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Q6P8J2 (SAT2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Diamine acetyltransferase 2

EC=2.3.1.57
Alternative name(s):
Polyamine N-acetyltransferase 2
Spermidine/spermine N(1)-acetyltransferase 2
Gene names
Name:Sat2
Synonyms:Ssat2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length170 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N1acetylspermine = putrescine By similarity.

Catalytic activity

Acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine.

Pathway

Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity. Note: Intracellular organelles By similarity.

Sequence similarities

Belongs to the acetyltransferase family.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 170170Diamine acetyltransferase 2
PRO_0000074599

Regions

Domain4 – 166163N-acetyltransferase
Region27 – 282Substrate binding By similarity
Region94 – 963Acetyl-CoA binding By similarity
Region102 – 1076Acetyl-CoA binding By similarity
Region133 – 1353Acetyl-CoA binding By similarity

Sites

Binding site921Substrate; via carbonyl oxygen By similarity
Binding site1401Acetyl-CoA By similarity
Binding site1521Substrate By similarity

Amino acid modifications

Modified residue291N6-acetyllysine Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q6P8J2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 5D82F98DAD0619AA

FASTA17019,305
        10         20         30         40         50         60 
MASTRIREAR ESDCGDIMRM IRELAEFEKL SHQVKISEEA LRADGFGENP FFHCLVAEII 

        70         80         90        100        110        120 
PAPGESQGSL VVGYGLYYFI YSTWTGRNVY LEDIYVMPQY RGQGIGTKII KKVAEVALNK 

       130        140        150        160        170 
GCSQFRLAVL DWNKKAVNLY KFLGAQDLTE SEGWLSFRFE GEAMRELAGR 

« Hide

References

[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.
[3]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-29, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL603707, AL731687 Genomic DNA. Translation: CAI51952.1.
BC061227 mRNA. Translation: AAH61227.1.
CCDSCCDS36194.1.
RefSeqNP_081267.1. NM_026991.2.
XP_006534175.1. XM_006534112.1.
UniGeneMm.340410.

3D structure databases

ProteinModelPortalQ6P8J2.
SMRQ6P8J2. Positions 2-170.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2111376.

PTM databases

PhosphoSiteQ6P8J2.

Proteomic databases

PaxDbQ6P8J2.
PRIDEQ6P8J2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000092969; ENSMUSP00000090647; ENSMUSG00000069835.
ENSMUST00000108656; ENSMUSP00000104296; ENSMUSG00000069835.
GeneID69215.
KEGGmmu:69215.
UCSCuc007jqq.1. mouse.

Organism-specific databases

CTD112483.
MGIMGI:1916465. Sat2.

Phylogenomic databases

eggNOGCOG0454.
GeneTreeENSGT00440000039972.
HOGENOMHOG000078521.
HOVERGENHBG063175.
InParanoidQ5F299.
KOK00657.
OMADWVGMRV.
OrthoDBEOG7M98HM.
PhylomeDBQ6P8J2.
TreeFamTF319736.

Enzyme and pathway databases

UniPathwayUPA00188; UER00363.

Gene expression databases

BgeeQ6P8J2.
CleanExMM_SAT2.
GenevestigatorQ6P8J2.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio328895.
PROQ6P8J2.
SOURCESearch...

Entry information

Entry nameSAT2_MOUSE
AccessionPrimary (citable) accession number: Q6P8J2
Secondary accession number(s): Q5F299
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot