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Q6P9X4 (TP4A2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein tyrosine phosphatase type IVA 2

EC=3.1.3.48
Alternative name(s):
Protein-tyrosine phosphatase 4a2
Protein-tyrosine phosphatase of regenerating liver 2
Short name=PRL-2
Gene names
Name:Ptp4a2
Synonyms:Prl2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length167 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulation

Inhibited by sodium orthovanadate and pentamidine By similarity.

Subunit structure

In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB By similarity.

Subcellular location

Cell membrane By similarity. Early endosome By similarity. Cytoplasm By similarity.

Tissue specificity

Anterior pituitary, liver, brain, adrenal gland, kidney, testis and heart. Expression in the anterior pituitary is 3 fold higher in male as compared to female. Ref.1

Post-translational modification

Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB By similarity.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 164164Protein tyrosine phosphatase type IVA 2
PRO_0000094787
Propeptide165 – 1673Removed in mature form By similarity
PRO_0000396733

Regions

Domain79 – 14567Tyrosine-protein phosphatase
Region102 – 1076Phosphate binding By similarity

Sites

Active site691Proton donor By similarity
Active site1011Phosphocysteine intermediate By similarity
Binding site1071Substrate By similarity

Amino acid modifications

Modified residue1641Cysteine methyl ester By similarity
Lipidation1641S-farnesyl cysteine By similarity
Disulfide bond46 ↔ 101 By similarity

Experimental info

Sequence conflict231T → A in CAA07417. Ref.1
Sequence conflict1571F → S in CAA07417. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P9X4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: E97B88BF87B87943

FASTA16719,127
        10         20         30         40         50         60 
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY DKAPVEKEGI 

        70         80         90        100        110        120 
HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH CVAGLGRAPV LVALALIECG 

       130        140        150        160 
MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR PKMRLRFRDT NGHCCVQ 

« Hide

References

« Hide 'large scale' references
[1]"Expression of a novel rat protein tyrosine phosphatase gene."
Carter D.A.
Biochim. Biophys. Acta 1442:405-408(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Pituitary anterior lobe.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pituitary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ007016 mRNA. Translation: CAA07417.1.
BC060549 mRNA. Translation: AAH60549.1.
RefSeqNP_445927.1. NM_053475.1.
XP_006239035.1. XM_006238973.1.
XP_006239036.1. XM_006238974.1.
XP_006239037.1. XM_006238975.1.
XP_006239038.1. XM_006238976.1.
UniGeneRn.167750.

3D structure databases

ProteinModelPortalQ6P9X4.
SMRQ6P9X4. Positions 6-157.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBQ6P9X4.

Proteomic databases

PRIDEQ6P9X4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000074415; ENSRNOP00000064832; ENSRNOG00000050044.
GeneID85237.
KEGGrno:85237.

Organism-specific databases

CTD8073.
RGD619786. Ptp4a2.

Phylogenomic databases

GeneTreeENSGT00390000009788.
HOVERGENHBG071295.
KOK18041.
OMANGHNCCV.
OrthoDBEOG7C8GJD.
PhylomeDBQ6P9X4.

Gene expression databases

GenevestigatorQ6P9X4.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio617278.

Entry information

Entry nameTP4A2_RAT
AccessionPrimary (citable) accession number: Q6P9X4
Secondary accession number(s): O88765
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families