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Protein

Ubiquitin carboxyl-terminal hydrolase 49

Gene

Usp49

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei259NucleophilePROSITE-ProRule annotation1
Active sitei612Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 85UBP-typePROSITE-ProRule annotationAdd BLAST62

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Protease, Thiol protease
Biological processmRNA processing, mRNA splicing, Ubl conjugation pathway
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiC19.073

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 49 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 49
Ubiquitin thioesterase 49
Ubiquitin-specific-processing protease 49
Gene namesi
Name:Usp49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2685391 Usp49

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806791 – 685Ubiquitin carboxyl-terminal hydrolase 49Add BLAST685

Proteomic databases

PaxDbiQ6P9L4
PRIDEiQ6P9L4

PTM databases

iPTMnetiQ6P9L4
PhosphoSitePlusiQ6P9L4

Expressioni

Gene expression databases

BgeeiENSMUSG00000090115
CleanExiMM_USP49
ExpressionAtlasiQ6P9L4 baseline and differential
GenevisibleiQ6P9L4 MM

Interactioni

Subunit structurei

Component of a complex with RUVBL1 and PSMC5.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000024779

Structurei

3D structure databases

ProteinModelPortaliQ6P9L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 654USPAdd BLAST405

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 85UBP-typePROSITE-ProRule annotationAdd BLAST62

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG1867 Eukaryota
ENOG410XQQ0 LUCA
GeneTreeiENSGT00890000139343
HOGENOMiHOG000015084
HOVERGENiHBG018027
InParanoidiQ6P9L4
KOiK11834
OMAiCLECATT
OrthoDBiEOG091G02YX
PhylomeDBiQ6P9L4
TreeFamiTF315281

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR001394 Peptidase_C19_UCH
IPR018200 USP_CS
IPR028889 USP_dom
IPR013083 Znf_RING/FYVE/PHD
IPR001607 Znf_UBP
PfamiView protein in Pfam
PF00443 UCH, 1 hit
PF02148 zf-UBP, 1 hit
SMARTiView protein in SMART
SM00290 ZnF_UBP, 1 hit
SUPFAMiSSF54001 SSF54001, 2 hits
PROSITEiView protein in PROSITE
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
PS50271 ZF_UBP, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P9L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRCKHVGRL RLAQDHSILN PQKWCCLQCA TTESAWACLK CSHVACGRYI
60 70 80 90 100
EDHALKHFEE TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL
110 120 130 140 150
AVRGQKQDLL ARRGRTLRST AAGEDVVPPQ RTPQGQPQML TALWYRRQRL
160 170 180 190 200
LAKTLRLWFQ KSSRGRAQLE QRRQEEALER KKEAARQRRR EVKRRLLEEL
210 220 230 240 250
ASAPPRKSAR LLLHAPGPVA VRPATLATSR RLSAAALNPR RQPAVAPGVT
260 270 280 290 300
GLRNLGNTCY MNSILQVLSH LQKFRECFLN LDPSTSEHLF PQATNGKAQL
310 320 330 340 350
SGRPASSSAA ELSVRSVRAQ GCEPQGLCWS SGASISRSLE LIQNKEPSSK
360 370 380 390 400
HISLCHELHT LFRVMWSGKW ALVSPFAMLH SVWSLIPAFR GYDQQDAQEF
410 420 430 440 450
LCELLHKVQQ ELESEGSTRR ILIPFSQRKL TKQVLKVVNT IFHGQLLSQV
460 470 480 490 500
TCISCNYKSN TIEPFWDLSL EFPERYHCIE KGFVPLNQTE CLLTEMLAKF
510 520 530 540 550
TETEALEGRI YACDQCNSKR RKSNPKPLVL SEARKQLMIY RLPQVLRLHL
560 570 580 590 600
KRFRWSGRNH REKIGVHVIF DQVLTMEPYC CRDMLSSLDK ETFAYDLSAV
610 620 630 640 650
VMHHGKGFGS GHYTAYCYNT EGGFWVHCND SKLDVCSVEE VCKTQAYILF
660 670 680
YTRRTVQGSA KLSEPHLQAQ VHSSSKDERR TYTLP
Length:685
Mass (Da):78,272
Last modified:July 5, 2004 - v1
Checksum:i0E090343A481AE29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL456179 Genomic DNA No translation available.
BC060712 mRNA Translation: AAH60712.1
CCDSiCCDS28852.1
RefSeqiNP_940813.1, NM_198421.1
UniGeneiMm.59393

Genome annotation databases

EnsembliENSMUST00000024779; ENSMUSP00000024779; ENSMUSG00000090115
GeneIDi224836
KEGGimmu:224836
UCSCiuc008cvv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiUBP49_MOUSE
AccessioniPrimary (citable) accession number: Q6P9L4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: June 20, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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