Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q6P8U6

- LIPP_MOUSE

UniProt

Q6P8U6 - LIPP_MOUSE

Protein

Pancreatic triacylglycerol lipase

Gene

Pnlip

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones By similarity.By similarity

    Catalytic activityi

    Triacylglycerol + H2O = diacylglycerol + a carboxylate.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei169 – 1691NucleophileBy similarity
    Active sitei193 – 1931Charge relay systemPROSITE-ProRule annotation
    Metal bindingi204 – 2041Calcium; via carbonyl oxygenBy similarity
    Metal bindingi207 – 2071Calcium; via carbonyl oxygenBy similarity
    Metal bindingi209 – 2091CalciumBy similarity
    Metal bindingi212 – 2121CalciumBy similarity
    Active sitei280 – 2801Charge relay systemPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. triglyceride lipase activity Source: UniProtKB-EC

    GO - Biological processi

    1. intestinal cholesterol absorption Source: MGI
    2. lipid catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198569. Retinoid metabolism and transport.
    REACT_204917. Digestion of dietary lipid.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pancreatic triacylglycerol lipase (EC:3.1.1.3)
    Short name:
    PL
    Short name:
    PTL
    Short name:
    Pancreatic lipase
    Gene namesi
    Name:Pnlip
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:97722. Pnlip.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 465449Pancreatic triacylglycerol lipasePRO_0000401139Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi20 ↔ 26PROSITE-ProRule annotation
    Disulfide bondi107 ↔ 118PROSITE-ProRule annotation
    Disulfide bondi254 ↔ 278PROSITE-ProRule annotation
    Disulfide bondi302 ↔ 313PROSITE-ProRule annotation
    Disulfide bondi316 ↔ 321PROSITE-ProRule annotation
    Disulfide bondi449 ↔ 465PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiQ6P8U6.
    PaxDbiQ6P8U6.
    PRIDEiQ6P8U6.

    PTM databases

    PhosphoSiteiQ6P8U6.

    Expressioni

    Tissue specificityi

    Pancreas.1 Publication

    Inductioni

    By colipase/CLPS in the presence of bile salts.

    Gene expression databases

    BgeeiQ6P8U6.
    GenevestigatoriQ6P8U6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000056377.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P8U6.
    SMRiQ6P8U6. Positions 18-465.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini355 – 465111PLATPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the AB hydrolase superfamily. Lipase family.Curated
    Contains 1 PLAT domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG40923.
    GeneTreeiENSGT00750000117234.
    HOGENOMiHOG000038552.
    HOVERGENiHBG003243.
    InParanoidiQ6P8U6.
    KOiK14073.
    OMAiVKFIWYN.
    OrthoDBiEOG7KSX8B.
    PhylomeDBiQ6P8U6.
    TreeFamiTF324997.

    Family and domain databases

    Gene3Di2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR002331. Lipase_panc.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view]
    PANTHERiPTHR11610. PTHR11610. 1 hit.
    PfamiPF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSiPR00823. PANCLIPASE.
    PR00821. TAGLIPASE.
    SMARTiSM00308. LH2. 1 hit.
    [Graphical view]
    SUPFAMiSSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEiPS00120. LIPASE_SER. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P8U6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLMLWTFAVL LGAVAGREVC FDKLGCFSDD APWSGTLDRP LKALPWSPAQ    50
    INTRFLLYTN ENPDNYQLIT SDASNIRNSN FRTNRKTRII IHGFIDKGEE 100
    NWLSDMCKNM FRVESVNCIC VDWKGGSRTT YTQATQNVRV VGAEVALLVN 150
    VLQSDLGYSL NNVHLIGHSL GSHIAGEAGK RTFGAIGRIT GLDPAEPYFQ 200
    GTPEEVRLDP TDAQFVDAIH TDAGPIIPNL GFGMSQTVGH LDFFPNGGIE 250
    MPGCQKNILS QIVDIDGIWE GTRNFAACNH LRSYKFYTDS IVNPTGFAGF 300
    SCSSYSLFTA NKCFPCGSGG CPQMGHYADR YPGKTSRLYQ TFYLNTGDKS 350
    NFARWRYQVT VTLSGQKVTG HILVSLFGNG GNSKQYEVFK GSLQPGTSHV 400
    NEFDSDVDVG DLQKVKFIWY NNVINPTLPK VGASRITVER NDGRVFNFCS 450
    QETVREDVLL TLSPC 465
    Length:465
    Mass (Da):51,428
    Last modified:July 5, 2004 - v1
    Checksum:i5CD39E8ABDF43A64
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY387690 mRNA. Translation: AAQ90020.1.
    CH466585 Genomic DNA. Translation: EDL01803.1.
    BC061061 mRNA. Translation: AAH61061.1.
    CCDSiCCDS29930.1.
    RefSeqiNP_081201.2. NM_026925.3.
    UniGeneiMm.20407.

    Genome annotation databases

    EnsembliENSMUST00000057270; ENSMUSP00000056377; ENSMUSG00000046008.
    GeneIDi69060.
    KEGGimmu:69060.
    UCSCiuc008iaq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY387690 mRNA. Translation: AAQ90020.1 .
    CH466585 Genomic DNA. Translation: EDL01803.1 .
    BC061061 mRNA. Translation: AAH61061.1 .
    CCDSi CCDS29930.1.
    RefSeqi NP_081201.2. NM_026925.3.
    UniGenei Mm.20407.

    3D structure databases

    ProteinModelPortali Q6P8U6.
    SMRi Q6P8U6. Positions 18-465.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000056377.

    PTM databases

    PhosphoSitei Q6P8U6.

    Proteomic databases

    MaxQBi Q6P8U6.
    PaxDbi Q6P8U6.
    PRIDEi Q6P8U6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000057270 ; ENSMUSP00000056377 ; ENSMUSG00000046008 .
    GeneIDi 69060.
    KEGGi mmu:69060.
    UCSCi uc008iaq.1. mouse.

    Organism-specific databases

    CTDi 5406.
    MGIi MGI:97722. Pnlip.

    Phylogenomic databases

    eggNOGi NOG40923.
    GeneTreei ENSGT00750000117234.
    HOGENOMi HOG000038552.
    HOVERGENi HBG003243.
    InParanoidi Q6P8U6.
    KOi K14073.
    OMAi VKFIWYN.
    OrthoDBi EOG7KSX8B.
    PhylomeDBi Q6P8U6.
    TreeFami TF324997.

    Enzyme and pathway databases

    Reactomei REACT_198569. Retinoid metabolism and transport.
    REACT_204917. Digestion of dietary lipid.

    Miscellaneous databases

    ChiTaRSi PNLIP. mouse.
    NextBioi 328500.
    PROi Q6P8U6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P8U6.
    Genevestigatori Q6P8U6.

    Family and domain databases

    Gene3Di 2.60.60.20. 1 hit.
    3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR000734. Lipase.
    IPR008976. Lipase_LipOase.
    IPR013818. Lipase_N.
    IPR002331. Lipase_panc.
    IPR016272. Lipoprotein_lipase_LIPH.
    IPR001024. PLAT/LH2_dom.
    [Graphical view ]
    PANTHERi PTHR11610. PTHR11610. 1 hit.
    Pfami PF00151. Lipase. 1 hit.
    PF01477. PLAT. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000865. Lipoprotein_lipase_LIPH. 1 hit.
    PRINTSi PR00823. PANCLIPASE.
    PR00821. TAGLIPASE.
    SMARTi SM00308. LH2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49723. SSF49723. 1 hit.
    SSF53474. SSF53474. 1 hit.
    PROSITEi PS00120. LIPASE_SER. 1 hit.
    PS50095. PLAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Feeding activates protein synthesis in mouse pancreas at the translational level without increase in mRNA."
      Sans M.D., Lee S.H., D'Alecy L.G., Williams J.A.
      Am. J. Physiol. 287:G667-G675(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    4. "Hydrolysis of retinyl esters by pancreatic triglyceride lipase."
      van Bennekum A.M., Fisher E.A., Blaner W.S., Harrison E.H.
      Biochemistry 39:4900-4906(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: CATALYTIC ACTIVITY, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLIPP_MOUSE
    AccessioniPrimary (citable) accession number: Q6P8U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 30, 2010
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3