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Protein

Forkhead box protein I1-ema

Gene

foxi1e

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Activates ectoderm, in addition to inhibiting mesoderm and endoderm formation; required at the blastula stage for normal formation of both the central nervous system and epidermis, the two early derivatives of the ectoderm. In addition, also required to maintain the regional identity of the animal cells of the blastula, the cells that are precursors of ectodermal structures. Also plays a role in differential adhesion, which limits cell mixing as primary germ layers become specified (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi123 – 217Fork-headPROSITE-ProRule annotationAdd BLAST95

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein I1-ema
Short name:
FoxI1-ema
Alternative name(s):
Ectodermally-expressed mesendoderm antagonist
FoxI3
Gene namesi
Name:foxi1e
Synonyms:ema, foxi1, foxi31 Publication
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
Proteomesi
  • UP000008143 Componenti: Unassembled WGS sequence

Organism-specific databases

XenbaseiXB-GENE-494125. foxi1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002748111 – 373Forkhead box protein I1-emaAdd BLAST373

Proteomic databases

PaxDbiQ6P8A3.

Expressioni

Gene expression databases

BgeeiENSXETG00000025404.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005340.

Structurei

3D structure databases

ProteinModelPortaliQ6P8A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000236333.
HOVERGENiHBG067944.
InParanoidiQ6P8A3.
KOiK09401.
OMAiFYNTINA.
OrthoDBiEOG091G0ESH.
TreeFamiTF316127.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR033065. Foxi1.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11829:SF180. PTHR11829:SF180. 1 hit.
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P8A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFDPQAHS PPRCGPQFPS IGQEPPEMNI YCDSIFHPQT MPSPQRPSNF
60 70 80 90 100
ETADYSTTAN PYLWLNGPSI TPPPYLPGSN TSHFMPQSYG MQRQLLPNMH
110 120 130 140 150
GLGGSDLGWL PIPSQEELMK LVRPPYSYSA LIAMAIHGAP DKRLTLSQIY
160 170 180 190 200
QYVADNFPFY NKSKAGWQNS IRHNLSLNDC FKKVPRDEDD PGKGNYWTLD
210 220 230 240 250
PNCEKMFDNG NFRRKRKRKS DVSPNGQISS DKPEGSPLNE SPKNGEHHDM
260 270 280 290 300
LGNSSPGTDD SSEKRSPPPS ITPCLNNFLS SMTAYVNSAN PVSRSVPLGL
310 320 330 340 350
TNEPSDRMGQ NMVGLNSYTP LSNMPSHGGS DWSSTISSSP FGYSSSVFNQ
360 370
FTPHFYNTIN ANNTLYNREG TEV
Length:373
Mass (Da):41,369
Last modified:July 5, 2004 - v1
Checksum:i9452FB1B4AD6B70F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061326 mRNA. Translation: AAH61326.1.
RefSeqiNP_988949.1. NM_203618.1.
UniGeneiStr.2357.

Genome annotation databases

EnsembliENSXETT00000005340; ENSXETP00000005340; ENSXETG00000025404.
GeneIDi394546.
KEGGixtr:394546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061326 mRNA. Translation: AAH61326.1.
RefSeqiNP_988949.1. NM_203618.1.
UniGeneiStr.2357.

3D structure databases

ProteinModelPortaliQ6P8A3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000005340.

Proteomic databases

PaxDbiQ6P8A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000005340; ENSXETP00000005340; ENSXETG00000025404.
GeneIDi394546.
KEGGixtr:394546.

Organism-specific databases

CTDi2299.
XenbaseiXB-GENE-494125. foxi1.

Phylogenomic databases

eggNOGiKOG2294. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00760000118904.
HOGENOMiHOG000236333.
HOVERGENiHBG067944.
InParanoidiQ6P8A3.
KOiK09401.
OMAiFYNTINA.
OrthoDBiEOG091G0ESH.
TreeFamiTF316127.

Gene expression databases

BgeeiENSXETG00000025404.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR033065. Foxi1.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11829:SF180. PTHR11829:SF180. 1 hit.
PfamiPF00250. Forkhead. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFXI1E_XENTR
AccessioniPrimary (citable) accession number: Q6P8A3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 5, 2004
Last modified: October 5, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.