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Protein

Protein orai-3

Gene

Orai3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Key regulator or component of store-operated Ca2+ channel and transcription factor NFAT nuclear import.By similarity

GO - Molecular functioni

GO - Biological processi

  • store-operated calcium entry Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein orai-3
Alternative name(s):
Transmembrane protein 142C
Gene namesi
Name:Orai3
Synonyms:Tmem142c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:3039586. Orai3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei63 – 8220HelicalSequence analysisAdd
BLAST
Transmembranei95 – 11521HelicalSequence analysisAdd
BLAST
Transmembranei157 – 17721HelicalSequence analysisAdd
BLAST
Transmembranei239 – 25921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 290290Protein orai-3PRO_0000234396Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei42 – 421PhosphoserineCombined sources
Modified residuei45 – 451PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6P8G8.
PRIDEiQ6P8G8.

PTM databases

iPTMnetiQ6P8G8.
PhosphoSiteiQ6P8G8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043964.
ExpressionAtlasiQ6P8G8. baseline and differential.
GenevisibleiQ6P8G8. MM.

Interactioni

Subunit structurei

Interacts with CRACR2A/EFCAB4B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050279.

Structurei

3D structure databases

ProteinModelPortaliQ6P8G8.
SMRiQ6P8G8. Positions 49-188, 238-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Orai family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4298. Eukaryota.
ENOG4110DSB. LUCA.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ6P8G8.
KOiK16058.
OMAiSATYRDF.
OrthoDBiEOG091G0E4P.
PhylomeDBiQ6P8G8.
TreeFamiTF313576.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030032. Orai-3.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 2 hits.
PTHR31501:SF6. PTHR31501:SF6. 2 hits.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P8G8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGEGDTGE QAPLNPEVDS PAGSATYREF VHRGYLDLMG ASQHSLRALS
60 70 80 90 100
WRRLYLSRAK LKASSRTSAL LSGFAMVAMV EVQLENDHEY PPGLLVAFSA
110 120 130 140 150
CTTVLVAVHL FALMVSTCLL PHIEAVSNIH NLNSVHQSPH QRLHRYVELA
160 170 180 190 200
WGFSTALGTF LFLAEVVLVG WVKFVPIGAP MGKPAPVVPM SQVPPVTVSL
210 220 230 240 250
SLASNLTPSS ASITTSQQPS KACPPRQVCD SAHGPGWQAA MASTAIMVPV
260 270 280 290
GLVFMAFALH FYRSLVAHKT DRHKQELEEL SRLQGELQAV
Length:290
Mass (Da):31,358
Last modified:July 5, 2004 - v1
Checksum:iF702164F9F1EB44B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136955 mRNA. Translation: BAE23186.1.
BC061259 mRNA. Translation: AAH61259.1.
CCDSiCCDS21878.1.
RefSeqiNP_940816.1. NM_198424.3.
UniGeneiMm.36852.

Genome annotation databases

EnsembliENSMUST00000061587; ENSMUSP00000050279; ENSMUSG00000043964.
GeneIDi269999.
KEGGimmu:269999.
UCSCiuc009jwr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136955 mRNA. Translation: BAE23186.1.
BC061259 mRNA. Translation: AAH61259.1.
CCDSiCCDS21878.1.
RefSeqiNP_940816.1. NM_198424.3.
UniGeneiMm.36852.

3D structure databases

ProteinModelPortaliQ6P8G8.
SMRiQ6P8G8. Positions 49-188, 238-288.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000050279.

PTM databases

iPTMnetiQ6P8G8.
PhosphoSiteiQ6P8G8.

Proteomic databases

PaxDbiQ6P8G8.
PRIDEiQ6P8G8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061587; ENSMUSP00000050279; ENSMUSG00000043964.
GeneIDi269999.
KEGGimmu:269999.
UCSCiuc009jwr.1. mouse.

Organism-specific databases

CTDi93129.
MGIiMGI:3039586. Orai3.

Phylogenomic databases

eggNOGiKOG4298. Eukaryota.
ENOG4110DSB. LUCA.
GeneTreeiENSGT00390000015354.
HOGENOMiHOG000246925.
HOVERGENiHBG081343.
InParanoidiQ6P8G8.
KOiK16058.
OMAiSATYRDF.
OrthoDBiEOG091G0E4P.
PhylomeDBiQ6P8G8.
TreeFamiTF313576.

Miscellaneous databases

PROiQ6P8G8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043964.
ExpressionAtlasiQ6P8G8. baseline and differential.
GenevisibleiQ6P8G8. MM.

Family and domain databases

InterProiIPR012446. CRAC_channel.
IPR030032. Orai-3.
[Graphical view]
PANTHERiPTHR31501. PTHR31501. 2 hits.
PTHR31501:SF6. PTHR31501:SF6. 2 hits.
PfamiPF07856. Orai-1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiORAI3_MOUSE
AccessioniPrimary (citable) accession number: Q6P8G8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.