Q6P988 (NOTUM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein notum homolog
EC=3.-.-.-

Gene names

Name:	NOTUM
ORF Names:	OK/SW-CL.30

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May deacetylate GlcNAc residues on cell surface glycans Potential. Ref.3
Subcellular location	Secreted By similarity.
Sequence similarities	Belongs to the pectinacetylesterase family.
Sequence caution	The sequence AAH36872.2 differs from that shown. Reason: Erroneous initiation. The sequence AAH60882.1 differs from that shown. Reason: Erroneous initiation. The sequence BAB93501.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 496	477	Protein notum homolog		PRO_0000318755
Sites
	Active site	232	1	Charge relay system By similarity
	Active site	340	1	Charge relay system By similarity
	Active site	389	1	Charge relay system By similarity
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	207	1	I → N in AAH36872. Ref.1
	Sequence conflict	244	1	R → L in AAH36872. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q6P988 [UniParc]. Last modified February 26, 2008. Version 2. Checksum: 00A7B3FB6436F544	FASTA	496	55,699
	10 20 30 40 50 60 MGRGVRVLLL LSLLHCAGGS EGRKTWRRRG QQPPPPPRTE AAPAAGQPVE SFPLDFTAVE 70 80 90 100 110 120 GNMDSFMAQV KSLAQSLYPC SAQQLNEDLR LHLLLNTSVT CNDGSPAGYY LKESRGSRRW 130 140 150 160 170 180 LLFLEGGWYC FNRENCDSRY DTMRRLMSSR DWPRTRTGTG ILSSQPEENP YWWNANMVFI 190 200 210 220 230 240 PYCSSDVWSG ASSKSEKNEY AFMGALIIQE VVRELLGRGL SGAKVLLLAG SSAGGTGVLL 250 260 270 280 290 300 NVDRVAEQLE KLGYPAIQVR GLADSGWFLD NKQYRHTDCV DTITCAPTEA IRRGIRYWNG 310 320 330 340 350 360 VVPERCRRQF QEGEEWNCFF GYKVYPTLRC PVFVVQWLFD EAQLTVDNVH LTGQPVQEGL 370 380 390 400 410 420 RLYIQNLGRE LRHTLKDVPA SFAPACLSHE IIIRSHWTDV QVKGTSLPRA LHCWDRSLHD 430 440 450 460 470 480 SHKASKTPLK GCPVHLVDSC PWPHCNPSCP TVRDQFTGQE MNVAQFLMHM GFDMQTVAQP 490 QGLEPSELLG MLSNGS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Placenta.
[2]	"Identification of immuno-peptidmics that recognized by tumor-reactive CTL generated from TIL of colon cancer patients." Shichijo S., Itoh K. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 102-496. Tissue: Colon adenocarcinoma.
[3]	"HSPG modification by the secreted enzyme Notum shapes the Wingless morphogen gradient." Giraldez A.J., Copley R.R., Cohen S.M. Dev. Cell 2:667-676(2002) [PubMed: 12015973] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC036872 mRNA. Translation: AAH36872.2. Different initiation. BC060882 mRNA. Translation: AAH60882.1. Different initiation. AB062438 mRNA. Translation: BAB93501.1. Different initiation.
IPI	IPI00465159.
RefSeq	NP_848588.3. NM_178493.5.
UniGene	Hs.106137.
3D structure databases
ProteinModelPortal	Q6P988.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6P988.
Polymorphism databases
DMDM	182628300.
Proteomic databases
PRIDE	Q6P988.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000409678; ENSP00000387310; ENSG00000185269.
GeneID	147111.
KEGG	hsa:147111.
NMPDR	fig|9606.3.peg.14596.
UCSC	uc002kcv.1. human.
Organism-specific databases
CTD	147111.
GeneCards	GC17M079910.
H-InvDB	HIX0039030.
HGNC	HGNC:27106. NOTUM.
HPA	HPA023041.
MIM	609847. gene.
neXtProt	NX_Q6P988.
PharmGKB	PA142671250.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14353.
GeneTree	ENSGT00390000015892.
HOGENOM	HBG446237.
HOVERGEN	HBG061551.
InParanoid	Q6P988.
OMA	KDVPASF.
OrthoDB	EOG4DV5M5.
PhylomeDB	Q6P988.
Gene expression databases
ArrayExpress	Q6P988.
Bgee	Q6P988.
CleanEx	HS_NOTUM.
Genevestigator	Q6P988.
Family and domain databases
ProtoNet	Search...
Other
NextBio	85545.
SOURCE	Search...

Entry information

Entry name

NOTUM_HUMAN

Accession

Primary (citable) accession number: Q6P988
Secondary accession number(s): Q8N410, Q8NI82

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 55 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.