Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane glycoprotein NMB

Gene

Gpnmb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Could be a melanogenic enzyme.By similarity

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-8857538 PTK6 promotes HIF1A stabilization

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane glycoprotein NMB
Gene namesi
Name:Gpnmb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi71008 Gpnmb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 500ExtracellularSequence analysisAdd BLAST478
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 572CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002471123 – 572Transmembrane glycoprotein NMBAdd BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi93N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi249N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi296N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi300N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi306N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi312N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi461N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi469N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei544PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P7C7
PRIDEiQ6P7C7

Expressioni

Gene expression databases

BgeeiENSRNOG00000008816
GenevisibleiQ6P7C7 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011945

Structurei

3D structure databases

SMRiQ6P7C7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini251 – 338PKDPROSITE-ProRule annotationAdd BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi556 – 558Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the PMEL/NMB family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE9P Eukaryota
ENOG4110Q2V LUCA
GeneTreeiENSGT00530000063573
HOGENOMiHOG000252941
HOVERGENiHBG051797
InParanoidiQ6P7C7
OMAiNFGDNTG
OrthoDBiEOG091G072N
PhylomeDBiQ6P7C7
TreeFamiTF334865

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR022409 PKD/Chitinase_dom
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
SMARTiView protein in SMART
SM00089 PKD, 1 hit
SUPFAMiSSF49299 SSF49299, 1 hit
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P7C7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESLCGVLVF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE NNQLRGWSSD
60 70 80 90 100
ENEWDEQLYP VWRRGEGRWK DSWEGGRVQA ALTSDSPALV GSNITFVVNL
110 120 130 140 150
VFPRCQKEDA NGNIVYERNC RSDLELASDP YVYNWTTGAD DEDWEDSTSQ
160 170 180 190 200
GQHLRFPDGK PFPRPHGRKK WNFVYVFHTL GQYFQKLGRC SARVSINTVN
210 220 230 240 250
LTVGPQVMEV IVFRRHGRAY IPISKVKDVY VITDQIPIFV TMYQKNDRNS
260 270 280 290 300
SDETFLRDLP IFFDVLIHDP SHFLNYSAIS YKWNFGDNTG LFVSNNHTLN
310 320 330 340 350
HTYVLNGTFN FNLTVQTAVP GPCPSPTPSP SSSTSPSPAS SPSPTLSTPS
360 370 380 390 400
PSLMPTGHKS MELSDISNEN CRINRYGYFR ATITIVDGIL EVNIIQVADV
410 420 430 440 450
PIPTPQPDNS LMDFIVTCKG ATPTEACTII SDPTCQIAQN RVCSPVAVDE
460 470 480 490 500
LCLLSVRRAF NGSGTYCVNF TLGDDASLAL TSALISIPGK DLGSPLRTVN
510 520 530 540 550
GVLISIGCLA MFVTMVTILL YKKHKTYKPI GNCTRNVVKG KGLSVFLSHA
560 570
KAPFSRGDRE KDPLLQDKPW ML
Length:572
Mass (Da):63,731
Last modified:July 5, 2004 - v1
Checksum:i99854F7773FF946C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061725 mRNA Translation: AAH61725.1
UniGeneiRn.13778

Genome annotation databases

EnsembliENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816
UCSCiRGD:71008 rat

Similar proteinsi

Entry informationi

Entry nameiGPNMB_RAT
AccessioniPrimary (citable) accession number: Q6P7C7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health