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Protein

Zinc finger protein 530

Gene

ZNF530

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 530
Gene namesi
Name:ZNF530
Synonyms:KIAA1508
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000183647.10.
HGNCiHGNC:29297. ZNF530.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi348327.
OpenTargetsiENSG00000183647.
PharmGKBiPA134892909.

Polymorphism and mutation databases

BioMutaiZNF530.
DMDMi158706493.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049971 – 599Zinc finger protein 530Add BLAST599

Proteomic databases

EPDiQ6P9A1.
MaxQBiQ6P9A1.
PaxDbiQ6P9A1.
PeptideAtlasiQ6P9A1.
PRIDEiQ6P9A1.

PTM databases

iPTMnetiQ6P9A1.
PhosphoSitePlusiQ6P9A1.

Expressioni

Gene expression databases

BgeeiENSG00000183647.
CleanExiHS_ZNF530.
ExpressionAtlasiQ6P9A1. baseline and differential.
GenevisibleiQ6P9A1. HS.

Organism-specific databases

HPAiHPA045868.

Interactioni

Protein-protein interaction databases

IntActiQ6P9A1. 1 interactor.
STRINGi9606.ENSP00000332861.

Structurei

3D structure databases

ProteinModelPortaliQ6P9A1.
SMRiQ6P9A1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 94KRABPROSITE-ProRule annotationAdd BLAST81

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri239 – 261C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri267 – 289C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri295 – 317C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri323 – 345C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri351 – 373C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri379 – 401C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri407 – 429C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri435 – 457C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri463 – 485C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri491 – 513C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri519 – 541C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri547 – 569C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri575 – 597C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119107.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ6P9A1.
KOiK09228.
OMAiCEICTPV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ6P9A1.
TreeFamiTF339848.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.40.10. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR036051. KRAB_dom_sf.
IPR036236. Znf_C2H2_sf.
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 8 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.

Sequencei

Sequence statusi: Complete.

Q6P9A1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAALRAPTQ QVFVAFEDVA IYFSQEEWEL LDEMQRLLYR DVMLENFAVM
60 70 80 90 100
ASLGCWCGAV DEGTPSAESV SVEELSQGRT PKADTSTDKS HPCEICTPVL
110 120 130 140 150
RDILQMIELH ASPCGQKLYL GGASRDFWMS SNLHQLQKLD NGEKLFKVDG
160 170 180 190 200
DQASFMMNCR FHVSGKPFTF GEVGRDFSAT SGLLQHQVTP TIERPHSRIR
210 220 230 240 250
HLRVPTGRKP LKYTESRKSF REKSVFIQHQ RADSGERPYK CSECGKSFSQ
260 270 280 290 300
SSGFLRHRKA HGRTRTHECS ECGKSFSRKT HLTQHQRVHT GERPYDCSEC
310 320 330 340 350
GKSFRQVSVL IQHQRVHTGE RPYECSECGK SFSHSTNLYR HRSAHTSTRP
360 370 380 390 400
YECSECGKSF SHSTNLFRHW RVHTGVRPYE CSECGKAFSC NIYLIHHQRF
410 420 430 440 450
HTGERPYVCS ECGKSFGQKS VLIQHQRVHT GERPYECSEC GKVFSQSSGL
460 470 480 490 500
FRHRRAHTKT KPYECSECEK SFSCKTDLIR HQTVHTGERP YECSVCGKSF
510 520 530 540 550
IRKTHLIRHQ TVHTNERPYE CDECGKSYSQ SSALLQHRRV HTGERPYECR
560 570 580 590
ECGKSFTRKN HLIQHKTVHT GERPYECSEC GKSFSQSSGL LRHRRVHVQ
Length:599
Mass (Da):68,837
Last modified:October 2, 2007 - v2
Checksum:i4A1E04810B74CEF2
GO

Sequence cautioni

The sequence AAC24609 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAA96032 differs from that shown. Intron retention.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03514464T → A1 PublicationCorresponds to variant dbSNP:rs9677004Ensembl.1
Natural variantiVAR_035145110H → Q2 PublicationsCorresponds to variant dbSNP:rs2360543Ensembl.1
Natural variantiVAR_035146124S → P1 PublicationCorresponds to variant dbSNP:rs17855076Ensembl.1
Natural variantiVAR_035147169T → M. Corresponds to variant dbSNP:rs11883343Ensembl.1
Natural variantiVAR_035148262G → S. Corresponds to variant dbSNP:rs9676259Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC003682 Genomic DNA. Translation: AAC24609.1. Sequence problems.
BC060865 mRNA. Translation: AAH60865.1.
AB040941 mRNA. Translation: BAA96032.1. Sequence problems.
CCDSiCCDS12955.1.
RefSeqiNP_001308910.1. NM_001321981.1.
NP_065931.3. NM_020880.4.
UniGeneiHs.662177.
Hs.97111.

Genome annotation databases

EnsembliENST00000332854; ENSP00000332861; ENSG00000183647.
ENST00000600619; ENSP00000472564; ENSG00000183647.
GeneIDi348327.
KEGGihsa:348327.
UCSCiuc002qpk.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZN530_HUMAN
AccessioniPrimary (citable) accession number: Q6P9A1
Secondary accession number(s): O43340, Q9P220
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: November 22, 2017
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families