECG KTFSRGYHLI LHHRIHTGEK PYECKECWKA
410 420 430 440 450
FSRYSQLISH QSIHIGVKPY DCKDCGKAFR LLSQLTQHQS VHAGEKPYSC
460 470 480 490 500
KECGKSFRLR QKLALHQSIH TGEKPFECKE CRKAFRLNSS LIQHLRIHSG
510 520 530
EKPYECKECK KAFRQHSHLT HHLKVHTVKV
Note: No experimental confirmation available.
Length:530
Mass (Da):62,122
Last modified:July 5, 2004 - v1
Checksum:i87CFAFB2A3CF1BD6
GO
Isoform 2 (identifier: Q6P9Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-76: VRQRKPCPD → TMGDPGRTN

Note: No experimental confirmation available.
Show »
Length:530
Mass (Da):61,972
Checksum:i5CB02D4226254B11
GO
Isoform 3 (identifier: Q6P9Y7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     76-83: DSETKDET → ARRDGASL
     84-530: Missing.

Note: No experimental confirmation available.
Show »
Length:83
Mass (Da):9,530
Checksum:i177ED4713203FAFF
GO

Sequence cautioni

The sequence BAC29755 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01808368 – 76VRQRKPCPD → TMGDPGRTN in isoform 2. 1 Publication9
Alternative sequenceiVSP_04623076 – 83DSETKDET → ARRDGASL in isoform 3. 1 Publication8
Alternative sequenceiVSP_04623184 – 530Missing in isoform 3. 1 PublicationAdd BLAST447

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037211 mRNA. Translation: BAC29755.1. Sequence problems.
BC060530 mRNA. Translation: AAH60530.1.
AK129467 mRNA. Translation: BAC98277.1.
CCDSiCCDS39876.1. [Q6P9Y7-1]
CCDS59724.1. [Q6P9Y7-3]
RefSeqiNP_001239448.1. NM_001252519.1.
NP_001240314.1. NM_001253385.1. [Q6P9Y7-3]
NP_808557.2. NM_177889.5. [Q6P9Y7-1]
UniGeneiMm.295906.

Genome annotation databases

EnsembliENSMUST00000080834; ENSMUSP00000079647; ENSMUSG00000098022. [Q6P9Y7-1]
ENSMUST00000183190; ENSMUSP00000138469; ENSMUSG00000098022. [Q6P9Y7-3]
GeneIDi330502.
KEGGimmu:330502.
UCSCiuc009gcz.2. mouse. [Q6P9Y7-1]
uc009gdc.2. mouse. [Q6P9Y7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK037211 mRNA. Translation: BAC29755.1. Sequence problems.
BC060530 mRNA. Translation: AAH60530.1.
AK129467 mRNA. Translation: BAC98277.1.
CCDSiCCDS39876.1. [Q6P9Y7-1]
CCDS59724.1. [Q6P9Y7-3]
RefSeqiNP_001239448.1. NM_001252519.1.
NP_001240314.1. NM_001253385.1. [Q6P9Y7-3]
NP_808557.2. NM_177889.5. [Q6P9Y7-1]
UniGeneiMm.295906.

3D structure databases

ProteinModelPortaliQ6P9Y7.
SMRiQ6P9Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236978. 2 interactors.
STRINGi10090.ENSMUSP00000079647.

PTM databases

PhosphoSitePlusiQ6P9Y7.

Proteomic databases

PaxDbiQ6P9Y7.
PRIDEiQ6P9Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080834; ENSMUSP00000079647; ENSMUSG00000098022. [Q6P9Y7-1]
ENSMUST00000183190; ENSMUSP00000138469; ENSMUSG00000098022. [Q6P9Y7-3]
GeneIDi330502.
KEGGimmu:330502.
UCSCiuc009gcz.2. mouse. [Q6P9Y7-1]
uc009gdc.2. mouse. [Q6P9Y7-3]

Organism-specific databases

CTDi284406.
MGIiMGI:1890753. Zfp82.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129704.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P9Y7.
KOiK09228.
OMAiHQRIHFV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P9Y7.
TreeFamiTF341817.

Miscellaneous databases

PROiQ6P9Y7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000098022.
CleanExiMM_ZFP82.
ExpressionAtlasiQ6P9Y7. baseline and differential.
GenevisibleiQ6P9Y7. MM.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFP82_MOUSE
AccessioniPrimary (citable) accession number: Q6P9Y7
Secondary accession number(s): Q6ZPG0, Q8BIP1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.