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Protein

Histone deacetylase

Gene

Hdac5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.UniRule annotation

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi688 – 6881ZincUniRule annotation
Metal bindingi690 – 6901ZincUniRule annotation
Metal bindingi696 – 6961ZincUniRule annotation
Metal bindingi773 – 7731ZincUniRule annotation
Active sitei825 – 8251UniRule annotation

GO - Molecular functioni

  1. core promoter binding Source: MGI
  2. histone deacetylase activity Source: MGI
  3. metal ion binding Source: UniProtKB-KW
  4. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  5. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  6. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  7. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  8. protein kinase C binding Source: MGI
  9. repressing transcription factor binding Source: MGI
  10. transcription corepressor activity Source: MGI
  11. transcription factor binding Source: MGI

GO - Biological processi

  1. heart development Source: MGI
  2. histone deacetylation Source: MGI
  3. multicellular organismal response to stress Source: MGI
  4. negative regulation of cell migration involved in sprouting angiogenesis Source: MGI
  5. negative regulation of myotube differentiation Source: MGI
  6. negative regulation of osteoblast differentiation Source: MGI
  7. negative regulation of transcription, DNA-templated Source: MGI
  8. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  9. osteoblast development Source: MGI
  10. positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. regulation of gene expression, epigenetic Source: MGI
  13. regulation of protein binding Source: MGI
  14. regulation of skeletal muscle fiber development Source: MGI
  15. regulation of striated muscle cell differentiation Source: MGI
  16. response to cocaine Source: MGI
  17. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation, RepressorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiREACT_278108. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_334977. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_349648. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. cytosol Source: MGI
  3. Golgi apparatus Source: MGI
  4. histone deacetylase complex Source: InterPro
  5. nuclear body Source: MGI
  6. nucleoplasm Source: MGI
  7. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6P9T4.

Expressioni

Gene expression databases

BgeeiQ6P9T4.
ExpressionAtlasiQ6P9T4. baseline and differential.
GenevestigatoriQ6P9T4.

Structurei

3D structure databases

ProteinModelPortaliQ6P9T4.
SMRiQ6P9T4. Positions 67-132, 673-1073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD type 2 subfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG057100.
KOiK11406.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q6P9T4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSPNESDGM SGREPSLEIL PRTPLHSIPV AVEVKPVLPG AMPSSMGGGG
60 70 80 90 100
GGSPSPVELR GALAGPMDPA LREQQLQQEL LVLKQQQQLQ KQLLFAEFQK
110 120 130 140 150
QHDHLTRQHE VQLQKHLKQQ QEMLAAKRQQ ELEQQRQREQ QRQEELEKQR
160 170 180 190 200
LEQQLLILRN KEKSKESAIA STEVKLRLQE FLLSKSKEPT PGGLNHSLPQ
210 220 230 240 250
HPKCWGAHHA SLDQSSPPQS GPPGTPPSYK LPLLGPYDSR DDFPLRKTAS
260 270 280 290 300
EPNLKVRSRL KQKVAERRSS PLLRRKDGTV ISTFKKRAVE ITGTGPGVSS
310 320 330 340 350
VCNSAPGSGP SSPNSSHSTI AENGFTGSVP NIPTEMIPQH RALPLDSSPN
360 370 380 390 400
QFSLYTSPSL PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ
410 420 430 440 450
GGTLTGKFMS TSSIPGCLLG VALEGDTSPH GHASLLQHVL LLEQARQQST
460 470 480 490 500
LIAVPLHGQS PLVTGERVAT SMRTVGKLPR HRPLSRTQSS PLPQSPQALQ
510 520 530 540 550
QLVMQQQHQQ FLEKQKQQQM QLGKILTKTG ELSRQPTTHP EETEEELTEQ
560 570 580 590 600
QEALLGEGAL TIPREGSTES ESTQEDLEEE EEEEEEEEED CIQVKDEDGE
610 620 630 640 650
SGPDEGPDLE ESSAGYKKLF ADAQQLQPLQ VYQAPLSLAT VPHQALGRTQ
660 670 680 690 700
SSPAAPGSMK SPTDQPTVVK HLFTTGVVYD TFMLKHQCMC GNTHVHPEHA
710 720 730 740 750
GRIQSIWSRL QETGLLGKCE RIRGRKATLD EIQTVHSEYH TLLYGTSPLN
760 770 780 790 800
RQKLDSKKLL GPISQKMYAM LPCGGIGVDS DTVWNEMHSS SAVRMAVGCL
810 820 830 840 850
VELAFKVAAG ELKNGFAIIR PPGHHAEEST AMGFCFFNSV AITAKLLQQK
860 870 880 890 900
LSVGKVLIVD WDIHHGNGTQ QAFYNDPSVL YISLHRYDNG NFFPGSGAPE
910 920 930 940 950
EVGGGPGVGY NVNVAWTGGV DPPIGDVEYL TAFRTVVMPI AQEFSPDVVL
960 970 980 990 1000
VSAGFDAVEG HLSPLGGYSV TARCFGHLTR QLMTLAGGRV VLALEGGHDL
1010 1020 1030 1040 1050
TAICDASEAC VSALLSVELQ PLDEAVLQQK PSVNAVATLE KVIEIQSKHW
1060 1070 1080 1090 1100
SCVQRFAAGL GCSLREAQTG EKEEAETVSA MALLSVGAEQ AQAVATQEHS
1110
PRPAEEPMEQ EPAL
Length:1,114
Mass (Da):121,148
Last modified:July 5, 2004 - v1
Checksum:i723F3070B7EEB522
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060609 mRNA. Translation: AAH60609.1.
RefSeqiNP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGeneiMm.22665.

Genome annotation databases

GeneIDi15184.
KEGGimmu:15184.
UCSCiuc007lqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060609 mRNA. Translation: AAH60609.1.
RefSeqiNP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGeneiMm.22665.

3D structure databases

ProteinModelPortaliQ6P9T4.
SMRiQ6P9T4. Positions 67-132, 673-1073.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6P9T4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15184.
KEGGimmu:15184.
UCSCiuc007lqu.1. mouse.

Organism-specific databases

CTDi10014.
MGIiMGI:1333784. Hdac5.

Phylogenomic databases

HOVERGENiHBG057100.
KOiK11406.

Enzyme and pathway databases

ReactomeiREACT_278108. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.
REACT_334977. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_349648. Constitutive Signaling by NOTCH1 PEST Domain Mutants.

Miscellaneous databases

ChiTaRSiHdac5. mouse.
NextBioi287701.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P9T4.
ExpressionAtlasiQ6P9T4. baseline and differential.
GenevestigatoriQ6P9T4.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: MouseImported.

Entry informationi

Entry nameiQ6P9T4_MOUSE
AccessioniPrimary (citable) accession number: Q6P9T4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.