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Protein

Cytochrome P450 20A1

Gene

Cyp20a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi409Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 20A1 (EC:1.14.-.-)
Gene namesi
Name:Cyp20a1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi735221. Cyp20a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003180971 – 462Cytochrome P450 20A1Add BLAST462

Proteomic databases

PaxDbiQ6P7D4.
PRIDEiQ6P7D4.

PTM databases

iPTMnetiQ6P7D4.
PhosphoSitePlusiQ6P7D4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023796.

Structurei

3D structure databases

ProteinModelPortaliQ6P7D4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000111913.
HOVERGENiHBG076231.
InParanoidiQ6P7D4.
KOiK07435.
PhylomeDBiQ6P7D4.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P7D4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLDFAIFAVT FLLALVGAVL YLYPASRQAS GIPGLTPTEE KDGNLPDIVN
60 70 80 90 100
SGSLHEFLVN LHGRYGPVVS FWFGRRLVVS LGTADALKQH FNPNKTLDPF
110 120 130 140 150
ETMLKSLLGY RSGAGSGSED HVRRRLYGDA VTAALQSNFP LLLKLSEELL
160 170 180 190 200
DKWLSYPETQ HIPLSQHMLG FALKFVTRMV LGDTFEGEQE VIRFQKIHGT
210 220 230 240 250
VWSEIGKGFL DGSLDKNTTR KNQYQEALMQ LEAILKKIIK ERKGGDFSQH
260 270 280 290 300
TFIDSLVQRN LNEQQILEDS VVFSLAGCIV TARLCTWAIH FLTTAEEVQK
310 320 330 340 350
KLHKEVDHVL GKGPITSEKI EQLRYCQQVL CETVRTAKLT PVSAQLQDIE
360 370 380 390 400
GKVGPFIIPK ETLVLYALGV VLQDASTWPS PHKFDPDRFA DEPVMKVFSS
410 420 430 440 450
LGFSGTWECP ELRFAYVVTT VLVSVLLKKL HLLAVDRQVF EMKYELVTSC
460
REETWITVSE RH
Length:462
Mass (Da):51,998
Last modified:July 5, 2004 - v1
Checksum:iD09CD1F59B323EEE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061716 mRNA. Translation: AAH61716.1.
RefSeqiNP_955433.1. NM_199401.1.
UniGeneiRn.101629.

Genome annotation databases

GeneIDi316435.
KEGGirno:316435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061716 mRNA. Translation: AAH61716.1.
RefSeqiNP_955433.1. NM_199401.1.
UniGeneiRn.101629.

3D structure databases

ProteinModelPortaliQ6P7D4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023796.

PTM databases

iPTMnetiQ6P7D4.
PhosphoSitePlusiQ6P7D4.

Proteomic databases

PaxDbiQ6P7D4.
PRIDEiQ6P7D4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi316435.
KEGGirno:316435.

Organism-specific databases

CTDi57404.
RGDi735221. Cyp20a1.

Phylogenomic databases

eggNOGiKOG0157. Eukaryota.
COG2124. LUCA.
HOGENOMiHOG000111913.
HOVERGENiHBG076231.
InParanoidiQ6P7D4.
KOiK07435.
PhylomeDBiQ6P7D4.

Miscellaneous databases

PROiQ6P7D4.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
SUPFAMiSSF48264. SSF48264. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCP20A_RAT
AccessioniPrimary (citable) accession number: Q6P7D4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.