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Protein

Protein B-Myc

Gene

Mycb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Seems to act as an inhibitor of cellular proliferation.1 Publication

GO - Molecular functioni

Enzyme and pathway databases

ReactomeiR-MMU-5689880. Ub-specific processing proteases.
R-MMU-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein B-Myc
Gene namesi
Name:Mycb
Synonyms:Bmyc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:88184. Bmyc.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi60S → A: Loss of phosphorylation. 1 Publication1
Mutagenesisi68S → A: Loss of phosphorylation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001273391 – 170Protein B-MycAdd BLAST170

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60Phosphoserine1 Publication1
Modified residuei68Phosphoserine1 Publication1

Post-translational modificationi

Rapidly degraded via the ubiquitin-proteasome pathway.

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P8Z1.
PRIDEiQ6P8Z1.

PTM databases

iPTMnetiQ6P8Z1.
PhosphoSitePlusiQ6P8Z1.

Expressioni

Tissue specificityi

Highly expressed in epididymis. Also expressed in hypothalamus, pituitary, uterus and ovary. Low expression in testis. Not detected in heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000049086.
CleanExiMM_BMYC.
ExpressionAtlasiQ6P8Z1. baseline and differential.
GenevisibleiQ6P8Z1. MM.

Interactioni

Protein-protein interaction databases

IntActiQ6P8Z1. 3 interactors.
MINTiMINT-217103.
STRINGi10090.ENSMUSP00000097885.

Structurei

3D structure databases

DisProtiDP00564.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00510000046414.
HOGENOMiHOG000041253.
HOVERGENiHBG079592.
InParanoidiQ6P8Z1.
KOiK09111.
OMAiWNGFSAS.
OrthoDBiEOG091G0ZJQ.
PhylomeDBiQ6P8Z1.

Family and domain databases

InterProiView protein in InterPro
IPR002418. Tscrpt_reg_Myc.
IPR012682. Tscrpt_reg_Myc_N.
PfamiView protein in Pfam
PF01056. Myc_N. 1 hit.
PRINTSiPR00044. LEUZIPPRMYC.

Sequencei

Sequence statusi: Complete.

Q6P8Z1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLHVSLANG NRDLDYDSVQ PYFMCDDEEE DVHHQQPPQP PAPSEDIWKK
60 70 80 90 100
FELLPTPRPS PGHAGLYSPP CEAVAVSFAP RDHDGDSFSI ADLPELPGGD
110 120 130 140 150
AVKQSFVCDP DDETFVKNII LQDCMWNGFS ASAKLVSKLD PYQAVRKEGT
160 170
GVSLAADVEP ATPPDCTCNT
Length:170
Mass (Da):18,526
Last modified:July 5, 2004 - v1
Checksum:iEF3BD10DD793C2D4
GO

Sequence cautioni

The sequence BAB28992 differs from that shown. Reason: Frameshift at position 161.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012810 mRNA. Translation: BAE43234.1.
AK013780 mRNA. Translation: BAB28992.1. Frameshift.
AK158603 mRNA. Translation: BAE34577.1.
BC061001 mRNA. Translation: AAH61001.1.
CCDSiCCDS15789.1.
RefSeqiNP_075815.2. NM_023326.2.
UniGeneiMm.330057.

Genome annotation databases

EnsembliENSMUST00000061483; ENSMUSP00000097885; ENSMUSG00000049086.
GeneIDi107771.
KEGGimmu:107771.
UCSCiuc008itg.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiMYCB_MOUSE
AccessioniPrimary (citable) accession number: Q6P8Z1
Secondary accession number(s): Q9D6E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot