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Protein

COMM domain-containing protein 3

Gene

Commd3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. May down-regulate activation of NF-kappa-B. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits.By similarity

GO - Biological processi

Keywordsi

Biological processIon transport, Sodium transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandSodium

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 3
Gene namesi
Name:Commd3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 17

Organism-specific databases

RGDi735116. Commd3.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773911 – 195COMM domain-containing protein 3Add BLAST195

Proteomic databases

PaxDbiQ6P9U3.
PRIDEiQ6P9U3.

PTM databases

iPTMnetiQ6P9U3.
PhosphoSitePlusiQ6P9U3.

Expressioni

Tissue specificityi

Expressed in kidney collecting duct cells and in the nuclei of proximal convoluted tubule cells in the kidney cortex (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000016383.
GenevisibleiQ6P9U3. RN.

Interactioni

Subunit structurei

Interacts (via COMM domain) with COMMD1 (via COMM domain). Interacts with NFKB1/p105. Interacts with CCDC22, CCDC93, SCNN1B, CUL3, CUL4A, CUL4B, CUL5.By similarity

Protein-protein interaction databases

IntActiQ6P9U3. 1 interactor.
STRINGi10116.ENSRNOP00000022201.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini124 – 193COMMPROSITE-ProRule annotationAdd BLAST70

Phylogenomic databases

eggNOGiENOG410IKHX. Eukaryota.
ENOG4111PD7. LUCA.
GeneTreeiENSGT00390000015971.
HOGENOMiHOG000231902.
HOVERGENiHBG051068.
InParanoidiQ6P9U3.
OMAiDASWRLE.
OrthoDBiEOG091G0O9G.
PhylomeDBiQ6P9U3.

Family and domain databases

InterProiView protein in InterPro
IPR017920. COMM.
PfamiView protein in Pfam
PF07258. COMM_domain. 1 hit.
PROSITEiView protein in PROSITE
PS51269. COMM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P9U3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSEYVQRG IQTLADPGSF DSSAFALLLR AAFQSLLDAQ ADEAALDHPD
60 70 80 90 100
LKHIDPVVLK HCHGAAATYI LEAGKHRVDK STLSTYLEDC KFDRERIELF
110 120 130 140 150
CTEYQNNKNS LEILLGSIGR ALPHITDVSW RLEYQIKTNQ LHKMCRPGYL
160 170 180 190
VTLNVENADS QSYPEISFSC SMEQLQDLVG KLKDASKSLE RATQL
Length:195
Mass (Da):21,932
Last modified:July 5, 2004 - v1
Checksum:i1DE015BC9312BB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060591 mRNA. Translation: AAH60591.1.
RefSeqiNP_942027.1. NM_198732.2.
UniGeneiRn.3471.

Genome annotation databases

EnsembliENSRNOT00000022201; ENSRNOP00000022201; ENSRNOG00000016383.
GeneIDi291339.
KEGGirno:291339.
UCSCiRGD:735116. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060591 mRNA. Translation: AAH60591.1.
RefSeqiNP_942027.1. NM_198732.2.
UniGeneiRn.3471.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P9U3. 1 interactor.
STRINGi10116.ENSRNOP00000022201.

PTM databases

iPTMnetiQ6P9U3.
PhosphoSitePlusiQ6P9U3.

Proteomic databases

PaxDbiQ6P9U3.
PRIDEiQ6P9U3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000022201; ENSRNOP00000022201; ENSRNOG00000016383.
GeneIDi291339.
KEGGirno:291339.
UCSCiRGD:735116. rat.

Organism-specific databases

CTDi23412.
RGDi735116. Commd3.

Phylogenomic databases

eggNOGiENOG410IKHX. Eukaryota.
ENOG4111PD7. LUCA.
GeneTreeiENSGT00390000015971.
HOGENOMiHOG000231902.
HOVERGENiHBG051068.
InParanoidiQ6P9U3.
OMAiDASWRLE.
OrthoDBiEOG091G0O9G.
PhylomeDBiQ6P9U3.

Enzyme and pathway databases

ReactomeiR-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ6P9U3.

Gene expression databases

BgeeiENSRNOG00000016383.
GenevisibleiQ6P9U3. RN.

Family and domain databases

InterProiView protein in InterPro
IPR017920. COMM.
PfamiView protein in Pfam
PF07258. COMM_domain. 1 hit.
PROSITEiView protein in PROSITE
PS51269. COMM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOMD3_RAT
AccessioniPrimary (citable) accession number: Q6P9U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: March 15, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.