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Q6P9T4

- Q6P9T4_MOUSE

UniProt

Q6P9T4 - Q6P9T4_MOUSE

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Protein
Submitted name:

Histone deacetylase 5

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi688 – 6881ZincUniRule annotation
Metal bindingi690 – 6901ZincUniRule annotation
Metal bindingi696 – 6961ZincUniRule annotation
Metal bindingi773 – 7731ZincUniRule annotation
Active sitei825 – 8251UniRule annotation

GO - Molecular functioni

  1. histone deacetylase activity Source: Ensembl
  2. transcription corepressor activity Source: MGI
  3. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. heart development Source: MGI
  2. multicellular organismal response to stress Source: MGI
  3. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  4. negative regulation of myotube differentiation Source: Ensembl
  5. negative regulation of osteoblast differentiation Source: MGI
  6. negative regulation of transcription, DNA-templated Source: MGI
  7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  8. osteoblast development Source: MGI
  9. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. regulation of protein binding Source: Ensembl
  12. regulation of skeletal muscle fiber development Source: MGI
  13. regulation of striated muscle cell differentiation Source: MGI
  14. response to cocaine Source: MGI
  15. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 5Imported
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. Golgi apparatus Source: Ensembl
  4. histone deacetylase complex Source: InterPro
  5. nuclear body Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6P9T4.

Expressioni

Gene expression databases

BgeeiQ6P9T4.
ExpressionAtlasiQ6P9T4. baseline and differential.
GenevestigatoriQ6P9T4.

Structurei

3D structure databases

ProteinModelPortaliQ6P9T4.
SMRiQ6P9T4. Positions 67-132, 673-1073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG057100.
KOiK11406.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q6P9T4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNSPNESDGM SGREPSLEIL PRTPLHSIPV AVEVKPVLPG AMPSSMGGGG
60 70 80 90 100
GGSPSPVELR GALAGPMDPA LREQQLQQEL LVLKQQQQLQ KQLLFAEFQK
110 120 130 140 150
QHDHLTRQHE VQLQKHLKQQ QEMLAAKRQQ ELEQQRQREQ QRQEELEKQR
160 170 180 190 200
LEQQLLILRN KEKSKESAIA STEVKLRLQE FLLSKSKEPT PGGLNHSLPQ
210 220 230 240 250
HPKCWGAHHA SLDQSSPPQS GPPGTPPSYK LPLLGPYDSR DDFPLRKTAS
260 270 280 290 300
EPNLKVRSRL KQKVAERRSS PLLRRKDGTV ISTFKKRAVE ITGTGPGVSS
310 320 330 340 350
VCNSAPGSGP SSPNSSHSTI AENGFTGSVP NIPTEMIPQH RALPLDSSPN
360 370 380 390 400
QFSLYTSPSL PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ
410 420 430 440 450
GGTLTGKFMS TSSIPGCLLG VALEGDTSPH GHASLLQHVL LLEQARQQST
460 470 480 490 500
LIAVPLHGQS PLVTGERVAT SMRTVGKLPR HRPLSRTQSS PLPQSPQALQ
510 520 530 540 550
QLVMQQQHQQ FLEKQKQQQM QLGKILTKTG ELSRQPTTHP EETEEELTEQ
560 570 580 590 600
QEALLGEGAL TIPREGSTES ESTQEDLEEE EEEEEEEEED CIQVKDEDGE
610 620 630 640 650
SGPDEGPDLE ESSAGYKKLF ADAQQLQPLQ VYQAPLSLAT VPHQALGRTQ
660 670 680 690 700
SSPAAPGSMK SPTDQPTVVK HLFTTGVVYD TFMLKHQCMC GNTHVHPEHA
710 720 730 740 750
GRIQSIWSRL QETGLLGKCE RIRGRKATLD EIQTVHSEYH TLLYGTSPLN
760 770 780 790 800
RQKLDSKKLL GPISQKMYAM LPCGGIGVDS DTVWNEMHSS SAVRMAVGCL
810 820 830 840 850
VELAFKVAAG ELKNGFAIIR PPGHHAEEST AMGFCFFNSV AITAKLLQQK
860 870 880 890 900
LSVGKVLIVD WDIHHGNGTQ QAFYNDPSVL YISLHRYDNG NFFPGSGAPE
910 920 930 940 950
EVGGGPGVGY NVNVAWTGGV DPPIGDVEYL TAFRTVVMPI AQEFSPDVVL
960 970 980 990 1000
VSAGFDAVEG HLSPLGGYSV TARCFGHLTR QLMTLAGGRV VLALEGGHDL
1010 1020 1030 1040 1050
TAICDASEAC VSALLSVELQ PLDEAVLQQK PSVNAVATLE KVIEIQSKHW
1060 1070 1080 1090 1100
SCVQRFAAGL GCSLREAQTG EKEEAETVSA MALLSVGAEQ AQAVATQEHS
1110
PRPAEEPMEQ EPAL
Length:1,114
Mass (Da):121,148
Last modified:July 5, 2004 - v1
Checksum:i723F3070B7EEB522
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060609 mRNA. Translation: AAH60609.1.
RefSeqiNP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGeneiMm.22665.

Genome annotation databases

GeneIDi15184.
KEGGimmu:15184.
UCSCiuc007lqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060609 mRNA. Translation: AAH60609.1 .
RefSeqi NP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGenei Mm.22665.

3D structure databases

ProteinModelPortali Q6P9T4.
SMRi Q6P9T4. Positions 67-132, 673-1073.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6P9T4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15184.
KEGGi mmu:15184.
UCSCi uc007lqu.1. mouse.

Organism-specific databases

CTDi 10014.
MGIi MGI:1333784. Hdac5.

Phylogenomic databases

HOVERGENi HBG057100.
KOi K11406.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi HDAC5. mouse.
NextBioi 287701.
SOURCEi Search...

Gene expression databases

Bgeei Q6P9T4.
ExpressionAtlasi Q6P9T4. baseline and differential.
Genevestigatori Q6P9T4.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: MouseImported.

Entry informationi

Entry nameiQ6P9T4_MOUSE
AccessioniPrimary (citable) accession number: Q6P9T4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)