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Protein

Protein tyrosine phosphatase type IVA 2

Gene

Ptp4a2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Inhibits geranylgeranyl transferase type II activity by blocking the association between RABGGTA and RABGGTB (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Enzyme regulationi

Inhibited by sodium orthovanadate and pentamidine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei69 – 691Proton donorBy similarity
Active sitei101 – 1011Phosphocysteine intermediateBy similarity
Binding sitei107 – 1071SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Protein tyrosine phosphatase type IVA 2 (EC:3.1.3.48)
Alternative name(s):
Protein-tyrosine phosphatase 4a2
Protein-tyrosine phosphatase of regenerating liver 2
Short name:
PRL-2
Gene namesi
Name:Ptp4a2
Synonyms:Prl2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi619786. Ptp4a2.

Subcellular locationi

Cell membrane By similarity. Early endosome By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. early endosome Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: Ensembl
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 164164Protein tyrosine phosphatase type IVA 2PRO_0000094787Add
BLAST
Propeptidei165 – 1673Removed in mature formBy similarityPRO_0000396733

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi46 ↔ 101By similarity
Modified residuei164 – 1641Cysteine methyl esterBy similarity
Lipidationi164 – 1641S-farnesyl cysteineBy similarity

Post-translational modificationi

Farnesylated. Farnesylation is required for membrane targeting and for interaction with RABGGTB (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Lipoprotein, Methylation, Prenylation

Proteomic databases

PRIDEiQ6P9X4.

Expressioni

Tissue specificityi

Anterior pituitary, liver, brain, adrenal gland, kidney, testis and heart. Expression in the anterior pituitary is 3 fold higher in male as compared to female.1 Publication

Gene expression databases

GenevestigatoriQ6P9X4.

Interactioni

Subunit structurei

In contrast to PTP4A1 and PTP4A3, does not interact with tubulin. Interacts with RABGGTB (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6P9X4.
SMRiQ6P9X4. Positions 6-157.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 14567Tyrosine-protein phosphataseAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni102 – 1076Phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000009788.
HOVERGENiHBG071295.
InParanoidiQ6P9X4.
KOiK18041.
OMAiAPIEKEG.
OrthoDBiEOG7C8GJD.
PhylomeDBiQ6P9X4.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9X4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNRPAPVEIS YENMRFLITH NPTNATLNKF TEELKKYGVT TLVRVCDATY
60 70 80 90 100
DKAPVEKEGI HVLDWPFDDG APPPNQIVDD WLNLLKTKFR EEPGCCVAVH
110 120 130 140 150
CVAGLGRAPV LVALALIECG MKYEDAVQFI RQKRRGAFNS KQLLYLEKYR
160
PKMRLRFRDT NGHCCVQ
Length:167
Mass (Da):19,127
Last modified:July 5, 2004 - v1
Checksum:iE97B88BF87B87943
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231T → A in CAA07417. (PubMed:9805001)Curated
Sequence conflicti157 – 1571F → S in CAA07417. (PubMed:9805001)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007016 mRNA. Translation: CAA07417.1.
BC060549 mRNA. Translation: AAH60549.1.
RefSeqiNP_445927.1. NM_053475.1.
UniGeneiRn.167750.

Genome annotation databases

EnsembliENSRNOT00000074415; ENSRNOP00000064832; ENSRNOG00000050044.
GeneIDi85237.
KEGGirno:85237.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ007016 mRNA. Translation: CAA07417.1.
BC060549 mRNA. Translation: AAH60549.1.
RefSeqiNP_445927.1. NM_053475.1.
UniGeneiRn.167750.

3D structure databases

ProteinModelPortaliQ6P9X4.
SMRiQ6P9X4. Positions 6-157.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ6P9X4.

Proteomic databases

PRIDEiQ6P9X4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000074415; ENSRNOP00000064832; ENSRNOG00000050044.
GeneIDi85237.
KEGGirno:85237.

Organism-specific databases

CTDi8073.
RGDi619786. Ptp4a2.

Phylogenomic databases

GeneTreeiENSGT00390000009788.
HOVERGENiHBG071295.
InParanoidiQ6P9X4.
KOiK18041.
OMAiAPIEKEG.
OrthoDBiEOG7C8GJD.
PhylomeDBiQ6P9X4.

Miscellaneous databases

NextBioi617278.

Gene expression databases

GenevestigatoriQ6P9X4.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel rat protein tyrosine phosphatase gene."
    Carter D.A.
    Biochim. Biophys. Acta 1442:405-408(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Pituitary anterior lobe.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pituitary.

Entry informationi

Entry nameiTP4A2_RAT
AccessioniPrimary (citable) accession number: Q6P9X4
Secondary accession number(s): O88765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.