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Q6P9L6

- KIF15_MOUSE

UniProt

Q6P9L6 - KIF15_MOUSE

Protein

Kinesin-like protein KIF15

Gene

Kif15

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi109 – 1168ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. microtubule motor activity Source: InterPro

    GO - Biological processi

    1. microtubule-based movement Source: InterPro

    Keywords - Molecular functioni

    Motor protein

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kinesin-like protein KIF15
    Alternative name(s):
    Kinesin-like protein 2
    Kinesin-like protein 7
    Gene namesi
    Name:Kif15
    Synonyms:Klp2, Knsl7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:1098258. Kif15.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeletonspindle By similarity
    Note: Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Localizes at the spindle poles and microtubules prior to anaphase. Localizes at the central spindle at anaphase. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells. Colocalizes with actin in interphase. Colocalizes in dendrites and in growth cone of axons with microtubules. Colocalizes with TPX2 in mitosis By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. kinesin complex Source: InterPro
    3. microtubule Source: UniProtKB-KW
    4. spindle Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Microtubule

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13871387Kinesin-like protein KIF15PRO_0000328685Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei568 – 5681PhosphoserineBy similarity
    Modified residuei1009 – 10091N6-acetyllysineBy similarity
    Modified residuei1141 – 11411PhosphoserineBy similarity
    Modified residuei1144 – 11441PhosphothreonineBy similarity
    Modified residuei1169 – 11691PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ6P9L6.
    PaxDbiQ6P9L6.
    PRIDEiQ6P9L6.

    PTM databases

    PhosphoSiteiQ6P9L6.

    Expressioni

    Tissue specificityi

    Expressed in brain (neurons in the external germinal layer of the cerebellum and in ventricular zones) (at protein level). Expressed in spleen and testis.2 Publications

    Gene expression databases

    BgeeiQ6P9L6.
    GenevestigatoriQ6P9L6.

    Interactioni

    Subunit structurei

    Interacts with MKI67 and TPX2.By similarity

    Protein-protein interaction databases

    IntActiQ6P9L6. 1 interaction.
    STRINGi10090.ENSMUSP00000035490.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P9L6.
    SMRiQ6P9L6. Positions 24-375.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 363338Kinesin motorPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili368 – 1132765Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.PROSITE-ProRule annotation
    Contains 1 kinesin motor domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiCOG5059.
    GeneTreeiENSGT00750000117462.
    HOGENOMiHOG000113225.
    HOVERGENiHBG062662.
    InParanoidiQ6P9L6.
    KOiK10400.
    OMAiEHHSAQM.
    OrthoDBiEOG7M0NQQ.
    PhylomeDBiQ6P9L6.
    TreeFamiTF320478.

    Family and domain databases

    Gene3Di3.40.850.10. 1 hit.
    InterProiIPR027640. Kinesin-like_fam.
    IPR024658. Kinesin-like_KLP2.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR24115. PTHR24115. 1 hit.
    PfamiPF00225. Kinesin. 1 hit.
    PF12711. Kinesin-relat_1. 1 hit.
    [Graphical view]
    PRINTSiPR00380. KINESINHEAVY.
    SMARTiSM00129. KISc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P9L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAPGCKSELR NVTNSHSNQP SNEGDAIKVF VRIRPAEEGA RSADGEQSFC     50
    LSVLSQTTLR LHSNPDPKTF VFDYVAGMDT TQESVFSTVA KSIVESCMSG 100
    YNGTIFAYGQ TGSGKTFTMM GPSDSDNFSH NLRGIIPRSF EYLFSLIDRE 150
    KEKAGAGKSF LCKCSFIEVY NEQIYDLLDS ASVGLYLREH IKKGVFVVGA 200
    VEQAVTSAAE TYQVLSRGWR NRRVASTSMN RESSRSHAVF TITIESMEKS 250
    SETVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT 300
    ALVDVGNGKQ RHICYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET 350
    LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLKEQ LSQFTSGQIT 400
    PESLLARDKE KTNYIEYFLE AMLFFKKSEQ EKKSLIEKIT QLEDLTLKKE 450
    KFIQSNKMIV KFREDQIMRL ERLHKEGRGS FLPEEQDRLL SELRDEVQTL 500
    REHVEHHPRL AKYAMENHSL REENRRLKLL APVKRAHEID AQSIARLEKA 550
    FAEVSSTETN DKGLQGFSPK ALKESSFFTN TEKLKAQLLQ IQTELNNSKQ 600
    EYEEFKELTR KKQLELESEL QSLQKANLNL ENLLEATKVC KRQEVSQLNK 650
    LHAETLKIIT TPTKAYQLCS RLVPKSSPEV GSFGFLCTES SSRLDNDILN 700
    EPVPPEMSEQ ALEAVSEELR TVQEQLSVLQ VKLDEEERKN LKLQQNVDKL 750
    EHHSTQMQEL FSSERSDWTK QQQEHVTQLS DLEKQLQDAQ TKNEFLKCEV 800
    HDLRIVLNSA DKELSLVKLE YSTFKENHEK ELSQLSERHV QVQLQLDNAR 850
    LENEKLLESQ ACLQDSYDNL QEVMKFEIDQ LSKNLQNCKQ ENETLKSDLH 900
    NLVELFEAEK ERNNKLSLQF EEDKENSSKE ILKVLETVRQ EKQKEMAKCE 950
    KQMAKIQKLE ESLLATENVI SSLEKSRESD KELVTNLMNQ IQELRISIGE 1000
    KSETIATLKQ ELQDINCKYN ASLADKEESK ELIRRQEVDI LELKETLRLR 1050
    ILSEDIERDM LCEDLAHATE QLNMLTEASK KHSGLLQSAQ EELTRKEALI 1100
    QELQHKLNQE KEEVEQKKNE FSLKMRQLEH VMGSATEYPQ SPKTPPHFQA 1150
    HLAKLLETQE QEIEDGRASK TSLQHLVTKL NEDREVKNAE ILRMKDQLCE 1200
    MENLRLESQQ LREKNWLLQR QLDDVKRQQE SGDQSHPDSQ QLKNEHEEII 1250
    KERLAKNKLI EEMLKMKTNL EEVQSALHSK EKACHRMSEE IERTRTLESR 1300
    AFQEKEQLRS KLEEMYEERE RTFLEMEMLK KQLEFLAEEN GKLVGHQNLH 1350
    QKIQYVVRLK KENIRLTEET EKLRAENLFL KEKKKEF 1387
    Length:1,387
    Mass (Da):160,120
    Last modified:July 5, 2004 - v1
    Checksum:i0FFA8F93B45D740A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti126 – 1261D → G in CAD90258. (PubMed:14618103)Curated
    Sequence conflicti159 – 1591S → N in CAD90258. (PubMed:14618103)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ560623 mRNA. Translation: CAD90258.1.
    BC060710 mRNA. Translation: AAH60710.1.
    AB001432 mRNA. Translation: BAA22392.1.
    CCDSiCCDS23651.1.
    RefSeqiNP_034750.1. NM_010620.1.
    UniGeneiMm.278920.

    Genome annotation databases

    EnsembliENSMUST00000040717; ENSMUSP00000035490; ENSMUSG00000036768.
    GeneIDi209737.
    KEGGimmu:209737.
    UCSCiuc009sfl.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ560623 mRNA. Translation: CAD90258.1 .
    BC060710 mRNA. Translation: AAH60710.1 .
    AB001432 mRNA. Translation: BAA22392.1 .
    CCDSi CCDS23651.1.
    RefSeqi NP_034750.1. NM_010620.1.
    UniGenei Mm.278920.

    3D structure databases

    ProteinModelPortali Q6P9L6.
    SMRi Q6P9L6. Positions 24-375.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q6P9L6. 1 interaction.
    STRINGi 10090.ENSMUSP00000035490.

    PTM databases

    PhosphoSitei Q6P9L6.

    Proteomic databases

    MaxQBi Q6P9L6.
    PaxDbi Q6P9L6.
    PRIDEi Q6P9L6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000040717 ; ENSMUSP00000035490 ; ENSMUSG00000036768 .
    GeneIDi 209737.
    KEGGi mmu:209737.
    UCSCi uc009sfl.1. mouse.

    Organism-specific databases

    CTDi 56992.
    MGIi MGI:1098258. Kif15.

    Phylogenomic databases

    eggNOGi COG5059.
    GeneTreei ENSGT00750000117462.
    HOGENOMi HOG000113225.
    HOVERGENi HBG062662.
    InParanoidi Q6P9L6.
    KOi K10400.
    OMAi EHHSAQM.
    OrthoDBi EOG7M0NQQ.
    PhylomeDBi Q6P9L6.
    TreeFami TF320478.

    Enzyme and pathway databases

    Reactomei REACT_196550. MHC class II antigen presentation.
    REACT_199117. Kinesins.

    Miscellaneous databases

    NextBioi 372779.
    PROi Q6P9L6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P9L6.
    Genevestigatori Q6P9L6.

    Family and domain databases

    Gene3Di 3.40.850.10. 1 hit.
    InterProi IPR027640. Kinesin-like_fam.
    IPR024658. Kinesin-like_KLP2.
    IPR001752. Kinesin_motor_dom.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR24115. PTHR24115. 1 hit.
    Pfami PF00225. Kinesin. 1 hit.
    PF12711. Kinesin-relat_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00380. KINESINHEAVY.
    SMARTi SM00129. KISc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS50067. KINESIN_MOTOR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development."
      Buster D.W., Baird D.H., Yu W., Solowska J.M., Chauviere M., Mazurek A., Kress M., Baas P.W.
      J. Neurocytol. 32:79-96(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c.
      Tissue: Embryo.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome."
      Nakagawa T., Tanaka Y., Matsuoka E., Kondo S., Okada Y., Noda Y., Kanai Y., Hirokawa N.
      Proc. Natl. Acad. Sci. U.S.A. 94:9654-9659(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 105-270, TISSUE SPECIFICITY.
      Strain: ICR.

    Entry informationi

    Entry nameiKIF15_MOUSE
    AccessioniPrimary (citable) accession number: Q6P9L6
    Secondary accession number(s): O35065, Q70MX5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3