Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TLD domain-containing protein 1

Gene

TLDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
TLD domain-containing protein 1
Alternative name(s):
TBC/LysM-associated domain-containing protein 1
Gene namesi
Name:TLDC1
Synonyms:KIAA1609
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:29325. TLDC1.

Subcellular locationi

GO - Cellular componenti

  • lysosomal membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi57707.
OpenTargetsiENSG00000140950.
PharmGKBiPA144596416.

Polymorphism and mutation databases

BioMutaiTLDC1.
DMDMi296434547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00003136402 – 456TLD domain-containing protein 1Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycine1 Publication1

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

EPDiQ6P9B6.
MaxQBiQ6P9B6.
PaxDbiQ6P9B6.
PeptideAtlasiQ6P9B6.
PRIDEiQ6P9B6.

PTM databases

iPTMnetiQ6P9B6.
PhosphoSitePlusiQ6P9B6.
SwissPalmiQ6P9B6.

Expressioni

Gene expression databases

BgeeiENSG00000140950.
CleanExiHS_KIAA1609.
ExpressionAtlasiQ6P9B6. baseline and differential.
GenevisibleiQ6P9B6. HS.

Organism-specific databases

HPAiHPA041020.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TRIP13Q156453EBI-746504,EBI-358993

Protein-protein interaction databases

BioGridi121731. 14 interactors.
IntActiQ6P9B6. 1 interactor.
STRINGi9606.ENSP00000343635.

Structurei

3D structure databases

ProteinModelPortaliQ6P9B6.
SMRiQ6P9B6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini268 – 412TLDAdd BLAST145

Sequence similaritiesi

Contains 1 TLD domain.Curated

Phylogenomic databases

eggNOGiKOG2557. Eukaryota.
ENOG410XR8F. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000031408.
HOVERGENiHBG103322.
InParanoidiQ6P9B6.
OMAiGFASHSW.
OrthoDBiEOG091G0BIQ.
PhylomeDBiQ6P9B6.
TreeFamiTF316541.

Family and domain databases

InterProiIPR006571. TLDc_dom.
[Graphical view]
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00584. TLDc. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P9B6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNSRSRVGR SFCSQFLPEE QAEIDQLFDA LSSDKNSPNV SSKSFSLKAL
60 70 80 90 100
QNHVGEALPP EMVTRLYDGM RRVDLTGKAK GPSENVSQEQ FTASMSHLLK
110 120 130 140 150
GNSEEKSLMI MKMISATEGP VKAREVQKFT EDLVGSVVHV LSHRQELRGW
160 170 180 190 200
TGKEAPGPNP RVQVLAAQLL SDMKLQDGKR LLGPQWLDYD CDRAVIEDWV
210 220 230 240 250
FRVPHVAIFL SVVICKGFLI LCSSLDLTTL VPERQVDQGR GFESILDVLS
260 270 280 290 300
VMYINAQLPR EQRHRWCLLF SSELHGHSFS QLCGHITHRG PCVAVLEDHD
310 320 330 340 350
KHVFGGFASC SWEVKPQFQG DNRCFLFSIC PSMAVYTHTG YNDHYMYLNH
360 370 380 390 400
GQQTIPNGLG MGGQHNYFGL WVDVDFGKGH SRAKPTCTTY NSPQLSAQEN
410 420 430 440 450
FQFDKMEVWA VGDPSEEQLA KGNKSILDAD PEAQALLEIS GHSRHSEGLR

EVPDDE
Length:456
Mass (Da):50,994
Last modified:May 18, 2010 - v2
Checksum:i3237DF7BB9818667
GO

Sequence cautioni

The sequence BAB13435 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03767510R → L.Corresponds to variant rs8046813dbSNPEnsembl.1
Natural variantiVAR_03767697H → Q.Corresponds to variant rs8055536dbSNPEnsembl.1
Natural variantiVAR_037677172D → E.2 PublicationsCorresponds to variant rs436278dbSNPEnsembl.1
Natural variantiVAR_037678220I → V.3 PublicationsCorresponds to variant rs431818dbSNPEnsembl.1
Natural variantiVAR_037679233E → D.Corresponds to variant rs34244563dbSNPEnsembl.1
Natural variantiVAR_037680267C → R.3 PublicationsCorresponds to variant rs422145dbSNPEnsembl.1
Natural variantiVAR_037681443S → L.Corresponds to variant rs34628943dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046829 mRNA. Translation: BAB13435.1. Different initiation.
AC022165 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95478.1.
BC023251 mRNA. Translation: AAH23251.1.
BC060844 mRNA. Translation: AAH60844.1.
AL137316 mRNA. Translation: CAB70693.1.
CCDSiCCDS32498.1.
PIRiT46288.
RefSeqiNP_065998.3. NM_020947.3.
XP_005256132.1. XM_005256075.2.
XP_006721303.1. XM_006721240.2.
XP_011521550.1. XM_011523248.2.
XP_011521551.1. XM_011523249.2.
XP_016878999.1. XM_017023510.1.
XP_016879000.1. XM_017023511.1.
UniGeneiHs.288274.

Genome annotation databases

EnsembliENST00000343629; ENSP00000343635; ENSG00000140950.
GeneIDi57707.
KEGGihsa:57707.
UCSCiuc002fib.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046829 mRNA. Translation: BAB13435.1. Different initiation.
AC022165 Genomic DNA. No translation available.
CH471114 Genomic DNA. Translation: EAW95478.1.
BC023251 mRNA. Translation: AAH23251.1.
BC060844 mRNA. Translation: AAH60844.1.
AL137316 mRNA. Translation: CAB70693.1.
CCDSiCCDS32498.1.
PIRiT46288.
RefSeqiNP_065998.3. NM_020947.3.
XP_005256132.1. XM_005256075.2.
XP_006721303.1. XM_006721240.2.
XP_011521550.1. XM_011523248.2.
XP_011521551.1. XM_011523249.2.
XP_016878999.1. XM_017023510.1.
XP_016879000.1. XM_017023511.1.
UniGeneiHs.288274.

3D structure databases

ProteinModelPortaliQ6P9B6.
SMRiQ6P9B6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121731. 14 interactors.
IntActiQ6P9B6. 1 interactor.
STRINGi9606.ENSP00000343635.

PTM databases

iPTMnetiQ6P9B6.
PhosphoSitePlusiQ6P9B6.
SwissPalmiQ6P9B6.

Polymorphism and mutation databases

BioMutaiTLDC1.
DMDMi296434547.

Proteomic databases

EPDiQ6P9B6.
MaxQBiQ6P9B6.
PaxDbiQ6P9B6.
PeptideAtlasiQ6P9B6.
PRIDEiQ6P9B6.

Protocols and materials databases

DNASUi57707.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343629; ENSP00000343635; ENSG00000140950.
GeneIDi57707.
KEGGihsa:57707.
UCSCiuc002fib.4. human.

Organism-specific databases

CTDi57707.
DisGeNETi57707.
GeneCardsiTLDC1.
HGNCiHGNC:29325. TLDC1.
HPAiHPA041020.
neXtProtiNX_Q6P9B6.
OpenTargetsiENSG00000140950.
PharmGKBiPA144596416.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2557. Eukaryota.
ENOG410XR8F. LUCA.
GeneTreeiENSGT00410000025363.
HOGENOMiHOG000031408.
HOVERGENiHBG103322.
InParanoidiQ6P9B6.
OMAiGFASHSW.
OrthoDBiEOG091G0BIQ.
PhylomeDBiQ6P9B6.
TreeFamiTF316541.

Miscellaneous databases

GenomeRNAii57707.
PROiQ6P9B6.

Gene expression databases

BgeeiENSG00000140950.
CleanExiHS_KIAA1609.
ExpressionAtlasiQ6P9B6. baseline and differential.
GenevisibleiQ6P9B6. HS.

Family and domain databases

InterProiIPR006571. TLDc_dom.
[Graphical view]
PfamiPF07534. TLD. 1 hit.
[Graphical view]
SMARTiSM00584. TLDc. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLDC1_HUMAN
AccessioniPrimary (citable) accession number: Q6P9B6
Secondary accession number(s): Q8IZ64, Q9HCG3, Q9NTE8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 18, 2010
Last modified: November 2, 2016
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.