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Q6P8J2

- SAT2_MOUSE

UniProt

Q6P8J2 - SAT2_MOUSE

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Protein

Diamine acetyltransferase 2

Gene

Sat2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N1acetylspermine = putrescine (By similarity).By similarity

Catalytic activityi

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate; via carbonyl oxygenBy similarity
Binding sitei140 – 1401Acetyl-CoABy similarity
Binding sitei152 – 1521SubstrateBy similarity

GO - Molecular functioni

  1. diamine N-acetyltransferase activity Source: MGI

GO - Biological processi

  1. nor-spermidine metabolic process Source: Ensembl
  2. putrescine acetylation Source: Ensembl
  3. putrescine catabolic process Source: UniProtKB-UniPathway
  4. spermidine acetylation Source: Ensembl
  5. spermidine metabolic process Source: MGI
  6. spermine acetylation Source: Ensembl
  7. spermine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00188; UER00363.

Names & Taxonomyi

Protein namesi
Recommended name:
Diamine acetyltransferase 2 (EC:2.3.1.57)
Alternative name(s):
Polyamine N-acetyltransferase 2
Spermidine/spermine N(1)-acetyltransferase 2
Gene namesi
Name:Sat2
Synonyms:Ssat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:1916465. Sat2.

Subcellular locationi

Cytoplasm By similarity
Note: Intracellular organelles.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 170170Diamine acetyltransferase 2PRO_0000074599Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ6P8J2.
PaxDbiQ6P8J2.
PRIDEiQ6P8J2.

PTM databases

PhosphoSiteiQ6P8J2.

Expressioni

Gene expression databases

BgeeiQ6P8J2.
CleanExiMM_SAT2.
GenevestigatoriQ6P8J2.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6P8J2.
SMRiQ6P8J2. Positions 2-170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 166163N-acetyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni27 – 282Substrate bindingBy similarity
Regioni94 – 963Acetyl-CoA bindingBy similarity
Regioni102 – 1076Acetyl-CoA bindingBy similarity
Regioni133 – 1353Acetyl-CoA bindingBy similarity

Sequence similaritiesi

Belongs to the acetyltransferase family.Curated
Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0454.
GeneTreeiENSGT00440000039972.
HOGENOMiHOG000078521.
HOVERGENiHBG063175.
InParanoidiQ6P8J2.
KOiK00657.
OMAiDWVGMRV.
OrthoDBiEOG7M98HM.
PhylomeDBiQ6P8J2.
TreeFamiTF319736.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P8J2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTRIREAR ESDCGDIMRM IRELAEFEKL SHQVKISEEA LRADGFGENP
60 70 80 90 100
FFHCLVAEII PAPGESQGSL VVGYGLYYFI YSTWTGRNVY LEDIYVMPQY
110 120 130 140 150
RGQGIGTKII KKVAEVALNK GCSQFRLAVL DWNKKAVNLY KFLGAQDLTE
160 170
SEGWLSFRFE GEAMRELAGR
Length:170
Mass (Da):19,305
Last modified:July 5, 2004 - v1
Checksum:i5D82F98DAD0619AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL603707, AL731687 Genomic DNA. Translation: CAI51952.1.
BC061227 mRNA. Translation: AAH61227.1.
CCDSiCCDS36194.1.
RefSeqiNP_081267.1. NM_026991.2.
XP_006534175.1. XM_006534112.1.
UniGeneiMm.340410.

Genome annotation databases

EnsembliENSMUST00000092969; ENSMUSP00000090647; ENSMUSG00000069835.
ENSMUST00000108656; ENSMUSP00000104296; ENSMUSG00000069835.
GeneIDi69215.
KEGGimmu:69215.
UCSCiuc007jqq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL603707 , AL731687 Genomic DNA. Translation: CAI51952.1 .
BC061227 mRNA. Translation: AAH61227.1 .
CCDSi CCDS36194.1.
RefSeqi NP_081267.1. NM_026991.2.
XP_006534175.1. XM_006534112.1.
UniGenei Mm.340410.

3D structure databases

ProteinModelPortali Q6P8J2.
SMRi Q6P8J2. Positions 2-170.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2111376.

PTM databases

PhosphoSitei Q6P8J2.

Proteomic databases

MaxQBi Q6P8J2.
PaxDbi Q6P8J2.
PRIDEi Q6P8J2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000092969 ; ENSMUSP00000090647 ; ENSMUSG00000069835 .
ENSMUST00000108656 ; ENSMUSP00000104296 ; ENSMUSG00000069835 .
GeneIDi 69215.
KEGGi mmu:69215.
UCSCi uc007jqq.1. mouse.

Organism-specific databases

CTDi 112483.
MGIi MGI:1916465. Sat2.

Phylogenomic databases

eggNOGi COG0454.
GeneTreei ENSGT00440000039972.
HOGENOMi HOG000078521.
HOVERGENi HBG063175.
InParanoidi Q6P8J2.
KOi K00657.
OMAi DWVGMRV.
OrthoDBi EOG7M98HM.
PhylomeDBi Q6P8J2.
TreeFami TF319736.

Enzyme and pathway databases

UniPathwayi UPA00188 ; UER00363 .

Miscellaneous databases

NextBioi 328895.
PROi Q6P8J2.
SOURCEi Search...

Gene expression databases

Bgeei Q6P8J2.
CleanExi MM_SAT2.
Genevestigatori Q6P8J2.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.
  3. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiSAT2_MOUSE
AccessioniPrimary (citable) accession number: Q6P8J2
Secondary accession number(s): Q5F299
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3