Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P9T4

- Q6P9T4_MOUSE

UniProt

Q6P9T4 - Q6P9T4_MOUSE

Protein
Submitted name:

Histone deacetylase 5

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: Ensembl
    2. protein binding Source: MGI
    3. transcription corepressor activity Source: MGI
    4. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. heart development Source: MGI
    2. multicellular organismal response to stress Source: MGI
    3. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
    4. negative regulation of myotube differentiation Source: Ensembl
    5. negative regulation of osteoblast differentiation Source: MGI
    6. negative regulation of transcription, DNA-templated Source: MGI
    7. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    8. osteoblast development Source: MGI
    9. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
    10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    11. regulation of protein binding Source: Ensembl
    12. regulation of skeletal muscle fiber development Source: MGI
    13. regulation of striated muscle cell differentiation Source: MGI
    14. response to cocaine Source: MGI
    15. response to drug Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Enzyme and pathway databases

    ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone deacetylase 5Imported
    Gene namesi
    Name:Hdac5Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1333784. Hdac5.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. cytosol Source: MGI
    3. Golgi apparatus Source: Ensembl
    4. histone deacetylase complex Source: InterPro
    5. nuclear body Source: MGI
    6. nucleus Source: MGI

    PTM / Processingi

    Proteomic databases

    PRIDEiQ6P9T4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ6P9T4.
    BgeeiQ6P9T4.
    GenevestigatoriQ6P9T4.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P9T4.
    SMRiQ6P9T4. Positions 67-132, 673-1073.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG057100.
    KOiK11406.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSiPR01270. HDASUPER.

    Sequencei

    Sequence statusi: Complete.

    Q6P9T4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSPNESDGM SGREPSLEIL PRTPLHSIPV AVEVKPVLPG AMPSSMGGGG     50
    GGSPSPVELR GALAGPMDPA LREQQLQQEL LVLKQQQQLQ KQLLFAEFQK 100
    QHDHLTRQHE VQLQKHLKQQ QEMLAAKRQQ ELEQQRQREQ QRQEELEKQR 150
    LEQQLLILRN KEKSKESAIA STEVKLRLQE FLLSKSKEPT PGGLNHSLPQ 200
    HPKCWGAHHA SLDQSSPPQS GPPGTPPSYK LPLLGPYDSR DDFPLRKTAS 250
    EPNLKVRSRL KQKVAERRSS PLLRRKDGTV ISTFKKRAVE ITGTGPGVSS 300
    VCNSAPGSGP SSPNSSHSTI AENGFTGSVP NIPTEMIPQH RALPLDSSPN 350
    QFSLYTSPSL PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ 400
    GGTLTGKFMS TSSIPGCLLG VALEGDTSPH GHASLLQHVL LLEQARQQST 450
    LIAVPLHGQS PLVTGERVAT SMRTVGKLPR HRPLSRTQSS PLPQSPQALQ 500
    QLVMQQQHQQ FLEKQKQQQM QLGKILTKTG ELSRQPTTHP EETEEELTEQ 550
    QEALLGEGAL TIPREGSTES ESTQEDLEEE EEEEEEEEED CIQVKDEDGE 600
    SGPDEGPDLE ESSAGYKKLF ADAQQLQPLQ VYQAPLSLAT VPHQALGRTQ 650
    SSPAAPGSMK SPTDQPTVVK HLFTTGVVYD TFMLKHQCMC GNTHVHPEHA 700
    GRIQSIWSRL QETGLLGKCE RIRGRKATLD EIQTVHSEYH TLLYGTSPLN 750
    RQKLDSKKLL GPISQKMYAM LPCGGIGVDS DTVWNEMHSS SAVRMAVGCL 800
    VELAFKVAAG ELKNGFAIIR PPGHHAEEST AMGFCFFNSV AITAKLLQQK 850
    LSVGKVLIVD WDIHHGNGTQ QAFYNDPSVL YISLHRYDNG NFFPGSGAPE 900
    EVGGGPGVGY NVNVAWTGGV DPPIGDVEYL TAFRTVVMPI AQEFSPDVVL 950
    VSAGFDAVEG HLSPLGGYSV TARCFGHLTR QLMTLAGGRV VLALEGGHDL 1000
    TAICDASEAC VSALLSVELQ PLDEAVLQQK PSVNAVATLE KVIEIQSKHW 1050
    SCVQRFAAGL GCSLREAQTG EKEEAETVSA MALLSVGAEQ AQAVATQEHS 1100
    PRPAEEPMEQ EPAL 1114
    Length:1,114
    Mass (Da):121,148
    Last modified:July 5, 2004 - v1
    Checksum:i723F3070B7EEB522
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060609 mRNA. Translation: AAH60609.1.
    RefSeqiNP_001071164.1. NM_001077696.1.
    NP_001271177.1. NM_001284248.1.
    NP_001271178.1. NM_001284249.1.
    NP_001271179.1. NM_001284250.1.
    NP_034542.3. NM_010412.3.
    UniGeneiMm.22665.

    Genome annotation databases

    GeneIDi15184.
    KEGGimmu:15184.
    UCSCiuc007lqu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC060609 mRNA. Translation: AAH60609.1 .
    RefSeqi NP_001071164.1. NM_001077696.1.
    NP_001271177.1. NM_001284248.1.
    NP_001271178.1. NM_001284249.1.
    NP_001271179.1. NM_001284250.1.
    NP_034542.3. NM_010412.3.
    UniGenei Mm.22665.

    3D structure databases

    ProteinModelPortali Q6P9T4.
    SMRi Q6P9T4. Positions 67-132, 673-1073.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6P9T4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15184.
    KEGGi mmu:15184.
    UCSCi uc007lqu.1. mouse.

    Organism-specific databases

    CTDi 10014.
    MGIi MGI:1333784. Hdac5.

    Phylogenomic databases

    HOVERGENi HBG057100.
    KOi K11406.

    Enzyme and pathway databases

    Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
    REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
    REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

    Miscellaneous databases

    ChiTaRSi HDAC5. mouse.
    NextBioi 287701.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P9T4.
    Bgeei Q6P9T4.
    Genevestigatori Q6P9T4.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR024643. Hist_deacetylase_Gln_rich_N.
    IPR017320. Histone_deAcase_II_euk.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF12203. HDAC4_Gln. 1 hit.
    PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
    PRINTSi PR01270. HDASUPER.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
      , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6Imported.
      Tissue: MouseImported.

    Entry informationi

    Entry nameiQ6P9T4_MOUSE
    AccessioniPrimary (citable) accession number: Q6P9T4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)