Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6P7C7

- GPNMB_RAT

UniProt

Q6P7C7 - GPNMB_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Transmembrane glycoprotein NMB

Gene

Gpnmb

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Could be a melanogenic enzyme.By similarity

GO - Molecular functioni

  1. heparin binding Source: Ensembl

GO - Biological processi

  1. bone mineralization Source: RGD
  2. cell adhesion Source: Ensembl
  3. osteoblast differentiation Source: RGD
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane glycoprotein NMB
Gene namesi
Name:Gpnmb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi71008. Gpnmb.

Subcellular locationi

Cell membrane By similarity; Single-pass type I membrane protein By similarity. Melanosome By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini23 – 500478ExtracellularSequence AnalysisAdd
BLAST
Transmembranei501 – 52121HelicalSequence AnalysisAdd
BLAST
Topological domaini522 – 57251CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle Source: Ensembl
  2. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222Sequence AnalysisAdd
BLAST
Chaini23 – 572550Transmembrane glycoprotein NMBPRO_0000024711Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi93 – 931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi134 – 1341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi200 – 2001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi249 – 2491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi275 – 2751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi300 – 3001N-linked (GlcNAc...)Sequence Analysis
Glycosylationi306 – 3061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi312 – 3121N-linked (GlcNAc...)Sequence Analysis
Glycosylationi461 – 4611N-linked (GlcNAc...)Sequence Analysis
Glycosylationi469 – 4691N-linked (GlcNAc...)Sequence Analysis
Modified residuei544 – 5441PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P7C7.
PRIDEiQ6P7C7.

Expressioni

Gene expression databases

GenevestigatoriQ6P7C7.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011945.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini251 – 33888PKDPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi556 – 5583Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the PMEL/NMB family.Curated
Contains 1 PKD domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG40272.
GeneTreeiENSGT00530000063573.
HOGENOMiHOG000252941.
HOVERGENiHBG051797.
InParanoidiQ6P7C7.
OMAiHTYVLNG.
OrthoDBiEOG7GXPB9.
PhylomeDBiQ6P7C7.
TreeFamiTF334865.

Family and domain databases

Gene3Di2.60.40.670. 1 hit.
InterProiIPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view]
PfamiPF00801. PKD. 1 hit.
[Graphical view]
SMARTiSM00089. PKD. 1 hit.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 1 hit.
PROSITEiPS50093. PKD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6P7C7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESLCGVLVF LLLAAGLPLQ AAKRFRDVLG HEQYPDHMRE NNQLRGWSSD
60 70 80 90 100
ENEWDEQLYP VWRRGEGRWK DSWEGGRVQA ALTSDSPALV GSNITFVVNL
110 120 130 140 150
VFPRCQKEDA NGNIVYERNC RSDLELASDP YVYNWTTGAD DEDWEDSTSQ
160 170 180 190 200
GQHLRFPDGK PFPRPHGRKK WNFVYVFHTL GQYFQKLGRC SARVSINTVN
210 220 230 240 250
LTVGPQVMEV IVFRRHGRAY IPISKVKDVY VITDQIPIFV TMYQKNDRNS
260 270 280 290 300
SDETFLRDLP IFFDVLIHDP SHFLNYSAIS YKWNFGDNTG LFVSNNHTLN
310 320 330 340 350
HTYVLNGTFN FNLTVQTAVP GPCPSPTPSP SSSTSPSPAS SPSPTLSTPS
360 370 380 390 400
PSLMPTGHKS MELSDISNEN CRINRYGYFR ATITIVDGIL EVNIIQVADV
410 420 430 440 450
PIPTPQPDNS LMDFIVTCKG ATPTEACTII SDPTCQIAQN RVCSPVAVDE
460 470 480 490 500
LCLLSVRRAF NGSGTYCVNF TLGDDASLAL TSALISIPGK DLGSPLRTVN
510 520 530 540 550
GVLISIGCLA MFVTMVTILL YKKHKTYKPI GNCTRNVVKG KGLSVFLSHA
560 570
KAPFSRGDRE KDPLLQDKPW ML
Length:572
Mass (Da):63,731
Last modified:July 5, 2004 - v1
Checksum:i99854F7773FF946C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061725 mRNA. Translation: AAH61725.1.
UniGeneiRn.13778.

Genome annotation databases

EnsembliENSRNOT00000011945; ENSRNOP00000011945; ENSRNOG00000008816.
UCSCiRGD:71008. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC061725 mRNA. Translation: AAH61725.1 .
UniGenei Rn.13778.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011945.

Proteomic databases

PaxDbi Q6P7C7.
PRIDEi Q6P7C7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011945 ; ENSRNOP00000011945 ; ENSRNOG00000008816 .
UCSCi RGD:71008. rat.

Organism-specific databases

RGDi 71008. Gpnmb.

Phylogenomic databases

eggNOGi NOG40272.
GeneTreei ENSGT00530000063573.
HOGENOMi HOG000252941.
HOVERGENi HBG051797.
InParanoidi Q6P7C7.
OMAi HTYVLNG.
OrthoDBi EOG7GXPB9.
PhylomeDBi Q6P7C7.
TreeFami TF334865.

Miscellaneous databases

PROi Q6P7C7.

Gene expression databases

Genevestigatori Q6P7C7.

Family and domain databases

Gene3Di 2.60.40.670. 1 hit.
InterProi IPR022409. PKD/Chitinase_dom.
IPR000601. PKD_dom.
[Graphical view ]
Pfami PF00801. PKD. 1 hit.
[Graphical view ]
SMARTi SM00089. PKD. 1 hit.
[Graphical view ]
SUPFAMi SSF49299. SSF49299. 1 hit.
PROSITEi PS50093. PKD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.

Entry informationi

Entry nameiGPNMB_RAT
AccessioniPrimary (citable) accession number: Q6P7C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3