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Protein

Acid ceramidase

Gene

Asah1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.By similarity

Catalytic activityi

N-acylsphingosine + H2O = a carboxylate + sphingosine.

GO - Molecular functioni

GO - Biological processi

  • lipid metabolic process Source: InterPro
  • lung development Source: RGD
  • response to organic substance Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1660662. Glycosphingolipid metabolism.
R-RNO-6798695. Neutrophil degranulation.

Protein family/group databases

MEROPSiC89.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Acid ceramidase (EC:3.5.1.23)
Short name:
AC
Short name:
ACDase
Short name:
Acid CDase
Alternative name(s):
Acylsphingosine deacylase
N-acylsphingosine amidohydrolase
Gene namesi
Name:Asah1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi621568. Asah1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Lysosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2331070.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000037810221 – 394Acid ceramidaseAdd BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Glycosylationi285N-linked (GlcNAc...)Sequence analysis1
Glycosylationi341N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6P7S1.
PRIDEiQ6P7S1.

PTM databases

SwissPalmiQ6P7S1.
UniCarbKBiQ6P7S1.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010034.
ExpressionAtlasiQ6P7S1. baseline and differential.
GenevisibleiQ6P7S1. RN.

Interactioni

Subunit structurei

Heterodimer of one alpha and one beta subunit.By similarity

Protein-protein interaction databases

IntActiQ6P7S1. 2 interactors.
STRINGi10116.ENSRNOP00000013463.

Chemistry databases

BindingDBiQ6P7S1.

Structurei

3D structure databases

ProteinModelPortaliQ6P7S1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the acid ceramidase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFSS. Eukaryota.
ENOG410XQ6Y. LUCA.
GeneTreeiENSGT00530000063548.
HOGENOMiHOG000007253.
InParanoidiQ6P7S1.
KOiK12348.
PhylomeDBiQ6P7S1.
TreeFamiTF313219.

Family and domain databases

Gene3Di3.60.60.10. 1 hit.
InterProiIPR016699. Acid_ceramidase-like.
IPR029130. Acid_ceramidase_N.
IPR029132. CBAH/NAAA_C.
IPR003199. Chologlycine_hydro/PeptC59.
[Graphical view]
PfamiPF02275. CBAH. 1 hit.
PF15508. NAAA-beta. 1 hit.
[Graphical view]
PIRSFiPIRSF017632. Acid_ceramidase-like. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P7S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGRSLLTWV LAAAVTCAQA QQVPPWTEDC RKSTYPPSGP TYRGPVPWYT
60 70 80 90 100
INLDLPPYKR WHELLAHKAP VLRTLVNSIS NLVNAFVPSG KIMQMVDEKL
110 120 130 140 150
PGLIGSIPGP FGEEMRGIAD VTGIPLGEII SFNIFYELFT MCTSIITEDG
160 170 180 190 200
KGHLLHGRNM DFGIFLGWNI NNNTWVVTEE LKPLTVNLDF QRNNKTVFKA
210 220 230 240 250
TSFAGYVGML TGFKPGLLSL TLNERFSLNG GYLGILEWMF GKKNAQWVGF
260 270 280 290 300
ITRSVLENST SYEEAKNILT KTKITAPAYF ILGGNQSGEG CVITRERKES
310 320 330 340 350
LDVYELDPKH GRWYVVQTNY DRWKNTLFLD DRRTPAKKCL NHTTQKNLSF
360 370 380 390
ATIYDVLSTK PVLNKLTVFT TLIDVTKDQF ESHLRDCPDP CIGW
Length:394
Mass (Da):44,443
Last modified:July 5, 2004 - v1
Checksum:i27608539E1E9ED20
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti375V → G in AAG43956 (Ref. 1) Curated1
Sequence conflicti379Q → P in AAG43956 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214647 mRNA. Translation: AAG43956.1.
BC061540 mRNA. Translation: AAH61540.1.
RefSeqiNP_445859.2. NM_053407.3.
UniGeneiRn.127798.

Genome annotation databases

EnsembliENSRNOT00000013463; ENSRNOP00000013463; ENSRNOG00000010034.
GeneIDi84431.
KEGGirno:84431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF214647 mRNA. Translation: AAG43956.1.
BC061540 mRNA. Translation: AAH61540.1.
RefSeqiNP_445859.2. NM_053407.3.
UniGeneiRn.127798.

3D structure databases

ProteinModelPortaliQ6P7S1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P7S1. 2 interactors.
STRINGi10116.ENSRNOP00000013463.

Chemistry databases

BindingDBiQ6P7S1.
ChEMBLiCHEMBL2331070.

Protein family/group databases

MEROPSiC89.001.

PTM databases

SwissPalmiQ6P7S1.
UniCarbKBiQ6P7S1.

Proteomic databases

PaxDbiQ6P7S1.
PRIDEiQ6P7S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013463; ENSRNOP00000013463; ENSRNOG00000010034.
GeneIDi84431.
KEGGirno:84431.

Organism-specific databases

CTDi427.
RGDi621568. Asah1.

Phylogenomic databases

eggNOGiENOG410IFSS. Eukaryota.
ENOG410XQ6Y. LUCA.
GeneTreeiENSGT00530000063548.
HOGENOMiHOG000007253.
InParanoidiQ6P7S1.
KOiK12348.
PhylomeDBiQ6P7S1.
TreeFamiTF313219.

Enzyme and pathway databases

ReactomeiR-RNO-1660662. Glycosphingolipid metabolism.
R-RNO-6798695. Neutrophil degranulation.

Miscellaneous databases

PROiQ6P7S1.

Gene expression databases

BgeeiENSRNOG00000010034.
ExpressionAtlasiQ6P7S1. baseline and differential.
GenevisibleiQ6P7S1. RN.

Family and domain databases

Gene3Di3.60.60.10. 1 hit.
InterProiIPR016699. Acid_ceramidase-like.
IPR029130. Acid_ceramidase_N.
IPR029132. CBAH/NAAA_C.
IPR003199. Chologlycine_hydro/PeptC59.
[Graphical view]
PfamiPF02275. CBAH. 1 hit.
PF15508. NAAA-beta. 1 hit.
[Graphical view]
PIRSFiPIRSF017632. Acid_ceramidase-like. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiASAH1_RAT
AccessioniPrimary (citable) accession number: Q6P7S1
Secondary accession number(s): Q9EQJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 16, 2009
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.