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Protein

ATM interactor

Gene

Atmin

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor. Plays a crucial role in cell survival and RAD51 foci formation in response to methylating DNA damage. Involved in regulating the activity of ATM in the absence of DNA damage. May play a role in stabilizing ATM (By similarity). Binds to the DYNLL1 promoter and activates its transcription.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 105C2H2-type 1Sequence analysisAdd BLAST26
Zinc fingeri161 – 181C2H2-type 2; degenerateSequence analysisAdd BLAST21

GO - Molecular functioni

  • dynein binding Source: MGI
  • metal ion binding Source: UniProtKB-KW
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • cellular response to DNA damage stimulus Source: UniProtKB-KW
  • motile cilium assembly Source: MGI
  • positive regulation of gene expression Source: MGI
  • positive regulation of non-motile cilium assembly Source: MGI
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

DNA damage, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
ATM interactorImported
Alternative name(s):
ATM/ATR-substrate CHK2-interacting zinc finger proteinBy similarity
Short name:
ASCIZBy similarity
Gene namesi
Name:AtminImported
Synonyms:Kiaa0431Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2682328. Atmin.

Subcellular locationi

  • Nucleus By similarity

  • Note: Nuclear, in discrete foci during G1 phase.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003550361 – 818ATM interactorAdd BLAST818

Proteomic databases

PaxDbiQ6P9S1.
PRIDEiQ6P9S1.

PTM databases

iPTMnetiQ6P9S1.
PhosphoSitePlusiQ6P9S1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000047388.
GenevisibleiQ6P9S1. MM.

Interactioni

Subunit structurei

Interacts via its C-terminus with ATM. Interacts with DYNLL; this interaction inhibits ATMIN transcriptional activity and hence may play a role in a feedback loop whereby DYNLL1 inhibits transactivation of its own promoter by ATMIN. ATMIN.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104727.

Structurei

3D structure databases

ProteinModelPortaliQ6P9S1.
SMRiQ6P9S1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni219 – 437Required for formation of RAD51 fociBy similarityAdd BLAST219

Sequence similaritiesi

Contains 2 C2H2-type zinc fingers.Sequence analysis

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri80 – 105C2H2-type 1Sequence analysisAdd BLAST26
Zinc fingeri161 – 181C2H2-type 2; degenerateSequence analysisAdd BLAST21

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013091.
HOGENOMiHOG000034178.
HOVERGENiHBG106238.
InParanoidiQ6P9S1.
OMAiQSYSCRG.
OrthoDBiEOG091G0EJB.
PhylomeDBiQ6P9S1.
TreeFamiTF331171.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAATEAAAAD SAGPAPGVPA TPASTRGAAA ASSPWRPPES RLQGSRPRPA
60 70 80 90 100
RARAAAPVPP ARELIQPTVS ELSRAVRTNI LCTVRGCGKI LPNSPALNMH
110 120 130 140 150
LVKSHRLQDG IVNPTIRKDL TTAPKFYCCP IKGCPRGPDR PFSQFSLVKQ
160 170 180 190 200
HFMKMHAEKK HKCSKCSNSY GTEWDLKRHE EDCGKTFQCT CGCPYASRTA
210 220 230 240 250
LQSHIYRTGH EIPAEHRDPP SKKRKMESYL QNQKLSSKTT EPLSDQAAPR
260 270 280 290 300
QDAAEPDAPE VKPAASLEDS CSAHTKKQSV ATPPRCPQKL LLPKPKVALV
310 320 330 340 350
KLPVMQFSPV PVFVPTAESS AQPVVLGVDH SSAAGTVHLV PLSVGALILS
360 370 380 390 400
LDSEACSLKE SLPLSKIISP VVEPMNTGVQ VNLGKSLCSP LQEVGSVCQR
410 420 430 440 450
TSISSSNVQT DLTYASANLI PSAQWLGPDS SVSSCSQTDL SFDSQVSLPV
460 470 480 490 500
SVHTQTLVPS SKVTSSIAAQ TDAFIDACFQ PGGVSRETQT SRMQNRTNDS
510 520 530 540 550
VPVGHTGLCG DIFESVHASY SVPTDTIMSS SLVAETGTHG LPPQSDPKIL
560 570 580 590 600
GQVMEKSAPV LNFSTQNGLL PAHTMTDNQT QTIDLLSDLE NILSSNLPGQ
610 620 630 640 650
TLDNRSLLSD TNPGPDAQLP AGSAQNSGID FDIEEFLSAS NIQTQTEESE
660 670 680 690 700
LSSMSTEPVL ESLDIETQTD VLLSDPSTQP YGFRAGSGFL GLEMFDTQTQ
710 720 730 740 750
TDLNFFLDSS PHLPLGSILK HSSFSMSTDS SDTETQTEGA CPARHLPALE
760 770 780 790 800
SKVQLSSTET QTMSSGFEPL GNLFLTSNET QTAMDDFLLA DLAWNTMESQ
810
FSSVETQTCA ELHAVSSF
Length:818
Mass (Da):87,424
Last modified:November 25, 2008 - v2
Checksum:iF083B47FE0621B35
GO

Sequence cautioni

The sequence AAH27752 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH60631 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC39849 differs from that shown. Reason: Frameshift at position 222.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 3MAA → MGP (PubMed:17525732).Curated3
Sequence conflicti1M → TRP in AAH27752 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162858 Genomic DNA. No translation available.
BC027752 mRNA. Translation: AAH27752.1. Sequence problems.
BC060631 mRNA. Translation: AAH60631.1. Different initiation.
AK122281 mRNA. Translation: BAC65563.1.
AK087334 mRNA. Translation: BAC39849.1. Frameshift.
CCDSiCCDS22694.2.
RefSeqiNP_808368.3. NM_177700.4.
UniGeneiMm.259736.

Genome annotation databases

EnsembliENSMUST00000109099; ENSMUSP00000104727; ENSMUSG00000047388.
GeneIDi234776.
KEGGimmu:234776.
UCSCiuc009nop.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162858 Genomic DNA. No translation available.
BC027752 mRNA. Translation: AAH27752.1. Sequence problems.
BC060631 mRNA. Translation: AAH60631.1. Different initiation.
AK122281 mRNA. Translation: BAC65563.1.
AK087334 mRNA. Translation: BAC39849.1. Frameshift.
CCDSiCCDS22694.2.
RefSeqiNP_808368.3. NM_177700.4.
UniGeneiMm.259736.

3D structure databases

ProteinModelPortaliQ6P9S1.
SMRiQ6P9S1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000104727.

PTM databases

iPTMnetiQ6P9S1.
PhosphoSitePlusiQ6P9S1.

Proteomic databases

PaxDbiQ6P9S1.
PRIDEiQ6P9S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109099; ENSMUSP00000104727; ENSMUSG00000047388.
GeneIDi234776.
KEGGimmu:234776.
UCSCiuc009nop.2. mouse.

Organism-specific databases

CTDi23300.
MGIiMGI:2682328. Atmin.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00390000013091.
HOGENOMiHOG000034178.
HOVERGENiHBG106238.
InParanoidiQ6P9S1.
OMAiQSYSCRG.
OrthoDBiEOG091G0EJB.
PhylomeDBiQ6P9S1.
TreeFamiTF331171.

Miscellaneous databases

PROiQ6P9S1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047388.
GenevisibleiQ6P9S1. MM.

Family and domain databases

InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 4 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATMIN_MOUSE
AccessioniPrimary (citable) accession number: Q6P9S1
Secondary accession number(s): Q05CB1, Q80U05, Q8C311
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: November 25, 2008
Last modified: November 30, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.