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Protein

Pyridoxal-dependent decarboxylase domain-containing protein 1

Gene

PDXDC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC:4.1.1.-)
Gene namesi
Name:PDXDC1
Synonyms:KIAA0251
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:28995. PDXDC1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162399182.

Polymorphism and mutation databases

BioMutaiPDXDC1.
DMDMi156633546.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 788788Pyridoxal-dependent decarboxylase domain-containing protein 1PRO_0000297677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei652 – 6521PhosphoserineCombined sources
Modified residuei687 – 6871PhosphothreonineBy similarity
Modified residuei691 – 6911PhosphothreonineCombined sources
Modified residuei710 – 7101PhosphoserineCombined sources
Modified residuei718 – 7181PhosphoserineCombined sources
Modified residuei748 – 7481PhosphoserineBy similarity
Modified residuei757 – 7571PhosphoserineCombined sources
Modified residuei786 – 7861PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6P996.
MaxQBiQ6P996.
PaxDbiQ6P996.
PRIDEiQ6P996.

PTM databases

iPTMnetiQ6P996.
PhosphoSiteiQ6P996.

Expressioni

Gene expression databases

BgeeiQ6P996.
CleanExiHS_PDXDC1.
ExpressionAtlasiQ6P996. baseline and differential.
GenevisibleiQ6P996. HS.

Organism-specific databases

HPAiHPA047369.
HPA049121.
HPA051484.

Interactioni

Protein-protein interaction databases

BioGridi116681. 39 interactions.
IntActiQ6P996. 4 interactions.
MINTiMINT-5003736.
STRINGi9606.ENSP00000379691.

Structurei

3D structure databases

ProteinModelPortaliQ6P996.
SMRiQ6P996. Positions 172-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.Curated

Phylogenomic databases

eggNOGiKOG0630. Eukaryota.
ENOG410XYFU. LUCA.
GeneTreeiENSGT00390000009628.
HOGENOMiHOG000115485.
HOVERGENiHBG069100.
InParanoidiQ6P996.
OMAiMEAPGRA.
PhylomeDBiQ6P996.
TreeFamiTF313101.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P996-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDASLEKIAD PTLAEMGKNL KEAVKMLEDS QRRTEEENGK KLISGDIPGP
60 70 80 90 100
LQGSGQDMVS ILQLVQNLMH GDEDEEPQSP RIQNIGEQGH MALLGHSLGA
110 120 130 140 150
YISTLDKEKL RKLTTRILSD TTLWLCRIFR YENGCAYFHE EEREGLAKIC
160 170 180 190 200
RLAIHSRYED FVVDGFNVLY NKKPVIYLSA AARPGLGQYL CNQLGLPFPC
210 220 230 240 250
LCRVPCNTVF GSQHQMDVAF LEKLIKDDIE RGRLPLLLVA NAGTAAVGHT
260 270 280 290 300
DKIGRLKELC EQYGIWLHVE GVNLATLALG YVSSSVLAAA KCDSMTMTPG
310 320 330 340 350
PWLGLPAVPA VTLYKHDDPA LTLVAGLTSN KPTDKLRALP LWLSLQYLGL
360 370 380 390 400
DGFVERIKHA CQLSQRLQES LKKVNYIKIL VEDELSSPVV VFRFFQELPG
410 420 430 440 450
SDPVFKAVPV PNMTPSGVGR ERHSCDALNR WLGEQLKQLV PASGLTVMDL
460 470 480 490 500
EAEGTCLRFS PLMTAAVLGT RGEDVDQLVA CIESKLPVLC CTLQLREEFK
510 520 530 540 550
QEVEATAGLL YVDDPNWSGI GVVRYEHAND DKSSLKSDPE GENIHAGLLK
560 570 580 590 600
KLNELESDLT FKIGPEYKSM KSCLYVGMAS DNVDAAELVE TIAATAREIE
610 620 630 640 650
ENSRLLENMT EVVRKGIQEA QVELQKASEE RLLEEGVLRQ IPVVGSVLNW
660 670 680 690 700
FSPVQALQKG RTFNLTAGSL ESTEPIYVYK AQGAGVTLPP TPSGSRTKQR
710 720 730 740 750
LPGQKPFKRS LRGSDALSET SSVSHIEDLE KVERLSSGPE QITLEASSTE
760 770 780
GHPGAPSPQH TDQTEAFQKG VPHPEDDHSQ VEGPESLR
Length:788
Mass (Da):86,707
Last modified:August 21, 2007 - v2
Checksum:i2BAFEDC0A1C13AD3
GO
Isoform 2 (identifier: Q6P996-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-216: Missing.
     432-452: LGEQLKQLVPASGLTVMDLEA → VRMAVTPLSFQVPVHHHPTCW
     453-788: Missing.

Show »
Length:429
Mass (Da):47,730
Checksum:iA2FFFC3D24DEAFFD
GO
Isoform 3 (identifier: Q6P996-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-15: Missing.
     54-129: Missing.

Show »
Length:697
Mass (Da):76,547
Checksum:i87825F4250E68775
GO
Isoform 4 (identifier: Q6P996-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-32: Missing.
     54-80: Missing.

Show »
Length:760
Mass (Da):83,571
Checksum:i6127FC4820F4F1B3
GO
Isoform 5 (identifier: Q6P996-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-80: Missing.

Show »
Length:761
Mass (Da):83,728
Checksum:i2D97292195CDE8DE
GO

Sequence cautioni

The sequence AAH33748.1 differs from that shown. Reason: Frameshift at position 369. Curated
The sequence AAZ14099.1 differs from that shown. Reason: Frameshift at position 369. Curated
The sequence BAA19780.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371E → G in BAG61167 (PubMed:14702039).Curated
Sequence conflicti53 – 531G → V in AAZ14099 (Ref. 5) Curated
Sequence conflicti82 – 821I → M in BAG61167 (PubMed:14702039).Curated
Sequence conflicti82 – 821I → M in AAZ14099 (Ref. 5) Curated
Sequence conflicti114 – 1141T → A in AAZ14099 (Ref. 5) Curated
Sequence conflicti178 – 1781L → F in AAZ14099 (Ref. 5) Curated
Sequence conflicti373 – 3731K → E in AAH60871 (PubMed:15489334).Curated
Sequence conflicti749 – 7491T → A in BAG61675 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti301 – 3011P → L.1 Publication
Corresponds to variant rs4985162 [ dbSNP | Ensembl ].
VAR_059252

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1515Missing in isoform 3. 1 PublicationVSP_055731Add
BLAST
Alternative sequencei32 – 321Missing in isoform 4. 1 PublicationVSP_055732
Alternative sequencei54 – 12976Missing in isoform 3. 1 PublicationVSP_055733Add
BLAST
Alternative sequencei54 – 8027Missing in isoform 4 and isoform 5. 1 PublicationVSP_055734Add
BLAST
Alternative sequencei194 – 21623Missing in isoform 2. 1 PublicationVSP_027341Add
BLAST
Alternative sequencei432 – 45221LGEQL…MDLEA → VRMAVTPLSFQVPVHHHPTC W in isoform 2. 1 PublicationVSP_027342Add
BLAST
Alternative sequencei453 – 788336Missing in isoform 2. 1 PublicationVSP_027343Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87438 mRNA. Translation: BAA19780.1. Different initiation.
AK299799 mRNA. Translation: BAG61675.1.
AK299111 mRNA. Translation: BAG61167.1.
AC138932 Genomic DNA. No translation available.
AC139256 Genomic DNA. No translation available.
BC025366 mRNA. Translation: AAH25366.2.
BC033748 mRNA. Translation: AAH33748.1. Frameshift.
BC036520 mRNA. Translation: AAH36520.1.
BC042104 mRNA. Translation: AAH42104.2.
BC060871 mRNA. Translation: AAH60871.1.
DQ111782 mRNA. Translation: AAZ14099.1. Frameshift.
CCDSiCCDS32393.1. [Q6P996-1]
CCDS66954.1. [Q6P996-5]
CCDS66955.1. [Q6P996-4]
CCDS66957.1. [Q6P996-3]
CCDS73831.1. [Q6P996-2]
RefSeqiNP_001272373.1. NM_001285444.1. [Q6P996-5]
NP_001272374.1. NM_001285445.1. [Q6P996-4]
NP_001272376.1. NM_001285447.1.
NP_001272377.1. NM_001285448.1. [Q6P996-3]
NP_001272379.1. NM_001285450.1. [Q6P996-2]
NP_055842.2. NM_015027.3. [Q6P996-1]
XP_006725288.1. XM_006725225.1. [Q6P996-1]
XP_006725291.1. XM_006725228.1. [Q6P996-5]
XP_006726660.1. XM_006726597.1. [Q6P996-1]
XP_006726663.1. XM_006726600.1. [Q6P996-5]
UniGeneiHs.370781.

Genome annotation databases

EnsembliENST00000396410; ENSP00000379691; ENSG00000179889. [Q6P996-1]
ENST00000450288; ENSP00000391147; ENSG00000179889. [Q6P996-3]
ENST00000455313; ENSP00000406703; ENSG00000179889. [Q6P996-2]
ENST00000569715; ENSP00000455070; ENSG00000179889. [Q6P996-5]
ENST00000613798; ENSP00000481784; ENSG00000275498. [Q6P996-2]
ENST00000614573; ENSP00000479054; ENSG00000276709. [Q6P996-2]
ENST00000614833; ENSP00000480418; ENSG00000275498. [Q6P996-3]
ENST00000618389; ENSP00000484595; ENSG00000275498. [Q6P996-1]
ENST00000619589; ENSP00000478686; ENSG00000275498. [Q6P996-5]
ENST00000627450; ENSP00000486662; ENSG00000179889. [Q6P996-4]
ENST00000631842; ENSP00000488664; ENSG00000275498. [Q6P996-4]
GeneIDi102724985.
23042.
KEGGihsa:102724985.
hsa:23042.
UCSCiuc002dcz.5. human. [Q6P996-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87438 mRNA. Translation: BAA19780.1. Different initiation.
AK299799 mRNA. Translation: BAG61675.1.
AK299111 mRNA. Translation: BAG61167.1.
AC138932 Genomic DNA. No translation available.
AC139256 Genomic DNA. No translation available.
BC025366 mRNA. Translation: AAH25366.2.
BC033748 mRNA. Translation: AAH33748.1. Frameshift.
BC036520 mRNA. Translation: AAH36520.1.
BC042104 mRNA. Translation: AAH42104.2.
BC060871 mRNA. Translation: AAH60871.1.
DQ111782 mRNA. Translation: AAZ14099.1. Frameshift.
CCDSiCCDS32393.1. [Q6P996-1]
CCDS66954.1. [Q6P996-5]
CCDS66955.1. [Q6P996-4]
CCDS66957.1. [Q6P996-3]
CCDS73831.1. [Q6P996-2]
RefSeqiNP_001272373.1. NM_001285444.1. [Q6P996-5]
NP_001272374.1. NM_001285445.1. [Q6P996-4]
NP_001272376.1. NM_001285447.1.
NP_001272377.1. NM_001285448.1. [Q6P996-3]
NP_001272379.1. NM_001285450.1. [Q6P996-2]
NP_055842.2. NM_015027.3. [Q6P996-1]
XP_006725288.1. XM_006725225.1. [Q6P996-1]
XP_006725291.1. XM_006725228.1. [Q6P996-5]
XP_006726660.1. XM_006726597.1. [Q6P996-1]
XP_006726663.1. XM_006726600.1. [Q6P996-5]
UniGeneiHs.370781.

3D structure databases

ProteinModelPortaliQ6P996.
SMRiQ6P996. Positions 172-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116681. 39 interactions.
IntActiQ6P996. 4 interactions.
MINTiMINT-5003736.
STRINGi9606.ENSP00000379691.

PTM databases

iPTMnetiQ6P996.
PhosphoSiteiQ6P996.

Polymorphism and mutation databases

BioMutaiPDXDC1.
DMDMi156633546.

Proteomic databases

EPDiQ6P996.
MaxQBiQ6P996.
PaxDbiQ6P996.
PRIDEiQ6P996.

Protocols and materials databases

DNASUi23042.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000396410; ENSP00000379691; ENSG00000179889. [Q6P996-1]
ENST00000450288; ENSP00000391147; ENSG00000179889. [Q6P996-3]
ENST00000455313; ENSP00000406703; ENSG00000179889. [Q6P996-2]
ENST00000569715; ENSP00000455070; ENSG00000179889. [Q6P996-5]
ENST00000613798; ENSP00000481784; ENSG00000275498. [Q6P996-2]
ENST00000614573; ENSP00000479054; ENSG00000276709. [Q6P996-2]
ENST00000614833; ENSP00000480418; ENSG00000275498. [Q6P996-3]
ENST00000618389; ENSP00000484595; ENSG00000275498. [Q6P996-1]
ENST00000619589; ENSP00000478686; ENSG00000275498. [Q6P996-5]
ENST00000627450; ENSP00000486662; ENSG00000179889. [Q6P996-4]
ENST00000631842; ENSP00000488664; ENSG00000275498. [Q6P996-4]
GeneIDi102724985.
23042.
KEGGihsa:102724985.
hsa:23042.
UCSCiuc002dcz.5. human. [Q6P996-1]

Organism-specific databases

CTDi23042.
GeneCardsiPDXDC1.
H-InvDBHIX0013196.
HIX0019757.
HIX0173252.
HGNCiHGNC:28995. PDXDC1.
HPAiHPA047369.
HPA049121.
HPA051484.
MIMi614244. gene.
neXtProtiNX_Q6P996.
PharmGKBiPA162399182.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0630. Eukaryota.
ENOG410XYFU. LUCA.
GeneTreeiENSGT00390000009628.
HOGENOMiHOG000115485.
HOVERGENiHBG069100.
InParanoidiQ6P996.
OMAiMEAPGRA.
PhylomeDBiQ6P996.
TreeFamiTF313101.

Miscellaneous databases

ChiTaRSiPDXDC1. human.
PROiQ6P996.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P996.
CleanExiHS_PDXDC1.
ExpressionAtlasiQ6P996. baseline and differential.
GenevisibleiQ6P996. HS.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
    Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
    DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4), VARIANT LEU-301.
    Tissue: Brain and Teratocarcinoma.
  3. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Brain, Cervix, Lung, Placenta and Testis.
  5. Li H., Nong W., Zhou G., Ke R., Shen C., Zhong G., Zheng Z., Liang M., Wen S., Lin L., Yang S.
    Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-371 (ISOFORM 1).
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
    Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
    Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-691, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-757, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-652 AND SER-718, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  11. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-710, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-786, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiPDXD1_HUMAN
AccessioniPrimary (citable) accession number: Q6P996
Secondary accession number(s): B4DR55
, B4DSL3, E7EMH5, E7EPL4, H3BNZ1, O00236, Q4F6X7, Q6PID7, Q86YF1, Q8N4Q9, Q8TBS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: August 21, 2007
Last modified: June 8, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.