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Q6P8W9

- HMGB4_MOUSE

UniProt

Q6P8W9 - HMGB4_MOUSE

Protein

High mobility group protein B4

Gene

Hmgb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi9 – 7971HMG box 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi93 – 16169HMG box 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    High mobility group protein B4
    Gene namesi
    Name:Hmgb4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 4

    Organism-specific databases

    MGIiMGI:1916567. Hmgb4.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181High mobility group protein B4PRO_0000269181Add
    BLAST

    Proteomic databases

    PRIDEiQ6P8W9.

    PTM databases

    PhosphoSiteiQ6P8W9.

    Expressioni

    Gene expression databases

    BgeeiQ6P8W9.
    CleanExiMM_HMGB4.
    GenevestigatoriQ6P8W9.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P8W9.
    SMRiQ6P8W9. Positions 1-161.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the HMGB family.Curated
    Contains 2 HMG box DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG288392.
    GeneTreeiENSGT00740000115458.
    HOGENOMiHOG000197861.
    HOVERGENiHBG009000.
    InParanoidiQ6P8W9.
    KOiK11297.
    OMAiHEKAKYE.
    OrthoDBiEOG7WHHBQ.
    PhylomeDBiQ6P8W9.
    TreeFamiTF105371.

    Family and domain databases

    Gene3Di1.10.30.10. 2 hits.
    InterProiIPR009071. HMG_box_dom.
    [Graphical view]
    PfamiPF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view]
    SMARTiSM00398. HMG. 2 hits.
    [Graphical view]
    SUPFAMiSSF47095. SSF47095. 2 hits.
    PROSITEiPS50118. HMG_BOX_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P8W9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEKDQLRPK VNVSSYIHFM LNFRNKFKEQ QPNTYLGFKE FSRKCSEKWR    50
    SISKHEKAKY EALAELDKAR YQQEMMNYIG KRRKRRKRDP KAPRKPPSSF 100
    LLFSRDHYAM LKQENPDWTV VQVAKAAGKM WSTTDEAEKK PYEQKAALMR 150
    AKYFEEQEAY RNQCQGRKGN FLESAKTSLK Q 181
    Length:181
    Mass (Da):21,604
    Last modified:July 5, 2004 - v1
    Checksum:iA41FDE8F08413DBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti66 – 661L → H in BAB24141. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005588 mRNA. Translation: BAB24141.1.
    BC061030 mRNA. Translation: AAH61030.1.
    CCDSiCCDS18671.1.
    RefSeqiNP_081312.2. NM_027036.3.
    UniGeneiMm.331893.

    Genome annotation databases

    EnsembliENSMUST00000053830; ENSMUSP00000059625; ENSMUSG00000048686.
    GeneIDi69317.
    KEGGimmu:69317.
    UCSCiuc008uva.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK005588 mRNA. Translation: BAB24141.1 .
    BC061030 mRNA. Translation: AAH61030.1 .
    CCDSi CCDS18671.1.
    RefSeqi NP_081312.2. NM_027036.3.
    UniGenei Mm.331893.

    3D structure databases

    ProteinModelPortali Q6P8W9.
    SMRi Q6P8W9. Positions 1-161.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q6P8W9.

    Proteomic databases

    PRIDEi Q6P8W9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053830 ; ENSMUSP00000059625 ; ENSMUSG00000048686 .
    GeneIDi 69317.
    KEGGi mmu:69317.
    UCSCi uc008uva.1. mouse.

    Organism-specific databases

    CTDi 127540.
    MGIi MGI:1916567. Hmgb4.

    Phylogenomic databases

    eggNOGi NOG288392.
    GeneTreei ENSGT00740000115458.
    HOGENOMi HOG000197861.
    HOVERGENi HBG009000.
    InParanoidi Q6P8W9.
    KOi K11297.
    OMAi HEKAKYE.
    OrthoDBi EOG7WHHBQ.
    PhylomeDBi Q6P8W9.
    TreeFami TF105371.

    Miscellaneous databases

    NextBioi 329122.
    PROi Q6P8W9.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P8W9.
    CleanExi MM_HMGB4.
    Genevestigatori Q6P8W9.

    Family and domain databases

    Gene3Di 1.10.30.10. 2 hits.
    InterProi IPR009071. HMG_box_dom.
    [Graphical view ]
    Pfami PF00505. HMG_box. 1 hit.
    PF09011. HMG_box_2. 1 hit.
    [Graphical view ]
    SMARTi SM00398. HMG. 2 hits.
    [Graphical view ]
    SUPFAMi SSF47095. SSF47095. 2 hits.
    PROSITEi PS50118. HMG_BOX_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.

    Entry informationi

    Entry nameiHMGB4_MOUSE
    AccessioniPrimary (citable) accession number: Q6P8W9
    Secondary accession number(s): Q9DAR4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 12, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3