Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase assembly protein COX11, mitochondrial

Gene

Cox11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.By similarity

GO - Molecular functioni

GO - Biological processi

  • negative regulation of glucokinase activity Source: MGI
Complete GO annotation...

Keywords - Ligandi

Copper

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase assembly protein COX11, mitochondrial
Gene namesi
Name:Cox11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917052. Cox11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini? – 94Mitochondrial matrixSequence analysis
Transmembranei95 – 11319HelicalSequence analysisAdd
BLAST
Topological domaini114 – 275162Mitochondrial intermembraneSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • mitochondrial inner membrane Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 275Cytochrome c oxidase assembly protein COX11, mitochondrialPRO_0000006081
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ6P8I6.
MaxQBiQ6P8I6.
PaxDbiQ6P8I6.
PeptideAtlasiQ6P8I6.
PRIDEiQ6P8I6.

PTM databases

PhosphoSiteiQ6P8I6.

Expressioni

Gene expression databases

BgeeiQ6P8I6.
ExpressionAtlasiQ6P8I6. baseline and differential.
GenevisibleiQ6P8I6. MM.

Interactioni

Subunit structurei

Interacts with CNNM4/ACDP4.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020851.

Structurei

3D structure databases

ProteinModelPortaliQ6P8I6.
SMRiQ6P8I6. Positions 144-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the COX11/CtaG family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2540. Eukaryota.
COG3175. LUCA.
GeneTreeiENSGT00390000007512.
HOGENOMiHOG000264965.
HOVERGENiHBG051085.
InParanoidiQ6P8I6.
KOiK02258.
OMAiRMARVDT.
OrthoDBiEOG7JMGFB.
PhylomeDBiQ6P8I6.
TreeFamiTF105072.

Family and domain databases

Gene3Di2.60.370.10. 1 hit.
HAMAPiMF_00155. CtaG.
InterProiIPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view]
PANTHERiPTHR21320. PTHR21320. 1 hit.
PfamiPF04442. CtaG_Cox11. 1 hit.
[Graphical view]
SUPFAMiSSF110111. SSF110111. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P8I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGGLWCPGWR LVASCGRGWR QPGWSGRTVV NAELVLRPGW DGLGGAERGL
60 70 80 90 100
RRLGTWKRPC GVRGPATQPP RRPRSSNPFQ RAQEDEWRRR NKTVLTYVAA
110 120 130 140 150
AAVGMLGASY AAVPLYRLYC QTTGLGGSAV AGHSSDQIEN MVPVKDRVIK
160 170 180 190 200
VTFNADVHAS LQWNFRPQQT EIYVVPGETA LAFYKAKNPT DKPVIGISTY
210 220 230 240 250
NVVPFEAGQY FNKIQCFCFE EQRLNPQEEV DMPVFFYIDP EFAEDPRMVN
260 270
VDLITLSYTF FEAKEGHKLP VPGYN
Length:275
Mass (Da):30,849
Last modified:July 5, 2004 - v1
Checksum:iF51774C9382CE8F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143937 mRNA. Translation: BAE25618.1.
AL646046, AL672199 Genomic DNA. Translation: CAI23913.1.
AL672199, AL646046 Genomic DNA. Translation: CAI24239.1.
BC061233 mRNA. Translation: AAH61233.1.
CCDSiCCDS25243.1.
RefSeqiNP_950173.1. NM_199008.2.
UniGeneiMm.151940.

Genome annotation databases

EnsembliENSMUST00000020851; ENSMUSP00000020851; ENSMUSG00000020544.
GeneIDi69802.
KEGGimmu:69802.
UCSCiuc007kwz.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143937 mRNA. Translation: BAE25618.1.
AL646046, AL672199 Genomic DNA. Translation: CAI23913.1.
AL672199, AL646046 Genomic DNA. Translation: CAI24239.1.
BC061233 mRNA. Translation: AAH61233.1.
CCDSiCCDS25243.1.
RefSeqiNP_950173.1. NM_199008.2.
UniGeneiMm.151940.

3D structure databases

ProteinModelPortaliQ6P8I6.
SMRiQ6P8I6. Positions 144-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020851.

PTM databases

PhosphoSiteiQ6P8I6.

Proteomic databases

EPDiQ6P8I6.
MaxQBiQ6P8I6.
PaxDbiQ6P8I6.
PeptideAtlasiQ6P8I6.
PRIDEiQ6P8I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020851; ENSMUSP00000020851; ENSMUSG00000020544.
GeneIDi69802.
KEGGimmu:69802.
UCSCiuc007kwz.1. mouse.

Organism-specific databases

CTDi1353.
MGIiMGI:1917052. Cox11.

Phylogenomic databases

eggNOGiKOG2540. Eukaryota.
COG3175. LUCA.
GeneTreeiENSGT00390000007512.
HOGENOMiHOG000264965.
HOVERGENiHBG051085.
InParanoidiQ6P8I6.
KOiK02258.
OMAiRMARVDT.
OrthoDBiEOG7JMGFB.
PhylomeDBiQ6P8I6.
TreeFamiTF105072.

Miscellaneous databases

PROiQ6P8I6.
SOURCEiSearch...

Gene expression databases

BgeeiQ6P8I6.
ExpressionAtlasiQ6P8I6. baseline and differential.
GenevisibleiQ6P8I6. MM.

Family and domain databases

Gene3Di2.60.370.10. 1 hit.
HAMAPiMF_00155. CtaG.
InterProiIPR023471. CtaG/Cox11_dom.
IPR007533. Cyt_c_oxidase_assmbl_CtaG.
[Graphical view]
PANTHERiPTHR21320. PTHR21320. 1 hit.
PfamiPF04442. CtaG_Cox11. 1 hit.
[Graphical view]
SUPFAMiSSF110111. SSF110111. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Spleen and Testis.

Entry informationi

Entry nameiCOX11_MOUSE
AccessioniPrimary (citable) accession number: Q6P8I6
Secondary accession number(s): Q3UNX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.