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Protein

Caskin-1

Gene

Caskin1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May link the scaffolding protein CASK to downstream intracellular effectors.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Caskin-1
Alternative name(s):
CASK-interacting protein 1
Gene namesi
Name:Caskin1
Synonyms:Kiaa1306
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2442952. Caskin1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000669811 – 1431Caskin-1Add BLAST1431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei253PhosphotyrosineCombined sources1
Modified residuei358PhosphoserineCombined sources1
Modified residuei398Omega-N-methylarginineBy similarity1
Modified residuei423PhosphoserineCombined sources1
Modified residuei432PhosphoserineCombined sources1
Modified residuei637PhosphoserineCombined sources1
Modified residuei650PhosphoserineCombined sources1
Modified residuei723PhosphoserineBy similarity1
Modified residuei728PhosphoserineCombined sources1
Modified residuei741PhosphothreonineBy similarity1
Modified residuei791PhosphoserineBy similarity1
Modified residuei891PhosphoserineBy similarity1
Modified residuei893PhosphoserineBy similarity1
Modified residuei989PhosphoserineCombined sources1
Modified residuei1067PhosphothreonineCombined sources1
Modified residuei1069PhosphoserineCombined sources1
Modified residuei1259PhosphoserineCombined sources1
Modified residuei1268PhosphothreonineCombined sources1
Modified residuei1363PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6P9K8.
PeptideAtlasiQ6P9K8.
PRIDEiQ6P9K8.

PTM databases

iPTMnetiQ6P9K8.
PhosphoSitePlusiQ6P9K8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000033597.
CleanExiMM_CASKIN1.
GenevisibleiQ6P9K8. MM.

Interactioni

Subunit structurei

Binds the CaM kinase domain of CASK. Forms a ternary complex with CASK and LIN7A, LIN7B or LIN7C. Competes with APBA1 that forms a similar complex with CASK and LIN7 proteins. The tripartite complex CASKIN1/CASK/LIN7(A/B/C) binds the cytoplasmic tail of NRXN1. Polymerizes, via the tandem SAM domains, to form long, 8 nM wide fibers, upon which other proteins can assemble (By similarity).By similarity

Protein-protein interaction databases

BioGridi234580. 2 interactors.
IntActiQ6P9K8. 3 interactors.
MINTiMINT-4113185.
STRINGi10090.ENSMUSP00000024958.

Structurei

3D structure databases

ProteinModelPortaliQ6P9K8.
SMRiQ6P9K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati48 – 77ANK 1Add BLAST30
Repeati81 – 110ANK 2Add BLAST30
Repeati114 – 143ANK 3Add BLAST30
Repeati147 – 176ANK 4Add BLAST30
Repeati188 – 217ANK 5Add BLAST30
Repeati220 – 249ANK 6Add BLAST30
Domaini281 – 347SH3PROSITE-ProRule annotationAdd BLAST67
Domaini476 – 539SAM 1PROSITE-ProRule annotationAdd BLAST64
Domaini545 – 609SAM 2PROSITE-ProRule annotationAdd BLAST65

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni375 – 471CASK-bindingBy similarityAdd BLAST97

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi761 – 878Pro-richAdd BLAST118
Compositional biasi1154 – 1356Pro-richAdd BLAST203

Sequence similaritiesi

Contains 6 ANK repeats.PROSITE-ProRule annotation
Contains 2 SAM (sterile alpha motif) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, SH3 domain

Phylogenomic databases

eggNOGiENOG410INAR. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ6P9K8.
OMAiPKIQGSP.
OrthoDBiEOG091G00P3.
PhylomeDBiQ6P9K8.
TreeFamiTF320582.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin-1.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR24177:SF12. PTHR24177:SF12. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9K8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGKEQELVQA VKAEDVGTAQ RLLQRPRPGK AKLLGSTKKI NVNFQDPDGF
60 70 80 90 100
SALHHAALNG NTELISLLLE AQAAVDIKDN KGMRPLHYAA WQGRKEPMKL
110 120 130 140 150
VLKAGSAVNV PSDEGHIPLH LAAQHGHYDV SEMLLQHQSN PCMVDNSGKT
160 170 180 190 200
PLDLACEFGR VGVVQLLLSS NMCAALLEPR PGDTTDPNGT SPLHLAAKNG
210 220 230 240 250
HIDIIRLLLQ AGIDINRQTK SGTALHEAAL CGKTEVVRLL LDSGINAQVR
260 270 280 290 300
NTYSQTALDI VHQFTTSQAS KEIKQLLREA SAALQVRATK DYCNNYDLTS
310 320 330 340 350
LNVKAGDIIT VLEQHPDGRW KGCIHDNRTG NDRVGYFPSS LGEAIVKRAG
360 370 380 390 400
SRTGSEPSPP QGGGSLGPSA PPEEIWVLRK PFAGGDRSGS LSNVAGGRST
410 420 430 440 450
GGHALHAGSE GVKLLATVLS QKSVSESSPG DSPVKPPEGS SGAARSQPPA
460 470 480 490 500
AHAGQVYGEQ PPKKLESASA SASEGKSAEA VSQWLATFQL QLYAPNFTSA
510 520 530 540 550
GYDLPTISRM TPEDLTAIGV TKPGHRKKIT AEISGLNIPD WLPEHKPANL
560 570 580 590 600
AVWLSMIGLA QYYKVLVDNG YENIDFITDI TWEDLQEIGI TKLGHQKKLM
610 620 630 640 650
LAVRKLAELQ KAEYSKYEGG PLRRKTPQSL EMMAIESPPP SEPAAAECQS
660 670 680 690 700
PKMTTFQDSE LSGELQAALS GPAEAGAAAV EKSSNHLPPT PRTTSRESSL
710 720 730 740 750
SGRARHISSS QELLGDGPPG PGSPMSRSQE YLLDEGMAPG TPPKEVRSSR
760 770 780 790 800
HGHSVKRASV PPVPGKPRQV LPSGASHFTP PQTPTKAQPG SPQALGGPHG
810 820 830 840 850
PATAKVKPTP QLLPPTDRPM SPRSLPQSPT HRGFAYVLPQ PVEGEVGPPA
860 870 880 890 900
PGPAPPPVPA AVPTLCLPPE TDVEPGRPKK RAHSLNRYAA SDSEPERDEL
910 920 930 940 950
LVPAAAGPYA TVQRRVGRSH SVRAPAGTDK NVNRSQSFAV RPRKKGPPPP
960 970 980 990 1000
PPKRSSSAMA SANLADEPAP DVEAEDGRLG VRAQRRRASD LAGSVDTGSA
1010 1020 1030 1040 1050
GSVKSIAAML ELSSIGGGGR AIRRPPEGHP TPRPASPEPG RVATVLASVK
1060 1070 1080 1090 1100
HKEAIGPDGE VVNRRRTLSG PVTGLLATAR RGSGEPAEQS HFMEDGTARQ
1110 1120 1130 1140 1150
RLRGPAKGEA SAEGPPLARV EASATLKRRI RAKQSQQENV KFILTESDTV
1160 1170 1180 1190 1200
KRRPKAKEPD TGPEPPPPLS VYQNGTATVR RRPTSEQAGP PELPPPPPPA
1210 1220 1230 1240 1250
EPPPADLMQL PPLPLPDGNA RKPVKPPVSP KPILSQPVSK IQGSPTPASK
1260 1270 1280 1290 1300
KVPLPGPGSP EVKRAHGTPP PVSPKPPPPP TAPKPAKALA GLQSSSATPS
1310 1320 1330 1340 1350
PVPSPARQPP AALIKPASSP PSQSASPVKP PSPGTPALHV PAKPPRAAAS
1360 1370 1380 1390 1400
VVSGPPVASD CASPGDSARQ KLEETSACLA AALQAVEEKI RQEDGQGPRP
1410 1420 1430
SSIEEKSTGS ILEDIGSMFD DLADQLDAML E
Note: No experimental confirmation available.
Length:1,431
Mass (Da):150,495
Last modified:March 15, 2005 - v2
Checksum:iF89BFB1B2B8926EF
GO
Isoform 2 (identifier: Q6P9K8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     477-547: Missing.

Note: No experimental confirmation available.
Show »
Length:1,360
Mass (Da):142,692
Checksum:i7EBBA250B6F29330
GO
Isoform 3 (identifier: Q6P9K8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1284-1342: Missing.

Note: No experimental confirmation available.
Show »
Length:1,372
Mass (Da):144,832
Checksum:iB2BF82B42AD11E09
GO
Isoform 4 (identifier: Q6P9K8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-365: SRTGSEPSPPQGGGS → KSTPLWREASRGHSA
     366-1431: Missing.

Note: No experimental confirmation available.
Show »
Length:365
Mass (Da):39,617
Checksum:iEAF68EC7094EE9E3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti274K → E in BAB29308 (PubMed:16141072).Curated1
Sequence conflicti969A → S in BAC34019 (PubMed:16141072).Curated1
Sequence conflicti1235S → A in BAC98137 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013121351 – 365SRTGS…QGGGS → KSTPLWREASRGHSA in isoform 4. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_013122366 – 1431Missing in isoform 4. 1 PublicationAdd BLAST1066
Alternative sequenceiVSP_013123477 – 547Missing in isoform 2. 1 PublicationAdd BLAST71
Alternative sequenceiVSP_0131241284 – 1342Missing in isoform 3. 1 PublicationAdd BLAST59

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014376 mRNA. Translation: BAB29308.1.
AK048449 mRNA. Translation: BAC33340.1.
AK049987 mRNA. Translation: BAC34019.1.
AK129327 mRNA. Translation: BAC98137.1.
BC060720 mRNA. Translation: AAH60720.1.
CCDSiCCDS50013.1. [Q6P9K8-1]
RefSeqiNP_082213.2. NM_027937.2. [Q6P9K8-1]
XP_006524378.1. XM_006524315.3. [Q6P9K8-2]
UniGeneiMm.70989.

Genome annotation databases

EnsembliENSMUST00000024958; ENSMUSP00000024958; ENSMUSG00000033597. [Q6P9K8-1]
GeneIDi268932.
KEGGimmu:268932.
UCSCiuc008awm.1. mouse. [Q6P9K8-4]
uc008awo.1. mouse. [Q6P9K8-2]
uc008awp.2. mouse. [Q6P9K8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014376 mRNA. Translation: BAB29308.1.
AK048449 mRNA. Translation: BAC33340.1.
AK049987 mRNA. Translation: BAC34019.1.
AK129327 mRNA. Translation: BAC98137.1.
BC060720 mRNA. Translation: AAH60720.1.
CCDSiCCDS50013.1. [Q6P9K8-1]
RefSeqiNP_082213.2. NM_027937.2. [Q6P9K8-1]
XP_006524378.1. XM_006524315.3. [Q6P9K8-2]
UniGeneiMm.70989.

3D structure databases

ProteinModelPortaliQ6P9K8.
SMRiQ6P9K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi234580. 2 interactors.
IntActiQ6P9K8. 3 interactors.
MINTiMINT-4113185.
STRINGi10090.ENSMUSP00000024958.

PTM databases

iPTMnetiQ6P9K8.
PhosphoSitePlusiQ6P9K8.

Proteomic databases

PaxDbiQ6P9K8.
PeptideAtlasiQ6P9K8.
PRIDEiQ6P9K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024958; ENSMUSP00000024958; ENSMUSG00000033597. [Q6P9K8-1]
GeneIDi268932.
KEGGimmu:268932.
UCSCiuc008awm.1. mouse. [Q6P9K8-4]
uc008awo.1. mouse. [Q6P9K8-2]
uc008awp.2. mouse. [Q6P9K8-1]

Organism-specific databases

CTDi57524.
MGIiMGI:2442952. Caskin1.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410INAR. Eukaryota.
COG0666. LUCA.
GeneTreeiENSGT00530000063104.
HOGENOMiHOG000049168.
HOVERGENiHBG051133.
InParanoidiQ6P9K8.
OMAiPKIQGSP.
OrthoDBiEOG091G00P3.
PhylomeDBiQ6P9K8.
TreeFamiTF320582.

Miscellaneous databases

ChiTaRSiCaskin1. mouse.
PROiQ6P9K8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033597.
CleanExiMM_CASKIN1.
GenevisibleiQ6P9K8. MM.

Family and domain databases

Gene3Di1.10.150.50. 2 hits.
1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR027013. Caskin-1.
IPR032117. Caskin_C.
IPR001660. SAM.
IPR013761. SAM/pointed.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR24177:SF12. PTHR24177:SF12. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF16632. Caskin-tail. 1 hit.
PF00536. SAM_1. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 6 hits.
SM00454. SAM. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS50105. SAM_DOMAIN. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCSKI1_MOUSE
AccessioniPrimary (citable) accession number: Q6P9K8
Secondary accession number(s): Q6ZPU2
, Q8BWU2, Q8BX99, Q9CXH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: March 15, 2005
Last modified: November 2, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.