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Protein

Carboxypeptidase A4

Gene

Cpa4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Metalloprotease that could be involved in the histone hyperacetylation pathway.By similarity

Catalytic activityi

Release of a C-terminal amino acid, with preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi180Zinc; catalyticBy similarity1
Metal bindingi183Zinc; catalyticBy similarity1
Binding sitei238SubstrateBy similarity1
Metal bindingi307Zinc; catalyticBy similarity1
Binding sitei359SubstrateBy similarity1
Active sitei381Proton donor/acceptorBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Carboxypeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM14.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Carboxypeptidase A4 (EC:3.4.17.-)
Gene namesi
Name:Cpa4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1919041. Cpa4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000000435917 – 113Activation peptideBy similarityAdd BLAST97
ChainiPRO_0000004360114 – 420Carboxypeptidase A4Add BLAST307

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi249 ↔ 272By similarity
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6P8K8.
PaxDbiQ6P8K8.
PeptideAtlasiQ6P8K8.
PRIDEiQ6P8K8.

PTM databases

PhosphoSitePlusiQ6P8K8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000039070.
CleanExiMM_CPA4.
GenevisibleiQ6P8K8. MM.

Interactioni

Subunit structurei

Interacts with LXN.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048558.

Structurei

3D structure databases

ProteinModelPortaliQ6P8K8.
SMRiQ6P8K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni180 – 183Substrate bindingBy similarity4
Regioni255 – 256Substrate bindingBy similarity2
Regioni308 – 309Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the peptidase M14 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ6P8K8.
KOiK08637.
OMAiIQKHGNF.
OrthoDBiEOG091G0HUI.
PhylomeDBiQ6P8K8.
TreeFamiTF317197.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P8K8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLLFFGAL IGAGICGRDK FFGDQVFRIN VRNGDEIRKL TELVNSDHLK
60 70 80 90 100
LSVWKSPSTF DRPVDILVPS VSLLPVKSFL KSQGLDYSVT IEDLQALLDN
110 120 130 140 150
EDEEMQHNEG IERSGDFNYG AYHPLEAIYH EMDSIATDFP ELVSRVKIGE
160 170 180 190 200
TFEKRPMYVL KFSTGGGKKR PAIWLNAGIH AREWISQATA IWTARKIVTD
210 220 230 240 250
YKKDPAITSI LKKVDIFLLP VANPDGYVYT QSQNRLWRKT RSRNPGSRCV
260 270 280 290 300
GADPNRNWNA SFAGEGTSDN PCSEVYHGSH PNSEVEVKSV VDFIQKHGNF
310 320 330 340 350
KCFIDLHSYS QLLMYPYGYT VKKAPDAEEL DDVARNAAQA LASLSGTKYR
360 370 380 390 400
VGPTCTTVYP ASGSSVDWAY DNGIKYAFTF ELRDTGYYGF LLPASQIIPT
410 420
AEETWLGLKT IMEHVRDHLY
Length:420
Mass (Da):47,339
Last modified:August 16, 2005 - v2
Checksum:i4A7B56A137C4B123
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti210I → V in AAH61206 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003823 mRNA. Translation: BAB23019.1.
AK030705 mRNA. Translation: BAC27090.1.
BC061206 mRNA. Translation: AAH61206.1.
CCDSiCCDS19975.1.
RefSeqiNP_082202.1. NM_027926.3.
UniGeneiMm.105759.

Genome annotation databases

EnsembliENSMUST00000049251; ENSMUSP00000048558; ENSMUSG00000039070.
GeneIDi71791.
KEGGimmu:71791.
UCSCiuc009bfo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK003823 mRNA. Translation: BAB23019.1.
AK030705 mRNA. Translation: BAC27090.1.
BC061206 mRNA. Translation: AAH61206.1.
CCDSiCCDS19975.1.
RefSeqiNP_082202.1. NM_027926.3.
UniGeneiMm.105759.

3D structure databases

ProteinModelPortaliQ6P8K8.
SMRiQ6P8K8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048558.

Protein family/group databases

MEROPSiM14.017.

PTM databases

PhosphoSitePlusiQ6P8K8.

Proteomic databases

MaxQBiQ6P8K8.
PaxDbiQ6P8K8.
PeptideAtlasiQ6P8K8.
PRIDEiQ6P8K8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049251; ENSMUSP00000048558; ENSMUSG00000039070.
GeneIDi71791.
KEGGimmu:71791.
UCSCiuc009bfo.1. mouse.

Organism-specific databases

CTDi51200.
MGIiMGI:1919041. Cpa4.

Phylogenomic databases

eggNOGiKOG2650. Eukaryota.
COG2866. LUCA.
GeneTreeiENSGT00760000119103.
HOGENOMiHOG000252967.
HOVERGENiHBG050815.
InParanoidiQ6P8K8.
KOiK08637.
OMAiIQKHGNF.
OrthoDBiEOG091G0HUI.
PhylomeDBiQ6P8K8.
TreeFamiTF317197.

Miscellaneous databases

PROiQ6P8K8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039070.
CleanExiMM_CPA4.
GenevisibleiQ6P8K8. MM.

Family and domain databases

Gene3Di3.30.70.340. 1 hit.
InterProiIPR003146. M14A_act_pep.
IPR000834. Peptidase_M14.
IPR009020. Propept_inh.
[Graphical view]
PfamiPF00246. Peptidase_M14. 1 hit.
PF02244. Propep_M14. 1 hit.
[Graphical view]
PRINTSiPR00765. CRBOXYPTASEA.
SMARTiSM00631. Zn_pept. 1 hit.
[Graphical view]
SUPFAMiSSF54897. SSF54897. 1 hit.
PROSITEiPS00132. CARBOXYPEPT_ZN_1. 1 hit.
PS00133. CARBOXYPEPT_ZN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBPA4_MOUSE
AccessioniPrimary (citable) accession number: Q6P8K8
Secondary accession number(s): Q8BMK6, Q9CTE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: November 2, 2016
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.