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Q6P9L4

- UBP49_MOUSE

UniProt

Q6P9L4 - UBP49_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 49

Gene

Usp49

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei259 – 2591NucleophilePROSITE-ProRule annotation
Active sitei612 – 6121Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. histone binding Source: UniProtKB
  3. ubiquitin-specific protease activity Source: UniProtKB
  4. ubiquitin thiolesterase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H2B conserved C-terminal lysine deubiquitination Source: UniProtKB
  2. mRNA splicing, via spliceosome Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

mRNA processing, mRNA splicing, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.073.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 49 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 49
Ubiquitin thioesterase 49
Ubiquitin-specific-processing protease 49
Gene namesi
Name:Usp49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2685391. Usp49.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Ubiquitin carboxyl-terminal hydrolase 49PRO_0000080679Add
BLAST

Proteomic databases

PRIDEiQ6P9L4.

PTM databases

PhosphoSiteiQ6P9L4.

Expressioni

Gene expression databases

BgeeiQ6P9L4.
CleanExiMM_USP49.
ExpressionAtlasiQ6P9L4. baseline and differential.
GenevestigatoriQ6P9L4.

Interactioni

Subunit structurei

Component of a complex with RUVBL1 and PSMC5.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6P9L4.
SMRiQ6P9L4. Positions 26-83, 246-652.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini250 – 654405USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00760000119203.
HOGENOMiHOG000015084.
HOVERGENiHBG018027.
InParanoidiQ6P9L4.
KOiK11834.
OMAiCLECATT.
OrthoDBiEOG7JX33S.
PhylomeDBiQ6P9L4.
TreeFamiTF315281.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9L4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDRCKHVGRL RLAQDHSILN PQKWCCLQCA TTESAWACLK CSHVACGRYI
60 70 80 90 100
EDHALKHFEE TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL
110 120 130 140 150
AVRGQKQDLL ARRGRTLRST AAGEDVVPPQ RTPQGQPQML TALWYRRQRL
160 170 180 190 200
LAKTLRLWFQ KSSRGRAQLE QRRQEEALER KKEAARQRRR EVKRRLLEEL
210 220 230 240 250
ASAPPRKSAR LLLHAPGPVA VRPATLATSR RLSAAALNPR RQPAVAPGVT
260 270 280 290 300
GLRNLGNTCY MNSILQVLSH LQKFRECFLN LDPSTSEHLF PQATNGKAQL
310 320 330 340 350
SGRPASSSAA ELSVRSVRAQ GCEPQGLCWS SGASISRSLE LIQNKEPSSK
360 370 380 390 400
HISLCHELHT LFRVMWSGKW ALVSPFAMLH SVWSLIPAFR GYDQQDAQEF
410 420 430 440 450
LCELLHKVQQ ELESEGSTRR ILIPFSQRKL TKQVLKVVNT IFHGQLLSQV
460 470 480 490 500
TCISCNYKSN TIEPFWDLSL EFPERYHCIE KGFVPLNQTE CLLTEMLAKF
510 520 530 540 550
TETEALEGRI YACDQCNSKR RKSNPKPLVL SEARKQLMIY RLPQVLRLHL
560 570 580 590 600
KRFRWSGRNH REKIGVHVIF DQVLTMEPYC CRDMLSSLDK ETFAYDLSAV
610 620 630 640 650
VMHHGKGFGS GHYTAYCYNT EGGFWVHCND SKLDVCSVEE VCKTQAYILF
660 670 680
YTRRTVQGSA KLSEPHLQAQ VHSSSKDERR TYTLP
Length:685
Mass (Da):78,272
Last modified:July 5, 2004 - v1
Checksum:i0E090343A481AE29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL456179 Genomic DNA. No translation available.
BC060712 mRNA. Translation: AAH60712.1.
CCDSiCCDS28852.1.
RefSeqiNP_940813.1. NM_198421.1.
UniGeneiMm.59393.

Genome annotation databases

EnsembliENSMUST00000024779; ENSMUSP00000024779; ENSMUSG00000090115.
GeneIDi224836.
KEGGimmu:224836.
UCSCiuc008cvv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL456179 Genomic DNA. No translation available.
BC060712 mRNA. Translation: AAH60712.1 .
CCDSi CCDS28852.1.
RefSeqi NP_940813.1. NM_198421.1.
UniGenei Mm.59393.

3D structure databases

ProteinModelPortali Q6P9L4.
SMRi Q6P9L4. Positions 26-83, 246-652.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.073.

PTM databases

PhosphoSitei Q6P9L4.

Proteomic databases

PRIDEi Q6P9L4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024779 ; ENSMUSP00000024779 ; ENSMUSG00000090115 .
GeneIDi 224836.
KEGGi mmu:224836.
UCSCi uc008cvv.1. mouse.

Organism-specific databases

CTDi 25862.
MGIi MGI:2685391. Usp49.

Phylogenomic databases

GeneTreei ENSGT00760000119203.
HOGENOMi HOG000015084.
HOVERGENi HBG018027.
InParanoidi Q6P9L4.
KOi K11834.
OMAi CLECATT.
OrthoDBi EOG7JX33S.
PhylomeDBi Q6P9L4.
TreeFami TF315281.

Miscellaneous databases

NextBioi 377415.
PROi Q6P9L4.
SOURCEi Search...

Gene expression databases

Bgeei Q6P9L4.
CleanExi MM_USP49.
ExpressionAtlasi Q6P9L4. baseline and differential.
Genevestigatori Q6P9L4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiUBP49_MOUSE
AccessioniPrimary (citable) accession number: Q6P9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3