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Protein

Anoctamin-6

Gene

Ano6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets, osteoblasts and fetal thymocytes. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.5 Publications

Enzyme regulationi

Exhibits synergistic gating by Ca2+ and voltage. Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions.1 Publication

GO - Molecular functioni

  • calcium activated cation channel activity Source: UniProtKB
  • intracellular calcium activated chloride channel activity Source: MGI
  • phospholipid scramblase activity Source: MGI
  • protein homodimerization activity Source: MGI
  • voltage-gated chloride channel activity Source: MGI
  • voltage-gated ion channel activity Source: UniProtKB

GO - Biological processi

  • activation of blood coagulation via clotting cascade Source: MGI
  • bleb assembly Source: UniProtKB
  • blood coagulation Source: UniProtKB
  • bone mineralization involved in bone maturation Source: MGI
  • calcium activated galactosylceramide scrambling Source: MGI
  • calcium activated phosphatidylcholine scrambling Source: MGI
  • calcium activated phosphatidylserine scrambling Source: MGI
  • calcium activated phospholipid scrambling Source: MGI
  • calcium ion transmembrane transport Source: UniProtKB
  • cation transport Source: MGI
  • chloride transmembrane transport Source: UniProtKB
  • chloride transport Source: MGI
  • dendritic cell chemotaxis Source: MGI
  • negative regulation of cell volume Source: UniProtKB
  • phosphatidylserine exposure on blood platelet Source: MGI
  • phospholipid scrambling Source: UniProtKB
  • pore complex assembly Source: MGI
  • positive regulation of apoptotic process Source: UniProtKB
  • positive regulation of bone mineralization Source: UniProtKB
  • positive regulation of endothelial cell apoptotic process Source: MGI
  • positive regulation of ion transmembrane transport Source: UniProtKB
  • positive regulation of monocyte chemotaxis Source: UniProtKB
  • positive regulation of phagocytosis, engulfment Source: UniProtKB
  • positive regulation of potassium ion export Source: BHF-UCL
  • purinergic nucleotide receptor signaling pathway Source: UniProtKB
  • regulation of anion transmembrane transport Source: MGI
  • sodium ion transmembrane transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Chloride channel, Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Lipid transport, Transport

Keywords - Ligandi

Chloride

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Chemistry

SwissLipidsiSLP:000000373.

Names & Taxonomyi

Protein namesi
Recommended name:
Anoctamin-6
Alternative name(s):
Small-conductance calcium-activated nonselective cation channel
Short name:
SCAN channel
Transmembrane protein 16F
Gene namesi
Name:Ano6
Synonyms:Tmem16f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2145890. Ano6.

Subcellular locationi

  • Cell membrane By similarity; Multi-pass membrane protein By similarity

  • Note: Shows an intracellular localization.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 295295CytoplasmicSequence analysisAdd
BLAST
Transmembranei296 – 31621HelicalSequence analysisAdd
BLAST
Topological domaini317 – 37660ExtracellularSequence analysisAdd
BLAST
Transmembranei377 – 39721HelicalSequence analysisAdd
BLAST
Topological domaini398 – 45558CytoplasmicSequence analysisAdd
BLAST
Transmembranei456 – 47621HelicalSequence analysisAdd
BLAST
Topological domaini477 – 51438ExtracellularSequence analysisAdd
BLAST
Transmembranei515 – 53521HelicalSequence analysisAdd
BLAST
Topological domaini536 – 55217CytoplasmicSequence analysisAdd
BLAST
Transmembranei553 – 57321HelicalSequence analysisAdd
BLAST
Topological domaini574 – 67097ExtracellularSequence analysisAdd
BLAST
Transmembranei671 – 69121HelicalSequence analysisAdd
BLAST
Topological domaini692 – 72635CytoplasmicSequence analysisAdd
BLAST
Transmembranei727 – 74721HelicalSequence analysisAdd
BLAST
Topological domaini748 – 82578ExtracellularSequence analysisAdd
BLAST
Transmembranei826 – 84621HelicalSequence analysisAdd
BLAST
Topological domaini847 – 91165CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit deficiencies in Ca2+-dependent phospholipid scramblase activity in platelets and defects in blood coagulation. They also show reduced skeleton size and skeletal deformities.2 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi409 – 4091D → G: Reduced activity and sensitivity to Ca(2+). 1 Publication
Mutagenesisi559 – 5591Q → K: Increased permeability to chloride ions. 1 Publication
Mutagenesisi667 – 6671E → Q: Significant reduction in sensitivity to Ca(2+). 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 911911Anoctamin-6PRO_0000191758Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence analysis
Glycosylationi362 – 3621N-linked (GlcNAc...)Sequence analysis
Glycosylationi492 – 4921N-linked (GlcNAc...); atypical1 Publication
Glycosylationi494 – 4941N-linked (GlcNAc...)1 Publication
Glycosylationi778 – 7781N-linked (GlcNAc...)Sequence analysis
Glycosylationi785 – 7851N-linked (GlcNAc...)1 Publication
Glycosylationi803 – 8031N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ6P9J9.
MaxQBiQ6P9J9.
PaxDbiQ6P9J9.
PRIDEiQ6P9J9.

PTM databases

iPTMnetiQ6P9J9.
PhosphoSiteiQ6P9J9.
SwissPalmiQ6P9J9.

Expressioni

Tissue specificityi

Predominant expression seen in epithelial tissues. Also found in skeletal system where it is primarily expressed in osteoblasts.2 Publications

Developmental stagei

At E14.5, expressed in lung epithelium and mesenchyme. At E16.5, expressed in esophageal epithelium and mesenchyme. In the caudal digestive tract, detected in small intestine epithelium at E14.5. Also detected at E14.5 in epithelium and mesenchyme of trachea, ovary, kidney and stomach. In the developing skeleton, expressed in developing rib perichondria at E14.5. Also expressed in the neural tube and dorsal root ganglia at E14.5. In developing skin, expression is restricted to basal layers of the epidermis at E16.5.1 Publication

Gene expression databases

BgeeiQ6P9J9.
GenevisibleiQ6P9J9. MM.

Interactioni

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

IntActiQ6P9J9. 2 interactions.
MINTiMINT-4114114.
STRINGi10090.ENSMUSP00000071770.

Structurei

3D structure databases

ProteinModelPortaliQ6P9J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the anoctamin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ6P9J9.
KOiK19500.
OMAiGYYTQML.
OrthoDBiEOG7BS48W.
PhylomeDBiQ6P9J9.
TreeFamiTF314265.

Family and domain databases

InterProiIPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031295. Anoctamin-6.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF21. PTHR12308:SF21. 1 hit.
PfamiPF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9J9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQMMTRKVLL NMELEEDDDE DGDIVLENFD QTIVCPTFGS LENQQDFRTP
60 70 80 90 100
EFEEFNGKPD SLFFTDGQRR IDFILVYEDE SKKENNKKGT NEKQKRKRQA
110 120 130 140 150
YESNLICHGL QLEATRSVSD DKLVFVKVHA PWEVLCTYAE IMHIKLPLKP
160 170 180 190 200
NDLKTRSPFG NLNWFTKVLR VNESVIKPEQ EFFTAPFEKS RMNDFYILDR
210 220 230 240 250
DSFFNPATRS RIVYFILSRV KYQVMNNVNK FGINRLVSSG IYKAAFPLHD
260 270 280 290 300
CRFNYESEDI SCPSERYLLY REWAHPRSIY KKQPLDLIRK YYGEKIGIYF
310 320 330 340 350
AWLGYYTQML LLAAVVGVAC FLYGYLDQDN CTWSKEVCDP DIGGQILMCP
360 370 380 390 400
QCDRLCPFWR LNITCESSKK LCIFDSFGTL IFAVFMGVWV TLFLEFWKRR
410 420 430 440 450
QAELEYEWDT VELQQEEQAR PEYEAQCNHV VINEITQEEE RIPFTTCGKC
460 470 480 490 500
IRVTLCASAV FFWILLIIAS VIGIIVYRLS VFIVFSTTLP KNPNGTDPIQ
510 520 530 540 550
KYLTPQMATS ITASIISFII IMILNTIYEK VAIMITNFEL PRTQTDYENS
560 570 580 590 600
LTMKMFLFQF VNYYSSCFYI AFFKGKFVGY PGDPVYLLGK YRSEECDPGG
610 620 630 640 650
CLLELTTQLT IIMGGKAIWN NIQEVLLPWV MNLIGRYKRV SGSEKITPRW
660 670 680 690 700
EQDYHLQPMG KLGLFYEYLE MIIQFGFVTL FVASFPLAPL LALVNNILEI
710 720 730 740 750
RVDAWKLTTQ FRRMVPEKAQ DIGAWQPIMQ GIAILAVVTN AMIIAFTSDM
760 770 780 790 800
IPRLVYYWSF SIPPYGDHTY YTMDGYINNT LSVFNITDFK NTDKENPYIG
810 820 830 840 850
LGNYTLCRYR DFRNPPGHPQ EYKHNIYYWH VIAAKLAFII VMEHIIYSVK
860 870 880 890 900
FFISYAIPDV SKITKSKIKR EKYLTQKLLH ESHLKDLTKN MGIIAERIGG
910
TVDNSVRPKL E
Length:911
Mass (Da):106,255
Last modified:July 5, 2004 - v1
Checksum:i33D7A6EF02635B39
GO
Isoform 2 (identifier: Q6P9J9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-427: Missing.
     428-436: NHVVINEIT → MALMAESLC

Note: No experimental confirmation available.
Show »
Length:484
Mass (Da):55,725
Checksum:iC3DCED460A9892A7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 427427Missing in isoform 2. 1 PublicationVSP_015654Add
BLAST
Alternative sequencei428 – 4369NHVVINEIT → MALMAESLC in isoform 2. 1 PublicationVSP_015655

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089300 mRNA. Translation: BAC40833.1.
BC060732 mRNA. Translation: AAH60732.1.
CCDSiCCDS37184.1. [Q6P9J9-1]
RefSeqiNP_001240742.1. NM_001253813.1.
NP_780553.2. NM_175344.4. [Q6P9J9-1]
UniGeneiMm.38087.

Genome annotation databases

EnsembliENSMUST00000071874; ENSMUSP00000071770; ENSMUSG00000064210. [Q6P9J9-1]
GeneIDi105722.
KEGGimmu:105722.
UCSCiuc007xju.2. mouse. [Q6P9J9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK089300 mRNA. Translation: BAC40833.1.
BC060732 mRNA. Translation: AAH60732.1.
CCDSiCCDS37184.1. [Q6P9J9-1]
RefSeqiNP_001240742.1. NM_001253813.1.
NP_780553.2. NM_175344.4. [Q6P9J9-1]
UniGeneiMm.38087.

3D structure databases

ProteinModelPortaliQ6P9J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P9J9. 2 interactions.
MINTiMINT-4114114.
STRINGi10090.ENSMUSP00000071770.

Chemistry

SwissLipidsiSLP:000000373.

PTM databases

iPTMnetiQ6P9J9.
PhosphoSiteiQ6P9J9.
SwissPalmiQ6P9J9.

Proteomic databases

EPDiQ6P9J9.
MaxQBiQ6P9J9.
PaxDbiQ6P9J9.
PRIDEiQ6P9J9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000071874; ENSMUSP00000071770; ENSMUSG00000064210. [Q6P9J9-1]
GeneIDi105722.
KEGGimmu:105722.
UCSCiuc007xju.2. mouse. [Q6P9J9-1]

Organism-specific databases

CTDi196527.
MGIiMGI:2145890. Ano6.

Phylogenomic databases

eggNOGiKOG2514. Eukaryota.
ENOG410XS4S. LUCA.
GeneTreeiENSGT00760000119015.
HOGENOMiHOG000006509.
HOVERGENiHBG069519.
InParanoidiQ6P9J9.
KOiK19500.
OMAiGYYTQML.
OrthoDBiEOG7BS48W.
PhylomeDBiQ6P9J9.
TreeFamiTF314265.

Enzyme and pathway databases

ReactomeiR-MMU-2672351. Stimuli-sensing channels.

Miscellaneous databases

ChiTaRSiAno6. mouse.
PROiQ6P9J9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P9J9.
GenevisibleiQ6P9J9. MM.

Family and domain databases

InterProiIPR032394. Anoct_dimer.
IPR007632. Anoctamin.
IPR031295. Anoctamin-6.
[Graphical view]
PANTHERiPTHR12308. PTHR12308. 1 hit.
PTHR12308:SF21. PTHR12308:SF21. 1 hit.
PfamiPF16178. Anoct_dimer. 1 hit.
PF04547. Anoctamin. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
    Tissue: Dendritic cell.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "Expression of TMEM16 paralogs during murine embryogenesis."
    Rock J.R., Harfe B.D.
    Dev. Dyn. 237:2566-2574(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.
  4. "The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation."
    Gundry R.L., Raginski K., Tarasova Y., Tchernyshyov I., Bausch-Fluck D., Elliott S.T., Boheler K.R., Van Eyk J.E., Wollscheid B.
    Mol. Cell. Proteomics 8:2555-2569(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-492; ASN-494; ASN-785 AND ASN-803.
    Tissue: Myoblast.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Lung, Pancreas and Spleen.
  6. Cited for: TISSUE SPECIFICITY.
  7. "Calcium-dependent phospholipid scrambling by TMEM16F."
    Suzuki J., Umeda M., Sims P.J., Nagata S.
    Nature 468:834-838(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."
    Duran C., Qu Z., Osunkoya A.O., Cui Y., Hartzell H.C.
    Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ABSENCE OF CALCIUM-ACTIVATED CHLORIDE CHANNEL ACTIVITY.
  9. "TMEM16F forms a Ca(2+)-activated cation channel required for lipid scrambling in platelets during blood coagulation."
    Yang H., Kim A., David T., Palmer D., Jin T., Tien J., Huang F., Cheng T., Coughlin S.R., Jan Y.N., Jan L.Y.
    Cell 151:111-122(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, ENZYME REGULATION, MUTAGENESIS OF ASP-409; GLN-559 AND GLU-667.
  10. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."
    Winpenny J.P., Gray M.A.
    Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  11. Cited for: REVIEW, FUNCTION.
  12. "Calcium-dependent phospholipid scramblase activity of TMEM16 protein family members."
    Suzuki J., Fujii T., Imao T., Ishihara K., Kuba H., Nagata S.
    J. Biol. Chem. 288:13305-13316(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  13. "Inactivation of Anoctamin-6/Tmem16f, a regulator of phosphatidylserine scrambling in osteoblasts, leads to decreased mineral deposition in skeletal tissues."
    Ehlen H.W., Chinenkova M., Moser M., Munter H.M., Krause Y., Gross S., Brachvogel B., Wuelling M., Kornak U., Vortkamp A.
    J. Bone Miner. Res. 28:246-259(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiANO6_MOUSE
AccessioniPrimary (citable) accession number: Q6P9J9
Secondary accession number(s): Q8C242
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.