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Protein

Diamine acetyltransferase 2

Gene

Sat2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N1acetylspermine = putrescine (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate; via carbonyl oxygenBy similarity
Binding sitei140 – 1401Acetyl-CoABy similarity
Binding sitei152 – 1521SubstrateBy similarity

GO - Molecular functioni

  1. diamine N-acetyltransferase activity Source: MGI

GO - Biological processi

  1. nor-spermidine metabolic process Source: MGI
  2. putrescine acetylation Source: MGI
  3. putrescine catabolic process Source: UniProtKB-UniPathway
  4. spermidine acetylation Source: MGI
  5. spermidine metabolic process Source: MGI
  6. spermine acetylation Source: MGI
  7. spermine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00188; UER00363.

Names & Taxonomyi

Protein namesi
Recommended name:
Diamine acetyltransferase 2 (EC:2.3.1.57)
Alternative name(s):
Polyamine N-acetyltransferase 2
Spermidine/spermine N(1)-acetyltransferase 2
Gene namesi
Name:Sat2
Synonyms:Ssat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1916465. Sat2.

Subcellular locationi

Cytoplasm By similarity
Note: Intracellular organelles.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Diamine acetyltransferase 2PRO_0000074599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6P8J2.
PaxDbiQ6P8J2.
PRIDEiQ6P8J2.

PTM databases

PhosphoSiteiQ6P8J2.

Expressioni

Gene expression databases

BgeeiQ6P8J2.
CleanExiMM_SAT2.
GenevestigatoriQ6P8J2.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6P8J2.
SMRiQ6P8J2. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 166163N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 282Substrate bindingBy similarity
Regioni94 – 963Acetyl-CoA bindingBy similarity
Regioni102 – 1076Acetyl-CoA bindingBy similarity
Regioni133 – 1353Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0454.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000078521.
HOVERGENiHBG063175.
InParanoidiQ6P8J2.
KOiK00657.
OMAiNPFFHCL.
OrthoDBiEOG7M98HM.
PhylomeDBiQ6P8J2.
TreeFamiTF319736.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P8J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTRIREAR ESDCGDIMRM IRELAEFEKL SHQVKISEEA LRADGFGENP
60 70 80 90 100
FFHCLVAEII PAPGESQGSL VVGYGLYYFI YSTWTGRNVY LEDIYVMPQY
110 120 130 140 150
RGQGIGTKII KKVAEVALNK GCSQFRLAVL DWNKKAVNLY KFLGAQDLTE
160 170
SEGWLSFRFE GEAMRELAGR
Length:170
Mass (Da):19,305
Last modified:July 5, 2004 - v1
Checksum:i5D82F98DAD0619AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603707, AL731687 Genomic DNA. Translation: CAI51952.1.
BC061227 mRNA. Translation: AAH61227.1.
CCDSiCCDS36194.1.
RefSeqiNP_081267.1. NM_026991.2.
XP_006534175.1. XM_006534112.2.
UniGeneiMm.340410.

Genome annotation databases

EnsembliENSMUST00000092969; ENSMUSP00000090647; ENSMUSG00000069835.
ENSMUST00000108656; ENSMUSP00000104296; ENSMUSG00000069835.
GeneIDi69215.
KEGGimmu:69215.
UCSCiuc007jqq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL603707, AL731687 Genomic DNA. Translation: CAI51952.1.
BC061227 mRNA. Translation: AAH61227.1.
CCDSiCCDS36194.1.
RefSeqiNP_081267.1. NM_026991.2.
XP_006534175.1. XM_006534112.2.
UniGeneiMm.340410.

3D structure databases

ProteinModelPortaliQ6P8J2.
SMRiQ6P8J2. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL2111376.

PTM databases

PhosphoSiteiQ6P8J2.

Proteomic databases

MaxQBiQ6P8J2.
PaxDbiQ6P8J2.
PRIDEiQ6P8J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092969; ENSMUSP00000090647; ENSMUSG00000069835.
ENSMUST00000108656; ENSMUSP00000104296; ENSMUSG00000069835.
GeneIDi69215.
KEGGimmu:69215.
UCSCiuc007jqq.1. mouse.

Organism-specific databases

CTDi112483.
MGIiMGI:1916465. Sat2.

Phylogenomic databases

eggNOGiCOG0454.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000078521.
HOVERGENiHBG063175.
InParanoidiQ6P8J2.
KOiK00657.
OMAiNPFFHCL.
OrthoDBiEOG7M98HM.
PhylomeDBiQ6P8J2.
TreeFamiTF319736.

Enzyme and pathway databases

UniPathwayiUPA00188; UER00363.

Miscellaneous databases

NextBioi328895.
PROiQ6P8J2.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P8J2.
CleanExiMM_SAT2.
GenevestigatoriQ6P8J2.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSAT2_MOUSE
AccessioniPrimary (citable) accession number: Q6P8J2
Secondary accession number(s): Q5F299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: April 1, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.