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Protein

Integrator complex subunit 5

Gene

INTS5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.

GO - Biological processi

  • snRNA processing Source: HGNC
  • snRNA transcription from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 5
Short name:
Int5
Gene namesi
Name:INTS5
Synonyms:KIAA1698
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:29352. INTS5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei534 – 55421HelicalSequence analysisAdd
BLAST
Transmembranei856 – 87621HelicalSequence analysisAdd
BLAST
Transmembranei930 – 95021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • integrator complex Source: HGNC
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671596.

Polymorphism and mutation databases

BioMutaiINTS5.
DMDMi74737528.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 10191018Integrator complex subunit 5PRO_0000259541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources
Modified residuei279 – 2791PhosphoserineCombined sources
Modified residuei1010 – 10101PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6P9B9.
MaxQBiQ6P9B9.
PaxDbiQ6P9B9.
PeptideAtlasiQ6P9B9.
PRIDEiQ6P9B9.

PTM databases

iPTMnetiQ6P9B9.
PhosphoSiteiQ6P9B9.

Expressioni

Gene expression databases

BgeeiENSG00000185085.
CleanExiHS_INTS5.
GenevisibleiQ6P9B9. HS.

Organism-specific databases

HPAiHPA056915.

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12.1 Publication

Protein-protein interaction databases

BioGridi123312. 59 interactions.
IntActiQ6P9B9. 12 interactions.
MINTiMINT-4539005.
STRINGi9606.ENSP00000327889.

Structurei

3D structure databases

ProteinModelPortaliQ6P9B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHRN. Eukaryota.
ENOG4110473. LUCA.
GeneTreeiENSGT00390000008374.
HOGENOMiHOG000220929.
HOVERGENiHBG079923.
InParanoidiQ6P9B9.
KOiK13142.
OMAiLRMFHDS.
OrthoDBiEOG091G03OL.
PhylomeDBiQ6P9B9.
TreeFamiTF323720.

Family and domain databases

InterProiIPR029444. INTS5_C.
IPR029445. INTS5_N.
[Graphical view]
PfamiPF14838. INTS5_C. 1 hit.
PF14837. INTS5_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSALCDPPGA PGPPGPAPAT HGPAPLSAQE LSQEIKAFLT GVDPILGHQL
60 70 80 90 100
SAREHARCGL LLLRSLPPAR AAVLDHLRGV FDESVRAHLA ALDETPVAGP
110 120 130 140 150
PHLRPPPPSH VPAGGPGLED VVQEVQQVLS EFIRANPKAW APVISAWSID
160 170 180 190 200
LMGQLSSTYS GQHQRVPHAT GALNELLQLW MGCRATRTLM DIYVQCLSAL
210 220 230 240 250
IGSCPDACVD ALLDTSVQHS PHFDWVVAHI GSSFPGTIIS RVLSCGLKDF
260 270 280 290 300
CVHGGAGGGA GSSGGSSSQT PSTDPFPGSP AIPAEKRVPK IASVVGILGH
310 320 330 340 350
LASRHGDSIR RELLRMFHDS LAGGSGGRSG DPSLQATVPF LLQLAVMSPA
360 370 380 390 400
LLGTVSGELV DCLKPPAVLS QLQQHLQGFP REELDNMLNL AVHLVSQASG
410 420 430 440 450
AGAYRLLQFL VDTAMPASVI TTQGLAVPDT VREACDRLIQ LLLLHLQKLV
460 470 480 490 500
HHRGGSPGEG VLGPPPPPRL VPFLDALKNH VGELCGETLR LERKRFLWQH
510 520 530 540 550
QLLGLLSVYT RPSCGPEALG HLLSRARSPE ELSLATQLYA GLVVSLSGLL
560 570 580 590 600
PLAFRSCLAR VHAGTLQPPF TARFLRNLAL LVGWEQQGGE GPAALGAHFG
610 620 630 640 650
ESASAHLSDL APLLLHPEEE VAEAAASLLA ICPFPSEALS PSQLLGLVRA
660 670 680 690 700
GVHRFFASLR LHGPPGVASA CQLLTRLSQT SPAGLKAVLQ LLVEGALHRG
710 720 730 740 750
NTELFGGQVD GDNETLSVVS ASLASASLLD TNRRHTAAVP GPGGIWSVFH
760 770 780 790 800
AGVIGRGLKP PKFVQSRNQQ EVIYNTQSLL SLLVHCCSAP GGTECGECWG
810 820 830 840 850
APILSPEAAK AVAVTLVESV CPDAAGAELA WPPEEHARAT VERDLRIGRR
860 870 880 890 900
FREQPLLFEL LKLVAAAPPA LCYCSVLLRG LLAALLGHWE ASRHPDTTHS
910 920 930 940 950
PWHLEASCTL VAVMAEGSLL PPALGNMHEV FSQLAPFEVR LLLLSVWGFL
960 970 980 990 1000
REHGPLPQKF IFQSERGRFI RDFSREGGGE GGPHLAVLHS VLHRNIDRLG
1010
LFSGRFQAPS PSTLLRQGT
Length:1,019
Mass (Da):107,995
Last modified:July 5, 2004 - v1
Checksum:iDD4E3B0E2A60F9E7
GO

Sequence cautioni

The sequence AAH28025 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028025 mRNA. Translation: AAH28025.1. Different initiation.
BC060841 mRNA. Translation: AAH60841.1.
AB051485 mRNA. Translation: BAB21789.1.
BK005724 mRNA. Translation: DAA05724.1.
CCDSiCCDS8027.1.
RefSeqiNP_085131.1. NM_030628.1.
UniGeneiHs.458390.

Genome annotation databases

EnsembliENST00000330574; ENSP00000327889; ENSG00000185085.
GeneIDi80789.
KEGGihsa:80789.
UCSCiuc001nud.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC028025 mRNA. Translation: AAH28025.1. Different initiation.
BC060841 mRNA. Translation: AAH60841.1.
AB051485 mRNA. Translation: BAB21789.1.
BK005724 mRNA. Translation: DAA05724.1.
CCDSiCCDS8027.1.
RefSeqiNP_085131.1. NM_030628.1.
UniGeneiHs.458390.

3D structure databases

ProteinModelPortaliQ6P9B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123312. 59 interactions.
IntActiQ6P9B9. 12 interactions.
MINTiMINT-4539005.
STRINGi9606.ENSP00000327889.

PTM databases

iPTMnetiQ6P9B9.
PhosphoSiteiQ6P9B9.

Polymorphism and mutation databases

BioMutaiINTS5.
DMDMi74737528.

Proteomic databases

EPDiQ6P9B9.
MaxQBiQ6P9B9.
PaxDbiQ6P9B9.
PeptideAtlasiQ6P9B9.
PRIDEiQ6P9B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330574; ENSP00000327889; ENSG00000185085.
GeneIDi80789.
KEGGihsa:80789.
UCSCiuc001nud.3. human.

Organism-specific databases

CTDi80789.
GeneCardsiINTS5.
H-InvDBHIX0009717.
HGNCiHGNC:29352. INTS5.
HPAiHPA056915.
MIMi611349. gene.
neXtProtiNX_Q6P9B9.
PharmGKBiPA142671596.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHRN. Eukaryota.
ENOG4110473. LUCA.
GeneTreeiENSGT00390000008374.
HOGENOMiHOG000220929.
HOVERGENiHBG079923.
InParanoidiQ6P9B9.
KOiK13142.
OMAiLRMFHDS.
OrthoDBiEOG091G03OL.
PhylomeDBiQ6P9B9.
TreeFamiTF323720.

Enzyme and pathway databases

ReactomeiR-HSA-6807505. RNA polymerase II transcribes snRNA genes.

Miscellaneous databases

ChiTaRSiINTS5. human.
GenomeRNAii80789.
PROiQ6P9B9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000185085.
CleanExiHS_INTS5.
GenevisibleiQ6P9B9. HS.

Family and domain databases

InterProiIPR029444. INTS5_C.
IPR029445. INTS5_N.
[Graphical view]
PfamiPF14838. INTS5_C. 1 hit.
PF14837. INTS5_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiINT5_HUMAN
AccessioniPrimary (citable) accession number: Q6P9B9
Secondary accession number(s): Q8N6W5, Q9C0G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.