Kinesin-like protein KIF11 - Mus musculus (Mouse)

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Q6P9P6 (KIF11_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 66. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Kinesin-like protein KIF11

Alternative name(s):
Kinesin-related motor protein Eg5

Gene names

Name:

Kif11

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1052 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Motor protein required for establishing a bipolar spindle. Blocking of KIF11 prevents centrosome migration and arrest cells in mitosis with monoastral microtubule arrays By similarity.
Subunit structure	Interacts with the thyroid hormone receptor in the presence of thyroid hormone. Component of a large chromatin remodeling complex, at least composed of MYSM1, PCAF, RBM10 and KIF11/TRIP5 By similarity.
Subcellular location	Cytoplasm. Cytoplasm › cytoskeleton › spindle pole By similarity.
Post-translational modification	Phosphorylated exclusively on serine during S phase, but on both serine and Thr-925 during mitosis, so controlling the association of KIF11 with the spindle apparatus (probably during early prophase).
Sequence similarities	Belongs to the kinesin-like protein family. BimC subfamily. Contains 1 kinesin-motor domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis
Cellular component	Cytoplasm Cytoskeleton Microtubule
Domain	Coiled coil
Ligand	ATP-binding Nucleotide-binding
Molecular function	Motor protein
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW microtubule-based movement Inferred from electronic annotation. Source: InterPro mitotic centrosome separation Inferred from mutant phenotype PubMed 12840069. Source: MGI spindle assembly involved in mitosis Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule associated complex Inferred from electronic annotation. Source: InterPro mitotic spindle Inferred from sequence orthology PubMed 23036704. Source: MGI spindle microtubule Inferred from electronic annotation. Source: Compara spindle pole Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW microtubule motor activity Inferred from electronic annotation. Source: InterPro protein kinase binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1052

1052

Kinesin-like protein KIF11 By similarity

PRO_0000253343

Regions

Domain

14 – 362

349

Kinesin-motor

Nucleotide binding

104 – 111

ATP By similarity

Coiled coil

364 – 478

115

Potential

Coiled coil

963 – 988

Potential

Amino acid modifications

Modified residue

145

N6-acetyllysine By similarity

Modified residue

457

Phosphothreonine By similarity

Modified residue

925

Phosphothreonine By similarity

Experimental info

Sequence conflict

152

E → D in CAA11228. Ref.2

Sequence conflict

246 – 247

ET → Q in CAA11228. Ref.2

Sequence conflict

572

S → C in CAA11228. Ref.2

Sequence conflict

755

L → R in CAA11228. Ref.2

Sequence conflict

871

A → R in CAA11228. Ref.2

Sequence conflict

994

H → L in CAA11228. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

Q6P9P6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2AE184121D8DCE5B
Show »

FASTA

1,052

118,027

        10         20         30         40         50         60 
MASQPSSLKK KEEKGRNIQV VVRCRPFNLA ERKANAHSVV ECDHARKEVS VRTAGLTDKT 

        70         80         90        100        110        120 
SKKTYTFDMV FGASTKQIDV YRSVVCPILD EVIMGYNCTI FAYGQTGTGK TFTMEGERSP 

       130        140        150        160        170        180 
NEVYTWEEDP LAGIIPRTLH QIFEKLTDNG TEFSVKVSLL EIYNEELFDL LSPSSDVSER 

       190        200        210        220        230        240 
LQMFDDPRNK RGVIIKGLEE ITVHNKDEVY QILEKGAAKR TTAATLMNAY SSRSHSVFSV 

       250        260        270        280        290        300 
TIHMKETTID GEELVKIGKL NLVDLAGSEN IGRSGAVDKR AREAGNINQS LLTLGRVITA 

       310        320        330        340        350        360 
LVERTPHIPY RESKLTRILQ DSLGGRTRTS IIATISPASF NLEETLSTLE YAHRAKNIMN 

       370        380        390        400        410        420 
KPEVNQKLTK KALIKEYTEE IERLKRDLAA AREKNGVYIS EESFRAMNGK VTVQEEQIVE 

       430        440        450        460        470        480 
LVEKIAVLEE ELSKATELFM DSKNELDQCK SDLQTKTQEL ETTQKHLQET KLQLVKEEYV 

       490        500        510        520        530        540 
SSALERTEKT LHDTASKLLN TVKETTRAVS GLHSKLDRKR AIDEHNAEAQ ESFGKNLNSL 

       550        560        570        580        590        600 
FNNMEELIKD GSAKQKAMLD VHKTLFGNLM SSSVSALDTI TTTALESLVS IPENVSARVS 

       610        620        630        640        650        660 
QISDMILEEQ SLAAQSKSVL QGLIDELVTD LFTSLKTIVA PSVVSILNIN KQLQHIFRAS 

       670        680        690        700        710        720 
STVAEKVEDQ KREIDSFLSI LCNNLHELRE NTVSSLVESQ KLCGDLTEDL KTIKETHSQE 

       730        740        750        760        770        780 
LCQLSSSWAE RFCALEKKYE NIQKPLNSIQ ENTELRSTDI INKTTVHSKK ILAESDGLLQ 

       790        800        810        820        830        840 
ELRHFNQEGT QLVEESVGHC SSLNSNLETV SQEITQKCGT LNTSTVHFSD QWASCLSKRK 

       850        860        870        880        890        900 
EELENLMEFV NGCCKASSSE ITKKVREQSA AVANQHSSFV AQMTSDEESC KAGSLELDKT 

       910        920        930        940        950        960 
IKTGLTKLNC FLKQDLKLDI PTGMTPERKK YLYPTTLVRT EPREQLLDQL QKKQPPMMLN 

       970        980        990       1000       1010       1020 
SSEASKETSQ DMDEEREALE QCTEELVSPE TTEHPSADCS SSRGLPFFQR KKPHGKDKEN 

      1030       1040       1050 
RGLNPVEKYK VEEASDLSIS KSRLPLHTSI NL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
[2]	"The nuclear/mitotic apparatus protein NuMA is a component of the somatodendritic microtubule arrays of the neuron." Ferhat L., Cook C., Kuriyama R., Baas P.W. J. Neurocytol. 27:887-899(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 38-1052.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC060670 mRNA. Translation: AAH60670.1. AJ223293 mRNA. Translation: CAA11228.1.
IPI	IPI00130218.
RefSeq	NP_034745.1. NM_010615.1.
UniGene	Mm.42203.
3D structure databases
HSSP	HSSP built from PDB template 1II6 based on UniProtKB P52732.
ProteinModelPortal	Q6P9P6.
SMR	Q6P9P6. Positions 16-401.
ModBase	Search...
PTM databases
PhosphoSite	Q6P9P6.
Proteomic databases
PaxDb	Q6P9P6.
PRIDE	Q6P9P6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000012587; ENSMUSP00000012587; ENSMUSG00000012443.
GeneID	16551.
KEGG	mmu:16551.
UCSC	uc008hin.1. mouse.
Organism-specific databases
CTD	3832.
MGI	MGI:1098231. Kif11.
Phylogenomic databases
eggNOG	COG5059.
GeneTree	ENSGT00680000099754.
HOGENOM	HOG000116164.
HOVERGEN	HBG005572.
InParanoid	Q6P9P6.
KO	K10398.
OMA	NGVYISE.
OrthoDB	EOG4MKNFG.
Gene expression databases
Bgee	Q6P9P6.
CleanEx	MM_KIF11.
Genevestigator	Q6P9P6.
GermOnline	ENSMUSG00000012443. Mus musculus.
Family and domain databases
Gene3D	3.40.850.10. 1 hit.
InterPro	IPR025901. Kinesin-assoc_MT-bd_dom. IPR019821. Kinesin_motor_CS. IPR001752. Kinesin_motor_dom. [Graphical view]
Pfam	PF00225. Kinesin. 1 hit. PF13931. Microtub_bind. 1 hit. [Graphical view]
PRINTS	PR00380. KINESINHEAVY.
SMART	SM00129. KISc. 1 hit. [Graphical view]
PROSITE	PS00411. KINESIN_MOTOR_DOMAIN1. 1 hit. PS50067. KINESIN_MOTOR_DOMAIN2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	290023.
SOURCE	Search...

Entry information

Entry name

KIF11_MOUSE

Accession

Primary (citable) accession number: Q6P9P6
Secondary accession number(s): Q9Z1J0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 17, 2006
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents