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Q6P7C7

- GPNMB_RAT

UniProt

Q6P7C7 - GPNMB_RAT

Protein

Transmembrane glycoprotein NMB

Gene

Gpnmb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Could be a melanogenic enzyme.By similarity

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. bone mineralization Source: RGD
    2. cell adhesion Source: Ensembl
    3. osteoblast differentiation Source: RGD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transmembrane glycoprotein NMB
    Gene namesi
    Name:Gpnmb
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi71008. Gpnmb.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type I membrane protein By similarity. Melanosome By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: Ensembl
    2. melanosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 572550Transmembrane glycoprotein NMBPRO_0000024711Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
    Modified residuei544 – 5441PhosphoserineBy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ6P7C7.
    PRIDEiQ6P7C7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P7C7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011945.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 500478ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini522 – 57251CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei501 – 52121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini251 – 33888PKDPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi556 – 5583Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the PMEL/NMB family.Curated
    Contains 1 PKD domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG40272.
    GeneTreeiENSGT00530000063573.
    HOGENOMiHOG000252941.
    HOVERGENiHBG051797.
    InParanoidiQ6P7C7.
    OMAiHTYVLNG.
    OrthoDBiEOG7GXPB9.
    PhylomeDBiQ6P7C7.
    TreeFamiTF334865.

    Family and domain databases

    Gene3Di2.60.40.670. 1 hit.
    InterProiIPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    [Graphical view]
    PfamiPF00801. PKD. 1 hit.
    [Graphical view]
    SMARTiSM00089. PKD. 1 hit.
    [Graphical view]
    SUPFAMiSSF49299. SSF49299. 1 hit.
    PROSITEiPS50093. PKD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6P7C7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESLCGVLVF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE NNQLRGWSSD    50
    ENEWDEQLYP VWRRGEGRWK DSWEGGRVQA ALTSDSPALV GSNITFVVNL 100
    VFPRCQKEDA NGNIVYERNC RSDLELASDP YVYNWTTGAD DEDWEDSTSQ 150
    GQHLRFPDGK PFPRPHGRKK WNFVYVFHTL GQYFQKLGRC SARVSINTVN 200
    LTVGPQVMEV IVFRRHGRAY IPISKVKDVY VITDQIPIFV TMYQKNDRNS 250
    SDETFLRDLP IFFDVLIHDP SHFLNYSAIS YKWNFGDNTG LFVSNNHTLN 300
    HTYVLNGTFN FNLTVQTAVP GPCPSPTPSP SSSTSPSPAS SPSPTLSTPS 350
    PSLMPTGHKS MELSDISNEN CRINRYGYFR ATITIVDGIL EVNIIQVADV 400
    PIPTPQPDNS LMDFIVTCKG ATPTEACTII SDPTCQIAQN RVCSPVAVDE 450
    LCLLSVRRAF NGSGTYCVNF TLGDDASLAL TSALISIPGK DLGSPLRTVN 500
    GVLISIGCLA MFVTMVTILL YKKHKTYKPI GNCTRNVVKG KGLSVFLSHA 550
    KAPFSRGDRE KDPLLQDKPW ML 572
    Length:572
    Mass (Da):63,731
    Last modified:July 5, 2004 - v1
    Checksum:i99854F7773FF946C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061725 mRNA. Translation: AAH61725.1.
    UniGeneiRn.13778.

    Genome annotation databases

    EnsembliENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816.
    UCSCiRGD:71008. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC061725 mRNA. Translation: AAH61725.1 .
    UniGenei Rn.13778.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011945.

    Proteomic databases

    PaxDbi Q6P7C7.
    PRIDEi Q6P7C7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011945 ; ENSRNOP00000011945 ; ENSRNOG00000008816 .
    UCSCi RGD:71008. rat.

    Organism-specific databases

    RGDi 71008. Gpnmb.

    Phylogenomic databases

    eggNOGi NOG40272.
    GeneTreei ENSGT00530000063573.
    HOGENOMi HOG000252941.
    HOVERGENi HBG051797.
    InParanoidi Q6P7C7.
    OMAi HTYVLNG.
    OrthoDBi EOG7GXPB9.
    PhylomeDBi Q6P7C7.
    TreeFami TF334865.

    Miscellaneous databases

    PROi Q6P7C7.

    Gene expression databases

    Genevestigatori Q6P7C7.

    Family and domain databases

    Gene3Di 2.60.40.670. 1 hit.
    InterProi IPR022409. PKD/Chitinase_dom.
    IPR000601. PKD_dom.
    [Graphical view ]
    Pfami PF00801. PKD. 1 hit.
    [Graphical view ]
    SMARTi SM00089. PKD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49299. SSF49299. 1 hit.
    PROSITEi PS50093. PKD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.

    Entry informationi

    Entry nameiGPNMB_RAT
    AccessioniPrimary (citable) accession number: Q6P7C7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3