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Protein

Transmembrane glycoprotein NMB

Gene

Gpnmb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Could be a melanogenic enzyme.By similarity

GO - Molecular functioni

GO - Biological processi

  • bone mineralization Source: RGD
  • cell adhesion Source: GO_Central
  • negative regulation of tumor necrosis factor production Source: Ensembl
  • osteoblast differentiation Source: RGD
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-8857538. PTK6 promotes HIF1A stabilization.

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane glycoprotein NMB
Gene namesi
Name:Gpnmb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71008. Gpnmb.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 500ExtracellularSequence analysisAdd BLAST478
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 572CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002471123 – 572Transmembrane glycoprotein NMBAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...)Sequence analysis1
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1
Glycosylationi200N-linked (GlcNAc...)Sequence analysis1
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi275N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi300N-linked (GlcNAc...)Sequence analysis1
Glycosylationi306N-linked (GlcNAc...)Sequence analysis1
Glycosylationi312N-linked (GlcNAc...)Sequence analysis1
Glycosylationi461N-linked (GlcNAc...)Sequence analysis1
Glycosylationi469N-linked (GlcNAc...)Sequence analysis1
Modified residuei544PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P7C7.
PRIDEiQ6P7C7.

Expressioni

Gene expression databases

BgeeiENSRNOG00000008816.
GenevisibleiQ6P7C7. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011945.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 338PKDPROSITE-ProRule annotationAdd BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi556 – 558Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the PMEL/NMB family.Curated
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9P. Eukaryota.
ENOG4110Q2V. LUCA.
GeneTreeiENSGT00530000063573.
HOGENOMiHOG000252941.
HOVERGENiHBG051797.
InParanoidiQ6P7C7.
OMAiFPGNQEK.
OrthoDBiEOG091G072N.
PhylomeDBiQ6P7C7.
TreeFamiTF334865.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
[Graphical view]
SMARTiSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P7C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLCGVLVF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE NNQLRGWSSD
60 70 80 90 100
ENEWDEQLYP VWRRGEGRWK DSWEGGRVQA ALTSDSPALV GSNITFVVNL
110 120 130 140 150
VFPRCQKEDA NGNIVYERNC RSDLELASDP YVYNWTTGAD DEDWEDSTSQ
160 170 180 190 200
GQHLRFPDGK PFPRPHGRKK WNFVYVFHTL GQYFQKLGRC SARVSINTVN
210 220 230 240 250
LTVGPQVMEV IVFRRHGRAY IPISKVKDVY VITDQIPIFV TMYQKNDRNS
260 270 280 290 300
SDETFLRDLP IFFDVLIHDP SHFLNYSAIS YKWNFGDNTG LFVSNNHTLN
310 320 330 340 350
HTYVLNGTFN FNLTVQTAVP GPCPSPTPSP SSSTSPSPAS SPSPTLSTPS
360 370 380 390 400
PSLMPTGHKS MELSDISNEN CRINRYGYFR ATITIVDGIL EVNIIQVADV
410 420 430 440 450
PIPTPQPDNS LMDFIVTCKG ATPTEACTII SDPTCQIAQN RVCSPVAVDE
460 470 480 490 500
LCLLSVRRAF NGSGTYCVNF TLGDDASLAL TSALISIPGK DLGSPLRTVN
510 520 530 540 550
GVLISIGCLA MFVTMVTILL YKKHKTYKPI GNCTRNVVKG KGLSVFLSHA
560 570
KAPFSRGDRE KDPLLQDKPW ML
Length:572
Mass (Da):63,731
Last modified:July 5, 2004 - v1
Checksum:i99854F7773FF946C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061725 mRNA. Translation: AAH61725.1.
UniGeneiRn.13778.

Genome annotation databases

EnsembliENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816.
UCSCiRGD:71008. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061725 mRNA. Translation: AAH61725.1.
UniGeneiRn.13778.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011945.

Proteomic databases

PaxDbiQ6P7C7.
PRIDEiQ6P7C7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816.
UCSCiRGD:71008. rat.

Organism-specific databases

RGDi71008. Gpnmb.

Phylogenomic databases

eggNOGiENOG410IE9P. Eukaryota.
ENOG4110Q2V. LUCA.
GeneTreeiENSGT00530000063573.
HOGENOMiHOG000252941.
HOVERGENiHBG051797.
InParanoidiQ6P7C7.
OMAiFPGNQEK.
OrthoDBiEOG091G072N.
PhylomeDBiQ6P7C7.
TreeFamiTF334865.

Enzyme and pathway databases

ReactomeiR-RNO-8857538. PTK6 promotes HIF1A stabilization.

Miscellaneous databases

PROiQ6P7C7.

Gene expression databases

BgeeiENSRNOG00000008816.
GenevisibleiQ6P7C7. RN.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
[Graphical view]
SMARTiSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPNMB_RAT
AccessioniPrimary (citable) accession number: Q6P7C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.