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Q6P9L6

- KIF15_MOUSE

UniProt

Q6P9L6 - KIF15_MOUSE

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Protein
Kinesin-like protein KIF15
Gene
Kif15, Klp2, Knsl7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 1168ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. microtubule motor activity Source: InterPro

GO - Biological processi

  1. microtubule-based movement Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF15
Alternative name(s):
Kinesin-like protein 2
Kinesin-like protein 7
Gene namesi
Name:Kif15
Synonyms:Klp2, Knsl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:1098258. Kif15.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity
Note: Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Localizes at the spindle poles and microtubules prior to anaphase. Localizes at the central spindle at anaphase. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells. Colocalizes with actin in interphase. Colocalizes in dendrites and in growth cone of axons with microtubules. Colocalizes with TPX2 in mitosis By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. kinesin complex Source: InterPro
  3. microtubule Source: UniProtKB-KW
  4. spindle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13871387Kinesin-like protein KIF15
PRO_0000328685Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei568 – 5681Phosphoserine By similarity
Modified residuei1009 – 10091N6-acetyllysine By similarity
Modified residuei1141 – 11411Phosphoserine By similarity
Modified residuei1144 – 11441Phosphothreonine By similarity
Modified residuei1169 – 11691Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ6P9L6.
PaxDbiQ6P9L6.
PRIDEiQ6P9L6.

PTM databases

PhosphoSiteiQ6P9L6.

Expressioni

Tissue specificityi

Expressed in brain (neurons in the external germinal layer of the cerebellum and in ventricular zones) (at protein level). Expressed in spleen and testis.2 Publications

Gene expression databases

BgeeiQ6P9L6.
GenevestigatoriQ6P9L6.

Interactioni

Subunit structurei

Interacts with MKI67 and TPX2 By similarity.

Protein-protein interaction databases

IntActiQ6P9L6. 1 interaction.
STRINGi10090.ENSMUSP00000035490.

Structurei

3D structure databases

ProteinModelPortaliQ6P9L6.
SMRiQ6P9L6. Positions 24-375.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 363338Kinesin motor
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili368 – 1132765 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiCOG5059.
GeneTreeiENSGT00750000117462.
HOGENOMiHOG000113225.
HOVERGENiHBG062662.
InParanoidiQ6P9L6.
KOiK10400.
OMAiEHHSAQM.
OrthoDBiEOG7M0NQQ.
PhylomeDBiQ6P9L6.
TreeFamiTF320478.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 1 hit.
PfamiPF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9L6-1 [UniParc]FASTAAdd to Basket

« Hide

MAPGCKSELR NVTNSHSNQP SNEGDAIKVF VRIRPAEEGA RSADGEQSFC     50
LSVLSQTTLR LHSNPDPKTF VFDYVAGMDT TQESVFSTVA KSIVESCMSG 100
YNGTIFAYGQ TGSGKTFTMM GPSDSDNFSH NLRGIIPRSF EYLFSLIDRE 150
KEKAGAGKSF LCKCSFIEVY NEQIYDLLDS ASVGLYLREH IKKGVFVVGA 200
VEQAVTSAAE TYQVLSRGWR NRRVASTSMN RESSRSHAVF TITIESMEKS 250
SETVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT 300
ALVDVGNGKQ RHICYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET 350
LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LSQFTSGQIT 400
PESLLARDKE KTNYIEYFLE AMLFFKKSEQ EKKSLIEKIT QLEDLTLKKE 450
KFIQSNKMIV KFREDQIMRL ERLHKEGRGS FLPEEQDRLL SELRDEVQTL 500
REHVEHHPRL AKYAMENHSL REENRRLKLL APVKRAHEID AQSIARLEKA 550
FAEVSSTETN DKGLQGFSPK ALKESSFFTN TEKLKAQLLQ IQTELNNSKQ 600
EYEEFKELTR KKQLELESEL QSLQKANLNL ENLLEATKVC KRQEVSQLNK 650
LHAETLKIIT TPTKAYQLCS RLVPKSSPEV GSFGFLCTES SSRLDNDILN 700
EPVPPEMSEQ ALEAVSEELR TVQEQLSVLQ VKLDEEERKN LKLQQNVDKL 750
EHHSTQMQEL FSSERSDWTK QQQEHVTQLS DLEKQLQDAQ TKNEFLKCEV 800
HDLRIVLNSA DKELSLVKLE YSTFKENHEK ELSQLSERHV QVQLQLDNAR 850
LENEKLLESQ ACLQDSYDNL QEVMKFEIDQ LSKNLQNCKQ ENETLKSDLH 900
NLVELFEAEK ERNNKLSLQF EEDKENSSKE ILKVLETVRQ EKQKEMAKCE 950
KQMAKIQKLE ESLLATENVI SSLEKSRESD KELVTNLMNQ IQELRISIGE 1000
KSETIATLKQ ELQDINCKYN ASLADKEESK ELIRRQEVDI LELKETLRLR 1050
ILSEDIERDM LCEDLAHATE QLNMLTEASK KHSGLLQSAQ EELTRKEALI 1100
QELQHKLNQE KEEVEQKKNE FSLKMRQLEH VMGSATEYPQ SPKTPPHFQA 1150
HLAKLLETQE QEIEDGRASK TSLQHLVTKL NEDREVKNAE ILRMKDQLCE 1200
MENLRLESQQ LREKNWLLQR QLDDVKRQQE SGDQSHPDSQ QLKNEHEEII 1250
KERLAKNKLI EEMLKMKTNL EEVQSALHSK EKACHRMSEE IERTRTLESR 1300
AFQEKEQLRS KLEEMYEERE RTFLEMEMLK KQLEFLAEEN GKLVGHQNLH 1350
QKIQYVVRLK KENIRLTEET EKLRAENLFL KEKKKEF 1387
Length:1,387
Mass (Da):160,120
Last modified:July 5, 2004 - v1
Checksum:i0FFA8F93B45D740A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261D → G in CAD90258. 1 Publication
Sequence conflicti159 – 1591S → N in CAD90258. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ560623 mRNA. Translation: CAD90258.1.
BC060710 mRNA. Translation: AAH60710.1.
AB001432 mRNA. Translation: BAA22392.1.
CCDSiCCDS23651.1.
RefSeqiNP_034750.1. NM_010620.1.
UniGeneiMm.278920.

Genome annotation databases

EnsembliENSMUST00000040717; ENSMUSP00000035490; ENSMUSG00000036768.
GeneIDi209737.
KEGGimmu:209737.
UCSCiuc009sfl.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ560623 mRNA. Translation: CAD90258.1 .
BC060710 mRNA. Translation: AAH60710.1 .
AB001432 mRNA. Translation: BAA22392.1 .
CCDSi CCDS23651.1.
RefSeqi NP_034750.1. NM_010620.1.
UniGenei Mm.278920.

3D structure databases

ProteinModelPortali Q6P9L6.
SMRi Q6P9L6. Positions 24-375.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q6P9L6. 1 interaction.
STRINGi 10090.ENSMUSP00000035490.

PTM databases

PhosphoSitei Q6P9L6.

Proteomic databases

MaxQBi Q6P9L6.
PaxDbi Q6P9L6.
PRIDEi Q6P9L6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000040717 ; ENSMUSP00000035490 ; ENSMUSG00000036768 .
GeneIDi 209737.
KEGGi mmu:209737.
UCSCi uc009sfl.1. mouse.

Organism-specific databases

CTDi 56992.
MGIi MGI:1098258. Kif15.

Phylogenomic databases

eggNOGi COG5059.
GeneTreei ENSGT00750000117462.
HOGENOMi HOG000113225.
HOVERGENi HBG062662.
InParanoidi Q6P9L6.
KOi K10400.
OMAi EHHSAQM.
OrthoDBi EOG7M0NQQ.
PhylomeDBi Q6P9L6.
TreeFami TF320478.

Enzyme and pathway databases

Reactomei REACT_196550. MHC class II antigen presentation.
REACT_199117. Kinesins.

Miscellaneous databases

NextBioi 372779.
PROi Q6P9L6.
SOURCEi Search...

Gene expression databases

Bgeei Q6P9L6.
Genevestigatori Q6P9L6.

Family and domain databases

Gene3Di 3.40.850.10. 1 hit.
InterProi IPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR24115. PTHR24115. 1 hit.
Pfami PF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view ]
PRINTSi PR00380. KINESINHEAVY.
SMARTi SM00129. KISc. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development."
    Buster D.W., Baird D.H., Yu W., Solowska J.M., Chauviere M., Mazurek A., Kress M., Baas P.W.
    J. Neurocytol. 32:79-96(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
    Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
    Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-270, TISSUE SPECIFICITY.
    Strain: ICR.

Entry informationi

Entry nameiKIF15_MOUSE
AccessioniPrimary (citable) accession number: Q6P9L6
Secondary accession number(s): O35065, Q70MX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi