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Q6P9F0 (CCD62_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Coiled-coil domain-containing protein 62
Alternative name(s):
Protein TSP-NY
Protein aaa
Gene names
Name:CCDC62
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length684 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. Ref.6

Subunit structure

Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter. Ref.5 Ref.6

Subcellular location

Cytoplasm. Nucleus. Note: Mainly nuclear. Ref.6

Tissue specificity

Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (Ref.6). Not detected in prostate by RT-PCR (Ref.7). Overexpressed in various cancers. Ref.1 Ref.4 Ref.6 Ref.7

Domain

Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2.

Sequence caution

The sequence AAG49396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainCoiled coil
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from direct assay. Source: HPA

plasma membrane

Inferred from direct assay. Source: HPA

   Molecular_functionestrogen receptor binding

Inferred from physical interaction. Source: ParkinsonsUK-UCL

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6P9F0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6P9F0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     668-684: KSEVPEESAQKNTFVSY → ISHLCGRQKADTNTE
Isoform 3 (identifier: Q6P9F0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
     240-257: IIRLKQEKSCLHDELLFT → MPNSSPKDPTTASGNGSK
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 684684Coiled-coil domain-containing protein 62
PRO_0000240247

Regions

Coiled coil11 – 160150 Potential
Coiled coil199 – 322124 Potential
Motif634 – 6385LXXLL motif 1
Motif650 – 6545LXXLL motif 2

Natural variations

Alternative sequence1 – 239239Missing in isoform 3.
VSP_019327
Alternative sequence240 – 25718IIRLK…ELLFT → MPNSSPKDPTTASGNGSK in isoform 3.
VSP_019328
Alternative sequence668 – 68417KSEVP…TFVSY → ISHLCGRQKADTNTE in isoform 2.
VSP_019329
Natural variant311Q → E in a colorectal cancer sample; somatic mutation. Ref.8
VAR_035498
Natural variant1411T → M.
Corresponds to variant rs58131754 [ dbSNP | Ensembl ].
VAR_061585
Natural variant3941T → K. Ref.3
Corresponds to variant rs17855031 [ dbSNP | Ensembl ].
VAR_026715

Experimental info

Mutagenesis637 – 6382LL → AA: Abrogates interaction with ESR1 and ESR2. Ref.5 Ref.6
Mutagenesis653 – 6542LL → AA: No effect on interaction with ESR1 or ESR2. Ref.5 Ref.6
Sequence conflict4861C → R in BAF85155. Ref.2
Sequence conflict6511S → N in AAG49396. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 13, 2006. Version 2.
Checksum: 071DCEC789E4DF60

FASTA68477,748
        10         20         30         40         50         60 
MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV HQQQLLSWEE 

        70         80         90        100        110        120 
DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ MECQTALQKT QLQLQEMAQK 

       130        140        150        160        170        180 
ATHSSLLSED LEARNETLSN TLVELSAQVG QLQAREQALT TMIKLKDKDI IEAVNHIADC 

       190        200        210        220        230        240 
SGKFKMLEHA LRDAKMAETC IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI 

       250        260        270        280        290        300 
IRLKQEKSCL HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN 

       310        320        330        340        350        360 
FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK SLFKDQKFEA 

       370        380        390        400        410        420 
MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT KDLVEKHNLP WSLGGKTQIE 

       430        440        450        460        470        480 
PENKITLCKI HTKSPKCHGT GVQNEGKQPS ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE 

       490        500        510        520        530        540 
KLDVECQDQM ERSEISCCQK NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP 

       550        560        570        580        590        600 
SKMQRIVRLK SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN 

       610        620        630        640        650        660 
SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL STLLPISHEN 

       670        680 
LTGSATNKSE VPEESAQKNT FVSY 

« Hide

Isoform 2 [UniParc].

Checksum: 2F866192CA92507B
Show »

FASTA68277,478
Isoform 3 [UniParc].

Checksum: 30D5CA8386F76AA1
Show »

FASTA44549,908

References

« Hide 'large scale' references
[1]"Cloning and characterization of a novel gene highly expressed in testis."
Shan Y.X., Yu L.
Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
Tissue: Cerebellum and Testis.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-394.
Tissue: Brain.
[4]"A novel testis specific protein (TSP-NY) gene from adult testis."
Li J.M., Chen R.H., Chen Q., Zhu H., Lin M., Zhou Z.M., Wang L.R., Zhou Y.D., Cheng L.J., Ying L.L., Zhu H., Sha J.H.
Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 176-684 (ISOFORM 2), TISSUE SPECIFICITY.
Tissue: Testis.
[5]"ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells."
Chen M., Ni J., Zhang Y., Muyan M., Yeh S.
Prostate 68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ESR1, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
[6]"CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells."
Chen M., Ni J., Chang H.C., Lin C.Y., Muyan M., Yeh S.
Carcinogenesis 30:841-850(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH ESR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
[7]"Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity."
Domae S., Nakamura Y., Nakamura Y., Uenaka A., Wada H., Nakata M., Oka M., Kishimoto K., Tsukamoto G., Yoshihama Y., Matsuoka J., Gochi A., Kohno S., Saika T., Sasaki A., Nakayama E., Ono T.
Int. J. Cancer 124:2347-2352(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-31.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY254201 mRNA. Translation: AAP13075.1.
AK097663 mRNA. Translation: BAG53505.1.
AK124633 mRNA. Translation: BAC85909.1.
AK292466 mRNA. Translation: BAF85155.1.
BC060796 mRNA. Translation: AAH60796.1.
AY009105 mRNA. Translation: AAG49396.1. Different initiation.
CCDSCCDS9238.1. [Q6P9F0-1]
RefSeqNP_958843.2. NM_201435.4. [Q6P9F0-1]
XP_006719706.1. XM_006719643.1. [Q6P9F0-1]
XP_006719707.1. XM_006719644.1. [Q6P9F0-2]
UniGeneHs.592008.

3D structure databases

ProteinModelPortalQ6P9F0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000253079.

PTM databases

PhosphoSiteQ6P9F0.

Polymorphism databases

DMDM108935965.

Proteomic databases

PaxDbQ6P9F0.
PRIDEQ6P9F0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000253079; ENSP00000253079; ENSG00000130783. [Q6P9F0-1]
ENST00000341952; ENSP00000341471; ENSG00000130783. [Q6P9F0-2]
ENST00000392440; ENSP00000376235; ENSG00000130783. [Q6P9F0-3]
ENST00000392441; ENSP00000376236; ENSG00000130783. [Q6P9F0-2]
ENST00000537566; ENSP00000445045; ENSG00000130783. [Q6P9F0-3]
GeneID84660.
KEGGhsa:84660.
UCSCuc001udc.3. human. [Q6P9F0-1]
uc001ude.3. human. [Q6P9F0-3]
uc021rfn.1. human. [Q6P9F0-2]

Organism-specific databases

CTD84660.
GeneCardsGC12P123259.
H-InvDBHIX0201861.
HGNCHGNC:30723. CCDC62.
HPAHPA058741.
MIM613481. gene.
neXtProtNX_Q6P9F0.
PharmGKBPA143485414.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG69709.
HOGENOMHOG000111426.
HOVERGENHBG081045.
InParanoidQ6P9F0.
OMATENNEQR.
OrthoDBEOG7XPZ53.
PhylomeDBQ6P9F0.
TreeFamTF329149.

Gene expression databases

ArrayExpressQ6P9F0.
BgeeQ6P9F0.
CleanExHS_CCDC62.
GenevestigatorQ6P9F0.

Family and domain databases

ProtoNetSearch...

Other

ChiTaRSCCDC62. human.
GenomeRNAi84660.
NextBio74633.
PROQ6P9F0.
SOURCESearch...

Entry information

Entry nameCCD62_HUMAN
AccessionPrimary (citable) accession number: Q6P9F0
Secondary accession number(s): A8K8V1 expand/collapse secondary AC list , B3KUP3, Q6ZVF2, Q86VJ0, Q9BYZ5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 13, 2006
Last sequence update: June 13, 2006
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM