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Q6P7C7 (GPNMB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane glycoprotein NMB
Gene names
Name:Gpnmb
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length572 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Could be a melanogenic enzyme By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein By similarity. Melanosome By similarity.

Sequence similarities

Belongs to the PMEL/NMB family.

Contains 1 PKD domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Chain23 – 572550Transmembrane glycoprotein NMB
PRO_0000024711

Regions

Topological domain23 – 500478Extracellular Potential
Transmembrane501 – 52121Helical; Potential
Topological domain522 – 57251Cytoplasmic Potential
Domain251 – 33888PKD
Motif556 – 5583Cell attachment site Potential

Amino acid modifications

Modified residue5441Phosphoserine By similarity
Glycosylation931N-linked (GlcNAc...) Potential
Glycosylation1341N-linked (GlcNAc...) Potential
Glycosylation2001N-linked (GlcNAc...) Potential
Glycosylation2491N-linked (GlcNAc...) Potential
Glycosylation2751N-linked (GlcNAc...) Potential
Glycosylation2961N-linked (GlcNAc...) Potential
Glycosylation3001N-linked (GlcNAc...) Potential
Glycosylation3061N-linked (GlcNAc...) Potential
Glycosylation3121N-linked (GlcNAc...) Potential
Glycosylation4611N-linked (GlcNAc...) Potential
Glycosylation4691N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6P7C7 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 99854F7773FF946C

FASTA57263,731
        10         20         30         40         50         60 
MESLCGVLVF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE NNQLRGWSSD ENEWDEQLYP 

        70         80         90        100        110        120 
VWRRGEGRWK DSWEGGRVQA ALTSDSPALV GSNITFVVNL VFPRCQKEDA NGNIVYERNC 

       130        140        150        160        170        180 
RSDLELASDP YVYNWTTGAD DEDWEDSTSQ GQHLRFPDGK PFPRPHGRKK WNFVYVFHTL 

       190        200        210        220        230        240 
GQYFQKLGRC SARVSINTVN LTVGPQVMEV IVFRRHGRAY IPISKVKDVY VITDQIPIFV 

       250        260        270        280        290        300 
TMYQKNDRNS SDETFLRDLP IFFDVLIHDP SHFLNYSAIS YKWNFGDNTG LFVSNNHTLN 

       310        320        330        340        350        360 
HTYVLNGTFN FNLTVQTAVP GPCPSPTPSP SSSTSPSPAS SPSPTLSTPS PSLMPTGHKS 

       370        380        390        400        410        420 
MELSDISNEN CRINRYGYFR ATITIVDGIL EVNIIQVADV PIPTPQPDNS LMDFIVTCKG 

       430        440        450        460        470        480 
ATPTEACTII SDPTCQIAQN RVCSPVAVDE LCLLSVRRAF NGSGTYCVNF TLGDDASLAL 

       490        500        510        520        530        540 
TSALISIPGK DLGSPLRTVN GVLISIGCLA MFVTMVTILL YKKHKTYKPI GNCTRNVVKG 

       550        560        570 
KGLSVFLSHA KAPFSRGDRE KDPLLQDKPW ML 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Prostate.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC061725 mRNA. Translation: AAH61725.1.
UniGeneRn.13778.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011945.

Proteomic databases

PaxDbQ6P7C7.
PRIDEQ6P7C7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816.
UCSCRGD:71008. rat.

Organism-specific databases

RGD71008. Gpnmb.

Phylogenomic databases

eggNOGNOG40272.
GeneTreeENSGT00530000063573.
HOGENOMHOG000252941.
HOVERGENHBG051797.
InParanoidQ6P7C7.
OMAHTYVLNG.
OrthoDBEOG7GXPB9.
TreeFamTF334865.

Gene expression databases

GenevestigatorQ6P7C7.

Family and domain databases

Gene3D2.60.40.670. 1 hit.
InterProIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamPF00801. PKD. 1 hit.
[Graphical view]
SMARTSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMSSF49299. SSF49299. 1 hit.
PROSITEPS50093. PKD. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ6P7C7.

Entry information

Entry nameGPNMB_RAT
AccessionPrimary (citable) accession number: Q6P7C7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families