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Protein

Forkhead box protein I1-ema

Gene

foxi1e

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates ectoderm, in addition to inhibiting mesoderm and endoderm formation; required at the blastula stage for normal formation of both the central nervous system and epidermis, the two early derivatives of the ectoderm. In addition, also required to maintain the regional identity of the animal cells of the blastula, the cells that are precursors of ectodermal structures. Also plays a role in differential adhesion, which limits cell mixing as primary germ layers become specified (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi123 – 217Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I1-ema
Short name:
FoxI1-ema
Alternative name(s):
Ectodermally-expressed mesendoderm antagonist
FoxI3
Gene namesi
Name:foxi1e
Synonyms:ema, foxi1, foxi31 Publication
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-494125 foxi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748111 – 373Forkhead box protein I1-emaAdd BLAST373

Proteomic databases

PaxDbiQ6P8A3
PRIDEiQ6P8A3

Expressioni

Gene expression databases

BgeeiENSXETG00000025404

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005340

Structurei

3D structure databases

ProteinModelPortaliQ6P8A3
SMRiQ6P8A3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000236333
HOVERGENiHBG067944
InParanoidiQ6P8A3
KOiK09401
OMAiGGEWANP
OrthoDBiEOG091G0ESH
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR033065 Foxi1
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR11829:SF180 PTHR11829:SF180, 1 hit
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6P8A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFDPQAHS PPRCGPQFPS IGQEPPEMNI YCDSIFHPQT MPSPQRPSNF
60 70 80 90 100
ETADYSTTAN PYLWLNGPSI TPPPYLPGSN TSHFMPQSYG MQRQLLPNMH
110 120 130 140 150
GLGGSDLGWL PIPSQEELMK LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY
160 170 180 190 200
QYVADNFPFY NKSKAGWQNS IRHNLSLNDC FKKVPRDEDD PGKGNYWTLD
210 220 230 240 250
PNCEKMFDNG NFRRKRKRKS DVSPNGQISS DKPEGSPLNE SPKNGEHHDM
260 270 280 290 300
LGNSSPGTDD SSEKRSPPPS ITPCLNNFLS SMTAYVNSAN PVSRSVPLGL
310 320 330 340 350
TNEPSDRMGQ NMVGLNSYTP LSNMPSHGGS DWSSTISSSP FGYSSSVFNQ
360 370
FTPHFYNTIN ANNTLYNREG TEV
Length:373
Mass (Da):41,369
Last modified:July 5, 2004 - v1
Checksum:i9452FB1B4AD6B70F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061326 mRNA Translation: AAH61326.1
RefSeqiNP_988949.1, NM_203618.1
UniGeneiStr.2357

Genome annotation databases

EnsembliENSXETT00000005340; ENSXETP00000005340; ENSXETG00000025404
GeneIDi394546
KEGGixtr:394546

Similar proteinsi

Entry informationi

Entry nameiFXI1E_XENTR
AccessioniPrimary (citable) accession number: Q6P8A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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