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Q6P9S0 (MTSSL_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MTSS1-like protein
Gene names
Name:Mtss1l
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length715 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May function in actin bundling.

Sequence similarities

Belongs to the MTSS1 family.

Contains 1 IMD (IRSp53/MIM homology) domain.

Contains 1 WH2 domain.

Ontologies

Keywords
   DomainCoiled coil
   LigandActin-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfilopodium assembly

Inferred from electronic annotation. Source: InterPro

signal transduction

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 715715MTSS1-like protein
PRO_0000319611

Regions

Domain1 – 249249IMD
Domain687 – 70418WH2
Coiled coil134 – 15623 Potential
Compositional bias249 – 33991Ser-rich

Amino acid modifications

Modified residue2571Phosphothreonine Ref.3
Modified residue2611Phosphoserine Ref.3
Modified residue4041Phosphoserine By similarity
Modified residue4191Phosphoserine Ref.5
Modified residue5421Phosphoserine By similarity
Modified residue5641Phosphoserine By similarity
Modified residue5751Phosphoserine Ref.4
Modified residue5871Phosphoserine By similarity
Modified residue5971Phosphoserine By similarity
Modified residue6021Phosphoserine By similarity
Modified residue6061Phosphothreonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6P9S0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 04AE3F9004A3561C

FASTA71576,844
        10         20         30         40         50         60 
METAEKECGA LGGLFQAIVN DMKSSYPIWE DFNSKAAKLH SQLRTTVLAA VAFLDAFQKV 

        70         80         90        100        110        120 
ADMATNTRGA TRDIGSALTR MCMRHRSIET KLRQFTNALL ESLINPLQER IEDWKKSANQ 

       130        140        150        160        170        180 
LDKDHAKEYK RARHEIKKKS SDTLKLQKKA RKGKGDLQPQ LDSALQDVND MYLLLEETEK 

       190        200        210        220        230        240 
QAVRRALIEE RGRFCTFITF LQPVVNGELT MLGEITHLQG IIDDLVVLTA DPHKLPPASE 

       250        260        270        280        290        300 
QVIKDLKGSD YSWSYQTPPS SPSSSNSRKS SMCSLAQPAT TRLSSVSSHD SGFVSQDPTY 

       310        320        330        340        350        360 
SKPPSPMPSD ITSQKSSSSA SSEASETCQS VSECSSPTSD WTKAGPHEQP SATTLQRRKD 

       370        380        390        400        410        420 
RVEHLRDTEP GPTGGGTVGS SGEEVPRTRM SPATIAAKHG EEVSPAASDL AMVLTRGLSL 

       430        440        450        460        470        480 
EHQKSSRDSL QYSSGYSTQT TTPSCSEDTI PSQGSDYDCY SVNGDADSEG PPEFDKSSTI 

       490        500        510        520        530        540 
PRNSNIAQNY RRLIQTKRPA STAGLPTAGL PTAMGLPSGA PPGVATIRRT PSTKPTVRRA 

       550        560        570        580        590        600 
LSSAGPIPIR PPIVPVKTPT VPDSPGYVGP TRAGSEECVF YTDEVASPLA PDLAKASPKR 

       610        620        630        640        650        660 
LSLPNTAWGS QSPEVASYGG GAAVGLATED EEQQLAANRH SLVEKLGELV AGAHALGEGQ 

       670        680        690        700        710 
FPFPTALSAT PSEETPTPPP AATSDPPAED MLVAIRRGVR LRRTVTNDRS APRIL

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 315-715.
Strain: C57BL/6J.
Tissue: Heart.
[3]"Phosphoproteomic analysis of the developing mouse brain."
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.
Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-257 AND SER-261, MASS SPECTROMETRY.
Tissue: Embryonic brain.
[4]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-575, MASS SPECTROMETRY.
Tissue: Brain cortex.
[5]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-419, MASS SPECTROMETRY.
Tissue: Melanoma.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC060632 mRNA. Translation: AAH60632.1.
AK052172 mRNA. Translation: BAC34868.1.
IPIIPI00387602.
RefSeqNP_941027.1. NM_198625.1.
UniGeneMm.490385.

3D structure databases

ProteinModelPortalQ6P9S0.
SMRQ6P9S0. Positions 5-241.
ModBaseSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000050211.

PTM databases

PhosphoSiteQ6P9S0.

Proteomic databases

PaxDbQ6P9S0.
PRIDEQ6P9S0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000052457; ENSMUSP00000050211; ENSMUSG00000033763.
GeneID244654.
KEGGmmu:244654.
UCSCuc009nkx.1. mouse.

Organism-specific databases

CTD92154.
MGIMGI:3039591. Mtss1l.

Phylogenomic databases

eggNOGNOG72831.
GeneTreeENSGT00390000002637.
HOGENOMHOG000113691.
HOVERGENHBG052530.
InParanoidQ6P9S0.
OMAYVGPTRA.
OrthoDBEOG4JHCFB.

Gene expression databases

ArrayExpressQ6P9S0.
BgeeQ6P9S0.
CleanExMM_BC060632.
GenevestigatorQ6P9S0.

Family and domain databases

InterProIPR013606. IRSp53/MIM_homology_IMD.
[Graphical view]
PfamPF08397. IMD. 1 hit.
[Graphical view]
PROSITEPS51338. IMD. 1 hit.
PS51082. WH2. False negative.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMTSS1L. mouse.
NextBio386361.
SOURCESearch...

Entry information

Entry nameMTSSL_MOUSE
AccessionPrimary (citable) accession number: Q6P9S0
Secondary accession number(s): Q8C7B7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 5, 2004
Last modified: May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents