Q6P9A3 (ZN549_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger protein 549

Gene names

Name:

ZNF549

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	640 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in transcriptional regulation.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 15 C2H2-type zinc fingers. Contains 1 KRAB domain.
Sequence caution	The sequence AAC24605.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q6P9A3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q6P9A3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     12-24: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 640	640	Zinc finger protein 549		PRO_0000234583
Regions
	Domain	27 – 140	114	KRAB
	Zinc finger	217 – 241	25	C2H2-type 1; degenerate
	Zinc finger	247 – 269	23	C2H2-type 2; degenerate
	Zinc finger	275 – 298	24	C2H2-type 3
	Zinc finger	304 – 326	23	C2H2-type 4
	Zinc finger	332 – 355	24	C2H2-type 5
	Zinc finger	361 – 383	23	C2H2-type 6
	Zinc finger	389 – 411	23	C2H2-type 7
	Zinc finger	417 – 439	23	C2H2-type 8
	Zinc finger	445 – 467	23	C2H2-type 9
	Zinc finger	473 – 495	23	C2H2-type 10
	Zinc finger	501 – 523	23	C2H2-type 11
	Zinc finger	529 – 551	23	C2H2-type 12
	Zinc finger	557 – 579	23	C2H2-type 13
	Zinc finger	585 – 607	23	C2H2-type 14
	Zinc finger	613 – 635	23	C2H2-type 15
Natural variations
	Alternative sequence	12 – 24	13	Missing in isoform 2.		VSP_018379
	Natural variant	8	1	I → N. Corresponds to variant rs12461014 [ dbSNP | Ensembl ].		VAR_059921
Experimental info
	Sequence conflict	84	1	S → P in BAC03834. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 2, 2010. Version 2. Checksum: CED338B5CC75DD97	FASTA	640	74,439
	10 20 30 40 50 60 MAEAALVITP QIPMVTEEFV KPSQGHVTFE DIAVYFSQEE WGLLDEAQRC LYHDVMLENF 70 80 90 100 110 120 SLMASVGCLH GIEAEEAPSE QTLSAQGVSQ ARTPKLGPSI PNAHSCEMCI LVMKDILYLS 130 140 150 160 170 180 EHQGTLPWQK PYTSVASGKW FSFGSNLQQH QNQDSGEKHI RKEESSALLL NSCKIPLSDN 190 200 210 220 230 240 LFPCKDVEKD FPTILGLLQH QTTHSRQEYA HRSRETFQQR RYKCEQVFNE KVHVTEHQRV 250 260 270 280 290 300 HTGEKAYKRR EYGKSLNSKY LFVEHQRTHN AEKPYVCNIC GKSFLHKQTL VGHQQRIHTR 310 320 330 340 350 360 ERSYVCIECG KSLSSKYSLV EHQRTHNGEK PYVCNVCGKS FRHKQTFVGH QQRIHTGERP 370 380 390 400 410 420 YVCMECGKSF IHSYDRIRHQ RVHTGEGAYQ CSECGKSFIY KQSLLDHHRI HTGERPYECK 430 440 450 460 470 480 ECGKAFIHKK RLLEHQRIHT GEKPYVCIIC GKSFIRSSDY MRHQRIHTGE RAYECSDCGK 490 500 510 520 530 540 AFISKQTLLK HHKIHTRERP YECSECGKGF YLEVKLLQHQ RIHTREQLCE CNECGKVFSH 550 560 570 580 590 600 QKRLLEHQKV HTGEKPCECS ECGKCFRHRT SLIQHQKVHS GERPYNCTAC EKAFIYKNKL 610 620 630 640 VEHQRIHTGE KPYECGKCGK AFNKRYSLVR HQKVHITEEP
	Isoform 2 [UniParc]. Checksum: 3CC79CEECD2272C7	FASTA	627	72,952
	10 20 30 40 50 60 MAEAALVITP QGHVTFEDIA VYFSQEEWGL LDEAQRCLYH DVMLENFSLM ASVGCLHGIE 70 80 90 100 110 120 AEEAPSEQTL SAQGVSQART PKLGPSIPNA HSCEMCILVM KDILYLSEHQ GTLPWQKPYT 130 140 150 160 170 180 SVASGKWFSF GSNLQQHQNQ DSGEKHIRKE ESSALLLNSC KIPLSDNLFP CKDVEKDFPT 190 200 210 220 230 240 ILGLLQHQTT HSRQEYAHRS RETFQQRRYK CEQVFNEKVH VTEHQRVHTG EKAYKRREYG 250 260 270 280 290 300 KSLNSKYLFV EHQRTHNAEK PYVCNICGKS FLHKQTLVGH QQRIHTRERS YVCIECGKSL 310 320 330 340 350 360 SSKYSLVEHQ RTHNGEKPYV CNVCGKSFRH KQTFVGHQQR IHTGERPYVC MECGKSFIHS 370 380 390 400 410 420 YDRIRHQRVH TGEGAYQCSE CGKSFIYKQS LLDHHRIHTG ERPYECKECG KAFIHKKRLL 430 440 450 460 470 480 EHQRIHTGEK PYVCIICGKS FIRSSDYMRH QRIHTGERAY ECSDCGKAFI SKQTLLKHHK 490 500 510 520 530 540 IHTRERPYEC SECGKGFYLE VKLLQHQRIH TREQLCECNE CGKVFSHQKR LLEHQKVHTG 550 560 570 580 590 600 EKPCECSECG KCFRHRTSLI QHQKVHSGER PYNCTACEKA FIYKNKLVEH QRIHTGEKPY 610 620 ECGKCGKAFN KRYSLVRHQK VHITEEP

References

[1]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Teratocarcinoma.
[2]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Placenta.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AK092236 mRNA. Translation: BAC03834.1. AK122749 mRNA. Translation: BAG53703.1. AC003682 Genomic DNA. Translation: AAC24605.1. Sequence problems. CH471135 Genomic DNA. Translation: EAW72511.1. BC060863 mRNA. Translation: AAH60863.1.
IPI	IPI00176222. IPI00743870.
RefSeq	NP_001186224.1. NM_001199295.1. NP_694995.2. NM_153263.2.
UniGene	Hs.730870.
3D structure databases
ProteinModelPortal	Q6P9A3.
SMR	Q6P9A3. Positions 21-75, 104-637.
ModBase	Search...
PTM databases
PhosphoSite	Q6P9A3.
Polymorphism databases
DMDM	311033505.
Proteomic databases
PaxDb	Q6P9A3.
PRIDE	Q6P9A3.
Protocols and materials databases
DNASU	256051.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000240719; ENSP00000240719; ENSG00000121406. ENST00000376233; ENSP00000365407; ENSG00000121406.
GeneID	256051.
KEGG	hsa:256051.
UCSC	uc002qpa.2. human.
Organism-specific databases
CTD	256051.
GeneCards	GC19P058038.
HGNC	HGNC:26632. ZNF549.
HPA	HPA039511.
neXtProt	NX_Q6P9A3.
PharmGKB	PA134905435.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000234617.
HOVERGEN	HBG018163.
InParanoid	Q6P9A3.
KO	K09228.
OMA	CEQVFNE.
OrthoDB	EOG40GCQ8.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
Bgee	Q6P9A3.
CleanEx	HS_ZNF549.
Genevestigator	Q6P9A3.
GermOnline	ENSG00000121406. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 15 hits.
InterPro	IPR001909. Krueppel-associated_box. IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Pfam	PF01352. KRAB. 1 hit. [Graphical view]
SMART	SM00349. KRAB. 1 hit. SM00355. ZnF_C2H2. 15 hits. [Graphical view]
SUPFAM	SSF109640. Krueppel-associated_box. 1 hit.
PROSITE	PS50805. KRAB. 1 hit. PS00028. ZINC_FINGER_C2H2_1. 13 hits. PS50157. ZINC_FINGER_C2H2_2. 15 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	256051.
NextBio	92700.

Entry information

Entry name

ZN549_HUMAN

Accession

Primary (citable) accession number: Q6P9A3
Secondary accession number(s): B3KV91, O43336, Q8NAR4

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 16, 2006
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.