FAM171B

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Protein FAM171B
Gene namesⁱ	Name:FAM171B Synonyms:KIAA1946 ORF Names:NPD019
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29412. FAM171B.

HGNCⁱ

HGNC:29412. FAM171B.

Subcellular locationⁱ

Membrane Curated; Single-pass type I membrane protein Curated

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	33 – 353	ExtracellularSequence analysisAdd BLAST	321
Transmembraneⁱ	354 – 374	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	375 – 826	CytoplasmicSequence analysisAdd BLAST	452

GO - Cellular componentⁱ

integral component of membrane Source: UniProtKB-KW

Complete GO annotation...

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000144369.
PharmGKBⁱ	PA162387220.

Polymorphism and mutation databases

BioMutaⁱ	FAM171B.
DMDMⁱ	313104238.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 32	Sequence analysisAdd BLAST		32
ChainⁱPRO_0000287148	33 – 826	Protein FAM171BAdd BLAST		794

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	108	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	113	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	213	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	268	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	794	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	Q6P995.
PaxDbⁱ	Q6P995.
PeptideAtlas More...PeptideAtlasⁱ	Q6P995.
PRIDEⁱ	Q6P995.

PTM databases

iPTMnetⁱ	Q6P995.
PhosphoSitePlusⁱ	Q6P995.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000144369.
CleanExⁱ	HS_FAM171B.
ExpressionAtlasⁱ	Q6P995. baseline and differential.
Genevisibleⁱ	Q6P995. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA010639. HPA013434.

HPAⁱ

HPA010639.
HPA013434.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127911. 13 interactors.
IntActⁱ	Q6P995. 3 interactors.
STRINGⁱ	9606.ENSP00000304108.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P995.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	43 – 58	Gln-richAdd BLAST		16

Sequence similaritiesⁱ

Belongs to the FAM171 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEWE. Eukaryota. ENOG410YAPI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063318.
HOVERGENⁱ	HBG107876.
InParanoidⁱ	Q6P995.
OMAⁱ	QVRHSFI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01Y7.
PhylomeDBⁱ	Q6P995.
TreeFamⁱ	TF331338.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018890. Uncharacterised_FAM171. IPR015943. WD40/YVTN_repeat-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10577. UPF0560. 2 hits.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q6P995-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARLCRRVPC TLLLGLAVVL LKARLVPAAA RAELSRSDLS LIQQQQQQQQ 
        60         70         80         90        100
QQQQQQKQLE EAEEERTEVP GATSTLTVPV SVFMLKVQVN DIISRQYLSQ 
       110        120        130        140        150
AVVEVFVNYT KTNSTVTKSN GAVLIKVPYK LGLSLTIIAY KDGYVLTPLP 
       160        170        180        190        200
WKTRRMPIYS SVTLSLFPQS QANIWLFEDT VLITGKLADA KSQPSVQFSK 
       210        220        230        240        250
ALIKLPDNHH ISNVTGYLTV LQQFLKVDNF LHTTGITLNK PGFENIELTP 
       260        270        280        290        300
LAAICVKIYS GGKELKVNGS IQVSLPLLRL NDISAGDRIP AWTFDMNTGA 
       310        320        330        340        350
WVNHGRGMVK EHNNHLIWTY DAPHLGYWIA APLPGTRGSG INEDSKDITA 
       360        370        380        390        400
YHTVFLTAIL GGTIVIVIGF FAVLLCYCRD KCGTPQKRER NITKLEVLKR 
       410        420        430        440        450
DQTTSTTHIN HISTVKVALK AEDKSQLFNA KNSSYSPQKK EPSKAETEER 
       460        470        480        490        500
VSMVKTRDDF KIYNEDVSFL SVNQNNYSRN PTQSLEPNVG SKQPKHINNN 
       510        520        530        540        550
LSSSLGDAQD EKRYLTGNEE AYGRSHIPEQ LMHIYSQPIA ILQTSDLFST 
       560        570        580        590        600
PEQLHTAKSA TLPRKGQLVY GQLMEPVNRE NFTQTLPKMP IHSHAQPPDA 
       610        620        630        640        650
REEDIILEGQ QSLPSQASDW SRYSSSLLES VSVPGTLNEA VVMTPFSSEL 
       660        670        680        690        700
QGISEQTLLE LSKGKPSPHP RAWFVSLDGK PVAQVRHSFI DLKKGKRTQS 
       710        720        730        740        750
NDTSLDSGVD MNELHSSRKL EREKTFIKSM HQPKILYLED LDLSSSESGT 
       760        770        780        790        800
TVCSPEDPAL RHILDGGSGV IMEHPGEESP GRKSTVEDFE ANTSPTKRRG 
       810        820 
RPPLAKRDSK TNIWKKREER PLIPIN

Length:826

Mass (Da):92,181

Last modified:November 30, 2010 - v3

Checksum:ⁱD79BF75EEFDAE9DE

GO

Isoform 2 (identifier: Q6P995-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
413-427: STVKVALKAEDKSQL → RNRRKSFHGKNSGRF
428-826: Missing.

« Hide

        10         20         30         40         50
MARLCRRVPC TLLLGLAVVL LKARLVPAAA RAELSRSDLS LIQQQQQQQQ 
        60         70         80         90        100
QQQQQQKQLE EAEEERTEVP GATSTLTVPV SVFMLKVQVN DIISRQYLSQ 
       110        120        130        140        150
AVVEVFVNYT KTNSTVTKSN GAVLIKVPYK LGLSLTIIAY KDGYVLTPLP 
       160        170        180        190        200
WKTRRMPIYS SVTLSLFPQS QANIWLFEDT VLITGKLADA KSQPSVQFSK 
       210        220        230        240        250
ALIKLPDNHH ISNVTGYLTV LQQFLKVDNF LHTTGITLNK PGFENIELTP 
       260        270        280        290        300
LAAICVKIYS GGKELKVNGS IQVSLPLLRL NDISAGDRIP AWTFDMNTGA 
       310        320        330        340        350
WVNHGRGMVK EHNNHLIWTY DAPHLGYWIA APLPGTRGSG INEDSKDITA 
       360        370        380        390        400
YHTVFLTAIL GGTIVIVIGF FAVLLCYCRD KCGTPQKRER NITKLEVLKR 
       410        420 
DQTTSTTHIN HIRNRRKSFH GKNSGRF

Show »

Length:427

Mass (Da):47,688

Checksum:ⁱ977A5161A80313F7

GO

Sequence cautionⁱ

The sequence AAL57220 differs from that shown. Reason: Frameshift at positions 235 and 262.Curated

The sequence BAC04380 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC04586 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	42	I → IQ in BAC03660 (PubMed:14702039).Curated	1
Sequence conflictⁱ	42	I → IQQ in AAH60872 (PubMed:15489334).Curated	1
Sequence conflictⁱ	42	I → IQQ in AAL57220 (Ref. 4) Curated	1
Sequence conflictⁱ	266	K → R in AAL57220 (Ref. 4) Curated	1
Sequence conflictⁱ	689	F → Y in BAC04380 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_032269	302	V → I1 PublicationCorresponds to variant dbSNP:rs17855085Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_040122	413 – 427	STVKV…DKSQL → RNRRKSFHGKNSGRF in isoform 2. 1 PublicationAdd BLAST		15
Alternative sequenceⁱVSP_040123	428 – 826	Missing in isoform 2. 1 PublicationAdd BLAST		399

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091423 mRNA. Translation: BAC03660.1. AK094578 mRNA. Translation: BAC04380.1. Different initiation. AK095604 mRNA. Translation: BAC04586.1. Different initiation. AC017101 Genomic DNA. Translation: AAY24258.1. BC060872 mRNA. Translation: AAH60872.1. AF361495 mRNA. Translation: AAL57220.1. Frameshift. AB075826 mRNA. Translation: BAB85532.1. AL834264 mRNA. Translation: CAD38939.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33347.1. [Q6P995-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_803237.3. NM_177454.3. [Q6P995-1]
UniGeneⁱ	Hs.28872.

Genome annotation databases

Ensemblⁱ	ENST00000304698; ENSP00000304108; ENSG00000144369. [Q6P995-1]
GeneIDⁱ	165215.
KEGGⁱ	hsa:165215.
UCSC genome browser More...UCSCⁱ	uc002upt.4. human. [Q6P995-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK091423 mRNA. Translation: BAC03660.1. AK094578 mRNA. Translation: BAC04380.1. Different initiation. AK095604 mRNA. Translation: BAC04586.1. Different initiation. AC017101 Genomic DNA. Translation: AAY24258.1. BC060872 mRNA. Translation: AAH60872.1. AF361495 mRNA. Translation: AAL57220.1. Frameshift. AB075826 mRNA. Translation: BAB85532.1. AL834264 mRNA. Translation: CAD38939.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33347.1. [Q6P995-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_803237.3. NM_177454.3. [Q6P995-1]
UniGeneⁱ	Hs.28872.

3D structure databases

ProteinModelPortalⁱ	Q6P995.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127911. 13 interactors.
IntActⁱ	Q6P995. 3 interactors.
STRINGⁱ	9606.ENSP00000304108.

PTM databases

iPTMnetⁱ	Q6P995.
PhosphoSitePlusⁱ	Q6P995.

Polymorphism and mutation databases

BioMutaⁱ	FAM171B.
DMDMⁱ	313104238.

Proteomic databases

EPDⁱ	Q6P995.
PaxDbⁱ	Q6P995.
PeptideAtlas More...PeptideAtlasⁱ	Q6P995.
PRIDEⁱ	Q6P995.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000304698; ENSP00000304108; ENSG00000144369. [Q6P995-1]
GeneIDⁱ	165215.
KEGGⁱ	hsa:165215.
UCSC genome browser More...UCSCⁱ	uc002upt.4. human. [Q6P995-1]

Organism-specific databases

CTDⁱ	165215.
GeneCardsⁱ	FAM171B.
H-InvDBⁱ	HIX0002658.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:29412. FAM171B.
Human Protein Atlas More...HPAⁱ	HPA010639. HPA013434.
neXtProtⁱ	NX_Q6P995.
Open Targets More...OpenTargetsⁱ	ENSG00000144369.
PharmGKBⁱ	PA162387220.
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEWE. Eukaryota. ENOG410YAPI. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063318.
HOVERGENⁱ	HBG107876.
InParanoidⁱ	Q6P995.
OMAⁱ	QVRHSFI.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01Y7.
PhylomeDBⁱ	Q6P995.
TreeFamⁱ	TF331338.

Miscellaneous databases

ChiTaRSⁱ	FAM171B. human.
GenomeRNAiⁱ	165215.
Protein Ontology More...PROⁱ	PR:Q6P995.

Gene expression databases

Bgeeⁱ	ENSG00000144369.
CleanExⁱ	HS_FAM171B.
ExpressionAtlasⁱ	Q6P995. baseline and differential.
Genevisibleⁱ	Q6P995. HS.

Family and domain databases

Gene3Dⁱ	2.130.10.10. 1 hit.
InterProⁱ	View protein in InterPro IPR018890. Uncharacterised_FAM171. IPR015943. WD40/YVTN_repeat-like_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF10577. UPF0560. 2 hits.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	F171B_HUMAN
Accessionⁱ	Q6P995Primary (citable) accession number: Q6P995 Secondary accession number(s): Q53SK3 Q8WYR8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
	Last sequence update:	November 30, 2010
	Last modified:	July 5, 2017
	This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6P995 (F171B_HUMAN)

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Protein FAM171B

Select a section on the left to see content.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ