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Protein

Superoxide dismutase

Gene

sod2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.UniRule annotation

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Divalent metal cationUniRule annotation1
Metal bindingi100Divalent metal cationUniRule annotation1
Metal bindingi185Divalent metal cationUniRule annotation1
Metal bindingi189Divalent metal cationUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • innate immune response Source: ZFIN
  • neutrophil homeostasis Source: ZFIN
  • removal of superoxide radicals Source: ZFIN
  • response to cadmium ion Source: ZFIN
  • response to methylmercury Source: ZFIN

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandMetal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-2151201 Transcriptional activation of mitochondrial biogenesis
R-DRE-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutaseUniRule annotation (EC:1.15.1.1UniRule annotation)
Gene namesi
Name:sod2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-030131-7742 sod2

Expressioni

Gene expression databases

BgeeiENSDARG00000042644

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000062555

Structurei

3D structure databases

SMRiQ6P980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 108Sod_Fe_NInterPro annotationAdd BLAST82
Domaini115 – 218Sod_Fe_CInterPro annotationAdd BLAST104

Sequence similaritiesi

Belongs to the iron/manganese superoxide dismutase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
GeneTreeiENSGT00390000011877
HOVERGENiHBG004451
KOiK04564
OMAiKWGSFDK
OrthoDBiEOG091G0MVL
TreeFamiTF105132

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCRVGYVRR CAATFNPLLG AVTSRQKHAL PDLTYDYGAL EPHICAEIMQ
60 70 80 90 100
LHHSKHHATY VNNLNVTEEK YQEALAKGDV TTQVSLQPAL KFNGGGHINH
110 120 130 140 150
TIFWTNLSPN GGGEPQGELL EAIKRDFGSF QKMKEKISAA TVAVQGSGWG
160 170 180 190 200
WLGFEKESGR LRIAACANQD PLQGTTGLIP LLGIDVWEHA YYLQYKNVRP
210 220
DYVKAIWNVV NWENVSERFQ AAKK
Length:224
Mass (Da):25,008
Last modified:July 5, 2004 - v1
Checksum:i7E184E4361F82066
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL929182 Genomic DNA No translation available.
BC060895 mRNA Translation: AAH60895.1
RefSeqiNP_956270.1, NM_199976.1
UniGeneiDr.6314

Genome annotation databases

EnsembliENSDART00000062556; ENSDARP00000062555; ENSDARG00000042644
GeneIDi335799
KEGGidre:335799

Similar proteinsi

Entry informationi

Entry nameiQ6P980_DANRE
AccessioniPrimary (citable) accession number: Q6P980
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 25, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health