Q6P9F0 (CCD62_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Coiled-coil domain-containing protein 62

Alternative name(s):
Protein TSP-NY
Protein aaa

Gene names

Name:

CCDC62

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	684 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Modulates also progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR. Ref.6
Subunit structure	Interacts with ESR1 and ESR2 in the presence of estradiol/E2. The interaction with ESR2 recruits CCDC62 to ER target genes, including cyclin-D1/CCND1 AP-1 promoter. Ref.5 Ref.6
Subcellular location	Cytoplasm. Nucleus. Note: Mainly nuclear. Ref.6
Tissue specificity	Highly expressed in adult testis. Expressed in both prostate epithelial and stromal cells, with predominant expression in epithelial cells (at protein level) (Ref.6). Not detected in prostate by RT-PCR (Ref.7). Overexpressed in various cancers. Ref.1 Ref.4 Ref.6 Ref.7
Domain	Contains 2 Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The first one is essential for the association with ESR1 and ESR2.
Sequence caution	The sequence AAG49396.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil Repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P9F0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P9F0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     668-684: KSEVPEESAQKNTFVSY → ISHLCGRQKADTNTE

Isoform 3 (identifier: Q6P9F0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-239: Missing.
     240-257: IIRLKQEKSCLHDELLFT → MPNSSPKDPTTASGNGSK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 684	684	Coiled-coil domain-containing protein 62		PRO_0000240247
Regions
	Coiled coil	11 – 160	150	Potential
	Coiled coil	199 – 322	124	Potential
	Motif	634 – 638	5	LXXLL motif 1
	Motif	650 – 654	5	LXXLL motif 2
Natural variations
	Alternative sequence	1 – 239	239	Missing in isoform 3.		VSP_019327
	Alternative sequence	240 – 257	18	IIRLK…ELLFT → MPNSSPKDPTTASGNGSK in isoform 3.		VSP_019328
	Alternative sequence	668 – 684	17	KSEVP…TFVSY → ISHLCGRQKADTNTE in isoform 2.		VSP_019329
	Natural variant	31	1	Q → E in a colorectal cancer sample; somatic mutation. Ref.8		VAR_035498
	Natural variant	141	1	T → M. Corresponds to variant rs58131754 [ dbSNP | Ensembl ].		VAR_061585
	Natural variant	394	1	T → K. Ref.3 Corresponds to variant rs17855031 [ dbSNP | Ensembl ].		VAR_026715
Experimental info
	Mutagenesis	637 – 638	2	LL → AA: Abrogates interaction with ESR1 and ESR2. Ref.5 Ref.6
	Mutagenesis	653 – 654	2	LL → AA: No effect on interaction with ESR1 or ESR2. Ref.5 Ref.6
	Sequence conflict	486	1	C → R in BAF85155. Ref.2
	Sequence conflict	651	1	S → N in AAG49396. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified June 13, 2006. Version 2. Checksum: 071DCEC789E4DF60	FASTA	684	77,748
	10 20 30 40 50 60 MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV HQQQLLSWEE 70 80 90 100 110 120 DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ MECQTALQKT QLQLQEMAQK 130 140 150 160 170 180 ATHSSLLSED LEARNETLSN TLVELSAQVG QLQAREQALT TMIKLKDKDI IEAVNHIADC 190 200 210 220 230 240 SGKFKMLEHA LRDAKMAETC IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI 250 260 270 280 290 300 IRLKQEKSCL HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN 310 320 330 340 350 360 FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK SLFKDQKFEA 370 380 390 400 410 420 MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT KDLVEKHNLP WSLGGKTQIE 430 440 450 460 470 480 PENKITLCKI HTKSPKCHGT GVQNEGKQPS ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE 490 500 510 520 530 540 KLDVECQDQM ERSEISCCQK NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP 550 560 570 580 590 600 SKMQRIVRLK SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN 610 620 630 640 650 660 SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL STLLPISHEN 670 680 LTGSATNKSE VPEESAQKNT FVSY
	Isoform 2 [UniParc]. Checksum: 2F866192CA92507B	FASTA	682	77,478
	10 20 30 40 50 60 MNPPAAFLAG RQNIGSEVEI STIEKQRKEL QLLIGELKDR DKELNDMVAV HQQQLLSWEE 70 80 90 100 110 120 DRQKVLTLEE RCSKLEGELH KRTEIIRSLT KKVKALESNQ MECQTALQKT QLQLQEMAQK 130 140 150 160 170 180 ATHSSLLSED LEARNETLSN TLVELSAQVG QLQAREQALT TMIKLKDKDI IEAVNHIADC 190 200 210 220 230 240 SGKFKMLEHA LRDAKMAETC IVKEKQDYKQ KLKALKIEVN KLKEDLNEKT TENNEQREEI 250 260 270 280 290 300 IRLKQEKSCL HDELLFTVER EKRKDELLNI AKSKQERTNS ELHNLRQIYV KQQSDLQFLN 310 320 330 340 350 360 FNVENSQELI QMYDSKMEES KALDSSRDMC LSDLENNHPK VDIKREKNQK SLFKDQKFEA 370 380 390 400 410 420 MLVQQNRSDK SSCDECKEKK QQIDTVFGEK SVITLSSIFT KDLVEKHNLP WSLGGKTQIE 430 440 450 460 470 480 PENKITLCKI HTKSPKCHGT GVQNEGKQPS ETPTLSDEKQ WHDVSVYLGL TNCPSSKHPE 490 500 510 520 530 540 KLDVECQDQM ERSEISCCQK NEACLGESGM CDSKCCHPSN FIIEAPGHMS DVEWMSIFKP 550 560 570 580 590 600 SKMQRIVRLK SGCTCSESIC GTQHDSPASE LIAIQDSHSL GSSKSALRED ETESSSNKKN 610 620 630 640 650 660 SPTSLLIYKD APAFNEKASI VLPSQDDFSP TSKLQRLLAE SRQMVTDLEL STLLPISHEN 670 680 LTGSATNISH LCGRQKADTN TE
	Isoform 3 [UniParc]. Checksum: 30D5CA8386F76AA1	FASTA	445	49,908
	10 20 30 40 50 60 MPNSSPKDPT TASGNGSKVE REKRKDELLN IAKSKQERTN SELHNLRQIY VKQQSDLQFL 70 80 90 100 110 120 NFNVENSQEL IQMYDSKMEE SKALDSSRDM CLSDLENNHP KVDIKREKNQ KSLFKDQKFE 130 140 150 160 170 180 AMLVQQNRSD KSSCDECKEK KQQIDTVFGE KSVITLSSIF TKDLVEKHNL PWSLGGKTQI 190 200 210 220 230 240 EPENKITLCK IHTKSPKCHG TGVQNEGKQP SETPTLSDEK QWHDVSVYLG LTNCPSSKHP 250 260 270 280 290 300 EKLDVECQDQ MERSEISCCQ KNEACLGESG MCDSKCCHPS NFIIEAPGHM SDVEWMSIFK 310 320 330 340 350 360 PSKMQRIVRL KSGCTCSESI CGTQHDSPAS ELIAIQDSHS LGSSKSALRE DETESSSNKK 370 380 390 400 410 420 NSPTSLLIYK DAPAFNEKAS IVLPSQDDFS PTSKLQRLLA ESRQMVTDLE LSTLLPISHE 430 440 NLTGSATNKS EVPEESAQKN TFVSY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and characterization of a novel gene highly expressed in testis." Shan Y.X., Yu L. Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3). Tissue: Cerebellum and Testis.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT LYS-394. Tissue: Brain.
[4]	"A novel testis specific protein (TSP-NY) gene from adult testis." Li J.M., Chen R.H., Chen Q., Zhu H., Lin M., Zhou Z.M., Wang L.R., Zhou Y.D., Cheng L.J., Ying L.L., Zhu H., Sha J.H. Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 176-684 (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Testis.
[5]	"ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells." Chen M., Ni J., Zhang Y., Muyan M., Yeh S. Prostate 68:1273-1282(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH ESR1, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
[6]	"CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells." Chen M., Ni J., Chang H.C., Lin C.Y., Muyan M., Yeh S. Carcinogenesis 30:841-850(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH ESR2, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF 637-LEU-LEU-638 AND 653-LEU-LEU-654.
[7]	"Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity." Domae S., Nakamura Y., Nakamura Y., Uenaka A., Wada H., Nakata M., Oka M., Kishimoto K., Tsukamoto G., Yoshihama Y., Matsuoka J., Gochi A., Kohno S., Saika T., Sasaki A., Nakayama E., Ono T. Int. J. Cancer 124:2347-2352(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[8]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-31.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY254201 mRNA. Translation: AAP13075.1. AK097663 mRNA. Translation: BAG53505.1. AK124633 mRNA. Translation: BAC85909.1. AK292466 mRNA. Translation: BAF85155.1. BC060796 mRNA. Translation: AAH60796.1. AY009105 mRNA. Translation: AAG49396.1. Different initiation.
IPI	IPI00185659. IPI00402053. IPI00759750.
RefSeq	NP_958843.2. NM_201435.4.
UniGene	Hs.592008.
3D structure databases
ProteinModelPortal	Q6P9F0.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000253079.
PTM databases
PhosphoSite	Q6P9F0.
Polymorphism databases
DMDM	108935965.
Proteomic databases
PaxDb	Q6P9F0.
PRIDE	Q6P9F0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000253079; ENSP00000253079; ENSG00000130783. ENST00000341952; ENSP00000341471; ENSG00000130783. ENST00000392440; ENSP00000376235; ENSG00000130783. ENST00000392441; ENSP00000376236; ENSG00000130783. ENST00000537566; ENSP00000445045; ENSG00000130783.
GeneID	84660.
KEGG	hsa:84660.
UCSC	uc001udc.3. human. uc001ude.3. human. uc021rfn.1. human.
Organism-specific databases
CTD	84660.
GeneCards	GC12P123259.
H-InvDB	HIX0201861.
HGNC	HGNC:30723. CCDC62.
HPA	HPA039021.
MIM	613481. gene.
neXtProt	NX_Q6P9F0.
PharmGKB	PA143485414.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG69709.
HOGENOM	HOG000111426.
HOVERGEN	HBG081045.
InParanoid	Q6P9F0.
OMA	TENNEQR.
PhylomeDB	Q6P9F0.
Gene expression databases
ArrayExpress	Q6P9F0.
Bgee	Q6P9F0.
CleanEx	HS_CCDC62.
Genevestigator	Q6P9F0.
GermOnline	ENSG00000130783. Homo sapiens.
Family and domain databases
ProtoNet	Search...
Other
ChiTaRS	CCDC62. human.
GenomeRNAi	84660.
NextBio	74633.
SOURCE	Search...

Entry information

Entry name

CCD62_HUMAN

Accession

Primary (citable) accession number: Q6P9F0
Secondary accession number(s): A8K8V1 , B3KUP3, Q6ZVF2, Q86VJ0, Q9BYZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 13, 2006
Last sequence update:	June 13, 2006
Last modified:	April 3, 2013
This is version 74 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.