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Protein

Zinc finger protein 449

Gene

ZNF449

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 449
Alternative name(s):
Zinc finger and SCAN domain-containing protein 19
Gene namesi
Name:ZNF449
Synonyms:ZSCAN19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000173275.12
HGNCiHGNC:21039 ZNF449
MIMi300627 gene
neXtProtiNX_Q6P9G9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173275
PharmGKBiPA134920699

Polymorphism and mutation databases

BioMutaiZNF449
DMDMi92090580

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475971 – 518Zinc finger protein 449Add BLAST518

Proteomic databases

PaxDbiQ6P9G9
PeptideAtlasiQ6P9G9
PRIDEiQ6P9G9

PTM databases

iPTMnetiQ6P9G9
PhosphoSitePlusiQ6P9G9

Expressioni

Gene expression databases

BgeeiENSG00000173275
CleanExiHS_ZNF449
GenevisibleiQ6P9G9 HS

Organism-specific databases

HPAiHPA018079

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SCAND1P570865EBI-10215956,EBI-745846

Protein-protein interaction databases

BioGridi128476, 4 interactors
IntActiQ6P9G9, 3 interactors
STRINGi9606.ENSP00000339585

Structurei

3D structure databases

ProteinModelPortaliQ6P9G9
SMRiQ6P9G9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 112SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00910000144000
HOGENOMiHOG000234619
HOVERGENiHBG018163
InParanoidiQ6P9G9
KOiK09230
OMAiPHKKKSP
OrthoDBiEOG091G02KC
PhylomeDBiQ6P9G9
TreeFamiTF336949

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 7 hits
SUPFAMiSSF57667 SSF57667, 4 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 7 hits
PS50157 ZINC_FINGER_C2H2_2, 7 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK
60 70 80 90 100
LWELCCQWLK PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER
110 120 130 140 150
VVSLIEDLQR ELEIPEQQVD MHDMLLEELA PVGTAHIPPT MHLESPALQV
160 170 180 190 200
MGPAQEAPVA EAWIPQAGPP ELNYGATGEC QNFLDPGYPL PKLDMNFSLE
210 220 230 240 250
NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK KMETMYPFIV
260 270 280 290 300
TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE
310 320 330 340 350
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP
360 370 380 390 400
HKCPECGKRF LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT
410 420 430 440 450
HSEEETYKCL ECGKSFCHGS SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL
460 470 480 490 500
TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI HLRIHTGEKP YKCTHCSKSF
510
RQRAGLIMHQ VTHFRGLI
Length:518
Mass (Da):59,932
Last modified:March 7, 2006 - v3
Checksum:iE6CDA288C489BAB8
GO
Isoform 2 (identifier: Q6P9G9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-164: DMHDMLLEEL...QEAPVAEAWI → RKECGIFVIG...SRVLFLFLFC
     165-518: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):19,232
Checksum:i4F8ACA64086C83B4
GO
Isoform 3 (identifier: Q6P9G9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-127: VDMHDMLLE → TFAAEYSHY
     128-518: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):15,111
Checksum:i52A619923A72EF04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124M → I in AAQ16305 (Ref. 1) Curated1
Sequence conflicti124M → I in CAD38639 (PubMed:17974005).Curated1
Sequence conflicti187G → V in AAQ16305 (Ref. 1) Curated1
Sequence conflicti187G → V in CAD38639 (PubMed:17974005).Curated1
Sequence conflicti293P → L in AAQ16305 (Ref. 1) Curated1
Sequence conflicti293P → L in CAD38639 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011951119 – 127VDMHDMLLE → TFAAEYSHY in isoform 3. 1 Publication9
Alternative sequenceiVSP_011949120 – 164DMHDM…AEAWI → RKECGIFVIGPKEVAEAAGT RPHICLYVIPQPQDFSRVLF LFLFC in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_011952128 – 518Missing in isoform 3. 1 PublicationAdd BLAST391
Alternative sequenceiVSP_011950165 – 518Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280801 mRNA Translation: AAQ16305.1
AK074194 mRNA Translation: BAB85013.1
AL833407 mRNA Translation: CAD38639.1
AL450472 Genomic DNA No translation available.
BC060768 mRNA Translation: AAH60768.1
BC065938 mRNA Translation: AAH65938.1
CCDSiCCDS14649.1 [Q6P9G9-1]
RefSeqiNP_689908.3, NM_152695.5 [Q6P9G9-1]
XP_011529614.1, XM_011531312.2 [Q6P9G9-1]
UniGeneiHs.28780

Genome annotation databases

EnsembliENST00000339249; ENSP00000339585; ENSG00000173275 [Q6P9G9-1]
ENST00000370761; ENSP00000359797; ENSG00000173275 [Q6P9G9-2]
GeneIDi203523
KEGGihsa:203523
UCSCiuc004eyr.5 human [Q6P9G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZN449_HUMAN
AccessioniPrimary (citable) accession number: Q6P9G9
Secondary accession number(s): Q5JRZ7
, Q5JRZ8, Q6NZX2, Q8N3Q1, Q8TED7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 134 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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