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Protein

Prostate androgen-regulated mucin-like protein 1 homolog

Gene

Parm1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May regulate TLP1 expression and telomerase activity, thus enabling certain prostatic cells to resist apoptosis.2 Publications

GO - Biological processi

  • apoptotic process Source: RGD
  • positive regulation of telomerase activity Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Prostate androgen-regulated mucin-like protein 1 homolog
Short name:
PARM-1
Alternative name(s):
Castration-induced prostatic apoptosis-related protein 1
Short name:
CIPAR-1
Prostatic androgen-repressed message 1 protein
Gene namesi
Name:Parm1
Synonyms:Cipar1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708342. Parm1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini21 – 244ExtracellularSequence analysisAdd BLAST224
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 296CytoplasmicSequence analysisAdd BLAST31

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000004550121 – 296Prostate androgen-regulated mucin-like protein 1 homologAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi62N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi108N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi168N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei284PhosphoserineCombined sources1

Post-translational modificationi

Highly N-glycosylated and O-glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P9X9.

PTM databases

iPTMnetiQ6P9X9.
PhosphoSitePlusiQ6P9X9.

Expressioni

Tissue specificityi

Expressed in prostate. Detected in other organs at low levels, these include the heart and various tissues of the urogenital tract. Not detected in mammary gland.1 Publication

Inductioni

Induced in prostate, after castration. This induction is reversed by androgen supplementation.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000003472.

Family & Domainsi

Sequence similaritiesi

Belongs to the PARM family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IVTQ. Eukaryota.
ENOG410XTVA. LUCA.
HOGENOMiHOG000280689.
HOVERGENiHBG082108.
InParanoidiQ6P9X9.
PhylomeDBiQ6P9X9.

Family and domain databases

InterProiView protein in InterPro
IPR031431. PARM1.
PANTHERiPTHR35453. PTHR35453. 1 hit.
PfamiView protein in Pfam
PF17061. PARM. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9X9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCKALITLC IFAAGLRVQG SPTPTLLPVS LTTKSTAPMA TWTTSAQHTA
60 70 80 90 100
MATTPVASAT HNASVLRTTA ASLTSQLPTH PREEAVTSPP LKREVNSTDS
110 120 130 140 150
SPTGFSSNSS GIHLAPTPEE HSLGSPETSV PATGSQSPTL LFSQGPTSAS
160 170 180 190 200
TSPATSPSEP LSASVTSNHS STVNNIQPTG APMAPASPTE EHSSSHTPTS
210 220 230 240 250
HVTEPVPKEK SPQDTEPGKV ICESETTTPF LIMQEVENAL SSGSIAAITV
260 270 280 290
TVIAVVLLVF GAAAYLKIRH SSYGRLLDDH DYGSWGNYNN PLYDDS
Length:296
Mass (Da):30,729
Last modified:July 5, 2004 - v1
Checksum:i450846B6BD760617
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti17R → M in CAB38095 (PubMed:10499539).Curated1
Sequence conflicti284S → SGS in CAB38095 (PubMed:10499539).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ010750 mRNA. Translation: CAB38095.1.
BC060539 mRNA. Translation: AAH60539.1.
RefSeqiNP_775137.1. NM_173114.1.
UniGeneiRn.127830.

Genome annotation databases

GeneIDi286894.
KEGGirno:286894.
UCSCiRGD:708342. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiPARM1_RAT
AccessioniPrimary (citable) accession number: Q6P9X9
Secondary accession number(s): Q9Z0P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 73 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families