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Protein

Zinc finger protein 530

Gene

ZNF530

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri239 – 26123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 530
Gene namesi
Name:ZNF530
Synonyms:KIAA1508
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:29297. ZNF530.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134892909.

Polymorphism and mutation databases

BioMutaiZNF530.
DMDMi158706493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Zinc finger protein 530PRO_0000304997Add
BLAST

Proteomic databases

EPDiQ6P9A1.
MaxQBiQ6P9A1.
PaxDbiQ6P9A1.
PeptideAtlasiQ6P9A1.
PRIDEiQ6P9A1.

PTM databases

iPTMnetiQ6P9A1.
PhosphoSiteiQ6P9A1.

Expressioni

Gene expression databases

BgeeiQ6P9A1.
CleanExiHS_ZNF530.
ExpressionAtlasiQ6P9A1. baseline and differential.
GenevisibleiQ6P9A1. HS.

Organism-specific databases

HPAiHPA045868.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000332861.

Structurei

3D structure databases

ProteinModelPortaliQ6P9A1.
SMRiQ6P9A1. Positions 166-597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 9481KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri239 – 26123C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri267 – 28923C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri295 – 31723C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri323 – 34523C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri351 – 37323C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri379 – 40123C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri407 – 42923C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri435 – 45723C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri463 – 48523C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri491 – 51323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri519 – 54123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri547 – 56923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri575 – 59723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P9A1.
KOiK09228.
OMAiCEICTPV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P9A1.
TreeFamiTF339848.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P9A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALRAPTQ QVFVAFEDVA IYFSQEEWEL LDEMQRLLYR DVMLENFAVM
60 70 80 90 100
ASLGCWCGAV DEGTPSAESV SVEELSQGRT PKADTSTDKS HPCEICTPVL
110 120 130 140 150
RDILQMIELH ASPCGQKLYL GGASRDFWMS SNLHQLQKLD NGEKLFKVDG
160 170 180 190 200
DQASFMMNCR FHVSGKPFTF GEVGRDFSAT SGLLQHQVTP TIERPHSRIR
210 220 230 240 250
HLRVPTGRKP LKYTESRKSF REKSVFIQHQ RADSGERPYK CSECGKSFSQ
260 270 280 290 300
SSGFLRHRKA HGRTRTHECS ECGKSFSRKT HLTQHQRVHT GERPYDCSEC
310 320 330 340 350
GKSFRQVSVL IQHQRVHTGE RPYECSECGK SFSHSTNLYR HRSAHTSTRP
360 370 380 390 400
YECSECGKSF SHSTNLFRHW RVHTGVRPYE CSECGKAFSC NIYLIHHQRF
410 420 430 440 450
HTGERPYVCS ECGKSFGQKS VLIQHQRVHT GERPYECSEC GKVFSQSSGL
460 470 480 490 500
FRHRRAHTKT KPYECSECEK SFSCKTDLIR HQTVHTGERP YECSVCGKSF
510 520 530 540 550
IRKTHLIRHQ TVHTNERPYE CDECGKSYSQ SSALLQHRRV HTGERPYECR
560 570 580 590
ECGKSFTRKN HLIQHKTVHT GERPYECSEC GKSFSQSSGL LRHRRVHVQ
Length:599
Mass (Da):68,837
Last modified:October 2, 2007 - v2
Checksum:i4A1E04810B74CEF2
GO

Sequence cautioni

The sequence AAC24609.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAA96032.1 differs from that shown.Intron retention.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti64 – 641T → A.1 Publication
Corresponds to variant rs9677004 [ dbSNP | Ensembl ].
VAR_035144
Natural varianti110 – 1101H → Q.2 Publications
Corresponds to variant rs2360543 [ dbSNP | Ensembl ].
VAR_035145
Natural varianti124 – 1241S → P.1 Publication
Corresponds to variant rs17855076 [ dbSNP | Ensembl ].
VAR_035146
Natural varianti169 – 1691T → M.
Corresponds to variant rs11883343 [ dbSNP | Ensembl ].
VAR_035147
Natural varianti262 – 2621G → S.
Corresponds to variant rs9676259 [ dbSNP | Ensembl ].
VAR_035148

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003682 Genomic DNA. Translation: AAC24609.1. Sequence problems.
BC060865 mRNA. Translation: AAH60865.1.
AB040941 mRNA. Translation: BAA96032.1. Sequence problems.
CCDSiCCDS12955.1.
RefSeqiNP_001308910.1. NM_001321981.1.
NP_065931.3. NM_020880.4.
UniGeneiHs.662177.
Hs.97111.

Genome annotation databases

EnsembliENST00000332854; ENSP00000332861; ENSG00000183647.
ENST00000600619; ENSP00000472564; ENSG00000183647.
GeneIDi348327.
KEGGihsa:348327.
UCSCiuc002qpk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003682 Genomic DNA. Translation: AAC24609.1. Sequence problems.
BC060865 mRNA. Translation: AAH60865.1.
AB040941 mRNA. Translation: BAA96032.1. Sequence problems.
CCDSiCCDS12955.1.
RefSeqiNP_001308910.1. NM_001321981.1.
NP_065931.3. NM_020880.4.
UniGeneiHs.662177.
Hs.97111.

3D structure databases

ProteinModelPortaliQ6P9A1.
SMRiQ6P9A1. Positions 166-597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000332861.

PTM databases

iPTMnetiQ6P9A1.
PhosphoSiteiQ6P9A1.

Polymorphism and mutation databases

BioMutaiZNF530.
DMDMi158706493.

Proteomic databases

EPDiQ6P9A1.
MaxQBiQ6P9A1.
PaxDbiQ6P9A1.
PeptideAtlasiQ6P9A1.
PRIDEiQ6P9A1.

Protocols and materials databases

DNASUi348327.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000332854; ENSP00000332861; ENSG00000183647.
ENST00000600619; ENSP00000472564; ENSG00000183647.
GeneIDi348327.
KEGGihsa:348327.
UCSCiuc002qpk.3. human.

Organism-specific databases

CTDi348327.
GeneCardsiZNF530.
HGNCiHGNC:29297. ZNF530.
HPAiHPA045868.
neXtProtiNX_Q6P9A1.
PharmGKBiPA134892909.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P9A1.
KOiK09228.
OMAiCEICTPV.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ6P9A1.
TreeFamiTF339848.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii348327.
PROiQ6P9A1.

Gene expression databases

BgeeiQ6P9A1.
CleanExiHS_ZNF530.
ExpressionAtlasiQ6P9A1. baseline and differential.
GenevisibleiQ6P9A1. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 3 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLN-110 AND PRO-124.
    Tissue: Placenta.
  3. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.
    DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 54-599, VARIANTS ALA-64 AND GLN-110.
    Tissue: Brain.

Entry informationi

Entry nameiZN530_HUMAN
AccessioniPrimary (citable) accession number: Q6P9A1
Secondary accession number(s): O43340, Q9P220
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: July 6, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.