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Q6P824

- GPD1L_XENTR

UniProt

Q6P824 - GPD1L_XENTR

Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

gpd1l

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Plays a role in regulating cardiac sodium current.By similarity

    Catalytic activityi

    sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei44 – 441NADBy similarity
    Binding sitei100 – 1001NADBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei156 – 1561NAD; via amide nitrogenBy similarity
    Active sitei207 – 2071Proton acceptorBy similarity
    Binding sitei272 – 2721NADBy similarity
    Binding sitei299 – 2991NAD; via amide nitrogenBy similarity
    Binding sitei301 – 3011NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi13 – 186NADBy similarity

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase [NAD+] activity Source: UniProtKB-EC
    2. NAD binding Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. glycerol-3-phosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    ReactomeiREACT_195675. Synthesis of PA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
    Gene namesi
    Name:gpd1l
    OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
    Taxonomic identifieri8364 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
    ProteomesiUP000008143: Unplaced

    Organism-specific databases

    XenbaseiXB-GENE-969902. gpd1l.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 352352Glycerol-3-phosphate dehydrogenase 1-like proteinPRO_0000286516Add
    BLAST

    Proteomic databases

    PRIDEiQ6P824.

    Expressioni

    Gene expression databases

    BgeeiQ6P824.

    Interactioni

    Protein-protein interaction databases

    STRINGi8364.ENSXETP00000032859.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P824.
    SMRiQ6P824. Positions 5-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni272 – 2732Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0240.
    GeneTreeiENSGT00390000003114.
    HOGENOMiHOG000246855.
    HOVERGENiHBG003669.
    InParanoidiQ6P824.
    KOiK00006.
    OMAiQIVYNNV.
    OrthoDBiEOG7ZKSBS.
    TreeFamiTF300836.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11728. PTHR11728. 1 hit.
    PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSiPR00077. GPDHDRGNASE.
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6P824-1 [UniParc]FASTAAdd to Basket

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    MALAGPLKVC IVGSGNWGSA VAKIIGHNVK NLKKFASTVN MWVFEENING    50
    RKLTEIINTE HENVKYLPGY KLPENVVAVP NLSDAVKDAD LLIFVIPHQF 100
    IHKICQEISG KVHRNALGIT LIKGIDEGPE GLRLISDIIR EKMDIDVSVL 150
    MGANIANEVA AEKFCETTIG SKNKEHGLLF KELLQTPNFR ITVVEDADTV 200
    ELCGALKNIV AVAAGFCDGL GCGDNTKAAV IRLGLMEMIA FANVFCKGPV 250
    SIATFLESCG VADLITTCYG GRNRKVSEAF VKSGKSIEEL EKEMLNGQKL 300
    QGPQTSAEVY RILQQKNMVN KFPLFTAVYQ ICYEGKPVED VISCLQSHPE 350
    HM 352
    Length:352
    Mass (Da):38,464
    Last modified:July 5, 2004 - v1
    Checksum:i2E08E289DCF0A934
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061407 mRNA. Translation: AAH61407.1.
    RefSeqiNP_989027.1. NM_203696.1.
    UniGeneiStr.4931.

    Genome annotation databases

    EnsembliENSXETT00000032859; ENSXETP00000032859; ENSXETG00000015022.
    GeneIDi394623.
    KEGGixtr:394623.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061407 mRNA. Translation: AAH61407.1 .
    RefSeqi NP_989027.1. NM_203696.1.
    UniGenei Str.4931.

    3D structure databases

    ProteinModelPortali Q6P824.
    SMRi Q6P824. Positions 5-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 8364.ENSXETP00000032859.

    Proteomic databases

    PRIDEi Q6P824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSXETT00000032859 ; ENSXETP00000032859 ; ENSXETG00000015022 .
    GeneIDi 394623.
    KEGGi xtr:394623.

    Organism-specific databases

    CTDi 23171.
    Xenbasei XB-GENE-969902. gpd1l.

    Phylogenomic databases

    eggNOGi COG0240.
    GeneTreei ENSGT00390000003114.
    HOGENOMi HOG000246855.
    HOVERGENi HBG003669.
    InParanoidi Q6P824.
    KOi K00006.
    OMAi QIVYNNV.
    OrthoDBi EOG7ZKSBS.
    TreeFami TF300836.

    Enzyme and pathway databases

    Reactomei REACT_195675. Synthesis of PA.

    Gene expression databases

    Bgeei Q6P824.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR013328. DH_multihelical.
    IPR006168. G3P_DH_NAD-dep.
    IPR006109. G3P_DH_NAD-dep_C.
    IPR017751. G3P_DH_NAD-dep_euk.
    IPR011128. G3P_DH_NAD-dep_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11728. PTHR11728. 1 hit.
    Pfami PF07479. NAD_Gly3P_dh_C. 1 hit.
    PF01210. NAD_Gly3P_dh_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000114. Glycerol-3-P_dh. 1 hit.
    PRINTSi PR00077. GPDHDRGNASE.
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR03376. glycerol3P_DH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiGPD1L_XENTR
    AccessioniPrimary (citable) accession number: Q6P824
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 15, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3