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Protein

Kinesin-like protein KIF15

Gene

Kif15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi109 – 116ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-MMU-983189 Kinesins

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF15
Alternative name(s):
Kinesin-like protein 2
Kinesin-like protein 7
Gene namesi
Name:Kif15
Synonyms:Klp2, Knsl7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1098258 Kif15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286851 – 1387Kinesin-like protein KIF15Add BLAST1387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei568PhosphoserineBy similarity1
Modified residuei1009N6-acetyllysineBy similarity1
Modified residuei1141PhosphoserineBy similarity1
Modified residuei1169PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P9L6
MaxQBiQ6P9L6
PaxDbiQ6P9L6
PeptideAtlasiQ6P9L6
PRIDEiQ6P9L6

PTM databases

iPTMnetiQ6P9L6
PhosphoSitePlusiQ6P9L6

Expressioni

Tissue specificityi

Expressed in brain (neurons in the external germinal layer of the cerebellum and in ventricular zones) (at protein level). Expressed in spleen and testis.2 Publications

Gene expression databases

BgeeiENSMUSG00000036768
ExpressionAtlasiQ6P9L6 baseline and differential

Interactioni

Subunit structurei

Interacts with MKI67 and TPX2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi229105, 8 interactors
IntActiQ6P9L6, 8 interactors
MINTiQ6P9L6
STRINGi10090.ENSMUSP00000035490

Structurei

3D structure databases

ProteinModelPortaliQ6P9L6
SMRiQ6P9L6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 363Kinesin motorPROSITE-ProRule annotationAdd BLAST338

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili368 – 1132Sequence analysisAdd BLAST765

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00910000143992
HOGENOMiHOG000113225
HOVERGENiHBG062662
InParanoidiQ6P9L6
KOiK10400
OMAiERDMLCE
OrthoDBiEOG091G00LM
PhylomeDBiQ6P9L6
TreeFamiTF320478

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR031794 HMMR_C
IPR027640 Kinesin-like_fam
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 5 hits
PfamiView protein in Pfam
PF15908 HMMR_C, 1 hit
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P9L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGCKSELR NVTNSHSNQP SNEGDAIKVF VRIRPAEEGA RSADGEQSFC
60 70 80 90 100
LSVLSQTTLR LHSNPDPKTF VFDYVAGMDT TQESVFSTVA KSIVESCMSG
110 120 130 140 150
YNGTIFAYGQ TGSGKTFTMM GPSDSDNFSH NLRGIIPRSF EYLFSLIDRE
160 170 180 190 200
KEKAGAGKSF LCKCSFIEVY NEQIYDLLDS ASVGLYLREH IKKGVFVVGA
210 220 230 240 250
VEQAVTSAAE TYQVLSRGWR NRRVASTSMN RESSRSHAVF TITIESMEKS
260 270 280 290 300
SETVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT
310 320 330 340 350
ALVDVGNGKQ RHICYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET
360 370 380 390 400
LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LSQFTSGQIT
410 420 430 440 450
PESLLARDKE KTNYIEYFLE AMLFFKKSEQ EKKSLIEKIT QLEDLTLKKE
460 470 480 490 500
KFIQSNKMIV KFREDQIMRL ERLHKEGRGS FLPEEQDRLL SELRDEVQTL
510 520 530 540 550
REHVEHHPRL AKYAMENHSL REENRRLKLL APVKRAHEID AQSIARLEKA
560 570 580 590 600
FAEVSSTETN DKGLQGFSPK ALKESSFFTN TEKLKAQLLQ IQTELNNSKQ
610 620 630 640 650
EYEEFKELTR KKQLELESEL QSLQKANLNL ENLLEATKVC KRQEVSQLNK
660 670 680 690 700
LHAETLKIIT TPTKAYQLCS RLVPKSSPEV GSFGFLCTES SSRLDNDILN
710 720 730 740 750
EPVPPEMSEQ ALEAVSEELR TVQEQLSVLQ VKLDEEERKN LKLQQNVDKL
760 770 780 790 800
EHHSTQMQEL FSSERSDWTK QQQEHVTQLS DLEKQLQDAQ TKNEFLKCEV
810 820 830 840 850
HDLRIVLNSA DKELSLVKLE YSTFKENHEK ELSQLSERHV QVQLQLDNAR
860 870 880 890 900
LENEKLLESQ ACLQDSYDNL QEVMKFEIDQ LSKNLQNCKQ ENETLKSDLH
910 920 930 940 950
NLVELFEAEK ERNNKLSLQF EEDKENSSKE ILKVLETVRQ EKQKEMAKCE
960 970 980 990 1000
KQMAKIQKLE ESLLATENVI SSLEKSRESD KELVTNLMNQ IQELRISIGE
1010 1020 1030 1040 1050
KSETIATLKQ ELQDINCKYN ASLADKEESK ELIRRQEVDI LELKETLRLR
1060 1070 1080 1090 1100
ILSEDIERDM LCEDLAHATE QLNMLTEASK KHSGLLQSAQ EELTRKEALI
1110 1120 1130 1140 1150
QELQHKLNQE KEEVEQKKNE FSLKMRQLEH VMGSATEYPQ SPKTPPHFQA
1160 1170 1180 1190 1200
HLAKLLETQE QEIEDGRASK TSLQHLVTKL NEDREVKNAE ILRMKDQLCE
1210 1220 1230 1240 1250
MENLRLESQQ LREKNWLLQR QLDDVKRQQE SGDQSHPDSQ QLKNEHEEII
1260 1270 1280 1290 1300
KERLAKNKLI EEMLKMKTNL EEVQSALHSK EKACHRMSEE IERTRTLESR
1310 1320 1330 1340 1350
AFQEKEQLRS KLEEMYEERE RTFLEMEMLK KQLEFLAEEN GKLVGHQNLH
1360 1370 1380
QKIQYVVRLK KENIRLTEET EKLRAENLFL KEKKKEF
Length:1,387
Mass (Da):160,120
Last modified:July 5, 2004 - v1
Checksum:i0FFA8F93B45D740A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126D → G in CAD90258 (PubMed:14618103).Curated1
Sequence conflicti159S → N in CAD90258 (PubMed:14618103).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560623 mRNA Translation: CAD90258.1
BC060710 mRNA Translation: AAH60710.1
AB001432 mRNA Translation: BAA22392.1
CCDSiCCDS23651.1
RefSeqiNP_034750.1, NM_010620.1
UniGeneiMm.278920

Genome annotation databases

EnsembliENSMUST00000040717; ENSMUSP00000035490; ENSMUSG00000036768
GeneIDi209737
KEGGimmu:209737
UCSCiuc009sfl.1 mouse

Similar proteinsi

Entry informationi

Entry nameiKIF15_MOUSE
AccessioniPrimary (citable) accession number: Q6P9L6
Secondary accession number(s): O35065, Q70MX5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health