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Q6P9L4

- UBP49_MOUSE

UniProt

Q6P9L4 - UBP49_MOUSE

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Protein

Ubiquitin carboxyl-terminal hydrolase 49

Gene
Usp49
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei259 – 2591Nucleophile By similarity
Active sitei612 – 6121Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 8562UBP-typeAdd
BLAST

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: UniProtKB
  2. histone binding Source: UniProtKB
  3. ubiquitin-specific protease activity Source: UniProtKB
  4. ubiquitin thiolesterase activity Source: UniProtKB
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. histone H2B conserved C-terminal lysine deubiquitination Source: UniProtKB
  2. mRNA splicing, via spliceosome Source: UniProtKB
  3. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Protease, Thiol protease

Keywords - Biological processi

mRNA processing, mRNA splicing, Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC19.073.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 49 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 49
Ubiquitin thioesterase 49
Ubiquitin-specific-processing protease 49
Gene namesi
Name:Usp49
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:2685391. Usp49.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 685685Ubiquitin carboxyl-terminal hydrolase 49PRO_0000080679Add
BLAST

Proteomic databases

PRIDEiQ6P9L4.

PTM databases

PhosphoSiteiQ6P9L4.

Expressioni

Gene expression databases

BgeeiQ6P9L4.
CleanExiMM_USP49.
GenevestigatoriQ6P9L4.

Interactioni

Subunit structurei

Component of a complex with RUVBL1 and PSMC5 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6P9L4.
SMRiQ6P9L4. Positions 26-83, 246-652.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini250 – 654405USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.
Contains 1 USP domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00750000117363.
HOGENOMiHOG000015084.
HOVERGENiHBG018027.
InParanoidiQ6P9L4.
KOiK11834.
OMAiCLECATT.
OrthoDBiEOG7JX33S.
PhylomeDBiQ6P9L4.
TreeFamiTF315281.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view]
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9L4-1 [UniParc]FASTAAdd to Basket

« Hide

MDRCKHVGRL RLAQDHSILN PQKWCCLQCA TTESAWACLK CSHVACGRYI    50
EDHALKHFEE TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL 100
AVRGQKQDLL ARRGRTLRST AAGEDVVPPQ RTPQGQPQML TALWYRRQRL 150
LAKTLRLWFQ KSSRGRAQLE QRRQEEALER KKEAARQRRR EVKRRLLEEL 200
ASAPPRKSAR LLLHAPGPVA VRPATLATSR RLSAAALNPR RQPAVAPGVT 250
GLRNLGNTCY MNSILQVLSH LQKFRECFLN LDPSTSEHLF PQATNGKAQL 300
SGRPASSSAA ELSVRSVRAQ GCEPQGLCWS SGASISRSLE LIQNKEPSSK 350
HISLCHELHT LFRVMWSGKW ALVSPFAMLH SVWSLIPAFR GYDQQDAQEF 400
LCELLHKVQQ ELESEGSTRR ILIPFSQRKL TKQVLKVVNT IFHGQLLSQV 450
TCISCNYKSN TIEPFWDLSL EFPERYHCIE KGFVPLNQTE CLLTEMLAKF 500
TETEALEGRI YACDQCNSKR RKSNPKPLVL SEARKQLMIY RLPQVLRLHL 550
KRFRWSGRNH REKIGVHVIF DQVLTMEPYC CRDMLSSLDK ETFAYDLSAV 600
VMHHGKGFGS GHYTAYCYNT EGGFWVHCND SKLDVCSVEE VCKTQAYILF 650
YTRRTVQGSA KLSEPHLQAQ VHSSSKDERR TYTLP 685
Length:685
Mass (Da):78,272
Last modified:July 5, 2004 - v1
Checksum:i0E090343A481AE29
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL456179 Genomic DNA. No translation available.
BC060712 mRNA. Translation: AAH60712.1.
CCDSiCCDS28852.1.
RefSeqiNP_940813.1. NM_198421.1.
UniGeneiMm.59393.

Genome annotation databases

EnsembliENSMUST00000024779; ENSMUSP00000024779; ENSMUSG00000090115.
GeneIDi224836.
KEGGimmu:224836.
UCSCiuc008cvv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL456179 Genomic DNA. No translation available.
BC060712 mRNA. Translation: AAH60712.1 .
CCDSi CCDS28852.1.
RefSeqi NP_940813.1. NM_198421.1.
UniGenei Mm.59393.

3D structure databases

ProteinModelPortali Q6P9L4.
SMRi Q6P9L4. Positions 26-83, 246-652.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.073.

PTM databases

PhosphoSitei Q6P9L4.

Proteomic databases

PRIDEi Q6P9L4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000024779 ; ENSMUSP00000024779 ; ENSMUSG00000090115 .
GeneIDi 224836.
KEGGi mmu:224836.
UCSCi uc008cvv.1. mouse.

Organism-specific databases

CTDi 25862.
MGIi MGI:2685391. Usp49.

Phylogenomic databases

GeneTreei ENSGT00750000117363.
HOGENOMi HOG000015084.
HOVERGENi HBG018027.
InParanoidi Q6P9L4.
KOi K11834.
OMAi CLECATT.
OrthoDBi EOG7JX33S.
PhylomeDBi Q6P9L4.
TreeFami TF315281.

Miscellaneous databases

NextBioi 377415.
PROi Q6P9L4.
SOURCEi Search...

Gene expression databases

Bgeei Q6P9L4.
CleanExi MM_USP49.
Genevestigatori Q6P9L4.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiUBP49_MOUSE
AccessioniPrimary (citable) accession number: Q6P9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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