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Protein

Coiled-coil domain-containing protein 62

Gene

CCDC62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR.1 Publication

GO - Molecular functioni

  • estrogen receptor binding Source: ParkinsonsUK-UCL
  • ligand-dependent nuclear receptor transcription coactivator activity Source: ParkinsonsUK-UCL

GO - Biological processi

  • cellular response to estradiol stimulus Source: ParkinsonsUK-UCL
  • positive regulation of transcription from RNA polymerase II promoter Source: ParkinsonsUK-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 62
Alternative name(s):
Protein TSP-NY
Protein aaa
Gene namesi
Name:CCDC62
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:30723. CCDC62.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

  • Note: Mainly nuclear.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: ParkinsonsUK-UCL
  • plasma membrane Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi637 – 638LL → AA: Abrogates interaction with ESR1 and ESR2. 2 Publications2
Mutagenesisi653 – 654LL → AA: No effect on interaction with ESR1 or ESR2. 2 Publications2

Organism-specific databases

DisGeNETi84660.
OpenTargetsiENSG00000130783.
PharmGKBiPA143485414.

Polymorphism and mutation databases

BioMutaiCCDC62.
DMDMi108935965.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002402471 – 684Coiled-coil domain-containing protein 62Add BLAST684

Proteomic databases

EPDiQ6P9F0.
PaxDbiQ6P9F0.
PeptideAtlasiQ6P9F0.
PRIDEiQ6P9F0.

PTM databases

iPTMnetiQ6P9F0.
PhosphoSitePlusiQ6P9F0.

Expressioni

Tissue specificityi

Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (PubMed:19126643). Not detected in prostate by RT-PCR (PubMed:19165854). Overexpressed in various cancers.4 Publications

Gene expression databases

BgeeiENSG00000130783.
CleanExiHS_CCDC62.
ExpressionAtlasiQ6P9F0. baseline and differential.
GenevisibleiQ6P9F0. HS.

Organism-specific databases

HPAiHPA039021.
HPA058741.

Interactioni

Subunit structurei

Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter.2 Publications

GO - Molecular functioni

  • estrogen receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

STRINGi9606.ENSP00000253079.

Structurei

3D structure databases

ProteinModelPortaliQ6P9F0.
SMRiQ6P9F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili11 – 160Sequence analysisAdd BLAST150
Coiled coili199 – 322Sequence analysisAdd BLAST124

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi634 – 638LXXLL motif 15
Motifi650 – 654LXXLL motif 25

Domaini

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IJN3. Eukaryota.
ENOG4111J0W. LUCA.
GeneTreeiENSGT00400000022269.
HOGENOMiHOG000111426.
HOVERGENiHBG081045.
InParanoidiQ6P9F0.
OMAiQEKSCLH.
OrthoDBiEOG091G0GCA.
PhylomeDBiQ6P9F0.
TreeFamiTF329149.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P9F0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV
60 70 80 90 100
HQQQLLSWEE DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ
110 120 130 140 150
MECQTALQKT QLQLQEMAQK ATHSSLLSED LEARNETLSN TLVELSAQVG
160 170 180 190 200
QLQAREQALT TMIKLKDKDI IEAVNHIADC SGKFKMLEHA LRDAKMAETC
210 220 230 240 250
IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI IRLKQEKSCL
260 270 280 290 300
HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN
310 320 330 340 350
FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK
360 370 380 390 400
SLFKDQKFEA MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT
410 420 430 440 450
KDLVEKHNLP WSLGGKTQIE PENKITLCKI HTKSPKCHGT GVQNEGKQPS
460 470 480 490 500
ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE KLDVECQDQM ERSEISCCQK
510 520 530 540 550
NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP SKMQRIVRLK
560 570 580 590 600
SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN
610 620 630 640 650
SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL
660 670 680
STLLPISHEN LTGSATNKSE VPEESAQKNT FVSY
Length:684
Mass (Da):77,748
Last modified:June 13, 2006 - v2
Checksum:i071DCEC789E4DF60
GO
Isoform 2 (identifier: Q6P9F0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-684: KSEVPEESAQKNTFVSY → ISHLCGRQKADTNTE

Show »
Length:682
Mass (Da):77,478
Checksum:i2F866192CA92507B
GO
Isoform 3 (identifier: Q6P9F0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
     240-257: IIRLKQEKSCLHDELLFT → MPNSSPKDPTTASGNGSK

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):49,908
Checksum:i30D5CA8386F76AA1
GO

Sequence cautioni

The sequence AAG49396 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti486C → R in BAF85155 (PubMed:14702039).Curated1
Sequence conflicti651S → N in AAG49396 (Ref. 4) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03549831Q → E in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_061585141T → M.Corresponds to variant rs58131754dbSNPEnsembl.1
Natural variantiVAR_026715394T → K.1 PublicationCorresponds to variant rs17855031dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0193271 – 239Missing in isoform 3. 1 PublicationAdd BLAST239
Alternative sequenceiVSP_019328240 – 257IIRLK…ELLFT → MPNSSPKDPTTASGNGSK in isoform 3. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_019329668 – 684KSEVP…TFVSY → ISHLCGRQKADTNTE in isoform 2. 3 PublicationsAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254201 mRNA. Translation: AAP13075.1.
AK097663 mRNA. Translation: BAG53505.1.
AK124633 mRNA. Translation: BAC85909.1.
AK292466 mRNA. Translation: BAF85155.1.
BC060796 mRNA. Translation: AAH60796.1.
AY009105 mRNA. Translation: AAG49396.1. Different initiation.
CCDSiCCDS9238.1. [Q6P9F0-1]
RefSeqiNP_958843.2. NM_201435.4. [Q6P9F0-1]
XP_006719706.1. XM_006719643.1. [Q6P9F0-1]
XP_006719707.1. XM_006719644.1. [Q6P9F0-2]
UniGeneiHs.592008.

Genome annotation databases

EnsembliENST00000253079; ENSP00000253079; ENSG00000130783. [Q6P9F0-1]
ENST00000341952; ENSP00000341471; ENSG00000130783. [Q6P9F0-2]
ENST00000392441; ENSP00000376236; ENSG00000130783. [Q6P9F0-2]
ENST00000537566; ENSP00000445045; ENSG00000130783. [Q6P9F0-3]
GeneIDi84660.
KEGGihsa:84660.
UCSCiuc001udc.4. human. [Q6P9F0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY254201 mRNA. Translation: AAP13075.1.
AK097663 mRNA. Translation: BAG53505.1.
AK124633 mRNA. Translation: BAC85909.1.
AK292466 mRNA. Translation: BAF85155.1.
BC060796 mRNA. Translation: AAH60796.1.
AY009105 mRNA. Translation: AAG49396.1. Different initiation.
CCDSiCCDS9238.1. [Q6P9F0-1]
RefSeqiNP_958843.2. NM_201435.4. [Q6P9F0-1]
XP_006719706.1. XM_006719643.1. [Q6P9F0-1]
XP_006719707.1. XM_006719644.1. [Q6P9F0-2]
UniGeneiHs.592008.

3D structure databases

ProteinModelPortaliQ6P9F0.
SMRiQ6P9F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000253079.

PTM databases

iPTMnetiQ6P9F0.
PhosphoSitePlusiQ6P9F0.

Polymorphism and mutation databases

BioMutaiCCDC62.
DMDMi108935965.

Proteomic databases

EPDiQ6P9F0.
PaxDbiQ6P9F0.
PeptideAtlasiQ6P9F0.
PRIDEiQ6P9F0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000253079; ENSP00000253079; ENSG00000130783. [Q6P9F0-1]
ENST00000341952; ENSP00000341471; ENSG00000130783. [Q6P9F0-2]
ENST00000392441; ENSP00000376236; ENSG00000130783. [Q6P9F0-2]
ENST00000537566; ENSP00000445045; ENSG00000130783. [Q6P9F0-3]
GeneIDi84660.
KEGGihsa:84660.
UCSCiuc001udc.4. human. [Q6P9F0-1]

Organism-specific databases

CTDi84660.
DisGeNETi84660.
GeneCardsiCCDC62.
H-InvDBHIX0201861.
HGNCiHGNC:30723. CCDC62.
HPAiHPA039021.
HPA058741.
MIMi613481. gene.
neXtProtiNX_Q6P9F0.
OpenTargetsiENSG00000130783.
PharmGKBiPA143485414.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJN3. Eukaryota.
ENOG4111J0W. LUCA.
GeneTreeiENSGT00400000022269.
HOGENOMiHOG000111426.
HOVERGENiHBG081045.
InParanoidiQ6P9F0.
OMAiQEKSCLH.
OrthoDBiEOG091G0GCA.
PhylomeDBiQ6P9F0.
TreeFamiTF329149.

Miscellaneous databases

ChiTaRSiCCDC62. human.
GenomeRNAii84660.
PROiQ6P9F0.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130783.
CleanExiHS_CCDC62.
ExpressionAtlasiQ6P9F0. baseline and differential.
GenevisibleiQ6P9F0. HS.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiCCD62_HUMAN
AccessioniPrimary (citable) accession number: Q6P9F0
Secondary accession number(s): A8K8V1
, B3KUP3, Q6ZVF2, Q86VJ0, Q9BYZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: November 2, 2016
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.