UniProtKB - Q6P995 (F171B_HUMAN)
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Protein
Protein FAM171B
Gene
FAM171B
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM171B |
Gene namesi | Name:FAM171B Synonyms:KIAA1946 ORF Names:NPD019 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000144369.12. |
HGNCi | HGNC:29412. FAM171B. |
neXtProti | NX_Q6P995. |
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 33 – 353 | ExtracellularSequence analysisAdd BLAST | 321 | |
Transmembranei | 354 – 374 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 375 – 826 | CytoplasmicSequence analysisAdd BLAST | 452 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000144369. |
PharmGKBi | PA162387220. |
Polymorphism and mutation databases
BioMutai | FAM171B. |
DMDMi | 313104238. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 32 | Sequence analysisAdd BLAST | 32 | |
ChainiPRO_0000287148 | 33 – 826 | Protein FAM171BAdd BLAST | 794 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 108 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 268 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 794 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q6P995. |
PaxDbi | Q6P995. |
PeptideAtlasi | Q6P995. |
PRIDEi | Q6P995. |
PTM databases
iPTMneti | Q6P995. |
PhosphoSitePlusi | Q6P995. |
Expressioni
Gene expression databases
Bgeei | ENSG00000144369. |
CleanExi | HS_FAM171B. |
ExpressionAtlasi | Q6P995. baseline and differential. |
Genevisiblei | Q6P995. HS. |
Organism-specific databases
HPAi | HPA010639. HPA013434. |
Interactioni
Protein-protein interaction databases
BioGridi | 127911. 16 interactors. |
IntActi | Q6P995. 3 interactors. |
STRINGi | 9606.ENSP00000304108. |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 43 – 58 | Gln-richAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the FAM171 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IEWE. Eukaryota. ENOG410YAPI. LUCA. |
GeneTreei | ENSGT00530000063318. |
HOVERGENi | HBG107876. |
InParanoidi | Q6P995. |
OMAi | QVRHSFI. |
OrthoDBi | EOG091G01Y7. |
PhylomeDBi | Q6P995. |
TreeFami | TF331338. |
Family and domain databases
InterProi | View protein in InterPro IPR018890. Uncharacterised_FAM171. |
PANTHERi | PTHR31626. PTHR31626. 1 hit. |
Pfami | View protein in Pfam PF10577. UPF0560. 2 hits. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6P995-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MARLCRRVPC TLLLGLAVVL LKARLVPAAA RAELSRSDLS LIQQQQQQQQ
60 70 80 90 100
QQQQQQKQLE EAEEERTEVP GATSTLTVPV SVFMLKVQVN DIISRQYLSQ
110 120 130 140 150
AVVEVFVNYT KTNSTVTKSN GAVLIKVPYK LGLSLTIIAY KDGYVLTPLP
160 170 180 190 200
WKTRRMPIYS SVTLSLFPQS QANIWLFEDT VLITGKLADA KSQPSVQFSK
210 220 230 240 250
ALIKLPDNHH ISNVTGYLTV LQQFLKVDNF LHTTGITLNK PGFENIELTP
260 270 280 290 300
LAAICVKIYS GGKELKVNGS IQVSLPLLRL NDISAGDRIP AWTFDMNTGA
310 320 330 340 350
WVNHGRGMVK EHNNHLIWTY DAPHLGYWIA APLPGTRGSG INEDSKDITA
360 370 380 390 400
YHTVFLTAIL GGTIVIVIGF FAVLLCYCRD KCGTPQKRER NITKLEVLKR
410 420 430 440 450
DQTTSTTHIN HISTVKVALK AEDKSQLFNA KNSSYSPQKK EPSKAETEER
460 470 480 490 500
VSMVKTRDDF KIYNEDVSFL SVNQNNYSRN PTQSLEPNVG SKQPKHINNN
510 520 530 540 550
LSSSLGDAQD EKRYLTGNEE AYGRSHIPEQ LMHIYSQPIA ILQTSDLFST
560 570 580 590 600
PEQLHTAKSA TLPRKGQLVY GQLMEPVNRE NFTQTLPKMP IHSHAQPPDA
610 620 630 640 650
REEDIILEGQ QSLPSQASDW SRYSSSLLES VSVPGTLNEA VVMTPFSSEL
660 670 680 690 700
QGISEQTLLE LSKGKPSPHP RAWFVSLDGK PVAQVRHSFI DLKKGKRTQS
710 720 730 740 750
NDTSLDSGVD MNELHSSRKL EREKTFIKSM HQPKILYLED LDLSSSESGT
760 770 780 790 800
TVCSPEDPAL RHILDGGSGV IMEHPGEESP GRKSTVEDFE ANTSPTKRRG
810 820
RPPLAKRDSK TNIWKKREER PLIPIN
Sequence cautioni
The sequence BAC04380 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC04586 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 42 | I → IQ in BAC03660 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 42 | I → IQQ in AAH60872 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 42 | I → IQQ in AAL57220 (Ref. 4) Curated | 1 | |
Sequence conflicti | 266 | K → R in AAL57220 (Ref. 4) Curated | 1 | |
Sequence conflicti | 689 | F → Y in BAC04380 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032269 | 302 | V → I1 PublicationCorresponds to variant dbSNP:rs17855085Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_040122 | 413 – 427 | STVKV…DKSQL → RNRRKSFHGKNSGRF in isoform 2. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_040123 | 428 – 826 | Missing in isoform 2. 1 PublicationAdd BLAST | 399 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK091423 mRNA. Translation: BAC03660.1. AK094578 mRNA. Translation: BAC04380.1. Different initiation. AK095604 mRNA. Translation: BAC04586.1. Different initiation. AC017101 Genomic DNA. Translation: AAY24258.1. BC060872 mRNA. Translation: AAH60872.1. AF361495 mRNA. Translation: AAL57220.1. Frameshift. AB075826 mRNA. Translation: BAB85532.1. AL834264 mRNA. Translation: CAD38939.1. |
CCDSi | CCDS33347.1. [Q6P995-1] |
RefSeqi | NP_803237.3. NM_177454.3. [Q6P995-1] |
UniGenei | Hs.28872. |
Genome annotation databases
Ensembli | ENST00000304698; ENSP00000304108; ENSG00000144369. [Q6P995-1] |
GeneIDi | 165215. |
KEGGi | hsa:165215. |
UCSCi | uc002upt.4. human. [Q6P995-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | F171B_HUMAN | |
Accessioni | Q6P995Primary (citable) accession number: Q6P995 Secondary accession number(s): Q53SK3 Q8WYR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 15, 2007 |
Last sequence update: | November 30, 2010 | |
Last modified: | February 28, 2018 | |
This is version 108 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |