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Q6P8W9

- HMGB4_MOUSE

UniProt

Q6P8W9 - HMGB4_MOUSE

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Protein
High mobility group protein B4
Gene
Hmgb4
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi9 – 7971HMG box 1
Add
BLAST
DNA bindingi93 – 16169HMG box 2
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
High mobility group protein B4
Gene namesi
Name:Hmgb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 4

Organism-specific databases

MGIiMGI:1916567. Hmgb4.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181High mobility group protein B4
PRO_0000269181Add
BLAST

Proteomic databases

PRIDEiQ6P8W9.

PTM databases

PhosphoSiteiQ6P8W9.

Expressioni

Gene expression databases

BgeeiQ6P8W9.
CleanExiMM_HMGB4.
GenevestigatoriQ6P8W9.

Structurei

3D structure databases

ProteinModelPortaliQ6P8W9.
SMRiQ6P8W9. Positions 1-161.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGB family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG288392.
GeneTreeiENSGT00740000115458.
HOGENOMiHOG000197861.
HOVERGENiHBG009000.
InParanoidiQ6P8W9.
KOiK11297.
OMAiHEKAKYE.
OrthoDBiEOG7WHHBQ.
PhylomeDBiQ6P8W9.
TreeFamiTF105371.

Family and domain databases

Gene3Di1.10.30.10. 2 hits.
InterProiIPR009071. HMG_box_dom.
[Graphical view]
PfamiPF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view]
SMARTiSM00398. HMG. 2 hits.
[Graphical view]
SUPFAMiSSF47095. SSF47095. 2 hits.
PROSITEiPS50118. HMG_BOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P8W9-1 [UniParc]FASTAAdd to Basket

« Hide

MGEKDQLRPK VNVSSYIHFM LNFRNKFKEQ QPNTYLGFKE FSRKCSEKWR    50
SISKHEKAKY EALAELDKAR YQQEMMNYIG KRRKRRKRDP KAPRKPPSSF 100
LLFSRDHYAM LKQENPDWTV VQVAKAAGKM WSTTDEAEKK PYEQKAALMR 150
AKYFEEQEAY RNQCQGRKGN FLESAKTSLK Q 181
Length:181
Mass (Da):21,604
Last modified:July 5, 2004 - v1
Checksum:iA41FDE8F08413DBA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661L → H in BAB24141. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005588 mRNA. Translation: BAB24141.1.
BC061030 mRNA. Translation: AAH61030.1.
CCDSiCCDS18671.1.
RefSeqiNP_081312.2. NM_027036.3.
UniGeneiMm.331893.

Genome annotation databases

EnsembliENSMUST00000053830; ENSMUSP00000059625; ENSMUSG00000048686.
GeneIDi69317.
KEGGimmu:69317.
UCSCiuc008uva.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK005588 mRNA. Translation: BAB24141.1 .
BC061030 mRNA. Translation: AAH61030.1 .
CCDSi CCDS18671.1.
RefSeqi NP_081312.2. NM_027036.3.
UniGenei Mm.331893.

3D structure databases

ProteinModelPortali Q6P8W9.
SMRi Q6P8W9. Positions 1-161.
ModBasei Search...

PTM databases

PhosphoSitei Q6P8W9.

Proteomic databases

PRIDEi Q6P8W9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053830 ; ENSMUSP00000059625 ; ENSMUSG00000048686 .
GeneIDi 69317.
KEGGi mmu:69317.
UCSCi uc008uva.1. mouse.

Organism-specific databases

CTDi 127540.
MGIi MGI:1916567. Hmgb4.

Phylogenomic databases

eggNOGi NOG288392.
GeneTreei ENSGT00740000115458.
HOGENOMi HOG000197861.
HOVERGENi HBG009000.
InParanoidi Q6P8W9.
KOi K11297.
OMAi HEKAKYE.
OrthoDBi EOG7WHHBQ.
PhylomeDBi Q6P8W9.
TreeFami TF105371.

Miscellaneous databases

NextBioi 329122.
PROi Q6P8W9.
SOURCEi Search...

Gene expression databases

Bgeei Q6P8W9.
CleanExi MM_HMGB4.
Genevestigatori Q6P8W9.

Family and domain databases

Gene3Di 1.10.30.10. 2 hits.
InterProi IPR009071. HMG_box_dom.
[Graphical view ]
Pfami PF00505. HMG_box. 1 hit.
PF09011. HMG_box_2. 1 hit.
[Graphical view ]
SMARTi SM00398. HMG. 2 hits.
[Graphical view ]
SUPFAMi SSF47095. SSF47095. 2 hits.
PROSITEi PS50118. HMG_BOX_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.

Entry informationi

Entry nameiHMGB4_MOUSE
AccessioniPrimary (citable) accession number: Q6P8W9
Secondary accession number(s): Q9DAR4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi