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Protein

MTSS1-like protein

Gene

Mtss1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling.By similarity

GO - Molecular functioni

  • actin monomer binding Source: MGI
  • GTPase activator activity Source: MGI
  • phosphatidylinositol-4,5-bisphosphate binding Source: MGI
  • Rac GTPase binding Source: MGI

GO - Biological processi

  • activation of GTPase activity Source: MGI
  • cellular response to platelet-derived growth factor stimulus Source: MGI
  • lamellipodium organization Source: MGI
  • membrane organization Source: MGI
  • plasma membrane organization Source: InterPro
  • ruffle assembly Source: InterPro

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MTSS1-like protein
Gene namesi
Name:Mtss1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3039591 Mtss1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003196111 – 715MTSS1-like proteinAdd BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei404PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei564PhosphoserineBy similarity1
Modified residuei575PhosphoserineCombined sources1
Modified residuei587PhosphoserineBy similarity1
Modified residuei597PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei606PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P9S0
PaxDbiQ6P9S0
PeptideAtlasiQ6P9S0
PRIDEiQ6P9S0

PTM databases

iPTMnetiQ6P9S0
PhosphoSitePlusiQ6P9S0

Expressioni

Gene expression databases

BgeeiENSMUSG00000033763
CleanExiMM_BC060632
ExpressionAtlasiQ6P9S0 baseline and differential
GenevisibleiQ6P9S0 MM

Interactioni

Subunit structurei

Interacts (via IMD domain) with RAC1; this interaction may be important to potentiate PDGF-induced RAC1 activation.By similarity

GO - Molecular functioni

  • actin monomer binding Source: MGI
  • Rac GTPase binding Source: MGI

Protein-protein interaction databases

BioGridi2326731 interactor.
IntActiQ6P9S0 1 interactor.
STRINGi10090.ENSMUSP00000050211

Structurei

3D structure databases

ProteinModelPortaliQ6P9S0
SMRiQ6P9S0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini687 – 704WH2Add BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili134 – 156Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi249 – 339Ser-richAdd BLAST91

Sequence similaritiesi

Belongs to the MTSS1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGVU Eukaryota
ENOG410XRT4 LUCA
GeneTreeiENSGT00390000002637
HOGENOMiHOG000113691
HOVERGENiHBG052530
InParanoidiQ6P9S0
KOiK20128
OMAiAEKECGA
OrthoDBiEOG091G083M
PhylomeDBiQ6P9S0
TreeFamiTF320619

Family and domain databases

Gene3Di1.20.1270.601 hit
InterProiView protein in InterPro
IPR030059 ABBA
IPR027267 AH/BAR_dom_sf
IPR013606 I-BAR_dom
IPR030127 MIM/ABBA
PANTHERiPTHR15708 PTHR15708, 1 hit
PTHR15708:SF8 PTHR15708:SF8, 1 hit
PfamiView protein in Pfam
PF08397 IMD, 1 hit
SUPFAMiSSF103657 SSF103657, 1 hit
PROSITEiView protein in PROSITE
PS51338 IMD, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P9S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKAAKLH SQLRTTVLAA
60 70 80 90 100
VAFLDAFQKV ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL
110 120 130 140 150
ESLINPLQER IEDWKKSANQ LDKDHAKEYK RARHEIKKKS SDTLKLQKKA
160 170 180 190 200
RKGKGDLQPQ LDSALQDVND MYLLLEETEK QAVRRALIEE RGRFCTFITF
210 220 230 240 250
LQPVVNGELT MLGEITHLQG IIDDLVVLTA DPHKLPPASE QVIKDLKGSD
260 270 280 290 300
YSWSYQTPPS SPSSSNSRKS SMCSLAQPAT TRLSSVSSHD SGFVSQDPTY
310 320 330 340 350
SKPPSPMPSD ITSQKSSSSA SSEASETCQS VSECSSPTSD WTKAGPHEQP
360 370 380 390 400
SATTLQRRKD RVEHLRDTEP GPTGGGTVGS SGEEVPRTRM SPATIAAKHG
410 420 430 440 450
EEVSPAASDL AMVLTRGLSL EHQKSSRDSL QYSSGYSTQT TTPSCSEDTI
460 470 480 490 500
PSQGSDYDCY SVNGDADSEG PPEFDKSSTI PRNSNIAQNY RRLIQTKRPA
510 520 530 540 550
STAGLPTAGL PTAMGLPSGA PPGVATIRRT PSTKPTVRRA LSSAGPIPIR
560 570 580 590 600
PPIVPVKTPT VPDSPGYVGP TRAGSEECVF YTDEVASPLA PDLAKASPKR
610 620 630 640 650
LSLPNTAWGS QSPEVASYGG GAAVGLATED EEQQLAANRH SLVEKLGELV
660 670 680 690 700
AGAHALGEGQ FPFPTALSAT PSEETPTPPP AATSDPPAED MLVAIRRGVR
710
LRRTVTNDRS APRIL
Length:715
Mass (Da):76,844
Last modified:July 5, 2004 - v1
Checksum:i04AE3F9004A3561C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060632 mRNA Translation: AAH60632.1
AK052172 mRNA Translation: BAC34868.1
CCDSiCCDS22664.1
RefSeqiNP_001297520.1, NM_001310591.1
NP_941027.1, NM_198625.2
UniGeneiMm.490385

Genome annotation databases

EnsembliENSMUST00000052457; ENSMUSP00000050211; ENSMUSG00000033763
GeneIDi244654
KEGGimmu:244654
UCSCiuc009nkx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMTSSL_MOUSE
AccessioniPrimary (citable) accession number: Q6P9S0
Secondary accession number(s): Q8C7B7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome