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Protein

Sorting nexin-31

Gene

Snx31

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in protein trafficking.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-31
Gene namesi
Name:Snx31
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1913946. Snx31.

Subcellular locationi

GO - Cellular componenti

  • early endosome Source: GO_Central
  • protein complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316041 – 439Sorting nexin-31Add BLAST439

Proteomic databases

PaxDbiQ6P8Y7.
PRIDEiQ6P8Y7.

PTM databases

PhosphoSitePlusiQ6P8Y7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000013611.
ExpressionAtlasiQ6P8Y7. baseline and differential.
GenevisibleiQ6P8Y7. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Upk3aQ9JKX84EBI-10636102,EBI-7947322

Protein-protein interaction databases

DIPiDIP-60339N.
IntActiQ6P8Y7. 2 interactors.
STRINGi10090.ENSMUSP00000013755.

Structurei

3D structure databases

ProteinModelPortaliQ6P8Y7.
SMRiQ6P8Y7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 109PXPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ6P8Y7.
KOiK17937.
OMAiRVKCWQV.
OrthoDBiEOG091G0BES.
PhylomeDBiQ6P8Y7.
TreeFamiTF318398.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6P8Y7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKMHFCIPVS QQRPDALGGR YVLYSVYLDG FLFCKVRYSQ LHRWDEQLRR
60 70 80 90 100
VFGNCLPPFP PKYYLAMTTA MAEERRDQLE RYLQNVTADP RVTRSDVFTE
110 120 130 140 150
FLTLVQLHTL NITIQNVELA VFLPDGRSIK VEGLTSDTAE RVLEVMAHKL
160 170 180 190 200
GLQPDLVGYF GLFLIQCFPE GKLSVVKKLA DFELPYTSLQ SSEMENCKIG
210 220 230 240 250
LRKWYLDPAL DSMLMDCRAA GDLLYMQAVQ DIEKEWMKPT QAQREELKAL
260 270 280 290 300
QKKENQTKFL ELSQEVRHYG YVQLDPCTCN HPEPGCGAQL SIGNNEISCC
310 320 330 340 350
ITLPNGQIQD IAFQMSRVKC WQVTFLGTLL DTDGPQRTLN QNLELRFQYS
360 370 380 390 400
EDSCQQWFVI YTKQAFFLSS CLKKMISERM TKLTEQSPEM QIEVPEQGRS
410 420 430
KKHPSQPSQQ KVYFNFLRKG KMKRSEGDYV WDTLMEEGL
Length:439
Mass (Da):50,862
Last modified:July 5, 2004 - v1
Checksum:i7EBA127EF76BE397
GO
Isoform 2 (identifier: Q6P8Y7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     410-410: Missing.

Note: No experimental confirmation available.
Show »
Length:438
Mass (Da):50,733
Checksum:i5A31734CF6503393
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288A → S in BAB29419 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033263410Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014536 mRNA. Translation: BAB29419.2.
AK034196 mRNA. Translation: BAC28627.1.
AK035226 mRNA. Translation: BAC28987.1.
BC061007 mRNA. Translation: AAH61007.1.
CCDSiCCDS27430.1. [Q6P8Y7-2]
RefSeqiNP_079988.3. NM_025712.4. [Q6P8Y7-2]
XP_006520208.1. XM_006520145.3. [Q6P8Y7-1]
UniGeneiMm.253627.

Genome annotation databases

EnsembliENSMUST00000013755; ENSMUSP00000013755; ENSMUSG00000013611. [Q6P8Y7-2]
ENSMUST00000161202; ENSMUSP00000124063; ENSMUSG00000013611. [Q6P8Y7-1]
GeneIDi66696.
KEGGimmu:66696.
UCSCiuc007vmv.1. mouse. [Q6P8Y7-2]
uc007vmw.1. mouse. [Q6P8Y7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014536 mRNA. Translation: BAB29419.2.
AK034196 mRNA. Translation: BAC28627.1.
AK035226 mRNA. Translation: BAC28987.1.
BC061007 mRNA. Translation: AAH61007.1.
CCDSiCCDS27430.1. [Q6P8Y7-2]
RefSeqiNP_079988.3. NM_025712.4. [Q6P8Y7-2]
XP_006520208.1. XM_006520145.3. [Q6P8Y7-1]
UniGeneiMm.253627.

3D structure databases

ProteinModelPortaliQ6P8Y7.
SMRiQ6P8Y7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60339N.
IntActiQ6P8Y7. 2 interactors.
STRINGi10090.ENSMUSP00000013755.

PTM databases

PhosphoSitePlusiQ6P8Y7.

Proteomic databases

PaxDbiQ6P8Y7.
PRIDEiQ6P8Y7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013755; ENSMUSP00000013755; ENSMUSG00000013611. [Q6P8Y7-2]
ENSMUST00000161202; ENSMUSP00000124063; ENSMUSG00000013611. [Q6P8Y7-1]
GeneIDi66696.
KEGGimmu:66696.
UCSCiuc007vmv.1. mouse. [Q6P8Y7-2]
uc007vmw.1. mouse. [Q6P8Y7-1]

Organism-specific databases

CTDi169166.
MGIiMGI:1913946. Snx31.

Phylogenomic databases

eggNOGiKOG3784. Eukaryota.
ENOG410XT9I. LUCA.
GeneTreeiENSGT00530000063147.
HOGENOMiHOG000007722.
HOVERGENiHBG061207.
InParanoidiQ6P8Y7.
KOiK17937.
OMAiRVKCWQV.
OrthoDBiEOG091G0BES.
PhylomeDBiQ6P8Y7.
TreeFamiTF318398.

Miscellaneous databases

PROiQ6P8Y7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000013611.
ExpressionAtlasiQ6P8Y7. baseline and differential.
GenevisibleiQ6P8Y7. MM.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX31_MOUSE
AccessioniPrimary (citable) accession number: Q6P8Y7
Secondary accession number(s): Q8BH14, Q9D690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.