ID   Q6P8P8_MOUSE            Unreviewed;       193 AA.
AC   Q6P8P8;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   27-MAR-2024, entry version 124.
DE   RecName: Full=Pulmonary surfactant-associated protein C {ECO:0000256|ARBA:ARBA00021869};
DE   AltName: Full=Pulmonary surfactant-associated proteolipid SPL(Val) {ECO:0000256|ARBA:ARBA00031633};
GN   Name=Sftpc {ECO:0000313|EMBL:AAH61137.1,
GN   ECO:0000313|Ensembl:ENSMUSP00000022692.4, ECO:0000313|MGI:MGI:109517};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAH61137.1};
RN   [1] {ECO:0000313|EMBL:AAH61137.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung and heart {ECO:0000313|EMBL:AAH61137.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RA   Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H.,
RA   Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M.,
RA   Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.,
RA   Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F.,
RA   Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T.,
RA   Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F.,
RA   Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E.,
RA   Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y.,
RA   Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E.,
RA   Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y.,
RA   Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W.,
RA   Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J.,
RA   Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S.,
RA   Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J.,
RA   Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W.,
RA   Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J.,
RA   Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I.,
RA   Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U.,
RA   Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A.,
RA   Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000022692.4, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000022692.4,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0007829|PubMed:21183079}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
RN   [4] {ECO:0000313|Ensembl:ENSMUSP00000022692.4}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000022692.4};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Pulmonary surfactant associated proteins promote alveolar
CC       stability by lowering the surface tension at the air-liquid interface
CC       in the peripheral air spaces. {ECO:0000256|ARBA:ARBA00002263}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film
CC       {ECO:0000256|ARBA:ARBA00004364}.
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DR   EMBL; BC061137; AAH61137.1; -; mRNA.
DR   RefSeq; NP_035489.2; NM_011359.2.
DR   ProteomicsDB; 330860; -.
DR   Antibodypedia; 3986; 485 antibodies from 34 providers.
DR   Ensembl; ENSMUST00000022692.5; ENSMUSP00000022692.4; ENSMUSG00000022097.5.
DR   GeneID; 20389; -.
DR   KEGG; mmu:20389; -.
DR   UCSC; uc007uoe.2; mouse.
DR   AGR; MGI:109517; -.
DR   CTD; 6440; -.
DR   MGI; MGI:109517; Sftpc.
DR   VEuPathDB; HostDB:ENSMUSG00000022097; -.
DR   GeneTree; ENSGT00390000017162; -.
DR   HOGENOM; CLU_087015_0_0_1; -.
DR   OMA; WRHRACY; -.
DR   OrthoDB; 5319594at2759; -.
DR   TreeFam; TF337317; -.
DR   BioGRID-ORCS; 20389; 0 hits in 78 CRISPR screens.
DR   ChiTaRS; Sftpc; mouse.
DR   Proteomes; UP000000589; Chromosome 14.
DR   Bgee; ENSMUSG00000022097; Expressed in right lung lobe and 55 other cell types or tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007585; P:respiratory gaseous exchange by respiratory system; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.390.150; -; 1.
DR   InterPro; IPR007084; BRICHOS_dom.
DR   InterPro; IPR001729; SP-C.
DR   InterPro; IPR018051; SP-C_palmitoylation_site.
DR   InterPro; IPR015091; Surfactant_protein_propep.
DR   PANTHER; PTHR10800; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; 1.
DR   PANTHER; PTHR10800:SF4; PULMONARY SURFACTANT-ASSOCIATED PROTEIN C; 1.
DR   Pfam; PF04089; BRICHOS; 1.
DR   Pfam; PF08999; SP_C-Propep; 1.
DR   SMART; SM01039; BRICHOS; 1.
DR   SMART; SM00019; SF_P; 1.
DR   PROSITE; PS50869; BRICHOS; 1.
DR   PROSITE; PS00341; SURFACT_PALMITOYL; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW   Gaseous exchange {ECO:0000256|ARBA:ARBA00022713};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|MaxQB:Q6P8P8,
KW   ECO:0007829|ProteomicsDB:Q6P8P8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Surface film {ECO:0000256|ARBA:ARBA00022439};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        36..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          94..193
FT                   /note="BRICHOS"
FT                   /evidence="ECO:0000259|PROSITE:PS50869"
FT   REGION          147..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   193 AA;  21027 MW;  1287B4AC19AC8301 CRC64;
     MDMSSKEVLM ESPPDYSAGP RSQFRIPCCP VHLKRLLIVV VVVVLVVVVI VGALLMGLHM
     SQKHTEMVLE MSIGAPETQK RLAPSERADT IATFSIGSTG IVVYDYQRLL TAYKPAPGTY
     CYIMKMAPES IPSLEAFARK LQNFQAKPST PTSKLGQEEG HDTGSESDSS GRDLAFLGLA
     VSTLCGELPL YYI
//