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Q6P9L6 (KIF15_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kinesin-like protein KIF15
Alternative name(s):
Kinesin-like protein 2
Kinesin-like protein 7
Gene names
Name:Kif15
Synonyms:Klp2, Knsl7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1387 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly By similarity.

Subunit structure

Interacts with MKI67 and TPX2 By similarity.

Subcellular location

Cytoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity. Note: Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Localizes at the spindle poles and microtubules prior to anaphase. Localizes at the central spindle at anaphase. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells. Colocalizes with actin in interphase. Colocalizes in dendrites and in growth cone of axons with microtubules. Colocalizes with TPX2 in mitosis By similarity.

Tissue specificity

Expressed in brain (neurons in the external germinal layer of the cerebellum and in ventricular zones) (at protein level). Expressed in spleen and testis. Ref.1 Ref.3

Sequence similarities

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.

Contains 1 kinesin motor domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Cytoskeleton
Microtubule
   DomainCoiled coil
   LigandATP-binding
Nucleotide-binding
   Molecular functionMotor protein
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmicrotubule-based movement

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

kinesin complex

Inferred from electronic annotation. Source: InterPro

microtubule

Inferred from electronic annotation. Source: UniProtKB-KW

spindle

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

microtubule motor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13871387Kinesin-like protein KIF15
PRO_0000328685

Regions

Domain26 – 363338Kinesin motor
Nucleotide binding109 – 1168ATP By similarity
Coiled coil368 – 1132765 Potential

Amino acid modifications

Modified residue5681Phosphoserine By similarity
Modified residue10091N6-acetyllysine By similarity
Modified residue11411Phosphoserine By similarity
Modified residue11441Phosphothreonine By similarity
Modified residue11691Phosphoserine By similarity

Experimental info

Sequence conflict1261D → G in CAD90258. Ref.1
Sequence conflict1591S → N in CAD90258. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q6P9L6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 0FFA8F93B45D740A

FASTA1,387160,120
        10         20         30         40         50         60 
MAPGCKSELR NVTNSHSNQP SNEGDAIKVF VRIRPAEEGA RSADGEQSFC LSVLSQTTLR 

        70         80         90        100        110        120 
LHSNPDPKTF VFDYVAGMDT TQESVFSTVA KSIVESCMSG YNGTIFAYGQ TGSGKTFTMM 

       130        140        150        160        170        180 
GPSDSDNFSH NLRGIIPRSF EYLFSLIDRE KEKAGAGKSF LCKCSFIEVY NEQIYDLLDS 

       190        200        210        220        230        240 
ASVGLYLREH IKKGVFVVGA VEQAVTSAAE TYQVLSRGWR NRRVASTSMN RESSRSHAVF 

       250        260        270        280        290        300 
TITIESMEKS SETVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT 

       310        320        330        340        350        360 
ALVDVGNGKQ RHICYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET LSTLNFAQRA 

       370        380        390        400        410        420 
KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LSQFTSGQIT PESLLARDKE KTNYIEYFLE 

       430        440        450        460        470        480 
AMLFFKKSEQ EKKSLIEKIT QLEDLTLKKE KFIQSNKMIV KFREDQIMRL ERLHKEGRGS 

       490        500        510        520        530        540 
FLPEEQDRLL SELRDEVQTL REHVEHHPRL AKYAMENHSL REENRRLKLL APVKRAHEID 

       550        560        570        580        590        600 
AQSIARLEKA FAEVSSTETN DKGLQGFSPK ALKESSFFTN TEKLKAQLLQ IQTELNNSKQ 

       610        620        630        640        650        660 
EYEEFKELTR KKQLELESEL QSLQKANLNL ENLLEATKVC KRQEVSQLNK LHAETLKIIT 

       670        680        690        700        710        720 
TPTKAYQLCS RLVPKSSPEV GSFGFLCTES SSRLDNDILN EPVPPEMSEQ ALEAVSEELR 

       730        740        750        760        770        780 
TVQEQLSVLQ VKLDEEERKN LKLQQNVDKL EHHSTQMQEL FSSERSDWTK QQQEHVTQLS 

       790        800        810        820        830        840 
DLEKQLQDAQ TKNEFLKCEV HDLRIVLNSA DKELSLVKLE YSTFKENHEK ELSQLSERHV 

       850        860        870        880        890        900 
QVQLQLDNAR LENEKLLESQ ACLQDSYDNL QEVMKFEIDQ LSKNLQNCKQ ENETLKSDLH 

       910        920        930        940        950        960 
NLVELFEAEK ERNNKLSLQF EEDKENSSKE ILKVLETVRQ EKQKEMAKCE KQMAKIQKLE 

       970        980        990       1000       1010       1020 
ESLLATENVI SSLEKSRESD KELVTNLMNQ IQELRISIGE KSETIATLKQ ELQDINCKYN 

      1030       1040       1050       1060       1070       1080 
ASLADKEESK ELIRRQEVDI LELKETLRLR ILSEDIERDM LCEDLAHATE QLNMLTEASK 

      1090       1100       1110       1120       1130       1140 
KHSGLLQSAQ EELTRKEALI QELQHKLNQE KEEVEQKKNE FSLKMRQLEH VMGSATEYPQ 

      1150       1160       1170       1180       1190       1200 
SPKTPPHFQA HLAKLLETQE QEIEDGRASK TSLQHLVTKL NEDREVKNAE ILRMKDQLCE 

      1210       1220       1230       1240       1250       1260 
MENLRLESQQ LREKNWLLQR QLDDVKRQQE SGDQSHPDSQ QLKNEHEEII KERLAKNKLI 

      1270       1280       1290       1300       1310       1320 
EEMLKMKTNL EEVQSALHSK EKACHRMSEE IERTRTLESR AFQEKEQLRS KLEEMYEERE 

      1330       1340       1350       1360       1370       1380 
RTFLEMEMLK KQLEFLAEEN GKLVGHQNLH QKIQYVVRLK KENIRLTEET EKLRAENLFL 


KEKKKEF 

« Hide

References

« Hide 'large scale' references
[1]"Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development."
Buster D.W., Baird D.H., Yu W., Solowska J.M., Chauviere M., Mazurek A., Kress M., Baas P.W.
J. Neurocytol. 32:79-96(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
Tissue: Embryo.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[3]"Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-270, TISSUE SPECIFICITY.
Strain: ICR.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ560623 mRNA. Translation: CAD90258.1.
BC060710 mRNA. Translation: AAH60710.1.
AB001432 mRNA. Translation: BAA22392.1.
CCDSCCDS23651.1.
RefSeqNP_034750.1. NM_010620.1.
UniGeneMm.278920.

3D structure databases

ProteinModelPortalQ6P9L6.
SMRQ6P9L6. Positions 24-375.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ6P9L6. 1 interaction.
STRING10090.ENSMUSP00000035490.

PTM databases

PhosphoSiteQ6P9L6.

Proteomic databases

MaxQBQ6P9L6.
PaxDbQ6P9L6.
PRIDEQ6P9L6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000040717; ENSMUSP00000035490; ENSMUSG00000036768.
GeneID209737.
KEGGmmu:209737.
UCSCuc009sfl.1. mouse.

Organism-specific databases

CTD56992.
MGIMGI:1098258. Kif15.

Phylogenomic databases

eggNOGCOG5059.
GeneTreeENSGT00750000117462.
HOGENOMHOG000113225.
HOVERGENHBG062662.
InParanoidQ6P9L6.
KOK10400.
OMAEHHSAQM.
OrthoDBEOG7M0NQQ.
PhylomeDBQ6P9L6.
TreeFamTF320478.

Gene expression databases

BgeeQ6P9L6.
GenevestigatorQ6P9L6.

Family and domain databases

Gene3D3.40.850.10. 1 hit.
InterProIPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR24115. PTHR24115. 1 hit.
PfamPF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view]
PRINTSPR00380. KINESINHEAVY.
SMARTSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio372779.
PROQ6P9L6.
SOURCESearch...

Entry information

Entry nameKIF15_MOUSE
AccessionPrimary (citable) accession number: Q6P9L6
Secondary accession number(s): O35065, Q70MX5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot