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Q6P824

- GPD1L_XENTR

UniProt

Q6P824 - GPD1L_XENTR

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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Plays a role in regulating cardiac sodium current.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADBy similarity
Binding sitei100 – 1001NADBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei156 – 1561NAD; via amide nitrogenBy similarity
Active sitei207 – 2071Proton acceptorBy similarity
Binding sitei272 – 2721NADBy similarity
Binding sitei299 – 2991NAD; via amide nitrogenBy similarity
Binding sitei301 – 3011NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_195675. Synthesis of PA.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:gpd1l
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-969902. gpd1l.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286516Add
BLAST

Proteomic databases

PRIDEiQ6P824.

Expressioni

Gene expression databases

BgeeiQ6P824.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032859.

Structurei

3D structure databases

ProteinModelPortaliQ6P824.
SMRiQ6P824. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni272 – 2732Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ6P824.
KOiK00006.
OMAiQIVYNNV.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P824-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NLKKFASTVN MWVFEENING
60 70 80 90 100
RKLTEIINTE HENVKYLPGY KLPENVVAVP NLSDAVKDAD LLIFVIPHQF
110 120 130 140 150
IHKICQEISG KVHRNALGIT LIKGIDEGPE GLRLISDIIR EKMDIDVSVL
160 170 180 190 200
MGANIANEVA AEKFCETTIG SKNKEHGLLF KELLQTPNFR ITVVEDADTV
210 220 230 240 250
ELCGALKNIV AVAAGFCDGL GCGDNTKAAV IRLGLMEMIA FANVFCKGPV
260 270 280 290 300
SIATFLESCG VADLITTCYG GRNRKVSEAF VKSGKSIEEL EKEMLNGQKL
310 320 330 340 350
QGPQTSAEVY RILQQKNMVN KFPLFTAVYQ ICYEGKPVED VISCLQSHPE

HM
Length:352
Mass (Da):38,464
Last modified:July 5, 2004 - v1
Checksum:i2E08E289DCF0A934
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061407 mRNA. Translation: AAH61407.1.
RefSeqiNP_989027.1. NM_203696.1.
UniGeneiStr.4931.

Genome annotation databases

EnsembliENSXETT00000032859; ENSXETP00000032859; ENSXETG00000015022.
GeneIDi394623.
KEGGixtr:394623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061407 mRNA. Translation: AAH61407.1 .
RefSeqi NP_989027.1. NM_203696.1.
UniGenei Str.4931.

3D structure databases

ProteinModelPortali Q6P824.
SMRi Q6P824. Positions 5-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 8364.ENSXETP00000032859.

Proteomic databases

PRIDEi Q6P824.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSXETT00000032859 ; ENSXETP00000032859 ; ENSXETG00000015022 .
GeneIDi 394623.
KEGGi xtr:394623.

Organism-specific databases

CTDi 23171.
Xenbasei XB-GENE-969902. gpd1l.

Phylogenomic databases

eggNOGi COG0240.
GeneTreei ENSGT00390000003114.
HOGENOMi HOG000246855.
HOVERGENi HBG003669.
InParanoidi Q6P824.
KOi K00006.
OMAi QIVYNNV.
OrthoDBi EOG7ZKSBS.
TreeFami TF300836.

Enzyme and pathway databases

Reactomei REACT_195675. Synthesis of PA.

Gene expression databases

Bgeei Q6P824.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11728. PTHR11728. 1 hit.
Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSi PR00077. GPDHDRGNASE.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGPD1L_XENTR
AccessioniPrimary (citable) accession number: Q6P824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3