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Protein

Serine/threonine-protein kinase OSR1

Gene

Oxsr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

By autophosphorylation on threonine.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei46ATPPROSITE-ProRule annotationBy similarity1
Active sitei146Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 31ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

  • ATP binding Source: UniProtKB
  • identical protein binding Source: MGI
  • magnesium ion binding Source: UniProtKB
  • protein serine/threonine kinase activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • activation of protein kinase activity Source: GO_Central
  • cellular hypotonic response Source: ParkinsonsUK-UCL
  • intracellular signal transduction Source: ParkinsonsUK-UCL
  • negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
  • negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
  • protein phosphorylation Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • response to oxidative stress Source: UniProtKB
  • signal transduction by protein phosphorylation Source: GO_Central
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase OSR1 (EC:2.7.11.1)
Alternative name(s):
Oxidative stress-responsive 1 protein
Gene namesi
Name:Oxsr1Imported
Synonyms:Osr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1917378 Oxsr1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000864572 – 527Serine/threonine-protein kinase OSR1Add BLAST526

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei310PhosphothreonineBy similarity1
Modified residuei324PhosphoserineBy similarity1
Modified residuei325PhosphoserineBy similarity1
Modified residuei339PhosphoserineCombined sources1
Modified residuei347PhosphoserineBy similarity1
Modified residuei359PhosphoserineBy similarity1
Modified residuei427PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P9R2
MaxQBiQ6P9R2
PaxDbiQ6P9R2
PeptideAtlasiQ6P9R2
PRIDEiQ6P9R2

PTM databases

iPTMnetiQ6P9R2
PhosphoSitePlusiQ6P9R2

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined, except thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000036737
CleanExiMM_OSR1
MM_OXSR1
ExpressionAtlasiQ6P9R2 baseline and differential
GenevisibleiQ6P9R2 MM

Interactioni

Subunit structurei

Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

ELMiQ6P9R2
IntActiQ6P9R2, 3 interactors
STRINGi10090.ENSMUSP00000042155

Structurei

3D structure databases

ProteinModelPortaliQ6P9R2
SMRiQ6P9R2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini17 – 291Protein kinasePROSITE-ProRule annotationAdd BLAST275

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
GeneTreeiENSGT00920000149013
HOGENOMiHOG000234204
HOVERGENiHBG108518
InParanoidiQ6P9R2
KOiK08835
OMAiRNEKCAI
OrthoDBiEOG091G0AKO
PhylomeDBiQ6P9R2
TreeFamiTF105339

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR024678 Kinase_OSR1/WNK_CCT
IPR028749 Oxsr1
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
PANTHERiPTHR24361:SF435 PTHR24361:SF435, 1 hit
PfamiView protein in Pfam
PF12202 OSR1_C, 1 hit
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK ERVAIKRINL
60 70 80 90 100
EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV
110 120 130 140 150
LDIIKHIVAK GEHKSGVLDE PTIATILREV LEGLEYLHKN GQIHRDVKAG
160 170 180 190 200
NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ
210 220 230 240 250
VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG
260 270 280 290 300
VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
310 320 330 340 350
QEKILQRAPT ISERSKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG
360 370 380 390 400
RAAISQLRSP RVKDSLSSSE LFAAAEPMGT LLQVPEQISA HLPQPAGQMP
410 420 430 440 450
TQPAQVSLLP PAEPAKPAQA QSSGERSQET KIPISLVLRL RNSKKELNDI
460 470 480 490 500
RFEFTPGRDT AEGVSQELIS AGLVDGRDLV IVAANLQKIV EEPQSNRSVT
510 520
FKLASGVEGS DIPDDGKLIG FAQLSIS
Length:527
Mass (Da):58,214
Last modified:July 5, 2004 - v1
Checksum:i72A09F0D732375E1
GO

Sequence cautioni

The sequence BAC27551 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC35996 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201V → F in BAC27551 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060645 mRNA Translation: AAH60645.1
AK031790 mRNA Translation: BAC27551.1 Different initiation.
AK075837 mRNA Translation: BAC35996.1 Different initiation.
CCDSiCCDS57714.1
RefSeqiNP_598746.2, NM_133985.2
XP_006511982.1, XM_006511919.3
UniGeneiMm.293565

Genome annotation databases

EnsembliENSMUST00000040853; ENSMUSP00000042155; ENSMUSG00000036737
GeneIDi108737
KEGGimmu:108737
UCSCiuc009sap.2 mouse

Similar proteinsi

Entry informationi

Entry nameiOXSR1_MOUSE
AccessioniPrimary (citable) accession number: Q6P9R2
Secondary accession number(s): Q8BVZ9, Q8C0B9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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