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Q6P7I0

- 3HAO_XENLA

UniProt

Q6P7I0 - 3HAO_XENLA

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Protein

3-hydroxyanthranilate 3,4-dioxygenase

Gene

haao

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.UniRule annotation

Catalytic activityi

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde.UniRule annotation

Cofactori

Fe2+ ion.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei43 – 431DioxygenUniRule annotation
Metal bindingi47 – 471Iron; catalyticUniRule annotation
Metal bindingi53 – 531Iron; catalyticUniRule annotation
Binding sitei53 – 531SubstrateUniRule annotation
Metal bindingi91 – 911Iron; catalyticUniRule annotation
Binding sitei95 – 951SubstrateUniRule annotation
Binding sitei105 – 1051SubstrateUniRule annotation

GO - Molecular functioni

  1. 3-hydroxyanthranilate 3,4-dioxygenase activity Source: UniProtKB-HAMAP
  2. ferrous iron binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' NAD biosynthetic process from tryptophan Source: UniProtKB-HAMAP
  2. anthranilate metabolic process Source: UniProtKB-HAMAP
  3. quinolinate biosynthetic process Source: UniProtKB-HAMAP
  4. tryptophan catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Dioxygenase, Oxidoreductase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00253; UER00330.

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyanthranilate 3,4-dioxygenaseUniRule annotation (EC:1.13.11.6UniRule annotation)
Alternative name(s):
3-hydroxyanthranilate oxygenaseUniRule annotation
Short name:
3-HAOUniRule annotation
3-hydroxyanthranilic acid dioxygenaseUniRule annotation
Short name:
HADUniRule annotation
Gene namesi
Name:haao
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-6254902. haao.

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2822823-hydroxyanthranilate 3,4-dioxygenasePRO_0000245467Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6P7I0.
SMRiQ6P7I0. Positions 5-279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 160160Domain A (catalytic)UniRule annotationAdd
BLAST
Regioni161 – 17717LinkerUniRule annotationAdd
BLAST
Regioni178 – 282105Domain BUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the 3-HAO family.UniRule annotation

Phylogenomic databases

HOVERGENiHBG000018.
KOiK00452.

Family and domain databases

Gene3Di2.60.120.10. 2 hits.
HAMAPiMF_00825. 3_HAO.
InterProiIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERiPTHR15497. PTHR15497. 1 hit.
PfamiPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFiPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMiSSF51182. SSF51182. 2 hits.
TIGRFAMsiTIGR03037. anthran_nbaC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P7I0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMAINVKKW IEENTEYFLP PVCNKLMHNQ QLKVMFVGGP NQRKDYHIEE
60 70 80 90 100
GEELFYQVEG DMCLKIVENG KHKDVHIKQG EMFLLPGRIP HSPQRYADTV
110 120 130 140 150
GLVFERRRLD TEKDGLRFYV EGSPEVLFEQ WFYCEDLGTQ LAPIMKEFFS
160 170 180 190 200
SKQYKSGKPD PDQPKAKMPF CLSTEQVMEP FSFQHWLNKH RLEIIQKKCV
210 220 230 240 250
SLFGDDHETK AVIYGGGESK QSKAQTDVWI WQLEGTSHVT LGNEVLKLGS
260 270 280
GDSLLVPEET LFSWTREDGS IALSTSQVPL PM
Length:282
Mass (Da):32,450
Last modified:July 5, 2004 - v1
Checksum:iBF4A6DA45A9BF420
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061663 mRNA. Translation: AAH61663.1.
RefSeqiNP_001083573.1. NM_001090104.1.
UniGeneiXl.34491.

Genome annotation databases

GeneIDi398998.
KEGGixla:398998.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC061663 mRNA. Translation: AAH61663.1 .
RefSeqi NP_001083573.1. NM_001090104.1.
UniGenei Xl.34491.

3D structure databases

ProteinModelPortali Q6P7I0.
SMRi Q6P7I0. Positions 5-279.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 398998.
KEGGi xla:398998.

Organism-specific databases

CTDi 23498.
Xenbasei XB-GENE-6254902. haao.

Phylogenomic databases

HOVERGENi HBG000018.
KOi K00452.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00330 .

Family and domain databases

Gene3Di 2.60.120.10. 2 hits.
HAMAPi MF_00825. 3_HAO.
InterProi IPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view ]
PANTHERi PTHR15497. PTHR15497. 1 hit.
Pfami PF06052. 3-HAO. 1 hit.
[Graphical view ]
PIRSFi PIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMi SSF51182. SSF51182. 2 hits.
TIGRFAMsi TIGR03037. anthran_nbaC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Kidney.

Entry informationi

Entry namei3HAO_XENLA
AccessioniPrimary (citable) accession number: Q6P7I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3