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Q6P7I0

- 3HAO_XENLA

UniProt

Q6P7I0 - 3HAO_XENLA

Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

    Catalytic activityi

    3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

    Cofactori

    Fe2+ ion.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei43 – 431DioxygenUniRule annotation
    Metal bindingi47 – 471Iron; catalyticUniRule annotation
    Metal bindingi53 – 531Iron; catalyticUniRule annotation
    Binding sitei53 – 531SubstrateUniRule annotation
    Metal bindingi91 – 911Iron; catalyticUniRule annotation
    Binding sitei95 – 951SubstrateUniRule annotation
    Binding sitei105 – 1051SubstrateUniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
    2. ferrous iron binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
    2. anthranilate metabolic process Source: UniProtKB-HAMAP
    3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
    4. tryptophan catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Dioxygenase, Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00253; UER00330.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
    Alternative name(s):
    3-hydroxyanthranilate oxygenaseUniRule annotation
    Short name:
    3-HAOUniRule annotation
    3-hydroxyanthranilic acid dioxygenaseUniRule annotation
    Short name:
    HADUniRule annotation
    Gene namesi
    Name:haao
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-6254902. haao.

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2822823-hydroxyanthranilate 3,4-dioxygenasePRO_0000245467Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliQ6P7I0.
    SMRiQ6P7I0. Positions 5-279.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 160160Domain A (catalytic)UniRule annotationAdd
    BLAST
    Regioni161 – 17717LinkerUniRule annotationAdd
    BLAST
    Regioni178 – 282105Domain BUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the 3-HAO family.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG000018.
    KOiK00452.

    Family and domain databases

    Gene3Di2.60.120.10. 2 hits.
    HAMAPiMF_00825. 3_HAO.
    InterProiIPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view]
    PANTHERiPTHR15497. PTHR15497. 1 hit.
    PfamiPF06052. 3-HAO. 1 hit.
    [Graphical view]
    PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMiSSF51182. SSF51182. 2 hits.
    TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6P7I0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMAINVKKW IEENTEYFLP PVCNKLMHNQ QLKVMFVGGP NQRKDYHIEE    50
    GEELFYQVEG DMCLKIVENG KHKDVHIKQG EMFLLPGRIP HSPQRYADTV 100
    GLVFERRRLD TEKDGLRFYV EGSPEVLFEQ WFYCEDLGTQ LAPIMKEFFS 150
    SKQYKSGKPD PDQPKAKMPF CLSTEQVMEP FSFQHWLNKH RLEIIQKKCV 200
    SLFGDDHETK AVIYGGGESK QSKAQTDVWI WQLEGTSHVT LGNEVLKLGS 250
    GDSLLVPEET LFSWTREDGS IALSTSQVPL PM 282
    Length:282
    Mass (Da):32,450
    Last modified:July 5, 2004 - v1
    Checksum:iBF4A6DA45A9BF420
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061663 mRNA. Translation: AAH61663.1.
    RefSeqiNP_001083573.1. NM_001090104.1.
    UniGeneiXl.34491.

    Genome annotation databases

    GeneIDi398998.
    KEGGixla:398998.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061663 mRNA. Translation: AAH61663.1 .
    RefSeqi NP_001083573.1. NM_001090104.1.
    UniGenei Xl.34491.

    3D structure databases

    ProteinModelPortali Q6P7I0.
    SMRi Q6P7I0. Positions 5-279.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 398998.
    KEGGi xla:398998.

    Organism-specific databases

    CTDi 23498.
    Xenbasei XB-GENE-6254902. haao.

    Phylogenomic databases

    HOVERGENi HBG000018.
    KOi K00452.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00330 .

    Family and domain databases

    Gene3Di 2.60.120.10. 2 hits.
    HAMAPi MF_00825. 3_HAO.
    InterProi IPR010329. 3hydroanth_dOase.
    IPR016700. 3hydroanth_dOase_met.
    IPR014710. RmlC-like_jellyroll.
    IPR011051. RmlC_Cupin.
    [Graphical view ]
    PANTHERi PTHR15497. PTHR15497. 1 hit.
    Pfami PF06052. 3-HAO. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
    SUPFAMi SSF51182. SSF51182. 2 hits.
    TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Kidney.

    Entry informationi

    Entry namei3HAO_XENLA
    AccessioniPrimary (citable) accession number: Q6P7I0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3