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Q6P8J2

- SAT2_MOUSE

UniProt

Q6P8J2 - SAT2_MOUSE

Protein

Diamine acetyltransferase 2

Gene

Sat2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N1acetylspermine = putrescine By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei92 – 921Substrate; via carbonyl oxygenBy similarity
    Binding sitei140 – 1401Acetyl-CoABy similarity
    Binding sitei152 – 1521SubstrateBy similarity

    GO - Molecular functioni

    1. diamine N-acetyltransferase activity Source: MGI

    GO - Biological processi

    1. putrescine catabolic process Source: UniProtKB-UniPathway
    2. spermidine metabolic process Source: MGI
    3. spermine metabolic process Source: MGI

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00188; UER00363.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Diamine acetyltransferase 2 (EC:2.3.1.57)
    Alternative name(s):
    Polyamine N-acetyltransferase 2
    Spermidine/spermine N(1)-acetyltransferase 2
    Gene namesi
    Name:Sat2
    Synonyms:Ssat2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:1916465. Sat2.

    Subcellular locationi

    Cytoplasm By similarity
    Note: Intracellular organelles.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 170170Diamine acetyltransferase 2PRO_0000074599Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei29 – 291N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ6P8J2.
    PRIDEiQ6P8J2.

    PTM databases

    PhosphoSiteiQ6P8J2.

    Expressioni

    Gene expression databases

    BgeeiQ6P8J2.
    CleanExiMM_SAT2.
    GenevestigatoriQ6P8J2.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P8J2.
    SMRiQ6P8J2. Positions 2-170.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 166163N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni27 – 282Substrate bindingBy similarity
    Regioni94 – 963Acetyl-CoA bindingBy similarity
    Regioni102 – 1076Acetyl-CoA bindingBy similarity
    Regioni133 – 1353Acetyl-CoA bindingBy similarity

    Sequence similaritiesi

    Belongs to the acetyltransferase family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0454.
    GeneTreeiENSGT00440000039972.
    HOGENOMiHOG000078521.
    HOVERGENiHBG063175.
    InParanoidiQ5F299.
    KOiK00657.
    OMAiDWVGMRV.
    OrthoDBiEOG7M98HM.
    PhylomeDBiQ6P8J2.
    TreeFamiTF319736.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P8J2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASTRIREAR ESDCGDIMRM IRELAEFEKL SHQVKISEEA LRADGFGENP    50
    FFHCLVAEII PAPGESQGSL VVGYGLYYFI YSTWTGRNVY LEDIYVMPQY 100
    RGQGIGTKII KKVAEVALNK GCSQFRLAVL DWNKKAVNLY KFLGAQDLTE 150
    SEGWLSFRFE GEAMRELAGR 170
    Length:170
    Mass (Da):19,305
    Last modified:July 5, 2004 - v1
    Checksum:i5D82F98DAD0619AA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL603707, AL731687 Genomic DNA. Translation: CAI51952.1.
    BC061227 mRNA. Translation: AAH61227.1.
    CCDSiCCDS36194.1.
    RefSeqiNP_081267.1. NM_026991.2.
    XP_006534175.1. XM_006534112.1.
    UniGeneiMm.340410.

    Genome annotation databases

    EnsembliENSMUST00000092969; ENSMUSP00000090647; ENSMUSG00000069835.
    ENSMUST00000108656; ENSMUSP00000104296; ENSMUSG00000069835.
    GeneIDi69215.
    KEGGimmu:69215.
    UCSCiuc007jqq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL603707 , AL731687 Genomic DNA. Translation: CAI51952.1 .
    BC061227 mRNA. Translation: AAH61227.1 .
    CCDSi CCDS36194.1.
    RefSeqi NP_081267.1. NM_026991.2.
    XP_006534175.1. XM_006534112.1.
    UniGenei Mm.340410.

    3D structure databases

    ProteinModelPortali Q6P8J2.
    SMRi Q6P8J2. Positions 2-170.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2111376.

    PTM databases

    PhosphoSitei Q6P8J2.

    Proteomic databases

    PaxDbi Q6P8J2.
    PRIDEi Q6P8J2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000092969 ; ENSMUSP00000090647 ; ENSMUSG00000069835 .
    ENSMUST00000108656 ; ENSMUSP00000104296 ; ENSMUSG00000069835 .
    GeneIDi 69215.
    KEGGi mmu:69215.
    UCSCi uc007jqq.1. mouse.

    Organism-specific databases

    CTDi 112483.
    MGIi MGI:1916465. Sat2.

    Phylogenomic databases

    eggNOGi COG0454.
    GeneTreei ENSGT00440000039972.
    HOGENOMi HOG000078521.
    HOVERGENi HBG063175.
    InParanoidi Q5F299.
    KOi K00657.
    OMAi DWVGMRV.
    OrthoDBi EOG7M98HM.
    PhylomeDBi Q6P8J2.
    TreeFami TF319736.

    Enzyme and pathway databases

    UniPathwayi UPA00188 ; UER00363 .

    Miscellaneous databases

    NextBioi 328895.
    PROi Q6P8J2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6P8J2.
    CleanExi MM_SAT2.
    Genevestigatori Q6P8J2.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.
    3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiSAT2_MOUSE
    AccessioniPrimary (citable) accession number: Q6P8J2
    Secondary accession number(s): Q5F299
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3