Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P902

- TXND2_MOUSE

UniProt

Q6P902 - TXND2_MOUSE

Protein

Thioredoxin domain-containing protein 2

Gene

Txndc2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

    GO - Molecular functioni

    1. protein disulfide isomerase activity Source: MGI
    2. protein disulfide oxidoreductase activity Source: InterPro

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. cell redox homeostasis Source: InterPro
    3. glycerol ether metabolic process Source: InterPro
    4. multicellular organismal development Source: UniProtKB-KW
    5. protein folding Source: GOC
    6. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thioredoxin domain-containing protein 2
    Alternative name(s):
    Spermatid-specific thioredoxin-1
    Short name:
    Sptrx-1
    Thioredoxin-4
    Gene namesi
    Name:Txndc2
    Synonyms:Sptrx, Sptrx1, Trx4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:2389312. Txndc2.

    Subcellular locationi

    GO - Cellular componenti

    1. motile cilium Source: MGI
    2. nucleolus Source: Ensembl
    3. outer dense fiber Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 515515Thioredoxin domain-containing protein 2PRO_0000120154Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi442 ↔ 445Redox-activePROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ6P902.
    PRIDEiQ6P902.

    PTM databases

    PhosphoSiteiQ6P902.

    Expressioni

    Tissue specificityi

    Testis-specific. Strongly expressed in the testicular seminiferous tubules, mostly in the round spermatids.2 Publications

    Developmental stagei

    Expressed during spermiogenesis, restricted to the postmeiotic phase of spermatogenesis. First detected in elongating spermatids tails during steps 9 and 10 and is prominent in this region during steps 11-16. Also weakly present in the cytoplasmic lobe of these spermatids. During the last steps of spermiogenesis (steps 17-19), it strongly diminishes in the tail but appears to increase or become concentrated in the shrinking cytoplasmic lobe. By the last step of spermiogenesis (late step 19), cytoplasmic localization is barely detectable in the resulting residual body but still detectable in the cytoplasmic droplet (at protein level). Detected in testis of pre-pubertal animals at very low level.2 Publications

    Gene expression databases

    BgeeiQ6P902.
    CleanExiMM_TXNDC2.
    GenevestigatoriQ6P902.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000054909.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P902.
    SMRiQ6P902. Positions 411-514.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati92 – 106151Add
    BLAST
    Repeati107 – 121152Add
    BLAST
    Repeati122 – 136153Add
    BLAST
    Repeati137 – 151154Add
    BLAST
    Repeati152 – 166155Add
    BLAST
    Repeati167 – 181156Add
    BLAST
    Repeati182 – 196157Add
    BLAST
    Repeati197 – 211158Add
    BLAST
    Repeati212 – 226159Add
    BLAST
    Repeati227 – 2411510Add
    BLAST
    Repeati242 – 2561511Add
    BLAST
    Repeati257 – 2711512Add
    BLAST
    Repeati272 – 2861513Add
    BLAST
    Repeati287 – 3011514Add
    BLAST
    Repeati302 – 3161515Add
    BLAST
    Repeati317 – 3311516Add
    BLAST
    Repeati332 – 3461517Add
    BLAST
    Repeati347 – 3621618Add
    BLAST
    Repeati363 – 3751319Add
    BLAST
    Repeati376 – 3901520Add
    BLAST
    Repeati391 – 4051521Add
    BLAST
    Domaini398 – 515118ThioredoxinPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni92 – 40531421 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-IAdd
    BLAST

    Sequence similaritiesi

    Contains 1 thioredoxin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Redox-active center, Repeat

    Phylogenomic databases

    eggNOGiCOG0526.
    HOGENOMiHOG000154719.
    HOVERGENiHBG087115.
    InParanoidiQ6P902.
    PhylomeDBiQ6P902.

    Family and domain databases

    Gene3Di3.40.30.10. 1 hit.
    InterProiIPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view]
    PANTHERiPTHR10438. PTHR10438. 1 hit.
    PfamiPF00085. Thioredoxin. 1 hit.
    [Graphical view]
    SUPFAMiSSF52833. SSF52833. 1 hit.
    PROSITEiPS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P902-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLNNGGKAN ERGSNENPLQ ALSKNEAFLV PEFLDTAQSK EKAIASKVSN    50
    TLHMSTEESE FPQQVSSTPM FSENTVHPRH EVSPKPSSKN TQLKQENISK 100
    SSGYSKQTNY SNTPKSLAKT THPKQGSTLK PATNSTHYRE DDIPKSSEDI 150
    IQPKKGDRPK SSEDIIQSKK EDRPKSSEDI IQSKKEDRPK SSEDIIQSKK 200
    EDRPKSSEDI IQSKKEDRPK SSEDIIQPKK EDRPKSSEDS VPSKKGDRPK 250
    SSEDSVQPKK EDRPKSSEDS VQSKEGEVHK PLKDSIQSKE TKVPKSPQDS 300
    IQSKEDKTHR PLKDSVQSKE SEEPKSSHES IQSKEDKIHK PLKDSIPSKE 350
    GDIPKSPEDT IQSQEEITAS EEDTIQSQEG NTIKSSEEDV QLSESKLLGL 400
    GAEIETLEEG LVRVIKDKEE FEEVLKDAGE KLVAVDFSAA WCGPCRMMKP 450
    LFHSLSLKHE DVIFLEVDTE DCEQLVQDCE IFHLPTFQFY KNEEKVGEFS 500
    GALVGKLERS ISELK 515
    Length:515
    Mass (Da):57,767
    Last modified:July 5, 2004 - v1
    Checksum:i46F178558C27A71A
    GO

    Sequence cautioni

    The sequence AAM94687.2 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF196282 mRNA. Translation: AAM94687.2. Different initiation.
    BC060981 mRNA. Translation: AAH60981.1.
    RefSeqiNP_001139474.1. NM_001146002.1.
    NP_705739.2. NM_153519.2.
    UniGeneiMm.255732.

    Genome annotation databases

    GeneIDi213272.
    KEGGimmu:213272.
    UCSCiuc008dge.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF196282 mRNA. Translation: AAM94687.2 . Different initiation.
    BC060981 mRNA. Translation: AAH60981.1 .
    RefSeqi NP_001139474.1. NM_001146002.1.
    NP_705739.2. NM_153519.2.
    UniGenei Mm.255732.

    3D structure databases

    ProteinModelPortali Q6P902.
    SMRi Q6P902. Positions 411-514.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000054909.

    PTM databases

    PhosphoSitei Q6P902.

    Proteomic databases

    PaxDbi Q6P902.
    PRIDEi Q6P902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 213272.
    KEGGi mmu:213272.
    UCSCi uc008dge.2. mouse.

    Organism-specific databases

    CTDi 84203.
    MGIi MGI:2389312. Txndc2.

    Phylogenomic databases

    eggNOGi COG0526.
    HOGENOMi HOG000154719.
    HOVERGENi HBG087115.
    InParanoidi Q6P902.
    PhylomeDBi Q6P902.

    Miscellaneous databases

    NextBioi 373905.
    PROi Q6P902.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P902.
    CleanExi MM_TXNDC2.
    Genevestigatori Q6P902.

    Family and domain databases

    Gene3Di 3.40.30.10. 1 hit.
    InterProi IPR005746. Thioredoxin.
    IPR012336. Thioredoxin-like_fold.
    IPR013766. Thioredoxin_domain.
    [Graphical view ]
    PANTHERi PTHR10438. PTHR10438. 1 hit.
    Pfami PF00085. Thioredoxin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52833. SSF52833. 1 hit.
    PROSITEi PS51352. THIOREDOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein."
      Jimenez A., Oko R., Gustafsson J.-A., Spyrou G., Pelto-Huikko M., Miranda-Vizuete A.
      Mol. Hum. Reprod. 8:710-718(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ENZYME ACTIVITY IN VITRO.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    3. "Developmental expression of spermatid-specific thioredoxin-1 protein: transient association to the longitudinal columns of the fibrous sheath during sperm tail formation."
      Yu Y., Oko R., Miranda-Vizuete A.
      Biol. Reprod. 67:1546-1554(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    4. "Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins."
      Jimenez A., Prieto-Alamo M.J., Fuentes-Almagro C.A., Jurado J., Gustafsson J.-A., Pueyo C., Miranda-Vizuete A.
      Biochem. Biophys. Res. Commun. 330:65-74(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTXND2_MOUSE
    AccessioniPrimary (citable) accession number: Q6P902
    Secondary accession number(s): Q8CJD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 5, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3