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Protein

Kinesin-like protein KIF11

Gene

Kif11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Motor protein required for establishing a bipolar spindle during mitosis. Required in non-mitotic cells for transport of secretory proteins from the Golgi complex to the cell surface.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi104 – 1118ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cell division Source: UniProtKB-KW
  • chromosome segregation Source: GO_Central
  • microtubule-based movement Source: GO_Central
  • mitotic centrosome separation Source: MGI
  • mitotic spindle assembly Source: UniProtKB
  • regulation of mitotic centrosome separation Source: UniProtKB
  • spindle assembly Source: MGI
  • spindle organization Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF11
Alternative name(s):
Kinesin-related motor protein Eg5
Gene namesi
Name:Kif11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1098231. Kif11.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeletonspindle pole By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10521052Kinesin-like protein KIF11By similarityPRO_0000253343Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei145 – 1451N6-acetyllysineBy similarity
Modified residuei457 – 4571PhosphothreonineBy similarity
Modified residuei925 – 9251PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated exclusively on serine during S phase, but on both serine and Thr-925 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P9P6.
MaxQBiQ6P9P6.
PaxDbiQ6P9P6.
PeptideAtlasiQ6P9P6.
PRIDEiQ6P9P6.

PTM databases

iPTMnetiQ6P9P6.
PhosphoSiteiQ6P9P6.

Expressioni

Gene expression databases

BgeeiQ6P9P6.
CleanExiMM_KIF11.
GenevisibleiQ6P9P6. MM.

Interactioni

Subunit structurei

Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200928. 3 interactions.
IntActiQ6P9P6. 1 interaction.
STRINGi10090.ENSMUSP00000012587.

Structurei

3D structure databases

ProteinModelPortaliQ6P9P6.
SMRiQ6P9P6. Positions 16-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 358342Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili364 – 478115Sequence analysisAdd
BLAST
Coiled coili963 – 98826Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0243. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG005572.
InParanoidiQ6P9P6.
KOiK10398.
OMAiNKNELDQ.
OrthoDBiEOG7VX8V8.
PhylomeDBiQ6P9P6.
TreeFamiTF105230.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR025901. Kinesin-assoc_MT-bd_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF13931. Microtub_bind. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9P6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASQPSSLKK KEEKGRNIQV VVRCRPFNLA ERKANAHSVV ECDHARKEVS
60 70 80 90 100
VRTAGLTDKT SKKTYTFDMV FGASTKQIDV YRSVVCPILD EVIMGYNCTI
110 120 130 140 150
FAYGQTGTGK TFTMEGERSP NEVYTWEEDP LAGIIPRTLH QIFEKLTDNG
160 170 180 190 200
TEFSVKVSLL EIYNEELFDL LSPSSDVSER LQMFDDPRNK RGVIIKGLEE
210 220 230 240 250
ITVHNKDEVY QILEKGAAKR TTAATLMNAY SSRSHSVFSV TIHMKETTID
260 270 280 290 300
GEELVKIGKL NLVDLAGSEN IGRSGAVDKR AREAGNINQS LLTLGRVITA
310 320 330 340 350
LVERTPHIPY RESKLTRILQ DSLGGRTRTS IIATISPASF NLEETLSTLE
360 370 380 390 400
YAHRAKNIMN KPEVNQKLTK KALIKEYTEE IERLKRDLAA AREKNGVYIS
410 420 430 440 450
EESFRAMNGK VTVQEEQIVE LVEKIAVLEE ELSKATELFM DSKNELDQCK
460 470 480 490 500
SDLQTKTQEL ETTQKHLQET KLQLVKEEYV SSALERTEKT LHDTASKLLN
510 520 530 540 550
TVKETTRAVS GLHSKLDRKR AIDEHNAEAQ ESFGKNLNSL FNNMEELIKD
560 570 580 590 600
GSAKQKAMLD VHKTLFGNLM SSSVSALDTI TTTALESLVS IPENVSARVS
610 620 630 640 650
QISDMILEEQ SLAAQSKSVL QGLIDELVTD LFTSLKTIVA PSVVSILNIN
660 670 680 690 700
KQLQHIFRAS STVAEKVEDQ KREIDSFLSI LCNNLHELRE NTVSSLVESQ
710 720 730 740 750
KLCGDLTEDL KTIKETHSQE LCQLSSSWAE RFCALEKKYE NIQKPLNSIQ
760 770 780 790 800
ENTELRSTDI INKTTVHSKK ILAESDGLLQ ELRHFNQEGT QLVEESVGHC
810 820 830 840 850
SSLNSNLETV SQEITQKCGT LNTSTVHFSD QWASCLSKRK EELENLMEFV
860 870 880 890 900
NGCCKASSSE ITKKVREQSA AVANQHSSFV AQMTSDEESC KAGSLELDKT
910 920 930 940 950
IKTGLTKLNC FLKQDLKLDI PTGMTPERKK YLYPTTLVRT EPREQLLDQL
960 970 980 990 1000
QKKQPPMMLN SSEASKETSQ DMDEEREALE QCTEELVSPE TTEHPSADCS
1010 1020 1030 1040 1050
SSRGLPFFQR KKPHGKDKEN RGLNPVEKYK VEEASDLSIS KSRLPLHTSI

NL
Length:1,052
Mass (Da):118,027
Last modified:July 5, 2004 - v1
Checksum:i2AE184121D8DCE5B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521E → D in CAA11228 (PubMed:10659681).Curated
Sequence conflicti246 – 2472ET → Q in CAA11228 (PubMed:10659681).Curated
Sequence conflicti572 – 5721S → C in CAA11228 (PubMed:10659681).Curated
Sequence conflicti755 – 7551L → R in CAA11228 (PubMed:10659681).Curated
Sequence conflicti871 – 8711A → R in CAA11228 (PubMed:10659681).Curated
Sequence conflicti994 – 9941H → L in CAA11228 (PubMed:10659681).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060670 mRNA. Translation: AAH60670.1.
AJ223293 mRNA. Translation: CAA11228.1.
CCDSiCCDS29777.1.
RefSeqiNP_034745.1. NM_010615.1.
UniGeneiMm.42203.

Genome annotation databases

EnsembliENSMUST00000012587; ENSMUSP00000012587; ENSMUSG00000012443.
GeneIDi16551.
KEGGimmu:16551.
UCSCiuc008hin.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC060670 mRNA. Translation: AAH60670.1.
AJ223293 mRNA. Translation: CAA11228.1.
CCDSiCCDS29777.1.
RefSeqiNP_034745.1. NM_010615.1.
UniGeneiMm.42203.

3D structure databases

ProteinModelPortaliQ6P9P6.
SMRiQ6P9P6. Positions 16-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200928. 3 interactions.
IntActiQ6P9P6. 1 interaction.
STRINGi10090.ENSMUSP00000012587.

PTM databases

iPTMnetiQ6P9P6.
PhosphoSiteiQ6P9P6.

Proteomic databases

EPDiQ6P9P6.
MaxQBiQ6P9P6.
PaxDbiQ6P9P6.
PeptideAtlasiQ6P9P6.
PRIDEiQ6P9P6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000012587; ENSMUSP00000012587; ENSMUSG00000012443.
GeneIDi16551.
KEGGimmu:16551.
UCSCiuc008hin.1. mouse.

Organism-specific databases

CTDi3832.
MGIiMGI:1098231. Kif11.

Phylogenomic databases

eggNOGiKOG0243. Eukaryota.
COG5059. LUCA.
GeneTreeiENSGT00840000129680.
HOGENOMiHOG000116164.
HOVERGENiHBG005572.
InParanoidiQ6P9P6.
KOiK10398.
OMAiNKNELDQ.
OrthoDBiEOG7VX8V8.
PhylomeDBiQ6P9P6.
TreeFamiTF105230.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-6811434. COPI-dependent Golgi-to-ER retrograde traffic.
R-MMU-983189. Kinesins.

Miscellaneous databases

PROiQ6P9P6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P9P6.
CleanExiMM_KIF11.
GenevisibleiQ6P9P6. MM.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR025901. Kinesin-assoc_MT-bd_dom.
IPR027640. Kinesin-like_fam.
IPR019821. Kinesin_motor_CS.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF13931. Microtub_bind. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00411. KINESIN_MOTOR_1. 1 hit.
PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  2. "The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron."
    Ferhat L., Cook C., Kuriyama R., Baas P.W.
    J. Neurocytol. 27:887-899(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-1052.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Spleen and Testis.

Entry informationi

Entry nameiKIF11_MOUSE
AccessioniPrimary (citable) accession number: Q6P9P6
Secondary accession number(s): Q9Z1J0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.