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Protein

Tripartite motif-containing protein 40

Gene

TRIM40

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 5643RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri66 – 10742B box-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • negative regulation of cell growth Source: Ensembl
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of NIK/NF-kappaB signaling Source: UniProtKB
  • negative regulation of protein catabolic process Source: UniProtKB
  • negative regulation of protein localization to nucleus Source: UniProtKB
  • protein neddylation Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 40
Alternative name(s):
Probable E3 NEDD8-protein ligase
RING finger protein 35
Gene namesi
Name:TRIM40
Synonyms:RNF35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:18736. TRIM40.

Subcellular locationi

GO - Cellular componenti

  • IkappaB kinase complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38663.

Polymorphism and mutation databases

DMDMi229463021.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 258258Tripartite motif-containing protein 40PRO_0000056260Add
BLAST

Proteomic databases

EPDiQ6P9F5.
PeptideAtlasiQ6P9F5.
PRIDEiQ6P9F5.

PTM databases

iPTMnetiQ6P9F5.
PhosphoSiteiQ6P9F5.

Expressioni

Tissue specificityi

Highly expressed in normal gastrointestinal epithelia but that is down-regulated in gastrointestinal carcinomas and chronic inflammatory lesions of the gastrointestinal tract.1 Publication

Gene expression databases

BgeeiENSG00000204614.
CleanExiHS_TRIM40.
GenevisibleiQ6P9F5. HS.

Organism-specific databases

HPAiHPA043818.

Interactioni

Subunit structurei

Interacts with NEDD8.1 Publication

Protein-protein interaction databases

BioGridi126432. 5 interactions.
IntActiQ6P9F5. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6P9F5.
SMRiQ6P9F5. Positions 9-59, 71-217.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 15953Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri14 – 5643RING-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri66 – 10742B box-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

GeneTreeiENSGT00710000106875.
HOGENOMiHOG000060264.
HOVERGENiHBG057956.
InParanoidiQ6P9F5.
KOiK12016.
OMAiEEGICPI.
OrthoDBiEOG091G0KAK.
PhylomeDBiQ6P9F5.
TreeFamiTF333491.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIPLQKDNQE EGVCPICQES LKEAVSTNCG HLFCRVCLTQ HVEKASASGV
60 70 80 90 100
FCCPLCRKPC SEEVLGTGYI CPNHQKRVCR FCEESRLLLC VECLVSPEHM
110 120 130 140 150
SHHELTIENA LSHYKERLNR RSRKLRKDIA ELQRLKAQQE KKLQALQFQV
160 170 180 190 200
DHGNHRLEAG PESQHQTREQ LGALPQQWLG QLEHMPAEAA RILDISRAVT
210 220 230 240 250
QLRSLVIDLE RTAKELDTNT LKNAGDLLNR SAPQKLEVIY PQLEKGVSEL

LLQPPQKL
Length:258
Mass (Da):29,336
Last modified:May 5, 2009 - v3
Checksum:iC360BECD4411F1DB
GO
Isoform 2 (identifier: Q6P9F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-176: Missing.

Note: No experimental confirmation available.
Show »
Length:229
Mass (Da):26,073
Checksum:i48DA1F84FB6DE152
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti142 – 1421K → Q.
Corresponds to variant rs12528473 [ dbSNP | Ensembl ].
VAR_055309
Natural varianti215 – 2151E → K.
Corresponds to variant rs757259 [ dbSNP | Ensembl ].
VAR_055310
Natural varianti244 – 2441E → K.
Corresponds to variant rs757259 [ dbSNP | Ensembl ].
VAR_057222

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 17629Missing in isoform 2. 1 PublicationVSP_012131Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF489517 mRNA. Translation: AAM09503.1.
AB110939 Genomic DNA. Translation: BAD13705.1.
AB110940 Genomic DNA. Translation: BAD13706.1.
AB202084 Genomic DNA. Translation: BAE78604.1.
AL669914 Genomic DNA. Translation: CAI18185.2.
BX322644 Genomic DNA. Translation: CAI18448.2.
AL671859 Genomic DNA. Translation: CAM24935.1.
BX322644 Genomic DNA. Translation: CAM25692.1.
CR788282 Genomic DNA. Translation: CAQ07454.1.
CR788282 Genomic DNA. Translation: CAQ07455.1.
BX927221 Genomic DNA. Translation: CAQ10306.1.
BX927221 Genomic DNA. Translation: CAQ10307.1.
CH471081 Genomic DNA. Translation: EAX03265.1.
CH471081 Genomic DNA. Translation: EAX03266.1.
BC060785 mRNA. Translation: AAH60785.1.
CCDSiCCDS4675.1. [Q6P9F5-2]
CCDS69069.1. [Q6P9F5-1]
RefSeqiNP_001273562.1. NM_001286633.1. [Q6P9F5-1]
NP_619645.1. NM_138700.4. [Q6P9F5-2]
XP_011512607.1. XM_011514305.1. [Q6P9F5-1]
XP_011512608.1. XM_011514306.1. [Q6P9F5-1]
UniGeneiHs.509439.

Genome annotation databases

EnsembliENST00000307859; ENSP00000308310; ENSG00000204614. [Q6P9F5-2]
ENST00000376724; ENSP00000365914; ENSG00000204614. [Q6P9F5-1]
ENST00000383610; ENSP00000373105; ENSG00000172524. [Q6P9F5-1]
ENST00000396581; ENSP00000379826; ENSG00000204614. [Q6P9F5-1]
ENST00000400651; ENSP00000383492; ENSG00000172524. [Q6P9F5-2]
ENST00000421981; ENSP00000403025; ENSG00000237046. [Q6P9F5-2]
ENST00000429471; ENSP00000393674; ENSG00000228001. [Q6P9F5-2]
ENST00000433713; ENSP00000389607; ENSG00000224496. [Q6P9F5-1]
ENST00000434151; ENSP00000388460; ENSG00000237046. [Q6P9F5-1]
ENST00000436951; ENSP00000416663; ENSG00000224496. [Q6P9F5-2]
ENST00000437563; ENSP00000416950; ENSG00000228001. [Q6P9F5-1]
ENST00000547289; ENSP00000446663; ENSG00000172524. [Q6P9F5-1]
ENST00000549728; ENSP00000447016; ENSG00000237046. [Q6P9F5-1]
ENST00000552119; ENSP00000448967; ENSG00000228001. [Q6P9F5-1]
ENST00000616351; ENSP00000483120; ENSG00000224496. [Q6P9F5-1]
GeneIDi135644.
KEGGihsa:135644.
UCSCiuc003npk.2. human. [Q6P9F5-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF489517 mRNA. Translation: AAM09503.1.
AB110939 Genomic DNA. Translation: BAD13705.1.
AB110940 Genomic DNA. Translation: BAD13706.1.
AB202084 Genomic DNA. Translation: BAE78604.1.
AL669914 Genomic DNA. Translation: CAI18185.2.
BX322644 Genomic DNA. Translation: CAI18448.2.
AL671859 Genomic DNA. Translation: CAM24935.1.
BX322644 Genomic DNA. Translation: CAM25692.1.
CR788282 Genomic DNA. Translation: CAQ07454.1.
CR788282 Genomic DNA. Translation: CAQ07455.1.
BX927221 Genomic DNA. Translation: CAQ10306.1.
BX927221 Genomic DNA. Translation: CAQ10307.1.
CH471081 Genomic DNA. Translation: EAX03265.1.
CH471081 Genomic DNA. Translation: EAX03266.1.
BC060785 mRNA. Translation: AAH60785.1.
CCDSiCCDS4675.1. [Q6P9F5-2]
CCDS69069.1. [Q6P9F5-1]
RefSeqiNP_001273562.1. NM_001286633.1. [Q6P9F5-1]
NP_619645.1. NM_138700.4. [Q6P9F5-2]
XP_011512607.1. XM_011514305.1. [Q6P9F5-1]
XP_011512608.1. XM_011514306.1. [Q6P9F5-1]
UniGeneiHs.509439.

3D structure databases

ProteinModelPortaliQ6P9F5.
SMRiQ6P9F5. Positions 9-59, 71-217.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126432. 5 interactions.
IntActiQ6P9F5. 1 interaction.

PTM databases

iPTMnetiQ6P9F5.
PhosphoSiteiQ6P9F5.

Polymorphism and mutation databases

DMDMi229463021.

Proteomic databases

EPDiQ6P9F5.
PeptideAtlasiQ6P9F5.
PRIDEiQ6P9F5.

Protocols and materials databases

DNASUi135644.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307859; ENSP00000308310; ENSG00000204614. [Q6P9F5-2]
ENST00000376724; ENSP00000365914; ENSG00000204614. [Q6P9F5-1]
ENST00000383610; ENSP00000373105; ENSG00000172524. [Q6P9F5-1]
ENST00000396581; ENSP00000379826; ENSG00000204614. [Q6P9F5-1]
ENST00000400651; ENSP00000383492; ENSG00000172524. [Q6P9F5-2]
ENST00000421981; ENSP00000403025; ENSG00000237046. [Q6P9F5-2]
ENST00000429471; ENSP00000393674; ENSG00000228001. [Q6P9F5-2]
ENST00000433713; ENSP00000389607; ENSG00000224496. [Q6P9F5-1]
ENST00000434151; ENSP00000388460; ENSG00000237046. [Q6P9F5-1]
ENST00000436951; ENSP00000416663; ENSG00000224496. [Q6P9F5-2]
ENST00000437563; ENSP00000416950; ENSG00000228001. [Q6P9F5-1]
ENST00000547289; ENSP00000446663; ENSG00000172524. [Q6P9F5-1]
ENST00000549728; ENSP00000447016; ENSG00000237046. [Q6P9F5-1]
ENST00000552119; ENSP00000448967; ENSG00000228001. [Q6P9F5-1]
ENST00000616351; ENSP00000483120; ENSG00000224496. [Q6P9F5-1]
GeneIDi135644.
KEGGihsa:135644.
UCSCiuc003npk.2. human. [Q6P9F5-1]

Organism-specific databases

CTDi135644.
GeneCardsiTRIM40.
HGNCiHGNC:18736. TRIM40.
HPAiHPA043818.
neXtProtiNX_Q6P9F5.
PharmGKBiPA38663.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00710000106875.
HOGENOMiHOG000060264.
HOVERGENiHBG057956.
InParanoidiQ6P9F5.
KOiK12016.
OMAiEEGICPI.
OrthoDBiEOG091G0KAK.
PhylomeDBiQ6P9F5.
TreeFamiTF333491.

Miscellaneous databases

ChiTaRSiTRIM40. human.
GenomeRNAii135644.
PROiQ6P9F5.

Gene expression databases

BgeeiENSG00000204614.
CleanExiHS_TRIM40.
GenevisibleiQ6P9F5. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR000315. Znf_B-box.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF00097. zf-C3HC4. 1 hit.
[Graphical view]
SMARTiSM00184. RING. 1 hit.
[Graphical view]
PROSITEiPS50119. ZF_BBOX. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI40_HUMAN
AccessioniPrimary (citable) accession number: Q6P9F5
Secondary accession number(s): Q5SRJ6, Q5SS36, Q8TD96
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: May 5, 2009
Last modified: September 7, 2016
This is version 110 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.