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Protein

Acid ceramidase

Gene

Asah1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.By similarity

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: InterPro
  • lung development Source: RGD
  • response to organic substance Source: RGD

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1660662 Glycosphingolipid metabolism
R-RNO-6798695 Neutrophil degranulation

Protein family/group databases

MEROPSiC89.001

Names & Taxonomyi

Protein namesi
Recommended name:
Acid ceramidase (EC:3.5.1.23)
Short name:
AC
Short name:
ACDase
Short name:
Acid CDase
Alternative name(s):
Acylsphingosine deacylase
N-acylsphingosine amidohydrolase
Gene namesi
Name:Asah1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi621568 Asah1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2331070

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000037810221 – 394Acid ceramidaseAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagine; alternateSequence analysis1
Glycosylationi258N-linked (HexNAc...) asparagine; alternateCombined sources1
Glycosylationi285N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6P7S1
PRIDEiQ6P7S1

PTM databases

SwissPalmiQ6P7S1
UniCarbKBiQ6P7S1

Expressioni

Gene expression databases

BgeeiENSRNOG00000010034
ExpressionAtlasiQ6P7S1 baseline and differential
GenevisibleiQ6P7S1 RN

Interactioni

Subunit structurei

Heterodimer of one alpha and one beta subunit.By similarity

Protein-protein interaction databases

IntActiQ6P7S1, 2 interactors
STRINGi10116.ENSRNOP00000013463

Chemistry databases

BindingDBiQ6P7S1

Structurei

3D structure databases

ProteinModelPortaliQ6P7S1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid ceramidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFSS Eukaryota
ENOG410XQ6Y LUCA
GeneTreeiENSGT00530000063548
HOGENOMiHOG000007253
InParanoidiQ6P7S1
KOiK12348
PhylomeDBiQ6P7S1
TreeFamiTF313219

Family and domain databases

InterProiView protein in InterPro
IPR016699 Acid_ceramidase-like
IPR029130 Acid_ceramidase_N
IPR029132 CBAH/NAAA_C
PfamiView protein in Pfam
PF02275 CBAH, 1 hit
PF15508 NAAA-beta, 1 hit
PIRSFiPIRSF017632 Acid_ceramidase-like, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P7S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRSLLTWV LAAAVTCAQA QQVPPWTEDC RKSTYPPSGP TYRGPVPWYT
60 70 80 90 100
INLDLPPYKR WHELLAHKAP VLRTLVNSIS NLVNAFVPSG KIMQMVDEKL
110 120 130 140 150
PGLIGSIPGP FGEEMRGIAD VTGIPLGEII SFNIFYELFT MCTSIITEDG
160 170 180 190 200
KGHLLHGRNM DFGIFLGWNI NNNTWVVTEE LKPLTVNLDF QRNNKTVFKA
210 220 230 240 250
TSFAGYVGML TGFKPGLLSL TLNERFSLNG GYLGILEWMF GKKNAQWVGF
260 270 280 290 300
ITRSVLENST SYEEAKNILT KTKITAPAYF ILGGNQSGEG CVITRERKES
310 320 330 340 350
LDVYELDPKH GRWYVVQTNY DRWKNTLFLD DRRTPAKKCL NHTTQKNLSF
360 370 380 390
ATIYDVLSTK PVLNKLTVFT TLIDVTKDQF ESHLRDCPDP CIGW
Length:394
Mass (Da):44,443
Last modified:July 5, 2004 - v1
Checksum:i27608539E1E9ED20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375V → G in AAG43956 (Ref. 1) Curated1
Sequence conflicti379Q → P in AAG43956 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214647 mRNA Translation: AAG43956.1
BC061540 mRNA Translation: AAH61540.1
RefSeqiNP_445859.2, NM_053407.3
UniGeneiRn.127798

Genome annotation databases

EnsembliENSRNOT00000013463; ENSRNOP00000013463; ENSRNOG00000010034
GeneIDi84431
KEGGirno:84431

Similar proteinsi

Entry informationi

Entry nameiASAH1_RAT
AccessioniPrimary (citable) accession number: Q6P7S1
Secondary accession number(s): Q9EQJ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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