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Q6P9F0

- CCD62_HUMAN

UniProt

Q6P9F0 - CCD62_HUMAN

Protein

Coiled-coil domain-containing protein 62

Gene

CCDC62

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (13 Jun 2006)
      Previous versions | rss
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    Functioni

    Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.1 Publication

    GO - Molecular functioni

    1. estrogen receptor binding Source: BHF-UCL
    2. ligand-dependent nuclear receptor transcription coactivator activity Source: BHF-UCL

    GO - Biological processi

    1. cellular response to estradiol stimulus Source: BHF-UCL
    2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 62
    Alternative name(s):
    Protein TSP-NY
    Protein aaa
    Gene namesi
    Name:CCDC62
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:30723. CCDC62.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication
    Note: Mainly nuclear.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: BHF-UCL
    3. plasma membrane Source: HPA

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi637 – 6382LL → AA: Abrogates interaction with ESR1 and ESR2.
    Mutagenesisi653 – 6542LL → AA: No effect on interaction with ESR1 or ESR2.

    Organism-specific databases

    PharmGKBiPA143485414.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 684684Coiled-coil domain-containing protein 62PRO_0000240247Add
    BLAST

    Proteomic databases

    PaxDbiQ6P9F0.
    PRIDEiQ6P9F0.

    PTM databases

    PhosphoSiteiQ6P9F0.

    Expressioni

    Tissue specificityi

    Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers.4 Publications

    Gene expression databases

    ArrayExpressiQ6P9F0.
    BgeeiQ6P9F0.
    CleanExiHS_CCDC62.
    GenevestigatoriQ6P9F0.

    Organism-specific databases

    HPAiHPA058741.

    Interactioni

    Subunit structurei

    Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.2 Publications

    Protein-protein interaction databases

    STRINGi9606.ENSP00000253079.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P9F0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili11 – 160150Sequence AnalysisAdd
    BLAST
    Coiled coili199 – 322124Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi634 – 6385LXXLL motif 1
    Motifi650 – 6545LXXLL motif 2

    Domaini

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG69709.
    HOGENOMiHOG000111426.
    HOVERGENiHBG081045.
    InParanoidiQ6P9F0.
    OMAiTENNEQR.
    OrthoDBiEOG7XPZ53.
    PhylomeDBiQ6P9F0.
    TreeFamiTF329149.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6P9F0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV    50
    HQQQLLSWEE DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ 100
    MECQTALQKT QLQLQEMAQK ATHSSLLSED LEARNETLSN TLVELSAQVG 150
    QLQAREQALT TMIKLKDKDI IEAVNHIADC SGKFKMLEHA LRDAKMAETC 200
    IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI IRLKQEKSCL 250
    HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN 300
    FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK 350
    SLFKDQKFEA MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT 400
    KDLVEKHNLP WSLGGKTQIE PENKITLCKI HTKSPKCHGT GVQNEGKQPS 450
    ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE KLDVECQDQM ERSEISCCQK 500
    NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP SKMQRIVRLK 550
    SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN 600
    SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL 650
    STLLPISHEN LTGSATNKSE VPEESAQKNT FVSY 684
    Length:684
    Mass (Da):77,748
    Last modified:June 13, 2006 - v2
    Checksum:i071DCEC789E4DF60
    GO
    Isoform 2 (identifier: Q6P9F0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         668-684: KSEVPEESAQKNTFVSY → ISHLCGRQKADTNTE

    Show »
    Length:682
    Mass (Da):77,478
    Checksum:i2F866192CA92507B
    GO
    Isoform 3 (identifier: Q6P9F0-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-239: Missing.
         240-257: IIRLKQEKSCLHDELLFT → MPNSSPKDPTTASGNGSK

    Note: No experimental confirmation available.

    Show »
    Length:445
    Mass (Da):49,908
    Checksum:i30D5CA8386F76AA1
    GO

    Sequence cautioni

    The sequence AAG49396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti486 – 4861C → R in BAF85155. (PubMed:14702039)Curated
    Sequence conflicti651 – 6511S → N in AAG49396. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti31 – 311Q → E in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035498
    Natural varianti141 – 1411T → M.
    Corresponds to variant rs58131754 [ dbSNP | Ensembl ].
    VAR_061585
    Natural varianti394 – 3941T → K.1 Publication
    Corresponds to variant rs17855031 [ dbSNP | Ensembl ].
    VAR_026715

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 239239Missing in isoform 3. 1 PublicationVSP_019327Add
    BLAST
    Alternative sequencei240 – 25718IIRLK…ELLFT → MPNSSPKDPTTASGNGSK in isoform 3. 1 PublicationVSP_019328Add
    BLAST
    Alternative sequencei668 – 68417KSEVP…TFVSY → ISHLCGRQKADTNTE in isoform 2. 3 PublicationsVSP_019329Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY254201 mRNA. Translation: AAP13075.1.
    AK097663 mRNA. Translation: BAG53505.1.
    AK124633 mRNA. Translation: BAC85909.1.
    AK292466 mRNA. Translation: BAF85155.1.
    BC060796 mRNA. Translation: AAH60796.1.
    AY009105 mRNA. Translation: AAG49396.1. Different initiation.
    CCDSiCCDS9238.1. [Q6P9F0-1]
    RefSeqiNP_958843.2. NM_201435.4. [Q6P9F0-1]
    XP_006719706.1. XM_006719643.1. [Q6P9F0-1]
    XP_006719707.1. XM_006719644.1. [Q6P9F0-2]
    UniGeneiHs.592008.

    Genome annotation databases

    EnsembliENST00000253079; ENSP00000253079; ENSG00000130783. [Q6P9F0-1]
    ENST00000341952; ENSP00000341471; ENSG00000130783. [Q6P9F0-2]
    ENST00000392440; ENSP00000376235; ENSG00000130783. [Q6P9F0-3]
    ENST00000392441; ENSP00000376236; ENSG00000130783. [Q6P9F0-2]
    ENST00000537566; ENSP00000445045; ENSG00000130783. [Q6P9F0-3]
    GeneIDi84660.
    KEGGihsa:84660.
    UCSCiuc001udc.3. human. [Q6P9F0-1]
    uc001ude.3. human. [Q6P9F0-3]
    uc021rfn.1. human. [Q6P9F0-2]

    Polymorphism databases

    DMDMi108935965.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY254201 mRNA. Translation: AAP13075.1 .
    AK097663 mRNA. Translation: BAG53505.1 .
    AK124633 mRNA. Translation: BAC85909.1 .
    AK292466 mRNA. Translation: BAF85155.1 .
    BC060796 mRNA. Translation: AAH60796.1 .
    AY009105 mRNA. Translation: AAG49396.1 . Different initiation.
    CCDSi CCDS9238.1. [Q6P9F0-1 ]
    RefSeqi NP_958843.2. NM_201435.4. [Q6P9F0-1 ]
    XP_006719706.1. XM_006719643.1. [Q6P9F0-1 ]
    XP_006719707.1. XM_006719644.1. [Q6P9F0-2 ]
    UniGenei Hs.592008.

    3D structure databases

    ProteinModelPortali Q6P9F0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000253079.

    PTM databases

    PhosphoSitei Q6P9F0.

    Polymorphism databases

    DMDMi 108935965.

    Proteomic databases

    PaxDbi Q6P9F0.
    PRIDEi Q6P9F0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000253079 ; ENSP00000253079 ; ENSG00000130783 . [Q6P9F0-1 ]
    ENST00000341952 ; ENSP00000341471 ; ENSG00000130783 . [Q6P9F0-2 ]
    ENST00000392440 ; ENSP00000376235 ; ENSG00000130783 . [Q6P9F0-3 ]
    ENST00000392441 ; ENSP00000376236 ; ENSG00000130783 . [Q6P9F0-2 ]
    ENST00000537566 ; ENSP00000445045 ; ENSG00000130783 . [Q6P9F0-3 ]
    GeneIDi 84660.
    KEGGi hsa:84660.
    UCSCi uc001udc.3. human. [Q6P9F0-1 ]
    uc001ude.3. human. [Q6P9F0-3 ]
    uc021rfn.1. human. [Q6P9F0-2 ]

    Organism-specific databases

    CTDi 84660.
    GeneCardsi GC12P123259.
    H-InvDB HIX0201861.
    HGNCi HGNC:30723. CCDC62.
    HPAi HPA058741.
    MIMi 613481. gene.
    neXtProti NX_Q6P9F0.
    PharmGKBi PA143485414.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG69709.
    HOGENOMi HOG000111426.
    HOVERGENi HBG081045.
    InParanoidi Q6P9F0.
    OMAi TENNEQR.
    OrthoDBi EOG7XPZ53.
    PhylomeDBi Q6P9F0.
    TreeFami TF329149.

    Miscellaneous databases

    ChiTaRSi CCDC62. human.
    GenomeRNAii 84660.
    NextBioi 74633.
    PROi Q6P9F0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6P9F0.
    Bgeei Q6P9F0.
    CleanExi HS_CCDC62.
    Genevestigatori Q6P9F0.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of a novel gene highly expressed in testis."
      Shan Y.X., Yu L.
      Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Cerebellum and Testis.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-394.
      Tissue: Brain.
    4. "A novel testis specific protein (TSP-NY) gene from adult testis."
      Li J.M., Chen R.H., Chen Q., Zhu H., Lin M., Zhou Z.M., Wang L.R., Zhou Y.D., Cheng L.J., Ying L.L., Zhu H., Sha J.H.
      Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 176-684 (ISOFORM 2), TISSUE SPECIFICITY.
      Tissue: Testis.
    5. "ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells."
      Chen M., Ni J., Zhang Y., Muyan M., Yeh S.
      Prostate 68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ESR1, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
    6. "CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."
      Chen M., Ni J., Chang H.C., Lin C.Y., Muyan M., Yeh S.
      Carcinogenesis 30:841-850(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ESR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
    7. Cited for: TISSUE SPECIFICITY.
    8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-31.

    Entry informationi

    Entry nameiCCD62_HUMAN
    AccessioniPrimary (citable) accession number: Q6P9F0
    Secondary accession number(s): A8K8V1
    , B3KUP3, Q6ZVF2, Q86VJ0, Q9BYZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 13, 2006
    Last sequence update: June 13, 2006
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3