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Q6P7I0 (3HAO_XENLA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-hydroxyanthranilate 3,4-dioxygenase

EC=1.13.11.6
Alternative name(s):
3-hydroxyanthranilate oxygenase
Short name=3-HAO
3-hydroxyanthranilic acid dioxygenase
Short name=HAD
Gene names
Name:haao
OrganismXenopus laevis (African clawed frog)
Taxonomic identifier8355 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Protein attributes

Sequence length282 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate By similarity. HAMAP-Rule MF_03019

Catalytic activity

3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde. HAMAP-Rule MF_03019

Cofactor

Fe2+ ion By similarity. HAMAP-Rule MF_03019

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. HAMAP-Rule MF_03019

Subunit structure

Monomer By similarity. HAMAP-Rule MF_03019

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_03019.

Sequence similarities

Belongs to the 3-HAO family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2822823-hydroxyanthranilate 3,4-dioxygenase HAMAP-Rule MF_03019
PRO_0000245467

Regions

Region1 – 160160Domain A (catalytic) By similarity
Region161 – 17717Linker By similarity
Region178 – 282105Domain B By similarity

Sites

Metal binding471Iron; catalytic By similarity
Metal binding531Iron; catalytic By similarity
Metal binding911Iron; catalytic By similarity
Binding site431Dioxygen By similarity
Binding site531Substrate By similarity
Binding site951Substrate By similarity
Binding site1051Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6P7I0 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: BF4A6DA45A9BF420

FASTA28232,450
        10         20         30         40         50         60 
MAMAINVKKW IEENTEYFLP PVCNKLMHNQ QLKVMFVGGP NQRKDYHIEE GEELFYQVEG 

        70         80         90        100        110        120 
DMCLKIVENG KHKDVHIKQG EMFLLPGRIP HSPQRYADTV GLVFERRRLD TEKDGLRFYV 

       130        140        150        160        170        180 
EGSPEVLFEQ WFYCEDLGTQ LAPIMKEFFS SKQYKSGKPD PDQPKAKMPF CLSTEQVMEP 

       190        200        210        220        230        240 
FSFQHWLNKH RLEIIQKKCV SLFGDDHETK AVIYGGGESK QSKAQTDVWI WQLEGTSHVT 

       250        260        270        280 
LGNEVLKLGS GDSLLVPEET LFSWTREDGS IALSTSQVPL PM 

« Hide

References

[1]NIH - Xenopus Gene Collection (XGC) project
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Kidney.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC061663 mRNA. Translation: AAH61663.1.
RefSeqNP_001083573.1. NM_001090104.1.
UniGeneXl.34491.

3D structure databases

ProteinModelPortalQ6P7I0.
SMRQ6P7I0. Positions 5-279.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID398998.
KEGGxla:398998.

Organism-specific databases

CTD23498.
XenbaseXB-GENE-6254902. haao.

Phylogenomic databases

HOVERGENHBG000018.
KOK00452.

Enzyme and pathway databases

UniPathwayUPA00253; UER00330.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00825. 3_HAO.
InterProIPR010329. 3hydroanth_dOase.
IPR016700. 3hydroanth_dOase_met.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR15497. PTHR15497. 1 hit.
PfamPF06052. 3-HAO. 1 hit.
[Graphical view]
PIRSFPIRSF017681. 3hydroanth_dOase_animal. 1 hit.
SUPFAMSSF51182. SSF51182. 2 hits.
TIGRFAMsTIGR03037. anthran_nbaC. 1 hit.
ProtoNetSearch...

Entry information

Entry name3HAO_XENLA
AccessionPrimary (citable) accession number: Q6P7I0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways