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Q6P9T4

- Q6P9T4_MOUSE

UniProt

Q6P9T4 - Q6P9T4_MOUSE

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Protein
Submitted name: Histone deacetylase 5
Gene
Hdac5
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: Ensembl
  2. protein binding Source: MGI
  3. transcription corepressor activity Source: MGI
  4. transcription regulatory region DNA binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

  1. heart development Source: MGI
  2. multicellular organismal response to stress Source: MGI
  3. negative regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  4. negative regulation of myotube differentiation Source: Ensembl
  5. negative regulation of osteoblast differentiation Source: MGI
  6. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  7. negative regulation of transcription, DNA-templated Source: MGI
  8. osteoblast development Source: MGI
  9. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  10. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  11. regulation of protein binding Source: Ensembl
  12. regulation of skeletal muscle fiber development Source: MGI
  13. regulation of striated muscle cell differentiation Source: MGI
  14. response to cocaine Source: MGI
  15. response to drug Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotations

Enzyme and pathway databases

ReactomeiREACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 5Imported
Gene namesi
Name:Hdac5Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1333784. Hdac5.

Subcellular locationi

GO - Cellular componenti

  1. Golgi apparatus Source: Ensembl
  2. cytoplasm Source: MGI
  3. cytosol Source: MGI
  4. histone deacetylase complex Source: InterPro
  5. nuclear body Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Proteomic databases

PRIDEiQ6P9T4.

Expressioni

Gene expression databases

ArrayExpressiQ6P9T4.
BgeeiQ6P9T4.
GenevestigatoriQ6P9T4.

Structurei

3D structure databases

ProteinModelPortaliQ6P9T4.
SMRiQ6P9T4. Positions 67-132, 673-1073.

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG057100.
KOiK11406.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037911. HDAC_II_euk. 1 hit.
PRINTSiPR01270. HDASUPER.

Sequencei

Sequence statusi: Complete.

Q6P9T4-1 [UniParc]FASTAAdd to Basket

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MNSPNESDGM SGREPSLEIL PRTPLHSIPV AVEVKPVLPG AMPSSMGGGG     50
GGSPSPVELR GALAGPMDPA LREQQLQQEL LVLKQQQQLQ KQLLFAEFQK 100
QHDHLTRQHE VQLQKHLKQQ QEMLAAKRQQ ELEQQRQREQ QRQEELEKQR 150
LEQQLLILRN KEKSKESAIA STEVKLRLQE FLLSKSKEPT PGGLNHSLPQ 200
HPKCWGAHHA SLDQSSPPQS GPPGTPPSYK LPLLGPYDSR DDFPLRKTAS 250
EPNLKVRSRL KQKVAERRSS PLLRRKDGTV ISTFKKRAVE ITGTGPGVSS 300
VCNSAPGSGP SSPNSSHSTI AENGFTGSVP NIPTEMIPQH RALPLDSSPN 350
QFSLYTSPSL PNISLGLQAT VTVTNSHLTA SPKLSTQQEA ERQALQSLRQ 400
GGTLTGKFMS TSSIPGCLLG VALEGDTSPH GHASLLQHVL LLEQARQQST 450
LIAVPLHGQS PLVTGERVAT SMRTVGKLPR HRPLSRTQSS PLPQSPQALQ 500
QLVMQQQHQQ FLEKQKQQQM QLGKILTKTG ELSRQPTTHP EETEEELTEQ 550
QEALLGEGAL TIPREGSTES ESTQEDLEEE EEEEEEEEED CIQVKDEDGE 600
SGPDEGPDLE ESSAGYKKLF ADAQQLQPLQ VYQAPLSLAT VPHQALGRTQ 650
SSPAAPGSMK SPTDQPTVVK HLFTTGVVYD TFMLKHQCMC GNTHVHPEHA 700
GRIQSIWSRL QETGLLGKCE RIRGRKATLD EIQTVHSEYH TLLYGTSPLN 750
RQKLDSKKLL GPISQKMYAM LPCGGIGVDS DTVWNEMHSS SAVRMAVGCL 800
VELAFKVAAG ELKNGFAIIR PPGHHAEEST AMGFCFFNSV AITAKLLQQK 850
LSVGKVLIVD WDIHHGNGTQ QAFYNDPSVL YISLHRYDNG NFFPGSGAPE 900
EVGGGPGVGY NVNVAWTGGV DPPIGDVEYL TAFRTVVMPI AQEFSPDVVL 950
VSAGFDAVEG HLSPLGGYSV TARCFGHLTR QLMTLAGGRV VLALEGGHDL 1000
TAICDASEAC VSALLSVELQ PLDEAVLQQK PSVNAVATLE KVIEIQSKHW 1050
SCVQRFAAGL GCSLREAQTG EKEEAETVSA MALLSVGAEQ AQAVATQEHS 1100
PRPAEEPMEQ EPAL 1114
Length:1,114
Mass (Da):121,148
Last modified:July 5, 2004 - v1
Checksum:i723F3070B7EEB522
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060609 mRNA. Translation: AAH60609.1.
RefSeqiNP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGeneiMm.22665.

Genome annotation databases

GeneIDi15184.
KEGGimmu:15184.
UCSCiuc007lqu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC060609 mRNA. Translation: AAH60609.1 .
RefSeqi NP_001071164.1. NM_001077696.1.
NP_001271177.1. NM_001284248.1.
NP_001271178.1. NM_001284249.1.
NP_001271179.1. NM_001284250.1.
NP_034542.3. NM_010412.3.
UniGenei Mm.22665.

3D structure databases

ProteinModelPortali Q6P9T4.
SMRi Q6P9T4. Positions 67-132, 673-1073.
ModBasei Search...

Proteomic databases

PRIDEi Q6P9T4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15184.
KEGGi mmu:15184.
UCSCi uc007lqu.1. mouse.

Organism-specific databases

CTDi 10014.
MGIi MGI:1333784. Hdac5.

Phylogenomic databases

HOVERGENi HBG057100.
KOi K11406.

Enzyme and pathway databases

Reactomei REACT_196464. NOTCH1 Intracellular Domain Regulates Transcription.
REACT_196589. Constitutive Signaling by NOTCH1 PEST Domain Mutants.
REACT_196591. Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.

Miscellaneous databases

ChiTaRSi HDAC5. mouse.
NextBioi 287701.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P9T4.
Bgeei Q6P9T4.
Genevestigatori Q6P9T4.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR024643. Hist_deacetylase_Gln_rich_N.
IPR017320. Histone_deAcase_II_euk.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF12203. HDAC4_Gln. 1 hit.
PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037911. HDAC_II_euk. 1 hit.
PRINTSi PR01270. HDASUPER.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: MouseImported.

Entry informationi

Entry nameiQ6P9T4_MOUSE
AccessioniPrimary (citable) accession number: Q6P9T4
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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