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Protein

GTPase IMAP family member 6

Gene

GIMAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei68 – 681GTPBy similarity
Binding sitei201 – 2011GTPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi47 – 559GTPBy similarity
Nucleotide bindingi164 – 1663GTPBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 6
Alternative name(s):
Immunity-associated nucleotide 2 protein
Short name:
IAN-2
Short name:
hIAN2
Immunity-associated nucleotide 6 protein
Short name:
IAN-6
Short name:
hIAN6
Gene namesi
Name:GIMAP6
Synonyms:IAN2, IAN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21918. GIMAP6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA128394720.

Polymorphism and mutation databases

BioMutaiGIMAP6.
DMDMi74737549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292GTPase IMAP family member 6PRO_0000333011Add
BLAST

Proteomic databases

MaxQBiQ6P9H5.
PaxDbiQ6P9H5.
PeptideAtlasiQ6P9H5.
PRIDEiQ6P9H5.

PTM databases

iPTMnetiQ6P9H5.
PhosphoSiteiQ6P9H5.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph nodes, lung and placenta. Expressed at moderate level in thymus, kidney, heart and digestive tract. Weakly expressed in other lymphoid tissues. Detected in T-cells.2 Publications

Gene expression databases

BgeeiQ6P9H5.
CleanExiHS_GIMAP6.
ExpressionAtlasiQ6P9H5. baseline and differential.
GenevisibleiQ6P9H5. HS.

Organism-specific databases

HPAiHPA026715.

Interactioni

Protein-protein interaction databases

BioGridi138878. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ6P9H5.
SMRiQ6P9H5. Positions 42-240.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 240203AIG1-type GAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFCF. Eukaryota.
ENOG4111I93. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ6P9H5.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ6P9H5.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEEYEQIP QENPPEELSQ DPVLELSGGL REKEQKTPRR LRLILMGKTG
60 70 80 90 100
SGKSATGNSI LGRDVFESKL STRPVTKTSQ RRSREWAGKE LEVIDTPNIL
110 120 130 140 150
SPQVSPEVAD AICQAIVLSA PGPHAVLLVT QLGRFTDEDQ QVVRRLQEVF
160 170 180 190 200
GVGVLGHTIL VFTRKEDLAG GSLEDYVRET NNQALAWLDV TLARRHCGFN
210 220 230 240 250
NRAQGEEQEA QLRELMEKVE AIMWENEGDY YSNKAYQYTQ QNFRLKELQE
260 270 280 290
RQVSQGQGSE DVPGEESWLE GLSQIQKESE EAHRCLLGKA DL
Length:292
Mass (Da):32,949
Last modified:July 5, 2004 - v1
Checksum:i366A26E07C523C6D
GO
Isoform 2 (identifier: Q6P9H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: MEEEEYEQIP...IDTPNILSPQ → MNKFPRRIPQKSCPRILCWSCQE

Show »
Length:212
Mass (Da):24,136
Checksum:iCC5B2E2BE8DEB1BD
GO
Isoform 3 (identifier: Q6P9H5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-62: REKEQKTPRRLRLILMGKTGSGKSATGNSILG → ARGGRRYLPSHRLIRPRAPRRAPGDTTGPVHG
     63-292: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:62
Mass (Da):6,944
Checksum:iF472AF2DFE13463F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti280 – 2801E → A in CAE45757 (PubMed:15474311).Curated
Isoform 3 (identifier: Q6P9H5-3)
Sequence conflicti46 – 461P → S in CD559670 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti65 – 651V → I.
Corresponds to variant rs17173519 [ dbSNP | Ensembl ].
VAR_049533
Natural varianti170 – 1701G → D.
Corresponds to variant rs11974345 [ dbSNP | Ensembl ].
VAR_043037
Natural varianti171 – 1711G → S.1 Publication
Corresponds to variant rs13234724 [ dbSNP | Ensembl ].
VAR_043038
Natural varianti237 – 2371Q → R.
Corresponds to variant rs11977216 [ dbSNP | Ensembl ].
VAR_043039

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 103103MEEEE…ILSPQ → MNKFPRRIPQKSCPRILCWS CQE in isoform 2. 2 PublicationsVSP_033436Add
BLAST
Alternative sequencei31 – 6232REKEQ…NSILG → ARGGRRYLPSHRLIRPRAPR RAPGDTTGPVHG in isoform 3. 1 PublicationVSP_045595Add
BLAST
Alternative sequencei63 – 292230Missing in isoform 3. 1 PublicationVSP_045596Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580952 mRNA. Translation: CAE45757.1.
AK026343 mRNA. Translation: BAB15455.1.
CR749355 mRNA. Translation: CAH18208.1.
AC069304 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54100.1.
CH471173 Genomic DNA. Translation: EAW54101.1.
BC060760 mRNA. Translation: AAH60760.1.
BC074744 mRNA. Translation: AAH74744.1.
CD559670 mRNA. No translation available.
CCDSiCCDS34778.1. [Q6P9H5-1]
CCDS59087.1. [Q6P9H5-3]
RefSeqiNP_001231000.1. NM_001244071.1. [Q6P9H5-3]
NP_001231001.1. NM_001244072.1.
NP_078987.3. NM_024711.5. [Q6P9H5-1]
UniGeneiHs.647105.

Genome annotation databases

EnsembliENST00000328902; ENSP00000330374; ENSG00000133561. [Q6P9H5-1]
ENST00000493969; ENSP00000418304; ENSG00000133561. [Q6P9H5-3]
GeneIDi474344.
KEGGihsa:474344.
UCSCiuc003whm.4. human. [Q6P9H5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580952 mRNA. Translation: CAE45757.1.
AK026343 mRNA. Translation: BAB15455.1.
CR749355 mRNA. Translation: CAH18208.1.
AC069304 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54100.1.
CH471173 Genomic DNA. Translation: EAW54101.1.
BC060760 mRNA. Translation: AAH60760.1.
BC074744 mRNA. Translation: AAH74744.1.
CD559670 mRNA. No translation available.
CCDSiCCDS34778.1. [Q6P9H5-1]
CCDS59087.1. [Q6P9H5-3]
RefSeqiNP_001231000.1. NM_001244071.1. [Q6P9H5-3]
NP_001231001.1. NM_001244072.1.
NP_078987.3. NM_024711.5. [Q6P9H5-1]
UniGeneiHs.647105.

3D structure databases

ProteinModelPortaliQ6P9H5.
SMRiQ6P9H5. Positions 42-240.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138878. 2 interactions.

PTM databases

iPTMnetiQ6P9H5.
PhosphoSiteiQ6P9H5.

Polymorphism and mutation databases

BioMutaiGIMAP6.
DMDMi74737549.

Proteomic databases

MaxQBiQ6P9H5.
PaxDbiQ6P9H5.
PeptideAtlasiQ6P9H5.
PRIDEiQ6P9H5.

Protocols and materials databases

DNASUi474344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328902; ENSP00000330374; ENSG00000133561. [Q6P9H5-1]
ENST00000493969; ENSP00000418304; ENSG00000133561. [Q6P9H5-3]
GeneIDi474344.
KEGGihsa:474344.
UCSCiuc003whm.4. human. [Q6P9H5-1]

Organism-specific databases

CTDi474344.
GeneCardsiGIMAP6.
HGNCiHGNC:21918. GIMAP6.
HPAiHPA026715.
neXtProtiNX_Q6P9H5.
PharmGKBiPA128394720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCF. Eukaryota.
ENOG4111I93. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ6P9H5.
OrthoDBiEOG7XM2Z9.
PhylomeDBiQ6P9H5.
TreeFamiTF330845.

Miscellaneous databases

GenomeRNAii474344.
PROiQ6P9H5.

Gene expression databases

BgeeiQ6P9H5.
CleanExiHS_GIMAP6.
ExpressionAtlasiQ6P9H5. baseline and differential.
GenevisibleiQ6P9H5. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family."
    Kruecken J., Schroetel R.M.U., Mueller I.U., Saiedani N., Marinovski P., Benten W.P.M., Stamm O., Wunderlich F.
    Gene 341:291-304(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT SER-171.
    Tissue: Small intestine.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Uterine endothelium.
  4. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
    Tissue: Placenta.
  7. "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells."
    Cambot M., Aresta S., Kahn-Perles B., de Gunzburg J., Romeo P.-H.
    Blood 99:3293-3301(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. Cited for: IDENTIFICATION.
  9. Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGIMA6_HUMAN
AccessioniPrimary (citable) accession number: Q6P9H5
Secondary accession number(s): C9J7B6
, D3DWZ4, Q5ZPR6, Q9H612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.