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Q6P7Z3 (Q6P7Z3_XENTR) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Proteasome subunit alpha type RuleBase RU000551
EC=3.4.25.1 RuleBase RU000551
Gene names
Name:psma6 EMBL CAJ81265.1 Ensembl ENSXETP00000054899 Xenbase XB-GENE-943786 Xenbase XB-FEAT-943785 Xenbase XB-FEAT-943786
Synonyms:MGC76321 EMBL AAH61438.1
ORF Names:TEgg062p03.1-001 EMBL CAJ81265.1
OrganismXenopus tropicalis (Western clawed frog) (Silurana tropicalis) EMBL AAH61438.1
Taxonomic identifier8364 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Silurana

Protein attributes

Sequence length246 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity By similarity. RuleBase RU000551

Catalytic activity

Cleavage of peptide bonds with very broad specificity. RuleBase RU000551

Subunit structure

The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits By similarity. RuleBase RU000551

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU000551.

Sequence similarities

Belongs to the peptidase T1A family. RuleBase RU000551

Sequences

Sequence LengthMass (Da)Tools
Q6P7Z3 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 37AC65601628FB5F

FASTA24627,408
        10         20         30         40         50         60 
MSRGSSAGFD RHITIFSPEG RLYQVEYAFK AINQGGLTSV AVRGKDCAVV VTQRKVPDKL 

        70         80         90        100        110        120 
LDSNTVTHLF RITESIGCVM TGMTADSRSQ VQRARYEAAN WKYKYGYEIP VDMLCKRIAD 

       130        140        150        160        170        180 
ISQVYTQNAE MRPLGCCMIL IGVDEENGPQ VFKCDPAGYY CGFKATTAGV KQTEATSFLE 

       190        200        210        220        230        240 
KKVKKKLDWT YEQTLETAIS CLSTVLSIDF KPSELEVGVV TVEDPKFRVL TEAEIDVHLV 


ALAERD

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAMC01044904 Genomic DNA. No translation available.
BC061438 mRNA. Translation: AAH61438.1.
CR761245 mRNA. Translation: CAJ81265.1.
RefSeqNP_989113.1. NM_203782.1.
UniGeneStr.22172.

3D structure databases

HSSPHSSP built from PDB template 1G65 based on UniProtKB P21243.
ProteinModelPortalQ6P7Z3.
SMRQ6P7Z3. Positions 2-245.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ6P7Z3.

Protein family/group databases

MEROPST01.971.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSXETT00000054899; ENSXETP00000054899; ENSXETG00000025884.
GeneID394718.
KEGGxtr:394718.

Organism-specific databases

CTD5687.
XenbaseXB-GENE-943786. psma6.

Phylogenomic databases

eggNOGveNOG06071.
GeneTreeENSGT00550000074807.
HOGENOMHBG499923.
HOVERGENHBG107363.
InParanoidQ6P7Z3.
OMAGKDCAVV.
OrthoDBEOG4BP1CH.

Gene expression databases

BgeeQ6P7Z3.

Family and domain databases

InterProIPR000426. Proteasome_asu_N.
IPR023332. Proteasome_suA-type.
IPR001353. Proteasome_sua/b.
[Graphical view]
KOK02730.
PfamPF00227. Proteasome. 1 hit.
PF10584. Proteasome_A_N. 1 hit.
[Graphical view]
SMARTSM00948. Proteasome_A_N. 1 hit.
[Graphical view]
PROSITEPS00388. PROTEASOME_A_1. 1 hit.
PS51475. PROTEASOME_A_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ6P7Z3_XENTR
AccessionPrimary (citable) accession number: Q6P7Z3
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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