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Q6P9F0

- CCD62_HUMAN

UniProt

Q6P9F0 - CCD62_HUMAN

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Protein
Coiled-coil domain-containing protein 62
Gene
CCDC62
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.1 Publication

GO - Molecular functioni

  1. estrogen receptor binding Source: BHF-UCL
  2. ligand-dependent nuclear receptor transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  1. cellular response to estradiol stimulus Source: BHF-UCL
  2. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 62
Alternative name(s):
Protein TSP-NY
Protein aaa
Gene namesi
Name:CCDC62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:30723. CCDC62.

Subcellular locationi

Cytoplasm. Nucleus
Note: Mainly nuclear.1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: BHF-UCL
  3. plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi637 – 6382LL → AA: Abrogates interaction with ESR1 and ESR2. 2 Publications
Mutagenesisi653 – 6542LL → AA: No effect on interaction with ESR1 or ESR2. 2 Publications

Organism-specific databases

PharmGKBiPA143485414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 684684Coiled-coil domain-containing protein 62
PRO_0000240247Add
BLAST

Proteomic databases

PaxDbiQ6P9F0.
PRIDEiQ6P9F0.

PTM databases

PhosphoSiteiQ6P9F0.

Expressioni

Tissue specificityi

Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (1 Publication). Not detected in prostate by RT-PCR (1 Publication). Overexpressed in various cancers.4 Publications

Gene expression databases

ArrayExpressiQ6P9F0.
BgeeiQ6P9F0.
CleanExiHS_CCDC62.
GenevestigatoriQ6P9F0.

Organism-specific databases

HPAiHPA058741.

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.2 Publications

Protein-protein interaction databases

STRINGi9606.ENSP00000253079.

Structurei

3D structure databases

ProteinModelPortaliQ6P9F0.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili11 – 160150 Reviewed prediction
Add
BLAST
Coiled coili199 – 322124 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi634 – 6385LXXLL motif 1
Motifi650 – 6545LXXLL motif 2

Domaini

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiNOG69709.
HOGENOMiHOG000111426.
HOVERGENiHBG081045.
InParanoidiQ6P9F0.
OMAiTENNEQR.
OrthoDBiEOG7XPZ53.
PhylomeDBiQ6P9F0.
TreeFamiTF329149.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6P9F0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV    50
HQQQLLSWEE DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ 100
MECQTALQKT QLQLQEMAQK ATHSSLLSED LEARNETLSN TLVELSAQVG 150
QLQAREQALT TMIKLKDKDI IEAVNHIADC SGKFKMLEHA LRDAKMAETC 200
IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI IRLKQEKSCL 250
HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN 300
FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK 350
SLFKDQKFEA MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT 400
KDLVEKHNLP WSLGGKTQIE PENKITLCKI HTKSPKCHGT GVQNEGKQPS 450
ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE KLDVECQDQM ERSEISCCQK 500
NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP SKMQRIVRLK 550
SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN 600
SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL 650
STLLPISHEN LTGSATNKSE VPEESAQKNT FVSY 684
Length:684
Mass (Da):77,748
Last modified:June 13, 2006 - v2
Checksum:i071DCEC789E4DF60
GO
Isoform 2 (identifier: Q6P9F0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-684: KSEVPEESAQKNTFVSY → ISHLCGRQKADTNTE

Show »
Length:682
Mass (Da):77,478
Checksum:i2F866192CA92507B
GO
Isoform 3 (identifier: Q6P9F0-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
     240-257: IIRLKQEKSCLHDELLFT → MPNSSPKDPTTASGNGSK

Note: No experimental confirmation available.

Show »
Length:445
Mass (Da):49,908
Checksum:i30D5CA8386F76AA1
GO

Sequence cautioni

The sequence AAG49396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti31 – 311Q → E in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035498
Natural varianti141 – 1411T → M.
Corresponds to variant rs58131754 [ dbSNP | Ensembl ].
VAR_061585
Natural varianti394 – 3941T → K.1 Publication
Corresponds to variant rs17855031 [ dbSNP | Ensembl ].
VAR_026715

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 239239Missing in isoform 3.
VSP_019327Add
BLAST
Alternative sequencei240 – 25718IIRLK…ELLFT → MPNSSPKDPTTASGNGSK in isoform 3.
VSP_019328Add
BLAST
Alternative sequencei668 – 68417KSEVP…TFVSY → ISHLCGRQKADTNTE in isoform 2.
VSP_019329Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti486 – 4861C → R in BAF85155. 1 Publication
Sequence conflicti651 – 6511S → N in AAG49396. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY254201 mRNA. Translation: AAP13075.1.
AK097663 mRNA. Translation: BAG53505.1.
AK124633 mRNA. Translation: BAC85909.1.
AK292466 mRNA. Translation: BAF85155.1.
BC060796 mRNA. Translation: AAH60796.1.
AY009105 mRNA. Translation: AAG49396.1. Different initiation.
CCDSiCCDS9238.1. [Q6P9F0-1]
RefSeqiNP_958843.2. NM_201435.4. [Q6P9F0-1]
XP_006719706.1. XM_006719643.1. [Q6P9F0-1]
XP_006719707.1. XM_006719644.1. [Q6P9F0-2]
UniGeneiHs.592008.

Genome annotation databases

EnsembliENST00000253079; ENSP00000253079; ENSG00000130783. [Q6P9F0-1]
ENST00000341952; ENSP00000341471; ENSG00000130783. [Q6P9F0-2]
ENST00000392440; ENSP00000376235; ENSG00000130783. [Q6P9F0-3]
ENST00000392441; ENSP00000376236; ENSG00000130783. [Q6P9F0-2]
ENST00000537566; ENSP00000445045; ENSG00000130783. [Q6P9F0-3]
GeneIDi84660.
KEGGihsa:84660.
UCSCiuc001udc.3. human. [Q6P9F0-1]
uc001ude.3. human. [Q6P9F0-3]
uc021rfn.1. human. [Q6P9F0-2]

Polymorphism databases

DMDMi108935965.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY254201 mRNA. Translation: AAP13075.1 .
AK097663 mRNA. Translation: BAG53505.1 .
AK124633 mRNA. Translation: BAC85909.1 .
AK292466 mRNA. Translation: BAF85155.1 .
BC060796 mRNA. Translation: AAH60796.1 .
AY009105 mRNA. Translation: AAG49396.1 . Different initiation.
CCDSi CCDS9238.1. [Q6P9F0-1 ]
RefSeqi NP_958843.2. NM_201435.4. [Q6P9F0-1 ]
XP_006719706.1. XM_006719643.1. [Q6P9F0-1 ]
XP_006719707.1. XM_006719644.1. [Q6P9F0-2 ]
UniGenei Hs.592008.

3D structure databases

ProteinModelPortali Q6P9F0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000253079.

PTM databases

PhosphoSitei Q6P9F0.

Polymorphism databases

DMDMi 108935965.

Proteomic databases

PaxDbi Q6P9F0.
PRIDEi Q6P9F0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000253079 ; ENSP00000253079 ; ENSG00000130783 . [Q6P9F0-1 ]
ENST00000341952 ; ENSP00000341471 ; ENSG00000130783 . [Q6P9F0-2 ]
ENST00000392440 ; ENSP00000376235 ; ENSG00000130783 . [Q6P9F0-3 ]
ENST00000392441 ; ENSP00000376236 ; ENSG00000130783 . [Q6P9F0-2 ]
ENST00000537566 ; ENSP00000445045 ; ENSG00000130783 . [Q6P9F0-3 ]
GeneIDi 84660.
KEGGi hsa:84660.
UCSCi uc001udc.3. human. [Q6P9F0-1 ]
uc001ude.3. human. [Q6P9F0-3 ]
uc021rfn.1. human. [Q6P9F0-2 ]

Organism-specific databases

CTDi 84660.
GeneCardsi GC12P123259.
H-InvDB HIX0201861.
HGNCi HGNC:30723. CCDC62.
HPAi HPA058741.
MIMi 613481. gene.
neXtProti NX_Q6P9F0.
PharmGKBi PA143485414.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG69709.
HOGENOMi HOG000111426.
HOVERGENi HBG081045.
InParanoidi Q6P9F0.
OMAi TENNEQR.
OrthoDBi EOG7XPZ53.
PhylomeDBi Q6P9F0.
TreeFami TF329149.

Miscellaneous databases

ChiTaRSi CCDC62. human.
GenomeRNAii 84660.
NextBioi 74633.
PROi Q6P9F0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q6P9F0.
Bgeei Q6P9F0.
CleanExi HS_CCDC62.
Genevestigatori Q6P9F0.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel gene highly expressed in testis."
    Shan Y.X., Yu L.
    Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Cerebellum and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-394.
    Tissue: Brain.
  4. "A novel testis specific protein (TSP-NY) gene from adult testis."
    Li J.M., Chen R.H., Chen Q., Zhu H., Lin M., Zhou Z.M., Wang L.R., Zhou Y.D., Cheng L.J., Ying L.L., Zhu H., Sha J.H.
    Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 176-684 (ISOFORM 2), TISSUE SPECIFICITY.
    Tissue: Testis.
  5. "ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells."
    Chen M., Ni J., Zhang Y., Muyan M., Yeh S.
    Prostate 68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ESR1, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
  6. "CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."
    Chen M., Ni J., Chang H.C., Lin C.Y., Muyan M., Yeh S.
    Carcinogenesis 30:841-850(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH ESR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
  7. Cited for: TISSUE SPECIFICITY.
  8. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-31.

Entry informationi

Entry nameiCCD62_HUMAN
AccessioniPrimary (citable) accession number: Q6P9F0
Secondary accession number(s): A8K8V1
, B3KUP3, Q6ZVF2, Q86VJ0, Q9BYZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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