Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

MTSS1-like protein

Gene

Mtss1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in plasma membrane dynamics. Potentiated PDGF-mediated formation of membrane ruffles and lamellipodia in fibroblasts, acting via RAC1 activation. May function in actin bundling.By similarity

GO - Molecular functioni

  • actin monomer binding Source: MGI
  • phosphatidylinositol-4,5-bisphosphate binding Source: MGI
  • Rac GTPase binding Source: MGI

GO - Biological processi

  • lamellipodium organization Source: MGI
  • membrane organization Source: MGI
  • plasma membrane organization Source: InterPro
  • ruffle assembly Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
MTSS1-like protein
Gene namesi
Name:Mtss1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3039591. Mtss1l.

Subcellular locationi

  • Cytoplasm By similarity
  • Cell projectionruffle By similarity

  • Note: Colocalizes with RAC1 within membrane ruffles.By similarity

GO - Cellular componenti

  • cortical actin cytoskeleton Source: MGI
  • lamellipodium Source: MGI
  • plasma membrane Source: MGI
  • ruffle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003196111 – 715MTSS1-like proteinAdd BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei257PhosphothreonineCombined sources1
Modified residuei261PhosphoserineCombined sources1
Modified residuei404PhosphoserineBy similarity1
Modified residuei542PhosphoserineBy similarity1
Modified residuei564PhosphoserineBy similarity1
Modified residuei575PhosphoserineCombined sources1
Modified residuei587PhosphoserineBy similarity1
Modified residuei597PhosphoserineCombined sources1
Modified residuei602PhosphoserineCombined sources1
Modified residuei606PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6P9S0.
PaxDbiQ6P9S0.
PeptideAtlasiQ6P9S0.
PRIDEiQ6P9S0.

PTM databases

iPTMnetiQ6P9S0.
PhosphoSitePlusiQ6P9S0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033763.
CleanExiMM_BC060632.
ExpressionAtlasiQ6P9S0. baseline and differential.
GenevisibleiQ6P9S0. MM.

Interactioni

Subunit structurei

Interacts (via IMD domain) with RAC1; this interaction may be important to potentiate PDGF-induced RAC1 activation.By similarity

GO - Molecular functioni

  • actin monomer binding Source: MGI
  • Rac GTPase binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050211.

Structurei

3D structure databases

ProteinModelPortaliQ6P9S0.
SMRiQ6P9S0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 249IMDPROSITE-ProRule annotationAdd BLAST249
Domaini687 – 704WH2Add BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili134 – 156Sequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi249 – 339Ser-richAdd BLAST91

Sequence similaritiesi

Belongs to the MTSS1 family.Curated
Contains 1 IMD (IRSp53/MIM homology) domain.PROSITE-ProRule annotation
Contains 1 WH2 domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IGVU. Eukaryota.
ENOG410XRT4. LUCA.
GeneTreeiENSGT00390000002637.
HOGENOMiHOG000113691.
HOVERGENiHBG052530.
InParanoidiQ6P9S0.
KOiK20128.
OMAiAEKECGA.
OrthoDBiEOG091G083M.
PhylomeDBiQ6P9S0.
TreeFamiTF320619.

Family and domain databases

InterProiIPR030059. ABBA.
IPR013606. I-BAR_dom.
IPR030127. MIM/ABBA.
[Graphical view]
PANTHERiPTHR15708. PTHR15708. 2 hits.
PTHR15708:SF8. PTHR15708:SF8. 2 hits.
PfamiPF08397. IMD. 1 hit.
[Graphical view]
PROSITEiPS51338. IMD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9S0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKAAKLH SQLRTTVLAA
60 70 80 90 100
VAFLDAFQKV ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL
110 120 130 140 150
ESLINPLQER IEDWKKSANQ LDKDHAKEYK RARHEIKKKS SDTLKLQKKA
160 170 180 190 200
RKGKGDLQPQ LDSALQDVND MYLLLEETEK QAVRRALIEE RGRFCTFITF
210 220 230 240 250
LQPVVNGELT MLGEITHLQG IIDDLVVLTA DPHKLPPASE QVIKDLKGSD
260 270 280 290 300
YSWSYQTPPS SPSSSNSRKS SMCSLAQPAT TRLSSVSSHD SGFVSQDPTY
310 320 330 340 350
SKPPSPMPSD ITSQKSSSSA SSEASETCQS VSECSSPTSD WTKAGPHEQP
360 370 380 390 400
SATTLQRRKD RVEHLRDTEP GPTGGGTVGS SGEEVPRTRM SPATIAAKHG
410 420 430 440 450
EEVSPAASDL AMVLTRGLSL EHQKSSRDSL QYSSGYSTQT TTPSCSEDTI
460 470 480 490 500
PSQGSDYDCY SVNGDADSEG PPEFDKSSTI PRNSNIAQNY RRLIQTKRPA
510 520 530 540 550
STAGLPTAGL PTAMGLPSGA PPGVATIRRT PSTKPTVRRA LSSAGPIPIR
560 570 580 590 600
PPIVPVKTPT VPDSPGYVGP TRAGSEECVF YTDEVASPLA PDLAKASPKR
610 620 630 640 650
LSLPNTAWGS QSPEVASYGG GAAVGLATED EEQQLAANRH SLVEKLGELV
660 670 680 690 700
AGAHALGEGQ FPFPTALSAT PSEETPTPPP AATSDPPAED MLVAIRRGVR
710
LRRTVTNDRS APRIL
Length:715
Mass (Da):76,844
Last modified:July 5, 2004 - v1
Checksum:i04AE3F9004A3561C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060632 mRNA. Translation: AAH60632.1.
AK052172 mRNA. Translation: BAC34868.1.
CCDSiCCDS22664.1.
RefSeqiNP_001297520.1. NM_001310591.1.
NP_941027.1. NM_198625.2.
UniGeneiMm.490385.

Genome annotation databases

EnsembliENSMUST00000052457; ENSMUSP00000050211; ENSMUSG00000033763.
GeneIDi244654.
KEGGimmu:244654.
UCSCiuc009nkx.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060632 mRNA. Translation: AAH60632.1.
AK052172 mRNA. Translation: BAC34868.1.
CCDSiCCDS22664.1.
RefSeqiNP_001297520.1. NM_001310591.1.
NP_941027.1. NM_198625.2.
UniGeneiMm.490385.

3D structure databases

ProteinModelPortaliQ6P9S0.
SMRiQ6P9S0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050211.

PTM databases

iPTMnetiQ6P9S0.
PhosphoSitePlusiQ6P9S0.

Proteomic databases

MaxQBiQ6P9S0.
PaxDbiQ6P9S0.
PeptideAtlasiQ6P9S0.
PRIDEiQ6P9S0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000052457; ENSMUSP00000050211; ENSMUSG00000033763.
GeneIDi244654.
KEGGimmu:244654.
UCSCiuc009nkx.1. mouse.

Organism-specific databases

CTDi92154.
MGIiMGI:3039591. Mtss1l.

Phylogenomic databases

eggNOGiENOG410IGVU. Eukaryota.
ENOG410XRT4. LUCA.
GeneTreeiENSGT00390000002637.
HOGENOMiHOG000113691.
HOVERGENiHBG052530.
InParanoidiQ6P9S0.
KOiK20128.
OMAiAEKECGA.
OrthoDBiEOG091G083M.
PhylomeDBiQ6P9S0.
TreeFamiTF320619.

Miscellaneous databases

ChiTaRSiMtss1l. mouse.
PROiQ6P9S0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033763.
CleanExiMM_BC060632.
ExpressionAtlasiQ6P9S0. baseline and differential.
GenevisibleiQ6P9S0. MM.

Family and domain databases

InterProiIPR030059. ABBA.
IPR013606. I-BAR_dom.
IPR030127. MIM/ABBA.
[Graphical view]
PANTHERiPTHR15708. PTHR15708. 2 hits.
PTHR15708:SF8. PTHR15708:SF8. 2 hits.
PfamiPF08397. IMD. 1 hit.
[Graphical view]
PROSITEiPS51338. IMD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTSSL_MOUSE
AccessioniPrimary (citable) accession number: Q6P9S0
Secondary accession number(s): Q8C7B7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.