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Protein

Zinc finger protein 449

Gene

ZNF449

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 449
Alternative name(s):
Zinc finger and SCAN domain-containing protein 19
Gene namesi
Name:ZNF449
Synonyms:ZSCAN19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:21039. ZNF449.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173275.
PharmGKBiPA134920699.

Polymorphism and mutation databases

BioMutaiZNF449.
DMDMi92090580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000475971 – 518Zinc finger protein 449Add BLAST518

Proteomic databases

PaxDbiQ6P9G9.
PeptideAtlasiQ6P9G9.
PRIDEiQ6P9G9.

PTM databases

iPTMnetiQ6P9G9.
PhosphoSitePlusiQ6P9G9.

Expressioni

Gene expression databases

BgeeiENSG00000173275.
CleanExiHS_ZNF449.
GenevisibleiQ6P9G9. HS.

Organism-specific databases

HPAiHPA018079.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SCAND1P570863EBI-10215956,EBI-745846

Protein-protein interaction databases

BioGridi128476. 3 interactors.
IntActiQ6P9G9. 1 interactor.
STRINGi9606.ENSP00000339585.

Structurei

3D structure databases

ProteinModelPortaliQ6P9G9.
SMRiQ6P9G9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 112SCAN boxPROSITE-ProRule annotationAdd BLAST83

Sequence similaritiesi

Contains 7 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri323 – 345C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 7PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000110971.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ6P9G9.
KOiK09230.
OMAiPVAEAWI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P9G9.
TreeFamiTF336949.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9G9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAVALGCAIQ ASLNQGSVFQ EYDTDCEVFR QRFRQFQYRE AAGPHEAFNK
60 70 80 90 100
LWELCCQWLK PKMRSKEQIL ELLVLEQFLT ILPTEIETWV REHCPENRER
110 120 130 140 150
VVSLIEDLQR ELEIPEQQVD MHDMLLEELA PVGTAHIPPT MHLESPALQV
160 170 180 190 200
MGPAQEAPVA EAWIPQAGPP ELNYGATGEC QNFLDPGYPL PKLDMNFSLE
210 220 230 240 250
NREEPWVKEL QDSKEMKQLL DSKIGFEIGI ENEEDTSKQK KMETMYPFIV
260 270 280 290 300
TLEGNALQGP ILQKDYVQLE NQWETPPEDL QTDLAKLVDQ QNPTLGETPE
310 320 330 340 350
NSNLEEPLNP KPHKKKSPGE KPHRCPQCGK CFARKSQLTG HQRIHSGEEP
360 370 380 390 400
HKCPECGKRF LRSSDLYRHQ RLHTGERPYE CTVCKKRFTR RSHLIGHQRT
410 420 430 440 450
HSEEETYKCL ECGKSFCHGS SLKRHLKTHT GEKPHRCHNC GKSFSRLTAL
460 470 480 490 500
TLHQRTHTEE RPFKCNYCGK SFRQRPSLVI HLRIHTGEKP YKCTHCSKSF
510
RQRAGLIMHQ VTHFRGLI
Length:518
Mass (Da):59,932
Last modified:March 7, 2006 - v3
Checksum:iE6CDA288C489BAB8
GO
Isoform 2 (identifier: Q6P9G9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-164: DMHDMLLEEL...QEAPVAEAWI → RKECGIFVIG...SRVLFLFLFC
     165-518: Missing.

Note: No experimental confirmation available.
Show »
Length:164
Mass (Da):19,232
Checksum:i4F8ACA64086C83B4
GO
Isoform 3 (identifier: Q6P9G9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-127: VDMHDMLLE → TFAAEYSHY
     128-518: Missing.

Note: No experimental confirmation available.
Show »
Length:127
Mass (Da):15,111
Checksum:i52A619923A72EF04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti124M → I in AAQ16305 (Ref. 1) Curated1
Sequence conflicti124M → I in CAD38639 (PubMed:17974005).Curated1
Sequence conflicti187G → V in AAQ16305 (Ref. 1) Curated1
Sequence conflicti187G → V in CAD38639 (PubMed:17974005).Curated1
Sequence conflicti293P → L in AAQ16305 (Ref. 1) Curated1
Sequence conflicti293P → L in CAD38639 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_011951119 – 127VDMHDMLLE → TFAAEYSHY in isoform 3. 1 Publication9
Alternative sequenceiVSP_011949120 – 164DMHDM…AEAWI → RKECGIFVIGPKEVAEAAGT RPHICLYVIPQPQDFSRVLF LFLFC in isoform 2. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_011952128 – 518Missing in isoform 3. 1 PublicationAdd BLAST391
Alternative sequenceiVSP_011950165 – 518Missing in isoform 2. 1 PublicationAdd BLAST354

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280801 mRNA. Translation: AAQ16305.1.
AK074194 mRNA. Translation: BAB85013.1.
AL833407 mRNA. Translation: CAD38639.1.
AL450472 Genomic DNA. Translation: CAI39872.1.
AL450472 Genomic DNA. Translation: CAI39873.1.
BC060768 mRNA. Translation: AAH60768.1.
BC065938 mRNA. Translation: AAH65938.1.
CCDSiCCDS14649.1. [Q6P9G9-1]
RefSeqiNP_689908.3. NM_152695.5. [Q6P9G9-1]
XP_011529614.1. XM_011531312.2. [Q6P9G9-1]
UniGeneiHs.28780.

Genome annotation databases

EnsembliENST00000339249; ENSP00000339585; ENSG00000173275. [Q6P9G9-1]
ENST00000370761; ENSP00000359797; ENSG00000173275. [Q6P9G9-2]
GeneIDi203523.
KEGGihsa:203523.
UCSCiuc004eyr.5. human. [Q6P9G9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280801 mRNA. Translation: AAQ16305.1.
AK074194 mRNA. Translation: BAB85013.1.
AL833407 mRNA. Translation: CAD38639.1.
AL450472 Genomic DNA. Translation: CAI39872.1.
AL450472 Genomic DNA. Translation: CAI39873.1.
BC060768 mRNA. Translation: AAH60768.1.
BC065938 mRNA. Translation: AAH65938.1.
CCDSiCCDS14649.1. [Q6P9G9-1]
RefSeqiNP_689908.3. NM_152695.5. [Q6P9G9-1]
XP_011529614.1. XM_011531312.2. [Q6P9G9-1]
UniGeneiHs.28780.

3D structure databases

ProteinModelPortaliQ6P9G9.
SMRiQ6P9G9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128476. 3 interactors.
IntActiQ6P9G9. 1 interactor.
STRINGi9606.ENSP00000339585.

PTM databases

iPTMnetiQ6P9G9.
PhosphoSitePlusiQ6P9G9.

Polymorphism and mutation databases

BioMutaiZNF449.
DMDMi92090580.

Proteomic databases

PaxDbiQ6P9G9.
PeptideAtlasiQ6P9G9.
PRIDEiQ6P9G9.

Protocols and materials databases

DNASUi203523.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339249; ENSP00000339585; ENSG00000173275. [Q6P9G9-1]
ENST00000370761; ENSP00000359797; ENSG00000173275. [Q6P9G9-2]
GeneIDi203523.
KEGGihsa:203523.
UCSCiuc004eyr.5. human. [Q6P9G9-1]

Organism-specific databases

CTDi203523.
GeneCardsiZNF449.
HGNCiHGNC:21039. ZNF449.
HPAiHPA018079.
MIMi300627. gene.
neXtProtiNX_Q6P9G9.
OpenTargetsiENSG00000173275.
PharmGKBiPA134920699.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00730000110971.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ6P9G9.
KOiK09230.
OMAiPVAEAWI.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P9G9.
TreeFamiTF336949.

Miscellaneous databases

GenomeRNAii203523.
PROiQ6P9G9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173275.
CleanExiHS_ZNF449.
GenevisibleiQ6P9G9. HS.

Family and domain databases

Gene3Di3.30.160.60. 7 hits.
InterProiIPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 1 hit.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 7 hits.
[Graphical view]
SUPFAMiSSF47353. SSF47353. 1 hit.
PROSITEiPS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN449_HUMAN
AccessioniPrimary (citable) accession number: Q6P9G9
Secondary accession number(s): Q5JRZ7
, Q5JRZ8, Q6NZX2, Q8N3Q1, Q8TED7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: March 7, 2006
Last modified: November 2, 2016
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.