Mid1ip1

Functionⁱ

Plays a role in the regulation of lipogenesis in liver. Up-regulates ACACA enzyme activity. Required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol and phospholipid. Involved in stabilization of microtubules (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

identical protein binding
Source: RGD
Inferred from sequence orthologyⁱ
- 20457939
protein C-terminus binding
Source: RGD
Inferred from sequence orthologyⁱ
- 15070402

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

lipid metabolic process Source: UniProtKB-KW
negative regulation of microtubule depolymerization Source: UniProtKB
positive regulation of fatty acid biosynthetic process Source: UniProtKB
positive regulation of ligase activity Source: UniProtKB
protein polymerization Source: UniProtKB
regulation of lipid biosynthetic process
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20233797

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Lipid biosynthesis, Lipid metabolism

Biological process

Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

Reactomeⁱ	R-RNO-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Reactomeⁱ

R-RNO-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mid1-interacting protein 1 Alternative name(s): Gastrulation-specific G12-like protein Mid1-interacting G12-like protein Protein STRAIT11499 homolog Spot 14-related protein Short name: S14R Short name: Spot 14-R
Gene namesⁱ	Name:Mid1ip1By similarity Synonyms:Mig12Imported
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome X

Organism-specific databases

Rat genome database More...RGDⁱ	1303258. Mid1ip1.

RGDⁱ

1303258. Mid1ip1.

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Microtubule, Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000123779	1 – 183	Mid1-interacting protein 1Add BLAST		183

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Modified residueⁱ	72	PhosphoserineCombined sources	1
Modified residueⁱ	75	PhosphoserineCombined sources	1
Modified residueⁱ	79	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6P7D5.

PaxDbⁱ

Q6P7D5.

PTM databases

iPTMnetⁱ	Q6P7D5.
PhosphoSitePlusⁱ	Q6P7D5.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000003228.
ExpressionAtlasⁱ	Q6P7D5. baseline and differential.
Genevisibleⁱ	Q6P7D5. RN.

Interactionⁱ

Subunit structureⁱ

Homodimer in the absence of THRSP. Heterodimer with THRSP. The homodimer interacts with ACACA and ACACB. Promotes polymerization of Acetyl-CoA carboxylase to form complexes that contain MID1IP1 and ACACA and/or ACACB. Interaction with THRSP interferes with ACACA binding (By similarity).By similarity

GO - Molecular functionⁱ

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000004305.

STRINGⁱ

10116.ENSRNOP00000004305.

Structureⁱ

3D structure databases

SMRⁱ	Q6P7D5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SPOT14 family.Sequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG410IGNP. Eukaryota. ENOG4111NGS. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044890.
HOGENOMⁱ	HOG000001157.
HOVERGENⁱ	HBG002528.
InParanoidⁱ	Q6P7D5.
OMAⁱ	IEWGVLQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Z4G.
PhylomeDBⁱ	Q6P7D5.
TreeFamⁱ	TF326826.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009786. Spot_14.
PANTHERⁱ	PTHR14315. PTHR14315. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07084. Spot_14. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6P7D5-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MMQICDTYNQ KHSLFNAMNR FIGAVNNMDQ TVMVPSLLRD VPLSEPDLDN 
        60         70         80         90        100
EVSVEVGGSG SCLEERTTPA PSPGSANGSF FAPSRDMYSH YVLLKSIRND 
       110        120        130        140        150
IEWGVLHQPS SPPAGSEEGT WKPKDILVGL SHLESTDAGE EDLEQQFHYH 
       160        170        180 
LRGLHTVLSK LTRKANILTN RYKQEIGFSN WGH

Length:183

Mass (Da):20,414

Last modified:July 5, 2004 - v1

Checksum:ⁱ0E987B0470CAB319

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC061715 mRNA. Translation: AAH61715.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_996833.1. NM_206950.1. XP_006256734.1. XM_006256672.3. XP_017457615.1. XM_017602126.1.
UniGeneⁱ	Rn.8267.

Genome annotation databases

Ensemblⁱ	ENSRNOT00000004305; ENSRNOP00000004305; ENSRNOG00000003228.
GeneIDⁱ	404280.
KEGGⁱ	rno:404280.
UCSC genome browser More...UCSCⁱ	RGD:1303258. rat.

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6P7D5	A7BKC9	Rattus norvegicus (Rat)	183	UniRef100_Q6P7D5	Cluster: Mid1-interacting protein 1	2

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6P7D5	Q9NPA3 K7BGJ0 F7BK64 G7Q2I6 A0A0D9SDW7 A0A2K6JRJ9 A0A2K5KZP7 A0A2I3HWT3 UPI00038EB1D6 UPI00042AB2E1 +55	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Macaca mulatta (Rhesus macaque) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys) Chinchilla lanigera (Long-tailed chinchilla) (Chinchilla villidera) Peromyscus maniculatus bairdii (Prairie deer mouse) And more	183	UniRef90_Q9NPA3	Cluster: Mid1-interacting protein 1	66

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q6P7D5	Q9CQ20 Q4FK31 F7D5Q6 F6XIS3 A0A1A6GHD1 A0A091DDE0 UPI0004547744 A0A1U7QTL4 UPI000A306BCF UPI00018BDA78 +76	Mus musculus (Mouse) Neotoma lepida (Desert woodrat) Fukomys damarensis (Damaraland mole rat) (Cryptomys damarensis) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) Mesocricetus auratus (Golden hamster) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Vicugna pacos (Alpaca) (Lama pacos) Odobenus rosmarus divergens (Pacific walrus) Crocodylus porosus (Saltwater crocodile) (Estuarine crocodile) Alligator mississippiensis (American alligator) And more	182	UniRef50_Q9CQ20	Cluster: Mid1-interacting protein 1	87

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC061715 mRNA. Translation: AAH61715.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_996833.1. NM_206950.1. XP_006256734.1. XM_006256672.3. XP_017457615.1. XM_017602126.1.
UniGeneⁱ	Rn.8267.

3D structure databases

SMRⁱ	Q6P7D5.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000004305.

STRINGⁱ

10116.ENSRNOP00000004305.

PTM databases

iPTMnetⁱ	Q6P7D5.
PhosphoSitePlusⁱ	Q6P7D5.

Proteomic databases

PaxDbⁱ	Q6P7D5.

PaxDbⁱ

Q6P7D5.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000004305; ENSRNOP00000004305; ENSRNOG00000003228.
GeneIDⁱ	404280.
KEGGⁱ	rno:404280.
UCSC genome browser More...UCSCⁱ	RGD:1303258. rat.

Organism-specific databases

CTDⁱ	58526.
Rat genome database More...RGDⁱ	1303258. Mid1ip1.

Phylogenomic databases

eggNOGⁱ	ENOG410IGNP. Eukaryota. ENOG4111NGS. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00500000044890.
HOGENOMⁱ	HOG000001157.
HOVERGENⁱ	HBG002528.
InParanoidⁱ	Q6P7D5.
OMAⁱ	IEWGVLQ.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0Z4G.
PhylomeDBⁱ	Q6P7D5.
TreeFamⁱ	TF326826.

Enzyme and pathway databases

Reactomeⁱ	R-RNO-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Reactomeⁱ

R-RNO-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6P7D5.

PROⁱ

PR:Q6P7D5.

Gene expression databases

Bgeeⁱ	ENSRNOG00000003228.
ExpressionAtlasⁱ	Q6P7D5. baseline and differential.
Genevisibleⁱ	Q6P7D5. RN.

Family and domain databases

InterProⁱ	View protein in InterPro IPR009786. Spot_14.
PANTHERⁱ	PTHR14315. PTHR14315. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07084. Spot_14. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M1IP1_RAT
Accessionⁱ	Q6P7D5Primary (citable) accession number: Q6P7D5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
	Last sequence update:	July 5, 2004
	Last modified:	December 20, 2017
	This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Supporting data

UniProtKB - Q6P7D5 (M1IP1_RAT)

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Mid1-interacting protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Nucleus

Other locations

Cytoskeleton

Cytosol

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ