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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role in regulating cardiac sodium current.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei44 – 441NADBy similarity
Binding sitei100 – 1001NADBy similarity
Binding sitei123 – 1231SubstrateBy similarity
Binding sitei156 – 1561NAD; via amide nitrogenBy similarity
Active sitei207 – 2071Proton acceptorBy similarity
Binding sitei272 – 2721NADBy similarity
Binding sitei299 – 2991NAD; via amide nitrogenBy similarity
Binding sitei301 – 3011NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi13 – 186NADBy similarity

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
  2. NAD binding Source: InterPro

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. glycerol-3-phosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

ReactomeiREACT_195675. Synthesis of PA.
REACT_249441. Triglyceride Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:gpd1l
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
ProteomesiUP000008143: Unplaced

Organism-specific databases

XenbaseiXB-GENE-969902. gpd1l.

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 352352Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286516Add
BLAST

Proteomic databases

PRIDEiQ6P824.

Expressioni

Gene expression databases

BgeeiQ6P824.

Interactioni

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032859.

Structurei

3D structure databases

ProteinModelPortaliQ6P824.
SMRiQ6P824. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni272 – 2732Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ6P824.
KOiK00006.
OMAiFEEDISG.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NLKKFASTVN MWVFEENING
60 70 80 90 100
RKLTEIINTE HENVKYLPGY KLPENVVAVP NLSDAVKDAD LLIFVIPHQF
110 120 130 140 150
IHKICQEISG KVHRNALGIT LIKGIDEGPE GLRLISDIIR EKMDIDVSVL
160 170 180 190 200
MGANIANEVA AEKFCETTIG SKNKEHGLLF KELLQTPNFR ITVVEDADTV
210 220 230 240 250
ELCGALKNIV AVAAGFCDGL GCGDNTKAAV IRLGLMEMIA FANVFCKGPV
260 270 280 290 300
SIATFLESCG VADLITTCYG GRNRKVSEAF VKSGKSIEEL EKEMLNGQKL
310 320 330 340 350
QGPQTSAEVY RILQQKNMVN KFPLFTAVYQ ICYEGKPVED VISCLQSHPE

HM
Length:352
Mass (Da):38,464
Last modified:July 5, 2004 - v1
Checksum:i2E08E289DCF0A934
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061407 mRNA. Translation: AAH61407.1.
RefSeqiNP_989027.1. NM_203696.1.
UniGeneiStr.4931.

Genome annotation databases

EnsembliENSXETT00000032859; ENSXETP00000032859; ENSXETG00000015022.
GeneIDi394623.
KEGGixtr:394623.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061407 mRNA. Translation: AAH61407.1.
RefSeqiNP_989027.1. NM_203696.1.
UniGeneiStr.4931.

3D structure databases

ProteinModelPortaliQ6P824.
SMRiQ6P824. Positions 5-347.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000032859.

Proteomic databases

PRIDEiQ6P824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSXETT00000032859; ENSXETP00000032859; ENSXETG00000015022.
GeneIDi394623.
KEGGixtr:394623.

Organism-specific databases

CTDi23171.
XenbaseiXB-GENE-969902. gpd1l.

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
InParanoidiQ6P824.
KOiK00006.
OMAiFEEDISG.
OrthoDBiEOG7ZKSBS.
TreeFamiTF300836.

Enzyme and pathway databases

ReactomeiREACT_195675. Synthesis of PA.
REACT_249441. Triglyceride Biosynthesis.

Gene expression databases

BgeeiQ6P824.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiGPD1L_XENTR
AccessioniPrimary (citable) accession number: Q6P824
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.