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Q6P7I0

- 3HAO_XENLA

UniProt

Q6P7I0 - 3HAO_XENLA

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Protein
3-hydroxyanthranilate 3,4-dioxygenase
Gene
haao
Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431Dioxygen By similarity
Metal bindingi47 – 471Iron; catalytic By similarity
Metal bindingi53 – 531Iron; catalytic By similarity
Binding sitei53 – 531Substrate By similarity
Metal bindingi91 – 911Iron; catalytic By similarity
Binding sitei95 – 951Substrate By similarity
Binding sitei105 – 1051Substrate By similarity

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenase (EC:1.13.11.6)
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name:
3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name:
HAD
Gene namesi
Name:haao
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254902. haao.

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2822823-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation
PRO_0000245467Add
BLAST

Interactioni

Subunit structurei

Monomer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6P7I0.
SMRiQ6P7I0. Positions 5-279.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 160160Domain A (catalytic) By similarity
Add
BLAST
Regioni161 – 17717Linker By similarity
Add
BLAST
Regioni178 – 282105Domain B By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.

Phylogenomic databases

HOVERGENiHBG000018.
KOiK00452.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P7I0-1 [UniParc]FASTAAdd to Basket

« Hide

MAMAINVKKW IEENTEYFLP PVCNKLMHNQ QLKVMFVGGP NQRKDYHIEE    50
GEELFYQVEG DMCLKIVENG KHKDVHIKQG EMFLLPGRIP HSPQRYADTV 100
GLVFERRRLD TEKDGLRFYV EGSPEVLFEQ WFYCEDLGTQ LAPIMKEFFS 150
SKQYKSGKPD PDQPKAKMPF CLSTEQVMEP FSFQHWLNKH RLEIIQKKCV 200
SLFGDDHETK AVIYGGGESK QSKAQTDVWI WQLEGTSHVT LGNEVLKLGS 250
GDSLLVPEET LFSWTREDGS IALSTSQVPL PM 282
Length:282
Mass (Da):32,450
Last modified:July 5, 2004 - v1
Checksum:iBF4A6DA45A9BF420
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061663 mRNA. Translation: AAH61663.1.
RefSeqiNP_001083573.1. NM_001090104.1.
UniGeneiXl.34491.

Genome annotation databases

GeneIDi398998.
KEGGixla:398998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061663 mRNA. Translation: AAH61663.1 .
RefSeqi NP_001083573.1. NM_001090104.1.
UniGenei Xl.34491.

3D structure databases

ProteinModelPortali Q6P7I0.
SMRi Q6P7I0. Positions 5-279.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398998.
KEGGi xla:398998.

Organism-specific databases

CTDi 23498.
Xenbasei XB-GENE-6254902. haao.

Phylogenomic databases

HOVERGENi HBG000018.
KOi K00452.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMi SSF51182. SSF51182. 2 hits.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry namei3HAO_XENLA
AccessioniPrimary (citable) accession number: Q6P7I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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