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Q6P9X4

- TP4A2_RAT

UniProt

Q6P9X4 - TP4A2_RAT

Protein

Protein tyrosine phosphatase type IVA 2

Gene

Ptp4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

    Enzyme regulationi

    Inhibited by sodium orthovanadate and pentamidine.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei69 – 691Proton donorBy similarity
    Active sitei101 – 1011Phosphocysteine intermediateBy similarity
    Binding sitei107 – 1071SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein tyrosine phosphatase type IVA 2 (EC:3.1.3.48)
    Alternative name(s):
    Protein-tyrosine phosphatase 4a2
    Protein-tyrosine phosphatase of regenerating liver 2
    Short name:
    PRL-2
    Gene namesi
    Name:Ptp4a2
    Synonyms:Prl2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi619786. Ptp4a2.

    Subcellular locationi

    Cell membrane By similarity. Early endosome By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. early endosome Source: UniProtKB-SubCell
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Endosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 164164Protein tyrosine phosphatase type IVA 2PRO_0000094787Add
    BLAST
    Propeptidei165 – 1673Removed in mature formBy similarityPRO_0000396733

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi46 ↔ 101By similarity
    Modified residuei164 – 1641Cysteine methyl esterBy similarity
    Lipidationi164 – 1641S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB By similarity.By similarity

    Keywords - PTMi

    Disulfide bond, Lipoprotein, Methylation, Prenylation

    Proteomic databases

    PRIDEiQ6P9X4.

    Expressioni

    Tissue specificityi

    Anterior pituitary, liver, brain, adrenal gland, kidney, testis and heart. Expression in the anterior pituitary is 3 fold higher in male as compared to female.1 Publication

    Gene expression databases

    GenevestigatoriQ6P9X4.

    Interactioni

    Subunit structurei

    In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P9X4.
    SMRiQ6P9X4. Positions 6-157.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 14567Tyrosine-protein phosphataseAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni102 – 1076Phosphate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    GeneTreeiENSGT00390000009788.
    HOVERGENiHBG071295.
    KOiK18041.
    OMAiNGHNCCV.
    OrthoDBiEOG7C8GJD.
    PhylomeDBiQ6P9X4.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P9X4-1 [UniParc]FASTAAdd to Basket

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    MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY    50
    DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH 100
    CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR 150
    PKMRLRFRDT NGHCCVQ 167
    Length:167
    Mass (Da):19,127
    Last modified:July 5, 2004 - v1
    Checksum:iE97B88BF87B87943
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti23 – 231T → A in CAA07417. (PubMed:9805001)Curated
    Sequence conflicti157 – 1571F → S in CAA07417. (PubMed:9805001)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007016 mRNA. Translation: CAA07417.1.
    BC060549 mRNA. Translation: AAH60549.1.
    RefSeqiNP_445927.1. NM_053475.1.
    XP_006239035.1. XM_006238973.1.
    XP_006239036.1. XM_006238974.1.
    XP_006239037.1. XM_006238975.1.
    XP_006239038.1. XM_006238976.1.
    UniGeneiRn.167750.

    Genome annotation databases

    EnsembliENSRNOT00000074415; ENSRNOP00000064832; ENSRNOG00000050044.
    GeneIDi85237.
    KEGGirno:85237.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ007016 mRNA. Translation: CAA07417.1 .
    BC060549 mRNA. Translation: AAH60549.1 .
    RefSeqi NP_445927.1. NM_053475.1.
    XP_006239035.1. XM_006238973.1.
    XP_006239036.1. XM_006238974.1.
    XP_006239037.1. XM_006238975.1.
    XP_006239038.1. XM_006238976.1.
    UniGenei Rn.167750.

    3D structure databases

    ProteinModelPortali Q6P9X4.
    SMRi Q6P9X4. Positions 6-157.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q6P9X4.

    Proteomic databases

    PRIDEi Q6P9X4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000074415 ; ENSRNOP00000064832 ; ENSRNOG00000050044 .
    GeneIDi 85237.
    KEGGi rno:85237.

    Organism-specific databases

    CTDi 8073.
    RGDi 619786. Ptp4a2.

    Phylogenomic databases

    GeneTreei ENSGT00390000009788.
    HOVERGENi HBG071295.
    KOi K18041.
    OMAi NGHNCCV.
    OrthoDBi EOG7C8GJD.
    PhylomeDBi Q6P9X4.

    Miscellaneous databases

    NextBioi 617278.

    Gene expression databases

    Genevestigatori Q6P9X4.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel rat protein tyrosine phosphatase gene."
      Carter D.A.
      Biochim. Biophys. Acta 1442:405-408(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Pituitary anterior lobe.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pituitary.

    Entry informationi

    Entry nameiTP4A2_RAT
    AccessioniPrimary (citable) accession number: Q6P9X4
    Secondary accession number(s): O88765
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3