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Protein

Immediate early response gene 2 protein

Gene

Ier2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (PubMed:17156131). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell motility Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: RGD
  • response to fibroblast growth factor Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 2 protein
Gene namesi
Name:Ier2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359581. Ier2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001904371 – 221Immediate early response gene 2 proteinAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6P7D3.
PRIDEiQ6P7D3.

Expressioni

Inductioni

Induced by basic fibroblast growth factor (bFGF).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067493.

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiQ6P7D3.
PhylomeDBiQ6P7D3.
TreeFamiTF331376.

Family and domain databases

InterProiView protein in InterPro
IPR008653. IER.
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiView protein in Pfam
PF05760. IER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6P7D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA
60 70 80 90 100
KVETHQPEFP PSRRALDPRL HPPREPEAAM EAATPDVEQP PEPMDTQEEV
110 120 130 140 150
LRVQETPALC DPPPARVSRK RRSSSDLSDG SDAGLVPSKK ARLEEVEGEA
160 170 180 190 200
TSEVSNRLQL PPAQTEGAFP NLARVLQRRF SSLLNCGPAV PPPTPPTCEA
210 220
KPACRPADNM LNVLVRTVVA F
Length:221
Mass (Da):24,596
Last modified:July 5, 2004 - v1
Checksum:i48E69A05D18BB945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061717 mRNA. Translation: AAH61717.1.
RefSeqiNP_001009541.1. NM_001009541.1.
UniGeneiRn.4298.

Genome annotation databases

GeneIDi494344.
KEGGirno:494344.

Similar proteinsi

Entry informationi

Entry nameiIER2_RAT
AccessioniPrimary (citable) accession number: Q6P7D3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families