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Q6P9T4 (Q6P9T4_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Hdac5 EMBL AAH60609.1 MGI 1333784
OrganismMus musculus (Mouse) EMBL AAH60609.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1114 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Molecular functionHydrolase SAAS SAAS000286
Gene Ontology (GO)
   Biological_processheart development

Inferred from genetic interaction PubMed 15367668. Source: MGI

multicellular organismal response to stress

Inferred from mutant phenotype PubMed 17988634. Source: MGI

negative regulation of cell migration involved in sprouting angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of myotube differentiation

Inferred from electronic annotation. Source: Ensembl

negative regulation of osteoblast differentiation

Inferred from mutant phenotype PubMed 15990875. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 10640276. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 16260608. Source: MGI

osteoblast development

Inferred from mutant phenotype PubMed 15990875. Source: MGI

positive regulation of sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of protein binding

Inferred from electronic annotation. Source: Ensembl

regulation of skeletal muscle fiber development

Inferred from genetic interaction PubMed 17786239. Source: MGI

regulation of striated muscle cell differentiation

Inferred from genetic interaction PubMed 17786239. Source: MGI

response to cocaine

Inferred from direct assay PubMed 17988634. Source: MGI

response to drug

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi apparatus

Inferred from electronic annotation. Source: Ensembl

cytoplasm

Inferred from direct assay PubMed 11081517. Source: MGI

cytosol

Inferred from direct assay PubMed 18198354PubMed 18332106. Source: MGI

histone deacetylase complex

Inferred from electronic annotation. Source: InterPro

nuclear body

Inferred from direct assay PubMed 11641275. Source: MGI

nucleus

Inferred from direct assay PubMed 11081517PubMed 18198354. Source: MGI

   Molecular_functionhistone deacetylase activity

Inferred from electronic annotation. Source: Ensembl

protein binding

Inferred from physical interaction PubMed 10640276PubMed 11641275PubMed 15601857PubMed 15990875PubMed 16260608PubMed 18332106. Source: MGI

transcription corepressor activity

Inferred from direct assay PubMed 10640276. Source: MGI

transcription regulatory region DNA binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q6P9T4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 723F3070B7EEB522

FASTA1,114121,148
        10         20         30         40         50         60 
MNSPNESDGM SGREPSLEIL PRTPLHSIPV AVEVKPVLPG AMPSSMGGGG GGSPSPVELR 

        70         80         90        100        110        120 
GALAGPMDPA LREQQLQQEL LVLKQQQQLQ KQLLFAEFQK QHDHLTRQHE VQLQKHLKQQ 

       130        140        150        160        170        180 
QEMLAAKRQQ ELEQQRQREQ QRQEELEKQR LEQQLLILRN KEKSKESAIA STEVKLRLQE 

       190        200        210        220        230        240 
FLLSKSKEPT PGGLNHSLPQ HPKCWGAHHA SLDQSSPPQS GPPGTPPSYK LPLLGPYDSR 

       250        260        270        280        290        300 
DDFPLRKTAS EPNLKVRSRL KQKVAERRSS PLLRRKDGTV ISTFKKRAVE ITGTGPGVSS 

       310        320        330        340        350        360 
VCNSAPGSGP SSPNSSHSTI AENGFTGSVP NIPTEMIPQH RALPLDSSPN QFSLYTSPSL 

       370        380        390        400        410        420 
PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ GGTLTGKFMS TSSIPGCLLG 

       430        440        450        460        470        480 
VALEGDTSPH GHASLLQHVL LLEQARQQST LIAVPLHGQS PLVTGERVAT SMRTVGKLPR 

       490        500        510        520        530        540 
HRPLSRTQSS PLPQSPQALQ QLVMQQQHQQ FLEKQKQQQM QLGKILTKTG ELSRQPTTHP 

       550        560        570        580        590        600 
EETEEELTEQ QEALLGEGAL TIPREGSTES ESTQEDLEEE EEEEEEEEED CIQVKDEDGE 

       610        620        630        640        650        660 
SGPDEGPDLE ESSAGYKKLF ADAQQLQPLQ VYQAPLSLAT VPHQALGRTQ SSPAAPGSMK 

       670        680        690        700        710        720 
SPTDQPTVVK HLFTTGVVYD TFMLKHQCMC GNTHVHPEHA GRIQSIWSRL QETGLLGKCE 

       730        740        750        760        770        780 
RIRGRKATLD EIQTVHSEYH TLLYGTSPLN RQKLDSKKLL GPISQKMYAM LPCGGIGVDS 

       790        800        810        820        830        840 
DTVWNEMHSS SAVRMAVGCL VELAFKVAAG ELKNGFAIIR PPGHHAEEST AMGFCFFNSV 

       850        860        870        880        890        900 
AITAKLLQQK LSVGKVLIVD WDIHHGNGTQ QAFYNDPSVL YISLHRYDNG NFFPGSGAPE 

       910        920        930        940        950        960 
EVGGGPGVGY NVNVAWTGGV DPPIGDVEYL TAFRTVVMPI AQEFSPDVVL VSAGFDAVEG 

       970        980        990       1000       1010       1020 
HLSPLGGYSV TARCFGHLTR QLMTLAGGRV VLALEGGHDL TAICDASEAC VSALLSVELQ 

      1030       1040       1050       1060       1070       1080 
PLDEAVLQQK PSVNAVATLE KVIEIQSKHW SCVQRFAAGL GCSLREAQTG EKEEAETVSA 

      1090       1100       1110 
MALLSVGAEQ AQAVATQEHS PRPAEEPMEQ EPAL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH60609.1.
Tissue: Mouse EMBL AAH60609.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC060609 mRNA. Translation: AAH60609.1.
RefSeqNP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGeneMm.22665.

3D structure databases

ProteinModelPortalQ6P9T4.
SMRQ6P9T4. Positions 67-132, 673-1073.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6P9T4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID15184.
KEGGmmu:15184.
UCSCuc007lqu.1. mouse.

Organism-specific databases

CTD10014.
MGIMGI:1333784. Hdac5.

Phylogenomic databases

HOVERGENHBG057100.
KOK11406.

Gene expression databases

ArrayExpressQ6P9T4.
BgeeQ6P9T4.
GenevestigatorQ6P9T4.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSPR01270. HDASUPER.
ProtoNetSearch...

Other

ChiTaRSHDAC5. mouse.
NextBio287701.
SOURCESearch...

Entry information

Entry nameQ6P9T4_MOUSE
AccessionPrimary (citable) accession number: Q6P9T4
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)