Reviewed, UniProtKB/Swiss-Prot Q6P7I0 (3HAO_XENLA)

Names and origin

Protein names

Recommended name:
    3-hydroxyanthranilate 3,4-dioxygenase
    EC=1.13.11.6
Alternative name(s):
    3-hydroxyanthranilic acid dioxygenase
      Short name=HAD
    3-hydroxyanthranilate oxygenase
      Short name=3-HAO

Gene names

Name:

haao

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	282 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.
Catalytic activity	3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.
Cofactor	Fe2+ ion By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the 3-HAO family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-hydroxyanthranilate 3,4-dioxygenase activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 282	282	3-hydroxyanthranilate 3,4-dioxygenase		PRO_0000245467
Sites
	Metal binding	47	1	Iron; catalytic By similarity
	Metal binding	53	1	Iron; catalytic By similarity
	Metal binding	91	1	Iron; catalytic By similarity
	Binding site	43	1	Dioxygen By similarity
	Binding site	53	1	Substrate By similarity
	Binding site	95	1	Substrate By similarity
	Binding site	105	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q6P7I0-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: BF4A6DA45A9BF420	FASTA	282	32,450
	10 20 30 40 50 60 MAMAINVKKW IEENTEYFLP PVCNKLMHNQ QLKVMFVGGP NQRKDYHIEE GEELFYQVEG 70 80 90 100 110 120 DMCLKIVENG KHKDVHIKQG EMFLLPGRIP HSPQRYADTV GLVFERRRLD TEKDGLRFYV 130 140 150 160 170 180 EGSPEVLFEQ WFYCEDLGTQ LAPIMKEFFS SKQYKSGKPD PDQPKAKMPF CLSTEQVMEP 190 200 210 220 230 240 FSFQHWLNKH RLEIIQKKCV SLFGDDHETK AVIYGGGESK QSKAQTDVWI WQLEGTSHVT 250 260 270 280 LGNEVLKLGS GDSLLVPEET LFSWTREDGS IALSTSQVPL PM

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC061663 mRNA. Translation: AAH61663.1.
RefSeq	NP_001083573.1.
UniGene	Xl.34491
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	398998.
KEGG	xla:398998.
Phylogenomic databases
HOVERGEN	Q6P7I0.
Enzyme and pathway databases
BRENDA	1.13.11.6. 648.
Family and domain databases
InterPro	IPR010329. 3hydroanth_dOase. IPR016700. 3hydroanth_dOase_met. [Graphical view]
Pfam	PF06052. 3-HAO. 1 hit. [Graphical view]
PIRSF	PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
TIGRFAMs	TIGR03037. anthran_nbaC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

3HAO_XENLA

Accession

Primary (citable) accession number: Q6P7I0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2006
Last sequence update:	July 5, 2004
Last modified:	September 22, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Xenopus annotation project