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Q6P9L4

- UBP49_MOUSE

UniProt

Q6P9L4 - UBP49_MOUSE

Protein

Ubiquitin carboxyl-terminal hydrolase 49

Gene

Usp49

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei259 – 2591NucleophilePROSITE-ProRule annotation
    Active sitei612 – 6121Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. cysteine-type endopeptidase activity Source: UniProtKB
    2. histone binding Source: UniProtKB
    3. ubiquitin-specific protease activity Source: UniProtKB
    4. ubiquitin thiolesterase activity Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. histone H2B conserved C-terminal lysine deubiquitination Source: UniProtKB
    2. mRNA splicing, via spliceosome Source: UniProtKB
    3. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    mRNA processing, mRNA splicing, Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiC19.073.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 49 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 49
    Ubiquitin thioesterase 49
    Ubiquitin-specific-processing protease 49
    Gene namesi
    Name:Usp49
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:2685391. Usp49.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 685685Ubiquitin carboxyl-terminal hydrolase 49PRO_0000080679Add
    BLAST

    Proteomic databases

    PRIDEiQ6P9L4.

    PTM databases

    PhosphoSiteiQ6P9L4.

    Expressioni

    Gene expression databases

    BgeeiQ6P9L4.
    CleanExiMM_USP49.
    GenevestigatoriQ6P9L4.

    Interactioni

    Subunit structurei

    Component of a complex with RUVBL1 and PSMC5.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P9L4.
    SMRiQ6P9L4. Positions 26-83, 246-652.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini250 – 654405USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri24 – 8562UBP-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    GeneTreeiENSGT00750000117363.
    HOGENOMiHOG000015084.
    HOVERGENiHBG018027.
    InParanoidiQ6P9L4.
    KOiK11834.
    OMAiCLECATT.
    OrthoDBiEOG7JX33S.
    PhylomeDBiQ6P9L4.
    TreeFamiTF315281.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    SMARTiSM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P9L4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRCKHVGRL RLAQDHSILN PQKWCCLQCA TTESAWACLK CSHVACGRYI    50
    EDHALKHFEE TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL 100
    AVRGQKQDLL ARRGRTLRST AAGEDVVPPQ RTPQGQPQML TALWYRRQRL 150
    LAKTLRLWFQ KSSRGRAQLE QRRQEEALER KKEAARQRRR EVKRRLLEEL 200
    ASAPPRKSAR LLLHAPGPVA VRPATLATSR RLSAAALNPR RQPAVAPGVT 250
    GLRNLGNTCY MNSILQVLSH LQKFRECFLN LDPSTSEHLF PQATNGKAQL 300
    SGRPASSSAA ELSVRSVRAQ GCEPQGLCWS SGASISRSLE LIQNKEPSSK 350
    HISLCHELHT LFRVMWSGKW ALVSPFAMLH SVWSLIPAFR GYDQQDAQEF 400
    LCELLHKVQQ ELESEGSTRR ILIPFSQRKL TKQVLKVVNT IFHGQLLSQV 450
    TCISCNYKSN TIEPFWDLSL EFPERYHCIE KGFVPLNQTE CLLTEMLAKF 500
    TETEALEGRI YACDQCNSKR RKSNPKPLVL SEARKQLMIY RLPQVLRLHL 550
    KRFRWSGRNH REKIGVHVIF DQVLTMEPYC CRDMLSSLDK ETFAYDLSAV 600
    VMHHGKGFGS GHYTAYCYNT EGGFWVHCND SKLDVCSVEE VCKTQAYILF 650
    YTRRTVQGSA KLSEPHLQAQ VHSSSKDERR TYTLP 685
    Length:685
    Mass (Da):78,272
    Last modified:July 5, 2004 - v1
    Checksum:i0E090343A481AE29
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL456179 Genomic DNA. No translation available.
    BC060712 mRNA. Translation: AAH60712.1.
    CCDSiCCDS28852.1.
    RefSeqiNP_940813.1. NM_198421.1.
    UniGeneiMm.59393.

    Genome annotation databases

    EnsembliENSMUST00000024779; ENSMUSP00000024779; ENSMUSG00000090115.
    GeneIDi224836.
    KEGGimmu:224836.
    UCSCiuc008cvv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL456179 Genomic DNA. No translation available.
    BC060712 mRNA. Translation: AAH60712.1 .
    CCDSi CCDS28852.1.
    RefSeqi NP_940813.1. NM_198421.1.
    UniGenei Mm.59393.

    3D structure databases

    ProteinModelPortali Q6P9L4.
    SMRi Q6P9L4. Positions 26-83, 246-652.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.073.

    PTM databases

    PhosphoSitei Q6P9L4.

    Proteomic databases

    PRIDEi Q6P9L4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000024779 ; ENSMUSP00000024779 ; ENSMUSG00000090115 .
    GeneIDi 224836.
    KEGGi mmu:224836.
    UCSCi uc008cvv.1. mouse.

    Organism-specific databases

    CTDi 25862.
    MGIi MGI:2685391. Usp49.

    Phylogenomic databases

    GeneTreei ENSGT00750000117363.
    HOGENOMi HOG000015084.
    HOVERGENi HBG018027.
    InParanoidi Q6P9L4.
    KOi K11834.
    OMAi CLECATT.
    OrthoDBi EOG7JX33S.
    PhylomeDBi Q6P9L4.
    TreeFami TF315281.

    Miscellaneous databases

    NextBioi 377415.
    PROi Q6P9L4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P9L4.
    CleanExi MM_USP49.
    Genevestigatori Q6P9L4.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    SMARTi SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiUBP49_MOUSE
    AccessioniPrimary (citable) accession number: Q6P9L4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3