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Protein

Basic leucine zipper and W2 domain-containing protein 1

Gene

Bzw1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enhances histone H4 gene transcription but does not seem to bind DNA directly.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Basic leucine zipper and W2 domain-containing protein 1
Gene namesi
Name:Bzw1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi735129. Bzw1.

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002546121 – 419Basic leucine zipper and W2 domain-containing protein 1Add BLAST419

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei12PhosphoserineBy similarity1
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei411PhosphoserineCombined sources1
Modified residuei413PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6P7P5.
PRIDEiQ6P7P5.

PTM databases

iPTMnetiQ6P7P5.
PhosphoSitePlusiQ6P7P5.

Expressioni

Gene expression databases

BgeeiENSRNOG00000013977.
GenevisibleiQ6P7P5. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019486.

Structurei

3D structure databases

ProteinModelPortaliQ6P7P5.
SMRiQ6P7P5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini247 – 414W2PROSITE-ProRule annotationAdd BLAST168

Sequence similaritiesi

Belongs to the BZW family.Curated

Phylogenomic databases

eggNOGiKOG2297. Eukaryota.
ENOG410XR08. LUCA.
GeneTreeiENSGT00390000012561.
HOGENOMiHOG000252932.
HOVERGENiHBG080940.
InParanoidiQ6P7P5.
OMAiMTALWIS.
OrthoDBiEOG091G090E.
PhylomeDBiQ6P7P5.
TreeFamiTF324313.

Family and domain databases

InterProiView protein in InterPro
IPR016024. ARM-type_fold.
IPR003307. W2_domain.
PfamiView protein in Pfam
PF02020. W2. 1 hit.
SMARTiView protein in SMART
SM00515. eIF5C. 1 hit.
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiView protein in PROSITE
PS51363. W2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P7P5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNQKQQKPT LSGQRFKTRK RDEKERFDPT QFQDCIIQGL TETGTDLEAV
60 70 80 90 100
AKFLDASGAK LDYRRYAETL FDILVAGGML APGGTLADDM MRTDVCVFAA
110 120 130 140 150
QEDLETMQAF AQVFNKLIRR YKYLEKGFED EVKKLLLFLK GFSESERNKL
160 170 180 190 200
AMLTGVLLAN GTLNASILNS LYNENLVKEG VSAAFAVKLF KSWINEKDIN
210 220 230 240 250
AVAASLRKVS MDNRLMELFP ANKQSVEHFT KYFTEAGLKE LSEYVRNQQT
260 270 280 290 300
IGARKELQKE LQEQMSRGDP FKDIILYVKE EMKKNNIPEP VVIGIVWSSV
310 320 330 340 350
MSTVEWNKKE ELVAEQAIKH LKQYSPLLAA FTTQGQSELT LLLKIQEYCY
360 370 380 390 400
DNIHFMKAFQ KIVVLFYKAE VLSEEPILKW YKDAHVAKGK SVFLEQMKKF
410
VEWLKNAEEE SESEAEEGD
Length:419
Mass (Da):48,043
Last modified:July 5, 2004 - v1
Checksum:i9E952D52F5796F60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061580 mRNA. Translation: AAH61580.1.
RefSeqiNP_942084.1. NM_198789.2.
UniGeneiRn.234367.

Genome annotation databases

EnsembliENSRNOT00000019486; ENSRNOP00000019486; ENSRNOG00000013977.
GeneIDi363232.
KEGGirno:363232.
UCSCiRGD:735129. rat.

Similar proteinsi

Entry informationi

Entry nameiBZW1_RAT
AccessioniPrimary (citable) accession number: Q6P7P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families