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Q6P902

- TXND2_MOUSE

UniProt

Q6P902 - TXND2_MOUSE

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Protein

Thioredoxin domain-containing protein 2

Gene
Txndc2, Sptrx, Sptrx1, Trx4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

GO - Molecular functioni

  1. protein disulfide isomerase activity Source: MGI
  2. protein disulfide oxidoreductase activity Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. cell redox homeostasis Source: InterPro
  3. glycerol ether metabolic process Source: InterPro
  4. multicellular organismal development Source: UniProtKB-KW
  5. protein folding Source: GOC
  6. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin domain-containing protein 2
Alternative name(s):
Spermatid-specific thioredoxin-1
Short name:
Sptrx-1
Thioredoxin-4
Gene namesi
Name:Txndc2
Synonyms:Sptrx, Sptrx1, Trx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2389312. Txndc2.

Subcellular locationi

GO - Cellular componenti

  1. motile cilium Source: MGI
  2. nucleolus Source: Ensembl
  3. outer dense fiber Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 515515Thioredoxin domain-containing protein 2PRO_0000120154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi442 ↔ 445Redox-active By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6P902.
PRIDEiQ6P902.

PTM databases

PhosphoSiteiQ6P902.

Expressioni

Tissue specificityi

Testis-specific. Strongly expressed in the testicular seminiferous tubules, mostly in the round spermatids.2 Publications

Developmental stagei

Expressed during spermiogenesis, restricted to the postmeiotic phase of spermatogenesis. First detected in elongating spermatids tails during steps 9 and 10 and is prominent in this region during steps 11-16. Also weakly present in the cytoplasmic lobe of these spermatids. During the last steps of spermiogenesis (steps 17-19), it strongly diminishes in the tail but appears to increase or become concentrated in the shrinking cytoplasmic lobe. By the last step of spermiogenesis (late step 19), cytoplasmic localization is barely detectable in the resulting residual body but still detectable in the cytoplasmic droplet (at protein level). Detected in testis of pre-pubertal animals at very low level.2 Publications

Gene expression databases

BgeeiQ6P902.
CleanExiMM_TXNDC2.
GenevestigatoriQ6P902.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054909.

Structurei

3D structure databases

ProteinModelPortaliQ6P902.
SMRiQ6P902. Positions 411-514.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati92 – 106151Add
BLAST
Repeati107 – 121152Add
BLAST
Repeati122 – 136153Add
BLAST
Repeati137 – 151154Add
BLAST
Repeati152 – 166155Add
BLAST
Repeati167 – 181156Add
BLAST
Repeati182 – 196157Add
BLAST
Repeati197 – 211158Add
BLAST
Repeati212 – 226159Add
BLAST
Repeati227 – 2411510Add
BLAST
Repeati242 – 2561511Add
BLAST
Repeati257 – 2711512Add
BLAST
Repeati272 – 2861513Add
BLAST
Repeati287 – 3011514Add
BLAST
Repeati302 – 3161515Add
BLAST
Repeati317 – 3311516Add
BLAST
Repeati332 – 3461517Add
BLAST
Repeati347 – 3621618Add
BLAST
Repeati363 – 3751319Add
BLAST
Repeati376 – 3901520Add
BLAST
Repeati391 – 4051521Add
BLAST
Domaini398 – 515118ThioredoxinAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni92 – 40531421 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-IAdd
BLAST

Sequence similaritiesi

Contains 1 thioredoxin domain.

Keywords - Domaini

Redox-active center, Repeat

Phylogenomic databases

eggNOGiCOG0526.
HOGENOMiHOG000154719.
HOVERGENiHBG087115.
InParanoidiQ6P902.
PhylomeDBiQ6P902.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P902-1 [UniParc]FASTAAdd to Basket

« Hide

MTLNNGGKAN ERGSNENPLQ ALSKNEAFLV PEFLDTAQSK EKAIASKVSN    50
TLHMSTEESE FPQQVSSTPM FSENTVHPRH EVSPKPSSKN TQLKQENISK 100
SSGYSKQTNY SNTPKSLAKT THPKQGSTLK PATNSTHYRE DDIPKSSEDI 150
IQPKKGDRPK SSEDIIQSKK EDRPKSSEDI IQSKKEDRPK SSEDIIQSKK 200
EDRPKSSEDI IQSKKEDRPK SSEDIIQPKK EDRPKSSEDS VPSKKGDRPK 250
SSEDSVQPKK EDRPKSSEDS VQSKEGEVHK PLKDSIQSKE TKVPKSPQDS 300
IQSKEDKTHR PLKDSVQSKE SEEPKSSHES IQSKEDKIHK PLKDSIPSKE 350
GDIPKSPEDT IQSQEEITAS EEDTIQSQEG NTIKSSEEDV QLSESKLLGL 400
GAEIETLEEG LVRVIKDKEE FEEVLKDAGE KLVAVDFSAA WCGPCRMMKP 450
LFHSLSLKHE DVIFLEVDTE DCEQLVQDCE IFHLPTFQFY KNEEKVGEFS 500
GALVGKLERS ISELK 515
Length:515
Mass (Da):57,767
Last modified:July 5, 2004 - v1
Checksum:i46F178558C27A71A
GO

Sequence cautioni

The sequence AAM94687.2 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF196282 mRNA. Translation: AAM94687.2. Different initiation.
BC060981 mRNA. Translation: AAH60981.1.
RefSeqiNP_001139474.1. NM_001146002.1.
NP_705739.2. NM_153519.2.
UniGeneiMm.255732.

Genome annotation databases

GeneIDi213272.
KEGGimmu:213272.
UCSCiuc008dge.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF196282 mRNA. Translation: AAM94687.2 . Different initiation.
BC060981 mRNA. Translation: AAH60981.1 .
RefSeqi NP_001139474.1. NM_001146002.1.
NP_705739.2. NM_153519.2.
UniGenei Mm.255732.

3D structure databases

ProteinModelPortali Q6P902.
SMRi Q6P902. Positions 411-514.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000054909.

PTM databases

PhosphoSitei Q6P902.

Proteomic databases

PaxDbi Q6P902.
PRIDEi Q6P902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 213272.
KEGGi mmu:213272.
UCSCi uc008dge.2. mouse.

Organism-specific databases

CTDi 84203.
MGIi MGI:2389312. Txndc2.

Phylogenomic databases

eggNOGi COG0526.
HOGENOMi HOG000154719.
HOVERGENi HBG087115.
InParanoidi Q6P902.
PhylomeDBi Q6P902.

Miscellaneous databases

NextBioi 373905.
PROi Q6P902.
SOURCEi Search...

Gene expression databases

Bgeei Q6P902.
CleanExi MM_TXNDC2.
Genevestigatori Q6P902.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view ]
PANTHERi PTHR10438. PTHR10438. 1 hit.
Pfami PF00085. Thioredoxin. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein."
    Jimenez A., Oko R., Gustafsson J.-A., Spyrou G., Pelto-Huikko M., Miranda-Vizuete A.
    Mol. Hum. Reprod. 8:710-718(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ENZYME ACTIVITY IN VITRO.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  3. "Developmental expression of spermatid-specific thioredoxin-1 protein: transient association to the longitudinal columns of the fibrous sheath during sperm tail formation."
    Yu Y., Oko R., Miranda-Vizuete A.
    Biol. Reprod. 67:1546-1554(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  4. "Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins."
    Jimenez A., Prieto-Alamo M.J., Fuentes-Almagro C.A., Jurado J., Gustafsson J.-A., Pueyo C., Miranda-Vizuete A.
    Biochem. Biophys. Res. Commun. 330:65-74(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiTXND2_MOUSE
AccessioniPrimary (citable) accession number: Q6P902
Secondary accession number(s): Q8CJD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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