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Q6P902 (TXND2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thioredoxin domain-containing protein 2
Alternative name(s):
Spermatid-specific thioredoxin-1
Short name=Sptrx-1
Thioredoxin-4
Gene names
Name:Txndc2
Synonyms:Sptrx, Sptrx1, Trx4
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length515 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Probably plays a regulatory role in sperm development. May participate in regulation of fibrous sheath (FS) assembly by supporting the formation of disulfide bonds during sperm tail morphogenesis. May also be required to rectify incorrect disulfide pairing and generate suitable pairs between the FS constituents. Can reduce disulfide bonds in vitro in the presence of NADP and thioredoxin reductase.

Subcellular location

Cytoplasm.

Tissue specificity

Testis-specific. Strongly expressed in the testicular seminiferous tubules, mostly in the round spermatids. Ref.1 Ref.3

Developmental stage

Expressed during spermiogenesis, restricted to the postmeiotic phase of spermatogenesis. First detected in elongating spermatids tails during steps 9 and 10 and is prominent in this region during steps 11-16. Also weakly present in the cytoplasmic lobe of these spermatids. During the last steps of spermiogenesis (steps 17-19), it strongly diminishes in the tail but appears to increase or become concentrated in the shrinking cytoplasmic lobe. By the last step of spermiogenesis (late step 19), cytoplasmic localization is barely detectable in the resulting residual body but still detectable in the cytoplasmic droplet (at protein level). Detected in testis of pre-pubertal animals at very low level. Ref.3 Ref.4

Sequence similarities

Contains 1 thioredoxin domain.

Sequence caution

The sequence AAM94687.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 515515Thioredoxin domain-containing protein 2
PRO_0000120154

Regions

Repeat92 – 106151
Repeat107 – 121152
Repeat122 – 136153
Repeat137 – 151154
Repeat152 – 166155
Repeat167 – 181156
Repeat182 – 196157
Repeat197 – 211158
Repeat212 – 226159
Repeat227 – 2411510
Repeat242 – 2561511
Repeat257 – 2711512
Repeat272 – 2861513
Repeat287 – 3011514
Repeat302 – 3161515
Repeat317 – 3311516
Repeat332 – 3461517
Repeat347 – 3621618
Repeat363 – 3751319
Repeat376 – 3901520
Repeat391 – 4051521
Domain398 – 515118Thioredoxin
Region92 – 40531421 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I

Amino acid modifications

Disulfide bond442 ↔ 445Redox-active By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6P902 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 46F178558C27A71A

FASTA51557,767
        10         20         30         40         50         60 
MTLNNGGKAN ERGSNENPLQ ALSKNEAFLV PEFLDTAQSK EKAIASKVSN TLHMSTEESE 

        70         80         90        100        110        120 
FPQQVSSTPM FSENTVHPRH EVSPKPSSKN TQLKQENISK SSGYSKQTNY SNTPKSLAKT 

       130        140        150        160        170        180 
THPKQGSTLK PATNSTHYRE DDIPKSSEDI IQPKKGDRPK SSEDIIQSKK EDRPKSSEDI 

       190        200        210        220        230        240 
IQSKKEDRPK SSEDIIQSKK EDRPKSSEDI IQSKKEDRPK SSEDIIQPKK EDRPKSSEDS 

       250        260        270        280        290        300 
VPSKKGDRPK SSEDSVQPKK EDRPKSSEDS VQSKEGEVHK PLKDSIQSKE TKVPKSPQDS 

       310        320        330        340        350        360 
IQSKEDKTHR PLKDSVQSKE SEEPKSSHES IQSKEDKIHK PLKDSIPSKE GDIPKSPEDT 

       370        380        390        400        410        420 
IQSQEEITAS EEDTIQSQEG NTIKSSEEDV QLSESKLLGL GAEIETLEEG LVRVIKDKEE 

       430        440        450        460        470        480 
FEEVLKDAGE KLVAVDFSAA WCGPCRMMKP LFHSLSLKHE DVIFLEVDTE DCEQLVQDCE 

       490        500        510 
IFHLPTFQFY KNEEKVGEFS GALVGKLERS ISELK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning, expression and characterization of mouse spermatid specific thioredoxin-1 gene and protein."
Jimenez A., Oko R., Gustafsson J.-A., Spyrou G., Pelto-Huikko M., Miranda-Vizuete A.
Mol. Hum. Reprod. 8:710-718(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, ENZYME ACTIVITY IN VITRO.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[3]"Developmental expression of spermatid-specific thioredoxin-1 protein: transient association to the longitudinal columns of the fibrous sheath during sperm tail formation."
Yu Y., Oko R., Miranda-Vizuete A.
Biol. Reprod. 67:1546-1554(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[4]"Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins."
Jimenez A., Prieto-Alamo M.J., Fuentes-Almagro C.A., Jurado J., Gustafsson J.-A., Pueyo C., Miranda-Vizuete A.
Biochem. Biophys. Res. Commun. 330:65-74(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF196282 mRNA. Translation: AAM94687.2. Different initiation.
BC060981 mRNA. Translation: AAH60981.1.
RefSeqNP_001139474.1. NM_001146002.1.
NP_705739.2. NM_153519.2.
UniGeneMm.255732.

3D structure databases

ProteinModelPortalQ6P902.
SMRQ6P902. Positions 411-514.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000054909.

PTM databases

PhosphoSiteQ6P902.

Proteomic databases

PaxDbQ6P902.
PRIDEQ6P902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID213272.
KEGGmmu:213272.
UCSCuc008dge.2. mouse.

Organism-specific databases

CTD84203.
MGIMGI:2389312. Txndc2.

Phylogenomic databases

eggNOGCOG0526.
HOGENOMHOG000154719.
HOVERGENHBG087115.
InParanoidQ6P902.
PhylomeDBQ6P902.

Gene expression databases

BgeeQ6P902.
CleanExMM_TXNDC2.
GenevestigatorQ6P902.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERPTHR10438. PTHR10438. 1 hit.
PfamPF00085. Thioredoxin. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio373905.
PROQ6P902.
SOURCESearch...

Entry information

Entry nameTXND2_MOUSE
AccessionPrimary (citable) accession number: Q6P902
Secondary accession number(s): Q8CJD1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot