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Protein

Serine/threonine-protein kinase OSR1

Gene

Oxsr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.By similarity1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Enzyme regulationi

By autophosphorylation on threonine.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461ATPPROSITE-ProRule annotationBy similarity
Active sitei146 – 1461Proton acceptorPROSITE-ProRule annotationBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 319ATPPROSITE-ProRule annotationBy similarity

GO - Molecular functioni

GO - Biological processi

  • cellular hypotonic response Source: ParkinsonsUK-UCL
  • intracellular signal transduction Source: UniProtKB
  • negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
  • negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • negative regulation of rubidium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • negative regulation of rubidium ion transport Source: ParkinsonsUK-UCL
  • peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
  • protein phosphorylation Source: UniProtKB
  • response to oxidative stress Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase OSR1 (EC:2.7.11.1)
Alternative name(s):
Oxidative stress-responsive 1 protein
Gene namesi
Name:Oxsr1Imported
Synonyms:Osr1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1917378. Oxsr1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 527526Serine/threonine-protein kinase OSR1PRO_0000086457Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei310 – 3101PhosphothreonineBy similarity
Modified residuei324 – 3241PhosphoserineBy similarity
Modified residuei325 – 3251PhosphoserineBy similarity
Modified residuei339 – 3391PhosphoserineCombined sources
Modified residuei347 – 3471PhosphoserineBy similarity
Modified residuei359 – 3591PhosphoserineBy similarity
Modified residuei427 – 4271PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P9R2.
MaxQBiQ6P9R2.
PaxDbiQ6P9R2.
PeptideAtlasiQ6P9R2.
PRIDEiQ6P9R2.

PTM databases

iPTMnetiQ6P9R2.
PhosphoSiteiQ6P9R2.

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined, except thymus.1 Publication

Gene expression databases

BgeeiENSMUSG00000036737.
CleanExiMM_OSR1.
MM_OXSR1.
ExpressionAtlasiQ6P9R2. baseline and differential.
GenevisibleiQ6P9R2. MM.

Interactioni

Subunit structurei

Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6P9R2. 3 interactions.
STRINGi10090.ENSMUSP00000042155.

Structurei

3D structure databases

ProteinModelPortaliQ6P9R2.
SMRiQ6P9R2. Positions 7-365, 433-527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 291275Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
GeneTreeiENSGT00840000129768.
HOGENOMiHOG000234204.
HOVERGENiHBG108518.
InParanoidiQ6P9R2.
KOiK08835.
OMAiEPCIATI.
OrthoDBiEOG091G0AKO.
PhylomeDBiQ6P9R2.
TreeFamiTF105339.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR028749. Oxsr1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24361:SF399. PTHR24361:SF399. 1 hit.
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEDSSALPW SINRDDYELQ EVIGSGATAV VQAAYCAPKK ERVAIKRINL
60 70 80 90 100
EKCQTSMDEL LKEIQAMSQC HHPNIVSYYT SFVVKDELWL VMKLLSGGSV
110 120 130 140 150
LDIIKHIVAK GEHKSGVLDE PTIATILREV LEGLEYLHKN GQIHRDVKAG
160 170 180 190 200
NILLGEDGSV QIADFGVSAF LATGGDITRN KVRKTFVGTP CWMAPEVMEQ
210 220 230 240 250
VRGYDFKADI WSFGITAIEL ATGAAPYHKY PPMKVLMLTL QNDPPSLETG
260 270 280 290 300
VQDKEMLKKY GKSFRKMISL CLQKDPEKRP TAAELLRHKF FQKAKNKEFL
310 320 330 340 350
QEKILQRAPT ISERSKKVRR VPGSSGRLHK TEDGGWEWSD DEFDEESEEG
360 370 380 390 400
RAAISQLRSP RVKDSLSSSE LFAAAEPMGT LLQVPEQISA HLPQPAGQMP
410 420 430 440 450
TQPAQVSLLP PAEPAKPAQA QSSGERSQET KIPISLVLRL RNSKKELNDI
460 470 480 490 500
RFEFTPGRDT AEGVSQELIS AGLVDGRDLV IVAANLQKIV EEPQSNRSVT
510 520
FKLASGVEGS DIPDDGKLIG FAQLSIS
Length:527
Mass (Da):58,214
Last modified:July 5, 2004 - v1
Checksum:i72A09F0D732375E1
GO

Sequence cautioni

The sequence BAC27551 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC35996 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti201 – 2011V → F in BAC27551 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060645 mRNA. Translation: AAH60645.1.
AK031790 mRNA. Translation: BAC27551.1. Different initiation.
AK075837 mRNA. Translation: BAC35996.1. Different initiation.
CCDSiCCDS57714.1.
RefSeqiNP_598746.2. NM_133985.2.
XP_006511982.1. XM_006511919.2.
UniGeneiMm.293565.

Genome annotation databases

EnsembliENSMUST00000040853; ENSMUSP00000042155; ENSMUSG00000036737.
GeneIDi108737.
KEGGimmu:108737.
UCSCiuc009sap.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060645 mRNA. Translation: AAH60645.1.
AK031790 mRNA. Translation: BAC27551.1. Different initiation.
AK075837 mRNA. Translation: BAC35996.1. Different initiation.
CCDSiCCDS57714.1.
RefSeqiNP_598746.2. NM_133985.2.
XP_006511982.1. XM_006511919.2.
UniGeneiMm.293565.

3D structure databases

ProteinModelPortaliQ6P9R2.
SMRiQ6P9R2. Positions 7-365, 433-527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P9R2. 3 interactions.
STRINGi10090.ENSMUSP00000042155.

PTM databases

iPTMnetiQ6P9R2.
PhosphoSiteiQ6P9R2.

Proteomic databases

EPDiQ6P9R2.
MaxQBiQ6P9R2.
PaxDbiQ6P9R2.
PeptideAtlasiQ6P9R2.
PRIDEiQ6P9R2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040853; ENSMUSP00000042155; ENSMUSG00000036737.
GeneIDi108737.
KEGGimmu:108737.
UCSCiuc009sap.2. mouse.

Organism-specific databases

CTDi9943.
MGIiMGI:1917378. Oxsr1.

Phylogenomic databases

eggNOGiKOG0582. Eukaryota.
ENOG410XSWS. LUCA.
GeneTreeiENSGT00840000129768.
HOGENOMiHOG000234204.
HOVERGENiHBG108518.
InParanoidiQ6P9R2.
KOiK08835.
OMAiEPCIATI.
OrthoDBiEOG091G0AKO.
PhylomeDBiQ6P9R2.
TreeFamiTF105339.

Miscellaneous databases

ChiTaRSiOxsr1. mouse.
PROiQ6P9R2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036737.
CleanExiMM_OSR1.
MM_OXSR1.
ExpressionAtlasiQ6P9R2. baseline and differential.
GenevisibleiQ6P9R2. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR024678. Kinase_OSR1/WNK_CCT.
IPR028749. Oxsr1.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
[Graphical view]
PANTHERiPTHR24361:SF399. PTHR24361:SF399. 1 hit.
PfamiPF12202. OSR1_C. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiOXSR1_MOUSE
AccessioniPrimary (citable) accession number: Q6P9R2
Secondary accession number(s): Q8BVZ9, Q8C0B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.