Q6P9L4 (UBP49_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ubiquitin carboxyl-terminal hydrolase 49
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 49
Ubiquitin thioesterase 49
Ubiquitin-specific-processing protease 49

Gene names

Name:

Usp49

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	685 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 UBP-type zinc finger.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Domain	Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 685	685	Ubiquitin carboxyl-terminal hydrolase 49		PRO_0000080679
Regions
	Zinc finger	24 – 85	62	UBP-type
Sites
	Active site	259	1	Nucleophile By similarity
	Active site	612	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P9L4 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0E090343A481AE29	FASTA	685	78,272
	10 20 30 40 50 60 MDRCKHVGRL RLAQDHSILN PQKWCCLQCA TTESAWACLK CSHVACGRYI EDHALKHFEE 70 80 90 100 110 120 TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDLL ARRGRTLRST 130 140 150 160 170 180 AAGEDVVPPQ RTPQGQPQML TALWYRRQRL LAKTLRLWFQ KSSRGRAQLE QRRQEEALER 190 200 210 220 230 240 KKEAARQRRR EVKRRLLEEL ASAPPRKSAR LLLHAPGPVA VRPATLATSR RLSAAALNPR 250 260 270 280 290 300 RQPAVAPGVT GLRNLGNTCY MNSILQVLSH LQKFRECFLN LDPSTSEHLF PQATNGKAQL 310 320 330 340 350 360 SGRPASSSAA ELSVRSVRAQ GCEPQGLCWS SGASISRSLE LIQNKEPSSK HISLCHELHT 370 380 390 400 410 420 LFRVMWSGKW ALVSPFAMLH SVWSLIPAFR GYDQQDAQEF LCELLHKVQQ ELESEGSTRR 430 440 450 460 470 480 ILIPFSQRKL TKQVLKVVNT IFHGQLLSQV TCISCNYKSN TIEPFWDLSL EFPERYHCIE 490 500 510 520 530 540 KGFVPLNQTE CLLTEMLAKF TETEALEGRI YACDQCNSKR RKSNPKPLVL SEARKQLMIY 550 560 570 580 590 600 RLPQVLRLHL KRFRWSGRNH REKIGVHVIF DQVLTMEPYC CRDMLSSLDK ETFAYDLSAV 610 620 630 640 650 660 VMHHGKGFGS GHYTAYCYNT EGGFWVHCND SKLDVCSVEE VCKTQAYILF YTRRTVQGSA 670 680 KLSEPHLQAQ VHSSSKDERR TYTLP

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC060712 mRNA. Translation: AAH60712.1.
IPI	IPI00420459.
RefSeq	NP_940813.1. NM_198421.1.
UniGene	Mm.59393.
3D structure databases
ProteinModelPortal	Q6P9L4.
SMR	Q6P9L4. Positions 26-83, 246-652.
ModBase	Search...
Protein family/group databases
MEROPS	C19.073.
PTM databases
PhosphoSite	Q6P9L4.
Proteomic databases
PRIDE	Q6P9L4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000024779; ENSMUSP00000024779; ENSMUSG00000090115.
GeneID	224836.
KEGG	mmu:224836.
UCSC	uc008cvv.1. mouse.
Organism-specific databases
CTD	25862.
MGI	MGI:2685391. Usp49.
Phylogenomic databases
GeneTree	ENSGT00690000101718.
HOGENOM	HOG000015084.
HOVERGEN	HBG018027.
InParanoid	Q6P9L4.
KO	K11834.
OMA	VRGQKQD.
OrthoDB	EOG4XGZZK.
Gene expression databases
ArrayExpress	Q6P9L4.
Bgee	Q6P9L4.
CleanEx	MM_USP49.
Genevestigator	Q6P9L4.
GermOnline	ENSMUSG00000023984. Mus musculus.
Family and domain databases
Gene3D	3.30.40.10. 1 hit.
InterPro	IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. IPR013083. Znf_RING/FYVE/PHD. IPR001607. Znf_UBP. [Graphical view]
Pfam	PF00443. UCH. 1 hit. PF02148. zf-UBP. 1 hit. [Graphical view]
SMART	SM00290. ZnF_UBP. 1 hit. [Graphical view]
PROSITE	PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. PS50271. ZF_UBP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	377415.
SOURCE	Search...

Entry information

Entry name

UBP49_MOUSE

Accession

Primary (citable) accession number: Q6P9L4

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 13, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program