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Protein

Superoxide dismutase

Gene

sod2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Divalent metal cationUniRule annotation1
Metal bindingi100Divalent metal cationUniRule annotation1
Metal bindingi185Divalent metal cationUniRule annotation1
Metal bindingi189Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: ZFIN
  • neutrophil homeostasis Source: ZFIN
  • removal of superoxide radicals Source: ZFIN
  • response to cadmium ion Source: ZFIN
  • response to methylmercury Source: ZFIN

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-2151201. Transcriptional activation of mitochondrial biogenesis.
R-DRE-3299685. Detoxification of Reactive Oxygen Species.

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sod2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-7742. sod2.

Expressioni

Gene expression databases

BgeeiENSDARG00000042644.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062555.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 108Sod_Fe_NInterPro annotationAdd BLAST82
Domaini115 – 218Sod_Fe_CInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0876. Eukaryota.
COG0605. LUCA.
GeneTreeiENSGT00390000011877.
HOVERGENiHBG004451.
KOiK04564.
OMAiKWGSFDK.
OrthoDBiEOG091G0MVL.
TreeFamiTF105132.

Family and domain databases

InterProiView protein in InterPro
IPR001189. Mn/Fe_SOD.
IPR019833. Mn/Fe_SOD_BS.
IPR019832. Mn/Fe_SOD_C.
IPR019831. Mn/Fe_SOD_N.
IPR036324. Mn/Fe_SOD_N_sf.
IPR036314. SOD_C_sf.
PfamiView protein in Pfam
PF02777. Sod_Fe_C. 1 hit.
PF00081. Sod_Fe_N. 1 hit.
PIRSFiPIRSF000349. SODismutase. 1 hit.
PRINTSiPR01703. MNSODISMTASE.
SUPFAMiSSF46609. SSF46609. 1 hit.
SSF54719. SSF54719. 1 hit.
PROSITEiView protein in PROSITE
PS00088. SOD_MN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCRVGYVRR CAATFNPLLG AVTSRQKHAL PDLTYDYGAL EPHICAEIMQ
60 70 80 90 100
LHHSKHHATY VNNLNVTEEK YQEALAKGDV TTQVSLQPAL KFNGGGHINH
110 120 130 140 150
TIFWTNLSPN GGGEPQGELL EAIKRDFGSF QKMKEKISAA TVAVQGSGWG
160 170 180 190 200
WLGFEKESGR LRIAACANQD PLQGTTGLIP LLGIDVWEHA YYLQYKNVRP
210 220
DYVKAIWNVV NWENVSERFQ AAKK
Length:224
Mass (Da):25,008
Last modified:July 5, 2004 - v1
Checksum:i7E184E4361F82066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929182 Genomic DNA. No translation available.
BC060895 mRNA. Translation: AAH60895.1.
RefSeqiNP_956270.1. NM_199976.1.
UniGeneiDr.6314.

Genome annotation databases

EnsembliENSDART00000062556; ENSDARP00000062555; ENSDARG00000042644.
GeneIDi335799.
KEGGidre:335799.

Similar proteinsi

Entry informationi

Entry nameiQ6P980_DANRE
AccessioniPrimary (citable) accession number: Q6P980
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 25, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported