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Q6P7B9

- ACOD2_RAT

UniProt

Q6P7B9 - ACOD2_RAT

Protein

Acyl-CoA desaturase 2

Gene

Scd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA.By similarity

    Catalytic activityi

    Stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + 2 H2O.

    Cofactori

    Iron.

    GO - Molecular functioni

    1. iron ion binding Source: InterPro
    2. stearoyl-CoA 9-desaturase activity Source: RGD

    GO - Biological processi

    1. fatty acid biosynthetic process Source: RGD
    2. myelination Source: RGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Keywords - Ligandi

    Iron

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acyl-CoA desaturase 2 (EC:1.14.19.1)
    Alternative name(s):
    Delta(9)-desaturase 2
    Short name:
    Delta-9 desaturase 2
    Fatty acid desaturase 2
    Stearoyl-CoA desaturase 2
    Gene namesi
    Name:Scd2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi621177. Scd2.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Acyl-CoA desaturase 2PRO_0000185401Add
    BLAST

    Proteomic databases

    PaxDbiQ6P7B9.
    PRIDEiQ6P7B9.

    PTM databases

    PhosphoSiteiQ6P7B9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6P7B9.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018090.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini2 – 7069CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini93 – 1019LumenalSequence Analysis
    Topological domaini119 – 21597CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini235 – 24915LumenalSequence AnalysisAdd
    BLAST
    Topological domaini273 – 35886CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei71 – 9222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 11817HelicalSequence AnalysisAdd
    BLAST
    Transmembranei216 – 23419HelicalSequence AnalysisAdd
    BLAST
    Transmembranei250 – 27223HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi119 – 1246Histidine box-1
    Motifi156 – 1605Histidine box-2
    Motifi297 – 3015Histidine box-3

    Domaini

    The histidine box domains may contain the active site and/or be involved in metal ion binding.

    Sequence similaritiesi

    Belongs to the fatty acid desaturase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1398.
    HOGENOMiHOG000270352.
    HOVERGENiHBG003367.
    InParanoidiQ6P7B9.
    KOiK00507.
    OrthoDBiEOG7ZPNKS.
    PhylomeDBiQ6P7B9.
    TreeFamiTF313251.

    Family and domain databases

    InterProiIPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view]
    PfamiPF00487. FA_desaturase. 1 hit.
    [Graphical view]
    PRINTSiPR00075. FACDDSATRASE.
    PROSITEiPS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6P7B9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPAHILQEIS GSYSATTTIT APPSGGQQNG GEKFEKNPHH WGADVRPEIK    50
    DDLYDPSYQD EEGPPPKLEY VWRNIVLMAL LHIGALYGIT LVPSCKVYTC 100
    LFAYLYYVIS ALGITAGAHR LWSHRTYKAR LPLRLFLIIA NTMAFQNDVY 150
    EWARDHRAHH KFSETHADPH NSRRGFFFSH VGWLLVRKHP AVKEKGGKLD 200
    MSDLKAEKLV MFQRRYYKPG LLLMCFILPT LVPWYCWGET FVNSLCVSTF 250
    LRYAVVLNAT WLVNSAAHLY GYRPYDKNIS SRENILVSMG AVGEGFHNYH 300
    HAFPYDYSAS EYRWHINFTT FFIDCMALLG LAYDRKRVSK AAVLARIKRT 350
    GEESCKSG 358
    Length:358
    Mass (Da):41,013
    Last modified:July 5, 2004 - v1
    Checksum:i24EAA2329011C4D9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti76 – 761V → I in BAA92436. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032243 mRNA. Translation: BAA92436.1.
    BC061737 mRNA. Translation: AAH61737.1.
    S75730 mRNA. Translation: AAB32826.1.
    RefSeqiNP_114029.1. NM_031841.1.
    UniGeneiRn.83595.

    Genome annotation databases

    GeneIDi83792.
    KEGGirno:83792.
    UCSCiRGD:621177. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB032243 mRNA. Translation: BAA92436.1 .
    BC061737 mRNA. Translation: AAH61737.1 .
    S75730 mRNA. Translation: AAB32826.1 .
    RefSeqi NP_114029.1. NM_031841.1.
    UniGenei Rn.83595.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018090.

    PTM databases

    PhosphoSitei Q6P7B9.

    Proteomic databases

    PaxDbi Q6P7B9.
    PRIDEi Q6P7B9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 83792.
    KEGGi rno:83792.
    UCSCi RGD:621177. rat.

    Organism-specific databases

    CTDi 6319.
    RGDi 621177. Scd2.

    Phylogenomic databases

    eggNOGi COG1398.
    HOGENOMi HOG000270352.
    HOVERGENi HBG003367.
    InParanoidi Q6P7B9.
    KOi K00507.
    OrthoDBi EOG7ZPNKS.
    PhylomeDBi Q6P7B9.
    TreeFami TF313251.

    Miscellaneous databases

    NextBioi 616377.

    Gene expression databases

    Genevestigatori Q6P7B9.

    Family and domain databases

    InterProi IPR005804. Fatty_acid_desaturase-1.
    IPR001522. Fatty_acid_desaturase-1_C.
    IPR015876. Fatty_acid_desaturase-1_core.
    [Graphical view ]
    Pfami PF00487. FA_desaturase. 1 hit.
    [Graphical view ]
    PRINTSi PR00075. FACDDSATRASE.
    PROSITEi PS00476. FATTY_ACID_DESATUR_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and tissue expression of rat stearoyl-CoA desaturase 2."
      Hoshino T., Ishiguro K., Ohtsu K.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    3. "Identification of novel mRNAs expressed in oligodendrocytes."
      Baba H., Fuss B., Watson J.B., Zane L.T., Macklin W.B.
      Neurochem. Res. 19:1091-1099(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-60.

    Entry informationi

    Entry nameiACOD2_RAT
    AccessioniPrimary (citable) accession number: Q6P7B9
    Secondary accession number(s): Q64066, Q9JMC9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3