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Protein

GTPase IMAP family member 6

Gene

GIMAP6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei68GTPBy similarity1
Binding sitei201GTPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi47 – 55GTPBy similarity9
Nucleotide bindingi164 – 166GTPBy similarity3

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase IMAP family member 6
Alternative name(s):
Immunity-associated nucleotide 2 protein
Short name:
IAN-2
Short name:
hIAN2
Immunity-associated nucleotide 6 protein
Short name:
IAN-6
Short name:
hIAN6
Gene namesi
Name:GIMAP6
Synonyms:IAN2, IAN6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:21918. GIMAP6.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133561.
PharmGKBiPA128394720.

Polymorphism and mutation databases

BioMutaiGIMAP6.
DMDMi74737549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330111 – 292GTPase IMAP family member 6Add BLAST292

Proteomic databases

MaxQBiQ6P9H5.
PaxDbiQ6P9H5.
PeptideAtlasiQ6P9H5.
PRIDEiQ6P9H5.

PTM databases

iPTMnetiQ6P9H5.
PhosphoSitePlusiQ6P9H5.

Expressioni

Tissue specificityi

Highly expressed in spleen, lymph nodes, lung and placenta. Expressed at moderate level in thymus, kidney, heart and digestive tract. Weakly expressed in other lymphoid tissues. Detected in T-cells.2 Publications

Gene expression databases

BgeeiENSG00000133561.
CleanExiHS_GIMAP6.
ExpressionAtlasiQ6P9H5. baseline and differential.
GenevisibleiQ6P9H5. HS.

Organism-specific databases

HPAiHPA026715.

Interactioni

Protein-protein interaction databases

BioGridi138878. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6P9H5.
SMRiQ6P9H5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 240AIG1-type GAdd BLAST203

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IFCF. Eukaryota.
ENOG4111I93. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ6P9H5.
PhylomeDBiQ6P9H5.
TreeFamiTF330845.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9H5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEEEYEQIP QENPPEELSQ DPVLELSGGL REKEQKTPRR LRLILMGKTG
60 70 80 90 100
SGKSATGNSI LGRDVFESKL STRPVTKTSQ RRSREWAGKE LEVIDTPNIL
110 120 130 140 150
SPQVSPEVAD AICQAIVLSA PGPHAVLLVT QLGRFTDEDQ QVVRRLQEVF
160 170 180 190 200
GVGVLGHTIL VFTRKEDLAG GSLEDYVRET NNQALAWLDV TLARRHCGFN
210 220 230 240 250
NRAQGEEQEA QLRELMEKVE AIMWENEGDY YSNKAYQYTQ QNFRLKELQE
260 270 280 290
RQVSQGQGSE DVPGEESWLE GLSQIQKESE EAHRCLLGKA DL
Length:292
Mass (Da):32,949
Last modified:July 5, 2004 - v1
Checksum:i366A26E07C523C6D
GO
Isoform 2 (identifier: Q6P9H5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-103: MEEEEYEQIP...IDTPNILSPQ → MNKFPRRIPQKSCPRILCWSCQE

Show »
Length:212
Mass (Da):24,136
Checksum:iCC5B2E2BE8DEB1BD
GO
Isoform 3 (identifier: Q6P9H5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     31-62: REKEQKTPRRLRLILMGKTGSGKSATGNSILG → ARGGRRYLPSHRLIRPRAPRRAPGDTTGPVHG
     63-292: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:62
Mass (Da):6,944
Checksum:iF472AF2DFE13463F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti280E → A in CAE45757 (PubMed:15474311).Curated1
Isoform 3 (identifier: Q6P9H5-3)
Sequence conflicti46P → S in CD559670 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04953365V → I.Corresponds to variant rs17173519dbSNPEnsembl.1
Natural variantiVAR_043037170G → D.Corresponds to variant rs11974345dbSNPEnsembl.1
Natural variantiVAR_043038171G → S.1 PublicationCorresponds to variant rs13234724dbSNPEnsembl.1
Natural variantiVAR_043039237Q → R.Corresponds to variant rs11977216dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0334361 – 103MEEEE…ILSPQ → MNKFPRRIPQKSCPRILCWS CQE in isoform 2. 2 PublicationsAdd BLAST103
Alternative sequenceiVSP_04559531 – 62REKEQ…NSILG → ARGGRRYLPSHRLIRPRAPR RAPGDTTGPVHG in isoform 3. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_04559663 – 292Missing in isoform 3. 1 PublicationAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580952 mRNA. Translation: CAE45757.1.
AK026343 mRNA. Translation: BAB15455.1.
CR749355 mRNA. Translation: CAH18208.1.
AC069304 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54100.1.
CH471173 Genomic DNA. Translation: EAW54101.1.
BC060760 mRNA. Translation: AAH60760.1.
BC074744 mRNA. Translation: AAH74744.1.
CD559670 mRNA. No translation available.
CCDSiCCDS34778.1. [Q6P9H5-1]
CCDS59087.1. [Q6P9H5-3]
RefSeqiNP_001231000.1. NM_001244071.1. [Q6P9H5-3]
NP_001231001.1. NM_001244072.1.
NP_078987.3. NM_024711.5. [Q6P9H5-1]
UniGeneiHs.647105.

Genome annotation databases

EnsembliENST00000328902; ENSP00000330374; ENSG00000133561. [Q6P9H5-1]
ENST00000493969; ENSP00000418304; ENSG00000133561. [Q6P9H5-3]
GeneIDi474344.
KEGGihsa:474344.
UCSCiuc003whm.4. human. [Q6P9H5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580952 mRNA. Translation: CAE45757.1.
AK026343 mRNA. Translation: BAB15455.1.
CR749355 mRNA. Translation: CAH18208.1.
AC069304 Genomic DNA. No translation available.
CH471173 Genomic DNA. Translation: EAW54100.1.
CH471173 Genomic DNA. Translation: EAW54101.1.
BC060760 mRNA. Translation: AAH60760.1.
BC074744 mRNA. Translation: AAH74744.1.
CD559670 mRNA. No translation available.
CCDSiCCDS34778.1. [Q6P9H5-1]
CCDS59087.1. [Q6P9H5-3]
RefSeqiNP_001231000.1. NM_001244071.1. [Q6P9H5-3]
NP_001231001.1. NM_001244072.1.
NP_078987.3. NM_024711.5. [Q6P9H5-1]
UniGeneiHs.647105.

3D structure databases

ProteinModelPortaliQ6P9H5.
SMRiQ6P9H5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi138878. 2 interactors.

PTM databases

iPTMnetiQ6P9H5.
PhosphoSitePlusiQ6P9H5.

Polymorphism and mutation databases

BioMutaiGIMAP6.
DMDMi74737549.

Proteomic databases

MaxQBiQ6P9H5.
PaxDbiQ6P9H5.
PeptideAtlasiQ6P9H5.
PRIDEiQ6P9H5.

Protocols and materials databases

DNASUi474344.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328902; ENSP00000330374; ENSG00000133561. [Q6P9H5-1]
ENST00000493969; ENSP00000418304; ENSG00000133561. [Q6P9H5-3]
GeneIDi474344.
KEGGihsa:474344.
UCSCiuc003whm.4. human. [Q6P9H5-1]

Organism-specific databases

CTDi474344.
GeneCardsiGIMAP6.
HGNCiHGNC:21918. GIMAP6.
HPAiHPA026715.
MIMi616960. gene.
neXtProtiNX_Q6P9H5.
OpenTargetsiENSG00000133561.
PharmGKBiPA128394720.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFCF. Eukaryota.
ENOG4111I93. LUCA.
GeneTreeiENSGT00760000118989.
HOGENOMiHOG000115747.
HOVERGENiHBG004016.
InParanoidiQ6P9H5.
PhylomeDBiQ6P9H5.
TreeFamiTF330845.

Miscellaneous databases

GenomeRNAii474344.
PROiQ6P9H5.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133561.
CleanExiHS_GIMAP6.
ExpressionAtlasiQ6P9H5. baseline and differential.
GenevisibleiQ6P9H5. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006703. G_AIG1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04548. AIG1. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51720. G_AIG1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGIMA6_HUMAN
AccessioniPrimary (citable) accession number: Q6P9H5
Secondary accession number(s): C9J7B6
, D3DWZ4, Q5ZPR6, Q9H612
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.