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Protein

Immediate early response gene 2 protein

Gene

Ier2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

DNA-binding protein that seems to act as a transcription factor (By similarity). Involved in the regulation of neuronal differentiation, acts upon JNK-signaling pathway activation and plays a role in neurite outgrowth in hippocampal cells (PubMed:17156131). May mediate with FIBP FGF-signaling in the establishment of laterality in the embryo (By similarity). Promotes cell motility, seems to stimulate tumor metastasis (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cell motility Source: UniProtKB
  • neuron differentiation Source: UniProtKB
  • response to fibroblast growth factor Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Immediate early response gene 2 protein
Gene namesi
Name:Ier2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1359581. Ier2.

Subcellular locationi

  • Cytoplasm By similarity
  • Nucleus By similarity

  • Note: Cytoplasmic during quiescence, translocates to the nucleus upon stimulation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 221221Immediate early response gene 2 proteinPRO_0000190437Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ6P7D3.
PRIDEiQ6P7D3.

Expressioni

Inductioni

Induced by basic fibroblast growth factor (bFGF).1 Publication

Gene expression databases

BgeeiENSRNOG00000047811.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067493.

Family & Domainsi

Sequence similaritiesi

Belongs to the IER family.Curated

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiQ6P7D3.
PhylomeDBiQ6P7D3.
TreeFamiTF331376.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6P7D3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVQKEAQRI MTLSVWKMYH SRMQRGGLRL HRSLQLSLVM RSARELYLSA
60 70 80 90 100
KVETHQPEFP PSRRALDPRL HPPREPEAAM EAATPDVEQP PEPMDTQEEV
110 120 130 140 150
LRVQETPALC DPPPARVSRK RRSSSDLSDG SDAGLVPSKK ARLEEVEGEA
160 170 180 190 200
TSEVSNRLQL PPAQTEGAFP NLARVLQRRF SSLLNCGPAV PPPTPPTCEA
210 220
KPACRPADNM LNVLVRTVVA F
Length:221
Mass (Da):24,596
Last modified:July 5, 2004 - v1
Checksum:i48E69A05D18BB945
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061717 mRNA. Translation: AAH61717.1.
RefSeqiNP_001009541.1. NM_001009541.1.
UniGeneiRn.4298.

Genome annotation databases

GeneIDi494344.
KEGGirno:494344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061717 mRNA. Translation: AAH61717.1.
RefSeqiNP_001009541.1. NM_001009541.1.
UniGeneiRn.4298.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067493.

Proteomic databases

PaxDbiQ6P7D3.
PRIDEiQ6P7D3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi494344.
KEGGirno:494344.

Organism-specific databases

CTDi9592.
RGDi1359581. Ier2.

Phylogenomic databases

eggNOGiENOG410IXGG. Eukaryota.
ENOG410Z3CN. LUCA.
HOGENOMiHOG000112998.
HOVERGENiHBG068883.
InParanoidiQ6P7D3.
PhylomeDBiQ6P7D3.
TreeFamiTF331376.

Miscellaneous databases

PROiQ6P7D3.

Gene expression databases

BgeeiENSRNOG00000047811.

Family and domain databases

InterProiIPR008653. IER.
[Graphical view]
PANTHERiPTHR15895. PTHR15895. 1 hit.
PfamiPF05760. IER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIER2_RAT
AccessioniPrimary (citable) accession number: Q6P7D3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.